cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
936 |
4. Check minimum number of eventsNone |
936 |
5. Include endpointsNone |
936 |
6. Filter based on genotype QC (FinnGen only) |
936 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M24
- Name in latin
- Alia vitia cartilaginum articularium
Similar endpoints
↥List of similar endpoints to
Other articular cartilage disorders
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7026 | 3215 | 3754 |
| Only index persons | 6071 | 2847 | 3224 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.09 | 0.10 |
| Only index persons | 0.11 | 0.10 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 37.19 | 39.65 | 34.93 |
| Only index persons | 35.55 | 37.92 | 33.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 936 | 460 | 476 |
| Unadjusted period prevalence (%) | 0.18 | 0.16 | 0.21 |
| Median age at first event (years) | 35.18 | 34.38 | 35.96 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 869
- Matched controls
- 8689
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M24.1
ICD-10 Finland
Other articular cartilage disorders
+∞
297.4
268
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
37.1
222.3
289
115
72498
ICD-8 Finland
Internal derangement of joint, Alio loco definito
+∞
212.4
195
*
72499
ICD-8 Finland
Internal derangement of joint, Derangement of other joints
+∞
207.8
191
*
7180F
ICD-9 Finland
Other derangement of joint, Articular cartilage disorder[NIVELRUSTON SAIRAUS,POLVI]
+∞
168.3
156
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
153.8
143
*
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
114.8
134.8
144
15
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
22.8
130.6
194
108
1220
FHL
Arthroscopy
46.1
124.7
153
40
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
58.0
109.8
129
26
1223
FHL
Arthroscopy and articular cartilage surgery
1025.0
95.8
92
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
29.0
89.9
123
49
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
52.9
89.6
107
23
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
16.8
88.1
145
102
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
16.8
88.1
145
102
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
314.6
85.2
85
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
64.8
80.7
93
16
M01AX05
ATC
glucosamine; oral
6.2
76.5
232
480
M25.5
ICD-10 Finland
Pain in joint
5.1
76.0
287
769
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
74.0
70
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
34.8
67.7
88
28
N02AX02
ATC
tramadol; systemic, rectal
3.6
66.9
452
2014
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
133.2
58.6
62
5
M22.4
ICD-10 Finland
Chondromalacia patellae
75.1
55.9
63
9
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
91.9
54.6
60
7
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.1
53.3
449
2226
M09AX01
ATC
hyaluronic acid; parenteral
18.2
50.9
80
48
M01AH05
ATC
etoricoxib; oral
2.9
49.9
550
3203
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
48.4
46
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
7.5
47.3
118
179
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
45.2
43
*
WX320
NOMESCO Finland
Spinalanesthesy
3.8
43.7
211
668
L15
ICPC
Knee symptom/complaint
4.0
43.6
201
611
M75.1
ICD-10 Finland
Rotator cuff syndrome
3.4
42.9
253
940
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
63.3
41.6
48
8
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
33.7
41.5
54
17
1221
FHL
Arthroscopy and meniscus surgery
25.9
40.2
56
23
M13.9
ICD-10 Finland
Arthritis, unspecified
12.4
39.2
72
63
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
71.4
36.3
41
6
L90
ICPC
Osteoarthrosis of knee
11.6
36.0
68
63
N02BE01
ATC
paracetamol; systemic, rectal
3.2
35.7
754
5853
