No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1071 |
4. Check minimum number of eventsNone |
1071 |
5. Include endpointsNone |
1071 |
6. Filter based on genotype QC (FinnGen only) |
1071 |
Control definitions (FinnGen only)
- Control exclude
- M13_OTHERBONE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M94
- Name in latin
- Chondromalacia
Similar endpoints
↥List of similar endpoints to
Chondromalacia
based on the number of shared cases.
Similar with more cases:
- Chondropathies
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6397 | 3429 | 2943 |
| Only index persons | 6277 | 3389 | 2888 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 43.93 | 44.37 | 43.45 |
| Only index persons | 43.84 | 44.31 | 43.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1071 | 660 | 411 |
| Unadjusted period prevalence (%) | 0.21 | 0.22 | 0.18 |
| Median age at first event (years) | 46.35 | 45.13 | 48.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 979
- Matched controls
- 9790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M94.2
ICD-10 Finland
Chondromalacia
+∞
323.0
979
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
24.4
280.3
422
295
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
25.1
184.8
268
145
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
9.4
163.6
391
646
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
8.5
139.7
351
605
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
8.3
113.3
281
455
M22.4
ICD-10 Finland
Chondromalacia patellae
16.1
109.1
184
139
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
11.0
106.6
217
247
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
53.7
81.5
97
20
M17.1
ICD-10 Finland
Other primary gonarthrosis
4.5
81.2
354
1090
M23.8
ICD-10 Finland
Other internal derangements of knee
9.1
62.0
137
172
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
14.0
57.0
100
79
M01AX05
ATC
glucosamine; oral
3.8
56.7
290
979
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
4.3
50.3
212
594
M25.5
ICD-10 Finland
Pain in joint
2.9
48.5
411
1961
NG2AA
NOMESCO Finland
Patella X-ray examination
11.1
43.3
84
82
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
3.8
40.8
195
602
M01AH05
ATC
etoricoxib; oral
2.5
38.7
692
4794
NGT99
NOMESCO Finland
Other operation on knee or lower leg
106.9
38.0
41
*
WX320
NOMESCO Finland
Spinalanesthesy
2.7
33.5
280
1265
L15
ICPC
Knee symptom/complaint
2.7
31.4
264
1189
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
3.9
30.8
138
398
S83.2
ICD-10 Finland
Tear of meniscus, current
4.2
30.7
125
330
NK4EA
NOMESCO Finland
Joint X-ray examintion with load or wrench not elsewhere classified
19.1
29.0
44
24
M01AB05
ATC
diclofenac; systemic, rectal
2.3
28.7
729
5509
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
4.2
26.4
106
276
M01AE02
ATC
naproxen; oral, rectal
2.1
26.1
624
4485
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
25.1
504
3350
M09AX01
ATC
hyaluronic acid; parenteral
5.0
23.4
78
168
N02AX02
ATC
tramadol; systemic, rectal
1.9
21.1
444
2932
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.8
20.4
90
254
M23.3
ICD-10 Finland
Other meniscus derangements
7.5
19.9
47
65
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
4.5
19.9
72
169
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
2.9
19.7
130
494
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
9.6
18.7
38
41
M01AC06
ATC
meloxicam; systemic, rectal
1.9
18.2
399
2631
Z00.0
ICD-10 Finland
General medical examination
2.2
17.1
198
1012
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.1
17.0
98
341
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.6
16.6
128
531
N02BE01
ATC
paracetamol; systemic, rectal
2.1
15.6
840
7299
M79.6
ICD-10 Finland
Pain in limb
1.8
15.1
357
2376
M01AH01
ATC
celecoxib; oral (coxibs)
