No definition available.
Acquired clawhand, clubhand, clawfoot and clubfoot
M13_CLAWCLUBHANDFOOT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
186 |
4. Check minimum number of eventsNone |
186 |
5. Include endpointsNone |
186 |
6. Filter based on genotype QC (FinnGen only) |
186 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M21
- Name in latin
- Deformitas [acquisita] manus sive pedis, typus talipes
Similar endpoints
↥List of similar endpoints to
Acquired clawhand, clubhand, clawfoot and clubfoot
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1250 | 679 | 569 |
| Only index persons | 1221 | 666 | 555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 48.01 | 49.30 | 46.45 |
| Only index persons | 47.95 | 49.50 | 46.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 186 | 108 | 78 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | 50.62 | 48.81 | 53.13 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 164
- Matched controls
- 1639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
237.1
164
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
645.5
50.2
47
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
32.4
41.5
55
25
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
157.9
36.4
37
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
23.2
35.5
52
32
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
25.3
34.5
49
27
M19.0
ICD-10 Finland
Primary arthrosis of other joints
48.9
29.4
35
9
NH3EA
NOMESCO Finland
Feet X-ray examination with load
160.3
26.5
27
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
24.8
24.2
34
17
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
+∞
23.5
22
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
38.7
23.3
29
9
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
139.5
23.2
24
*
M25.5
ICD-10 Finland
Pain in joint
7.0
22.6
64
137
B01AB05
ATC
enoxaparin; parenteral
6.0
22.4
77
211
L16
ICPC
Ankle symptom/complaint
11.3
21.9
43
50
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
30.4
21.3
28
11
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
226.0
20.0
20
*
NH1FA
NOMESCO Finland
Weight-bearing X-ray of ankle
226.0
20.0
20
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
226.0
20.0
20
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
53.1
19.8
23
5
WX320
NOMESCO Finland
Spinalanesthesy
6.6
19.3
56
120
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
113.1
19.0
20
*
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
75.3
18.2
20
*
Q66.0
ICD-10 Finland
Talipes equinovarus
200.7
17.9
18
*
L17
ICPC
Foot/toe symptom/complaint
5.2
17.7
65
183
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
71.0
17.1
19
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
4.2
17.1
97
417
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
17.0
16
*
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
188.2
16.8
17
*
N03AX12
ATC
gabapentin; oral
6.4
16.8
48
99
SPAT1229
SPAT
Assessment of need for aid
15.1
16.4
27
21
M17.1
ICD-10 Finland
Other primary gonarthrosis
14.4
16.1
27
22
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
15.9
15
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
22.8
15.6
22
11
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
35.5
15.2
19
6
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
17.6
14.9
23
15
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
14.8
14
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
14.8
14
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
6.3
14.5
41
82
Z01.8
ICD-10 Finland
Other specified special examinations
4.5
14.0
57
173
N02AJ06
ATC
codeine and paracetamol; systemic
3.8
13.8
76
302
NHG22
NOMESCO Finland
Fusion of subtalar joint
54.6
13.1
15
*
Q66.7
ICD-10 Finland
Pes cavus
+∞
12.7
12
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.5
12.2
48
138
M16.1
ICD-10 Finland
Other primary coxarthrosis
50.7
12.1
14
*
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
10.9
11.7
22
23
NHL20
NOMESCO Finland
Myotomy or tenotomy of foot
+∞
11.6
11
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
128.6
11.6
12
*
M77.4
ICD-10 Finland
Metatarsalgia
9.2
11.6
24
30
WX702
NOMESCO Finland
Supraglottic ventilation device
10.4
11.4
22
24
NH1AD
NOMESCO Finland
Ankle and foot CT
22.0
11.4
16
8
SPAT1153
SPAT
Removal of sutures
3.5
11.3
65
257
N02AX02
ATC
tramadol; systemic, rectal
3.2
11.0
82
391
N02BE01
ATC
paracetamol; systemic, rectal
4.6
10.9
148
1091
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
9.9
10.7
21
24
M79.6
ICD-10 Finland
Pain in limb
3.3
10.6
68
290
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
13.3
10.6
18
15
ZXA00
NOMESCO Finland
Right side
3.7
10.6
52
181
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
117.1
10.5
11
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
35.0
10.5
13
*
L15
ICPC
Knee symptom/complaint
4.6
10.5
38
100
N03AX16
ATC
pregabalin; oral
3.9
10.4
48
158
TQW40