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
15.8
35.3
58
39
M01AH01
ATC
celecoxib; oral (coxibs)
3.5
35.0
184
615
M20.1
ICD-10 Finland
Hallux valgus (acquired)
12.5
34.6
63
54
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
34.6
33
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
+∞
34.6
33
*
ZXA05
NOMESCO Finland
Left side
2.9
34.1
245
1021
ZXA00
NOMESCO Finland
Right side
2.9
33.8
261
1135
M79.6
ICD-10 Finland
Pain in limb
2.6
31.5
310
1549
N03AX16
ATC
pregabalin; oral
2.9
30.9
224
928
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
5.9
30.7
90
168
B01AB05
ATC
enoxaparin; parenteral
2.7
30.5
269
1256
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.3
29.8
82
141
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
6.5
29.1
78
129
N03AX12
ATC
gabapentin; oral
3.4
29.0
158
535
1225
FHL
Arthroscopy and other therapeutic procedure
26.1
29.0
40
16
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
155.0
28.8
30
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
32.1
28.3
37
12
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
28.3
27
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
5.2
27.9
90
188
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
27.4
321
1726
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.6
27.4
133
411
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
27.2
26
*
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
5.7
27.2
81
154
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
144.4
26.8
28
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
6.6
26.1
69
112
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.0
26.0
110
302
NFF25
NOMESCO Finland
Cleaning of hip joint, arthroscopic
268.0
25.8
26
*
M03BX02
ATC
tizanidine; oral
2.1
25.3
546
3827
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
25.1
24
*
S83.2
ICD-10 Finland
Tear of meniscus, current
5.7
24.9
74
140
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
8.4
24.3
54
68
M01AB05
ATC
diclofenac; systemic, rectal
2.1
24.0
577
4190
B01AX06
ATC
[U] rivaroxaban; oral
69.4
23.9
27
*
P01BA02
ATC
hydroxychloroquine; oral
8.0
23.6
54
71
B01AF01
ATC
rivaroxaban; oral
3.9
23.5
104
296
M01AC06
ATC
meloxicam; systemic, rectal
2.2
22.8
309
1747
9254
FHL
Arthrotomy (includes biopsy, revision, loose removal, fixation, and similar procedures)
41.3
22.8
28
7
M17.5
ICD-10 Finland
Other secondary gonarthrosis
235.8
22.7
23
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
9.6
22.5
46
50
M23.8
ICD-10 Finland
Other internal derangements of knee
16.3
22.5
36
23
S18
ICPC
Laceration/cut
2.1
21.8
351
2127
84400
ICD-8 Finland
Sprains and strains of knee and leg
14.5
21.0
35
25
1222
FHL
Arthroscopy and synovial surgery
61.6
21.0
24
*
M25.2
ICD-10 Finland
Flail joint
+∞
20.9
20
*
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
214.8
20.7
21
*
9243
FHL
Plastic of the patella and its tendons
49.2
20.2
24
5
M01AX17
ATC
nimesulide; oral
2.3
20.1
215
1076
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
75.2
19.8
22
*
H02AB06
ATC
prednisolone; systemic
2.0
19.8
376
2408
M02AA07
ATC
piroxicam; topical
2.1
19.4
307
1826
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
16.0
19.4
31
20
X58
ICD-10 Finland
Exposure to other specified factors
2.8
18.9
129
504
71301
ICD-8 Finland
Osteo-arthritis and allied conditions, Arthritis (arthrosis) genus
+∞
18.8
18
*
L13
ICPC
Hip symptom/complaint
3.0
18.7
118
436
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
193.9
18.6
19
*
R03AC02
ATC
salbutamol; inhalant
1.9
18.5
433
2973
ACC51
NOMESCO Finland
Release of median nerve
4.0
18.5
77
208
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
11.4
17.8
33
30
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
68.0
17.8
20
*
M10.9
ICD-10 Finland
Gout, unspecified
5.9
17.8
50
89
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