2.0
14.2
197
1081
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.7
13.8
100
402
N03AX16
ATC
pregabalin; oral
1.9
13.7
242
1452
1220
FHL
Arthroscopy
3.7
13.6
60
171
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.5
13.4
112
487
M24.2
ICD-10 Finland
Disorder of ligament
6.1
13.1
35
59
M01AE01
ATC
ibuprofen; systemic, rectal
2.2
12.5
893
8099
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
12.4
260
1644
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
12.2
184
1038
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.8
12.1
250
1572
NGE15
NOMESCO Finland
Incision fo capsule of knee joint, arthroscopic
18.3
12.1
18
10
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
3.0
12.0
69
239
ZXA05
NOMESCO Finland
Left side
1.8
11.8
236
1466
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
11.7
391
2829
NHE20
NOMESCO Finland
Plastic repair of capsule or ligament of ankle joint with transplant
19.2
11.6
17
9
A02BC05
ATC
esomeprazole; systemic
1.6
11.4
395
2874
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
11.4
372
2666
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
4.5
11.3
39
89
ZXA00
NOMESCO Finland
Right side
1.7
11.3
251
1612
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
6.9
11.2
27
40
NG1BA
NOMESCO Finland
Knee extensive X-ray examination
5.2
11.0
33
65
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
10.9
267
1761
J01DB01
ATC
cefalexin; oral
1.7
10.6
790
6946
M89.0
ICD-10 Finland
Algoneurodystrophy
+∞
10.4
10
*
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
10.4
10
*
1223
FHL
Arthroscopy and articular cartilage surgery
7.8
10.4
23
30
H25.8
ICD-10 Finland
Other senile cataract
2.5
10.4
80
333
B01AX06
ATC
[U] rivaroxaban; oral
4.8
10.2
33
71
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
4.0
10.1
39
100
M01AX17
ATC
nimesulide; oral
1.7
10.0
231
1491
ZXD20
NOMESCO Finland
Day surgery
2.0
10.0
133
713
X58
ICD-10 Finland
Exposure to other specified factors
2.0
10.0
140
765
B01AF01
ATC
rivaroxaban; oral
2.1
9.8
111
558
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
9.6
118
612
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
9.6
258
1739
M01AE11
ATC
tiaprofenic acid; oral, rectal
3.3
9.5
47
148
SPAT1153
SPAT
Removal of sutures
1.6
9.4
286
1988
WX111
NOMESCO Finland
Local infiltration anesthesia
3.7
9.4
40
112
NBG00
NOMESCO Finland
Plastic operation on acromioclavicular joint
5.4
9.4
27
51
NBG10
NOMESCO Finland
Acromioplastia
4.0
9.4
36
92
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
3.1
9.3
50
168
M54.5
ICD-10 Finland
Low back pain
1.6
9.1
319
2297
R05FA02
ATC
opium derivatives and expectorants; systemic
1.5
9.0
373
2791
1222
FHL
Arthroscopy and synovial surgery
7.5
9.0
20
27
XG410
NOMESCO Finland
Flow-volume spirometry
3.0
8.7
50
174
M02AA07
ATC
piroxicam; topical
1.6
8.7
332
2434
M03BX02
ATC
tizanidine; oral
1.5
8.7
621
5234
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.6
325
2376
L08
ICPC
Shoulder symptom/complaint
1.7
8.6
176
1092
M70.6
ICD-10 Finland
Trochanteric bursitis
2.0
8.6
114
611
J01AA02
ATC
doxycycline; systemic
1.6
8.4
750
6618
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.2
8.3
80
373
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
8.3
96
486
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
3.6
8.2
36
104
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
8.2
148
881
M71.2
ICD-10 Finland
Synovial cyst of popliteal space [Baker]
3.3
8.1
39
122
WZA90
NOMESCO Finland
Other doctors statement
1.6
8.0
206
1368
N02AA05
ATC
oxycodone; systemic
1.9
7.9
111
607
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
7.9
605
5122
M01AH02
ATC
rofecoxib; oral
1.9
7.8
121
683
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
7.8
461
3693
M01AB16
ATC
aceclofenac; oral
3.1
7.8
40
131