NOMESCO Finland
Remowal of suture of skin
7.4
10.2
24
37
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.4
10.1
58
227
M20.1
ICD-10 Finland
Hallux valgus (acquired)
18.2
10.1
15
9
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.2
9.8
40
118
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
105.8
9.5
10
*
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
23.3
9.5
13
6
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.6
9.5
47
164
G60.0
ICD-10 Finland
Hereditary motor and sensory neuropathy
+∞
9.5
9
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
9.5
9
*
M01AH05
ATC
etoricoxib; oral
2.8
9.3
103
611
NHL30
NOMESCO Finland
Suture or reinsertion of tendon of foot
39.0
9.1
11
*
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
7.4
9.0
21
32
ZXA05
NOMESCO Finland
Left side
3.5
9.0
45
158
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.7
8.9
31
78
M67.0
ICD-10 Finland
Short Achilles tendon (acquired)
52.8
8.8
10
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.9
8.7
24
46
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
3.1
8.6
54
223
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
5.7
8.4
24
48
75400
ICD-8 Finland
Clubfoot (congenital), Pes equino-varus adductus
+∞
8.4
8
*
7545B
ICD-9 Finland
Certain congenital musculoskeletal deformities, Varus deformities of feet[TALIPES EQUINOVARUS CONGENITUS]
+∞
8.4
8
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
8.4
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.3
8.3
31
84
WX110
NOMESCO Finland
Local anesthesy
2.8
8.0
125
875
SAA02
NOMESCO Finland
Basic examination of mouth
2.8
8.0
122
840
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
9.2
8.0
16
19
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
8.0
38
127
S92.3
ICD-10 Finland
Fracture of metatarsal bone
8.7
7.8
16
20
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
8.7
7.8
16
20
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
47.2
7.8
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.9
7.7
56
250
WX720
NOMESCO Finland
Own respiration
7.4
7.5
17
25
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
14.3
7.5
12
9
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
83.7
7.5
8
*
L84
ICD-10 Finland
Corns and callosities
10.1
7.4
14
15
M20.2
ICD-10 Finland
Hallux rigidus
+∞
7.3
7
*
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
+∞
7.3
7
*
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
7.3
7
*
M21.6
ICD-10 Finland
Other acquired deformities of ankle and foot
+∞
7.3
7
*
L28
ICPC
Limited function/disability (L)
4.3
7.3
27
72
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
12.8
7.2
12
10
A02BC05
ATC
esomeprazole; systemic
2.6
7.2
71
375
UJF32
NOMESCO Finland
Coloscopy
3.0
7.2
46
189
G56.0
ICD-10 Finland
Carpal tunnel syndrome
4.1
7.2
28
79
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.2
7.1
40
151
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.8
7.0
19
36
M01AH01
ATC
celecoxib; oral (coxibs)
3.5
6.9
33
110
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
11.6
6.9
12
11
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.0
6.8
18
33
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
23.6
6.7
9
*
L88
ICPC
Rheumatoid/seropositive arthritis
23.6
6.7
9
*
WX400
NOMESCO Finland
Inhalation anesthesy
7.4
6.7
15
22
B01AF01
ATC
rivaroxaban; oral
5.4
6.6
19
39
X59
ICD-10 Finland
Exposure to unspecified factor
3.1
6.6
38
146
M01AE03
ATC
ketoprofen; systemic, rectal
2.5
6.6
66
350
WX213
NOMESCO Finland
Lower leg blockade
72.5
6.5
7
*
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
72.5
6.5
7
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
72.5
6.5
7
*
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
72.5
6.5
7
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
72.5
6.5
7
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.2
6.5
19
40
L29
ICPC
Musculoskeletal sympt/complt other
6.2
6.3
16
28
WX704
NOMESCO Finland
Intubation
4.4
6.3
22
56
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
6.3
6
*
WX210
NOMESCO Finland
Plexus blockade of nervus ichiadicus
+∞
6.3
6
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
6.3
74
425
WX725
NOMESCO Finland
Noninvasive ventilation
6.0
6.2
16
29
S09
ICPC
Infected finger/toe
13.2
6.2
10
8
H3600, E103
ICD-10 Finland
NA
13.2
6.2
10
8
M02AA07
ATC
piroxicam; topical
2.5
6.1
60
310
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.8
6.1
43
185
L13
ICPC
Hip symptom/complaint
3.8
6.1
25
74
SPAT1234
SPAT
Support of social functional capacity
7.7
6.1
13
18
Mortality – FinRegistry
↥Association
Association between endpoint M13_CLAWCLUBHANDFOOT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_CLAWCLUBHANDFOOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_CLAWCLUBHANDFOOT – Acquired clawhand, clubhand, clawfoot and clubfoot
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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