17.8
17
*
J01AA02
ATC
doxycycline; systemic
2.0
17.7
670
5430
M24.2
ICD-10 Finland
Disorder of ligament
97.0
17.6
19
*
NBB20
NOMESCO Finland
Primary total prosthetic replacement of humero-scapular joint
97.0
17.6
19
*
M19.2
ICD-10 Finland
Other secondary arthrosis
183.4
17.6
18
*
M20.2
ICD-10 Finland
Hallux rigidus
42.9
17.3
21
5
M01AE02
ATC
naproxen; oral, rectal
1.9
17.3
455
3225
N02AA05
ATC
oxycodone; systemic
2.7
17.2
126
512
R4110
NOMESCO Finland
Physiotherapy
2.1
17.2
227
1241
A02BC02
ATC
pantoprazole; systemic
1.9
17.1
530
3966
M01AE03
ATC
ketoprofen; systemic, rectal
1.9
16.9
321
2021
J01DB01
ATC
cefalexin; oral
2.0
16.8
675
5525
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
4.9
16.7
55
118
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
16.5
158
741
N06AA09
ATC
amitriptyline; systemic
3.1
16.4
97
342
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
4.0
16.4
67
178
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
40.9
16.4
20
5
L08
ICPC
Shoulder symptom/complaint
2.3
16.2
163
782
J01DA01
ATC
[U] cefalexin; systemic
1.8
16.2
519
3896
M54.5
ICD-10 Finland
Low back pain
2.0
16.2
264
1564
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
16.1
84
272
7180A
ICD-9 Finland
Other derangement of joint, Articular cartilage disorder[NIVELRUSTON SAIRAUS,OLKANIVEL]
+∞
15.7
15
*
72490
ICD-8 Finland
NA
+∞
15.7
15
*
NG2AA
NOMESCO Finland
Patella X-ray examination
19.6
15.6
23
12
M24.4
ICD-10 Finland
Recurrent dislocation and subluxation of joint
162.7
15.5
16
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
162.7
15.5
16
*
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
38.8
15.4
19
5
NG1DA
NOMESCO Finland
X-ray of knees
38.8
15.4
19
5
NGF00
NOMESCO Finland
Excision of plica of synovy of knee
38.8
15.4
19
5
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
15.4
310
1980
A02BC03
ATC
lansoprazole; oral
2.0
15.2
233
1344
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
6.5
15.2
39
62
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
2.5
15.1
132
588
L17
ICPC
Foot/toe symptom/complaint
2.1
15.1
196
1058
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.2
15.0
80
264
L04AA13
ATC
leflunomide; oral
32.3
14.8
19
6
1224
FHL
Arthroscopy and loose removal
57.7
14.8
17
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
14.7
236
1381
M19.9
ICD-10 Finland
Arthrosis, unspecified
7.9
14.7
33
43
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.8
14.7
49
107
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
14.6
14
*
NGF40
NOMESCO Finland
Repair of defect of cartilage in the knee joint with transplant
+∞
14.6
14
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
14.6
14
*
M01AE01
ATC
ibuprofen; systemic, rectal
2.1
14.5
748
6478
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
13.7
14.3
24
18
M54.4
ICD-10 Finland
Lumbago with sciatica
2.3
14.2
137
645
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.3
14.0
73
237
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
3.7
14.0
62
177
SPAT1153
SPAT
Removal of sutures
1.9
13.8
248
1507
A02BC01
ATC
omeprazole; systemic
2.0
13.7
220
1283
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.5
13.6
64
192
9271
FHL
Hallux surgery
76.3
13.6
15
*
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
142.0
13.5
14
*
M70.6
ICD-10 Finland
Trochanteric bursitis
2.8
13.4
87
328
72908
ICD-8 Finland
Other diseases of joint, Alii definiti
18.6
13.4
20
11
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.7
13.4
59
168
L40.5
ICD-10 Finland
Arthropathic psoriasis
21.5
13.4
19
9
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
13.3
211
1221
NF1AA
NOMESCO Finland
Hip X-ray examination
4.2
13.3
51
128
A02BC05
ATC
esomeprazole; systemic
1.8
13.3
332
2250
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