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.5
7.8
561
4682
M01AB55
ATC
diclofenac, combinations; oral
2.3
7.7
66
293
T93.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of lower limb
7.5
7.7
17
23
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.7
404
3159
M22.2
ICD-10 Finland
Patellofemoral disorders
18.5
7.6
11
6
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.8
7.6
145
880
M25.2
ICD-10 Finland
Flail joint
5.5
7.6
21
39
S83.4
ICD-10 Finland
Sprain and strain involving (fibular)(tibial) collateral ligament of knee
3.0
7.5
40
135
H02AB06
ATC
prednisolone; systemic
1.5
7.5
414
3268
NF1AA
NOMESCO Finland
Hip X-ray examination
2.2
7.5
72
338
A02BC02
ATC
pantoprazole; systemic
1.5
7.5
591
5006
J01FA10
ATC
azithromycin; systemic
1.4
7.3
555
4653
M02AA10
ATC
ketoprofen; topical
1.7
7.2
150
934
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
7.2
529
4397
R06AE07
ATC
cetirizine; oral
1.5
7.2
395
3103
M77.1
ICD-10 Finland
Lateral epicondylitis
2.1
7.2
83
419
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
7.1
72
346
H02BX01
ATC
methylprednisolone, combinations; systemic
2.7
7.0
45
171
9243
FHL
Plastic of the patella and its tendons
6.4
7.0
17
27
M01AC01
ATC
piroxicam; systemic, rectal
1.8
6.9
127
763
M23
ICD-10 Finland
Internal derangement of knee
3.8
6.8
27
73
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.7
6.8
134
820
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.1
6.7
24
59
W19
ICD-10 Finland
Unspecified fall
2.0
6.7
82
425
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
6.7
353
2743
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
3.4
6.7
30
90
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.9
6.6
91
497
00000
ICD-8 Finland
NA
5.7
6.5
17
30
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
6.4
494
4110
N03AX12
ATC
gabapentin; oral
1.7
6.4
141
892
WX002
NOMESCO Finland
Sedation and analgesia
1.6
6.4
172
1148
M67.2
ICD-10 Finland
Synovial hypertrophy, not elsewhere classified
14.4
6.4
10
7
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.5
6.4
48
198
M76.3
ICD-10 Finland
Iliotibial band syndrome
8.2
6.3
13
16
NG1BG
SPAT
NA
3.5
6.3
27
78
7188E
ICD-9 Finland
Other derangement of joint, Other joint derangement, not elsewhere classified[MB ARTICULI, LIGAM ET CARTILAG AL DEF,LONKKANIVEL]
11.1
6.3
11
10
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
6.2
673
5936
NGF40
NOMESCO Finland
Repair of defect of cartilage in the knee joint with transplant
26.9
6.2
8
*
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.2
199
1384
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.7
6.1
38
143
M13.9
ICD-10 Finland
Arthritis, unspecified
2.1
6.1
67
333
R03BA05
ATC
fluticasone; inhalant
1.6
6.1
163
1085
WX290
NOMESCO Finland
Other blockade of nerve
1.4
6.1
415
3365
1225
FHL
Arthroscopy and other therapeutic procedure
5.2
6.0
17
33
Mortality – FinRegistry
↥Association
Association between endpoint M13_CHONDROMALACIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CHONDROMALACIA | 0.686 [0.57, 0.83] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.102 |
During the follow-up period (1.1.1998 — 31.12.2019), 116 out of 3100 females with M13_CHONDROMALACIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CHONDROMALACIA | 0.576 [0.49, 0.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 2662 males with M13_CHONDROMALACIA died.
Mortality risk
Mortality risk for people of age
years, who have M13_CHONDROMALACIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.059% | 0.107% |
| 5 | 0.404% | 0.732% |
| 10 | 0.936% | 1.884% |
| 15 | 1.833% | 3.6% |
| 20 | 3.238% | 6.105% |
Relationships between endpoints
↥Index endpoint: M13_CHONDROMALACIA – Chondromalacia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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