13.3
278
1780
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.0
13.2
32
47
S83.5
ICD-10 Finland
Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
5.3
13.2
40
79
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
13.1
68
221
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
12.8
251
1567
J01FA10
ATC
azithromycin; systemic
1.7
12.8
458
3445
M02AA10
ATC
ketoprofen; topical
2.3
12.8
125
588
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
70.9
12.6
14
*
M01AB08
ATC
etodolac; oral
3.0
12.6
74
262
SPAT1202
SPAT
Intra-articular injection
8.9
12.6
26
30
NGC60
NOMESCO Finland
Exchange or addition of patellar part
+∞
12.5
12
*
212
Kela drug reimbursment
Gout
+∞
12.5
12
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
12.5
12
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
12.5
12
*
M23.4
ICD-10 Finland
Loose body in knee
+∞
12.5
12
*
NGF20
NOMESCO Finland
Operation for osteochondritis of knee, open
131.7
12.5
13
*
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
9.2
12.3
25
28
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.4
12.3
60
186
N06AX21
ATC
duloxetine; oral
2.6
12.2
90
366
NGE35
NOMESCO Finland
Plastic repair of ligament of knee not using prosthetic material, anterior cruciate, arthroscopic
7.1
12.2
29
42
M01AE11
ATC
tiaprofenic acid; oral, rectal
4.8
12.1
40
87
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
27.1
12.1
16
6
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
8.8
12.1
25
29
R03DC03
ATC
montelukast; oral
2.2
11.9
133
665
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
4.1
11.8
45
113
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.5
11.7
91
382
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
16.7
11.7
18
11
M35.7
ICD-10 Finland
Hypermobility syndrome
16.7
11.7
18
11
M48.0
ICD-10 Finland
Spinal stenosis
2.5
11.7
93
395
A07EC01
ATC
sulfasalazine; oral, rectal
4.0
11.6
46
120
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
11.3
11.6
21
19
L89
ICPC
Osteoarthrosis of hip
8.8
11.6
24
28
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.8
11.5
49
136
M22.1
ICD-10 Finland
Recurrent subluxation of patella
+∞
11.5
11
*
NGK30
NOMESCO Finland
Angulation, rotation or displacement osteotomy of knee or lower leg
+∞
11.5
11
*
7174A
ICD-9 Finland
Internal derangement of knee, Derangement of lateral meniscus
+∞
11.5
11
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
11.5
11
*
D07AC01
ATC
betamethasone; topical
1.7
11.5
271
1787
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
121.5
11.4
12
*
WX110
NOMESCO Finland
Local anesthesy
1.7
11.4
550
4429
NHF25
NOMESCO Finland
Operation for debridement of ankle joint, arthroscopic
15.3
11.3
18
12
A02BA02
ATC
ranitidine; systemic
2.0
11.2
163
911
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
6.2
11.1
29
48
L88
ICPC
Rheumatoid/seropositive arthritis
10.2
11.0
21
21
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
43.9
10.9
13
*
R01AD12
ATC
fluticasone furoate; nasal
1.8
10.9
220
1375
M04AA01
ATC
allopurinol; systemic
2.5
10.9
88
377
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
12.1
10.9
19
16
J04AB02
ATC
rifampicin; systemic
12.1
10.9
19
16
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
10.9
138
730
NGU20
NOMESCO Finland
Removal of internal fixation device from knee or lower leg
8.4
10.8
23
28
S43.0
ICD-10 Finland
Dislocation of shoulder joint
4.3
10.8
39
94
M22.0
ICD-10 Finland
Recurrent dislocation of patella
60.7
10.6
12
*
TNG10
NOMESCO Finland
Puncture of knee
60.7
10.6
12
*
9255
FHL
Joint auger removal
60.7
10.6
12
*
NGT60
NOMESCO Finland
Forcible manipulation of knee joint
60.7
10.6
12
*
M01AH02
ATC
rofecoxib; oral
2.4
10.6
94
420
72221
ICD-8 Finland
Osteochondrosis, Dissecans
111.2
10.4
11
*
M24.8
ICD-10 Finland
Other specific joint derangements, not elsewhere classified
111.2
10.4
11
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
10.4
10
*
7180G
ICD-9 Finland
Other derangement of joint, Articular cartilage disorder[NIVELRUSTON SAIRAUS,NILKKA]
+∞
10.4
10
*
NGC20
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, normal prosthesis
+∞
10.4
10
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
10.4
10
*
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
10.4
10
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
10.4
10
*
E8859
ICD-8 Finland
Fall on same level from slipping, stumbling or tripping
4.0
10.4
41
107
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
12.2
10.4
18
15
L16
ICPC
Ankle symptom/complaint
2.5
10.4
79
328
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
9.7
10.3
20
21
L29
ICPC
Musculoskeletal sympt/complt other
2.9
10.3
63
228
M93.2
ICD-10 Finland
Osteochondritis dissecans
23.7
10.3
14
6
G56.2
ICD-10 Finland
Lesion of ulnar nerve
4.3
10.3
37
89
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
5.7
10.2
28
50
S80.0
ICD-10 Finland
Contusion of knee
3.2
10.1
53
174
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
10.1
89
400
WZA00
NOMESCO Finland
Short statement of of health and health related matters
3.5
10.0
46
137
9241
FHL
Due to repeated dislocation of the shoulder joint plastic
40.5
10.0
12
*
WZA90
NOMESCO Finland
Other doctors statement
1.9
10.0
162
940
J01FA06
ATC
roxithromycin; oral
1.6
10.0
321
2291
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
5.3
9.9
29
56
M77.4
ICD-10 Finland
Metatarsalgia
3.7
9.8
42
118
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
26.3
9.8
13
5
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.9
9.8
20
23
NBF25
NOMESCO Finland
Operation for humeroscapular osteochondritis, arthroscopic
6.6
9.8
24
37
H02AB04
ATC
methylprednisolone; systemic
2.1
9.7
116
598
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
9.7
137
756
M18.0
ICD-10 Finland
Primary arthrosis of first carpometacarpal joints, bilateral
55.6
9.7
11
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
9.6
129
696
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.3
9.6
48
153
RD211
NOMESCO Finland
NA
3.4
9.6
46
142
M01AB55
ATC
diclofenac, combinations; oral
3.1
9.5
51
171
ZX140
NOMESCO Finland
Intra articular
101.0
9.4
10
*
7183A
ICD-9 Finland
Other derangement of joint, Recurrent dislocation of joint[LUXATIO HABITUALIS, OLKANIVEL]
+∞
9.4
9
*
72904
ICD-8 Finland
Other diseases of joint, Dislocatio spontanea
+∞
9.4
9
*
NHG82
NOMESCO Finland
Fusion of other tarsal joint
+∞
9.4
9
*
M03BC01
ATC
orphenadrine (citrate); systemic
1.8
9.4
180
1104
M23.3
ICD-10 Finland
Other meniscus derangements
21.9
9.4
13
6
R06AE07
ATC
cetirizine; oral
1.6
9.3
332
2421
S93.4
ICD-10 Finland
Sprain and strain of ankle
2.5
9.3
75
321
M79.1
ICD-10 Finland
Myalgia
2.2
9.2
95
459
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.2
9.2
46
147
Z50.1
ICD-10 Finland
Other physical therapy
3.2
9.2
46
147
M10.0
ICD-10 Finland
Idiopathic gout
7.8
9.2
20
26
R01AD01
ATC
beclometasone; nasal
1.9
9.1
131
725
R06.0
ICD-10 Finland
Dyspnoea
1.8
9.1
176
1079
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
11.6
9.1
16
14
NF1DA
NOMESCO Finland
X-ray of hips
11.6
9.1
16
14
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
7.1
9.1
21
30
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.4
9.0
42
127
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
9.0
541
4468
M19.8
ICD-10 Finland
Other specified arthrosis
5.3
9.0
26
50
R03AC03
ATC
terbutaline; inhalant
2.1
8.8
105
541
TQW40
NOMESCO Finland
Remowal of suture of skin
2.7
8.8
59
228
E883A
ICD-9 Finland
Fall into hole or other opening in surface
3.1
8.7
46
153
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
50.5
8.7
10
*
RF210
NOMESCO Finland
NA
5.3
8.7
25
48
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.0
8.6
108
566
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
8.6
471
3788
M01AB01
ATC
indometacin; systemic, rectal
2.6
8.6
62
251
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.3
8.6
79
363
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
20.2
8.5
12
6
T93.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of lower limb
20.2
8.5
12
6
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
7.4
8.5
19
26
R4120
NOMESCO Finland
Occupational therapy
2.8
8.5
53
196
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
2.3
8.4
75
337
9056A
ICD-9 Finland
Late effects of musculoskeletal and connective tissue injuries, Late effect of dislocation
90.8
8.4
9
*
NGH20
NOMESCO Finland
Reduction of dislocation of knee joint, open
90.8
8.4
9
*
J01FF01
ATC
clindamycin; systemic
1.7
8.4
197
1280
G47.3
ICD-10 Finland
Sleep apnoea
1.8
8.4
168
1039
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
6.3
8.3
21
34
NGE15
NOMESCO Finland
Incision fo capsule of knee joint, arthroscopic
+∞
8.3
8
*
NGC99
NOMESCO Finland
Other secondary prosthetic replacement inknee joint, other or unspecified
+∞
8.3
8
*
NGC00
NOMESCO Finland
Exchange of a loose part of prosthesis in knee joint
+∞
8.3
8
*
M23.5
ICD-10 Finland
Chronic instability of knee
+∞
8.3
8
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
+∞
8.3
8
*
7188E
ICD-9 Finland
Other derangement of joint, Other joint derangement, not elsewhere classified[MB ARTICULI, LIGAM ET CARTILAG AL DEF,LONKKANIVEL]
+∞
8.3
8
*
Z71.8
ICD-10 Finland
Other specified counselling
1.8
8.3
169
1049
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
4.5
8.3
28
64
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
8.2
157
960
J01CA04
ATC
amoxicillin; systemic
1.6
8.1
627
5417
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
8.1
197
1292
9057A
ICD-9 Finland
Late effects of musculoskeletal and connective tissue injuries, Late effect of sprain and strain without mention of tendon injury
17.3
8.1
12
7
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
17.3
8.1
12
7
N04BC05
ATC
pramipexole; oral
2.6
8.1
56
222
L03
ICPC
Low back symptom/complaint
1.8
8.0
162
1003
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
22.2
8.0
11
5
N02AC04
ATC
dextropropoxyphene; oral
4.0
8.0
30
76
NBG10
NOMESCO Finland
Acromioplastia
4.8
8.0
25
53
R05
ICD-10 Finland
Cough
1.8
8.0
139
822
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.2
7.9
39
124
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.7
7.9
52
200
L28
ICPC
Limited function/disability (L)
2.0
7.8
98
512
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
7.8
151
922
S83.0
ICD-10 Finland
Dislocation of patella
8.5
7.8
16
19
M15
ICD-10 Finland
Polyarthrosis
4.1
7.8
29
73
L04AB01
ATC
etanercept; parenteral
15.2
7.7
12
8
M96.0
ICD-10 Finland
Pseudarthrosis after fusion or arthrodesis
45.4
7.7
9
*
R01AD09
ATC
mometasone; nasal
1.5
7.7
334
2528
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.6
318
2381
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.5
285
2087
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
7.5
187
1233
WX002
NOMESCO Finland
Sedation and analgesia
1.8
7.5
138
830
SPAT1212
SPAT
Extensive examination of musculoskeletal system
2.4
7.4
60
257
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.7
7.4
47
177
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
4.2
7.3
26
63
A01
ICPC
Pain general/multiple sites
2.5
7.3
54
221
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
7.3
143
875
M16.3
ICD-10 Finland
Other dysplastic coxarthrosis
+∞
7.3
7
*
NK4EA
NOMESCO Finland
Joint X-ray examintion with load or wrench not elsewhere classified
+∞
7.3
7
*
NG1AD
NOMESCO Finland
Knee CT examination
9.5
7.3
14
15
M01AC01
ATC
piroxicam; systemic, rectal
1.9
7.3
102
560
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
7.3
102
561
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
7.2
79
392
M17.2
ICD-10 Finland
Post-traumatic gonarthrosis, bilateral
30.3
7.2
9
*
L20
ICPC
Joint symptom/complaint NOS
4.1
7.1
26
65
ZXA10
NOMESCO Finland
Bilateral
1.8
7.1
132
798
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
6.1
7.1
18
30
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
6.1
7.1
18
30
E0000UV
ATC
NA
1.5
7.1
273
2003
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.1
374
2936
WX200
NOMESCO Finland
Interscalenous plexus blockade
4.8
7.0
22
47
M16
ICD-10 Finland
Coxarthrosis [arthrosis of hip]
4.8
7.0
22
47
R52.1
ICD-10 Finland
Chronic intractable pain
10.1
7.0
13
13
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
7.0
391
3100
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.5
6.9
30
87
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
6.9
66
309
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
5.5
6.9
19
35
WX204
NOMESCO Finland
Axillary plexus blockaced
4.1
6.9
25
62
NB1AD
NOMESCO Finland
Shoulder CT examination
7.6
6.9
15
20
R03AK07
ATC
formoterol and budesonide; inhalant
1.7
6.9
146
918
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
13.9
6.9
11
8
M18.1
ICD-10 Finland
Other primary arthrosis of first carpometacarpal joint
13.9
6.9
11
8
8449X
ICD-9 Finland
Sprains and strains of knee and leg, Unspecified site of knee and leg
13.9
6.9
11
8
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
13.9
6.9
11
8
XA402
NOMESCO Finland
ENMG
4.2
6.8
24
58
NGB10
NOMESCO Finland
Primary partial prosthetic replacement of knee joint, demi prosthesis
40.3
6.8
8
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
40.3
6.8
8
*
9244
FHL
Plastic or reconstruction of ligaments of the knee other than the lumbar region
16.8
6.7
10
6
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.7
203
1400
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
6.7
210
1464
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
6.6
116
684
S83.3
ICD-10 Finland
Tear of articular cartilage of knee, current
7.9
6.6
14
18
WX702
NOMESCO Finland
Supraglottic ventilation device
2.9
6.6
38
134
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.6
6.6
44
172
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.9
6.6
25
65
M01AH03
ATC
valdecoxib; oral
2.4
6.6
53
229
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
6.6
58
262
RF410
NOMESCO Finland
NA
8.8
6.6
13
15
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.7
6.5
42
159
92700
ICD-8 Finland
Contusion of hip, thigh, leg and ankle, Current injury
10.1
6.5
12
12
H02AB07
ATC
prednisone; oral
1.9
6.5
96
537
AA1AD
NOMESCO Finland
CT of head and brain
1.6
6.5
176
1182
M54.3
ICD-10 Finland
Sciatica
2.5
6.5
47
193
L01
ICPC
Neck symptom/complaint
1.9
6.5
90
492
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
5.4
6.5
18
34
NFB50
NOMESCO Finland
Primary total prosthetic replacement of hip joint using cement
70.3
6.4
7
*
NGF30
NOMESCO Finland
Fixation of loose body of joint of knee
70.3
6.4
7
*
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
14.4
6.4
10
7
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
14.4
6.4
10
7
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.5
6.4
244
1777
J01FA09
ATC
clarithromycin; systemic
1.5
6.4
231
1661
NH1AD
NOMESCO Finland
Ankle and foot CT
5.0
6.4
19
39
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
5.0
6.4
19
39
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.5
6.3
46
189
L04AB04
ATC
adalimumab; parenteral
8.2
6.3
13
16
R03BA05
ATC
fluticasone; inhalant
1.7
6.3
130
810
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.6
6.3
26
73
SPAT1229
SPAT
Assessment of need for aid
2.4
6.3
51
221
D07AB02
ATC
hydrocortisone butyrate; topical
1.6
6.3
204
1432
M54.6
ICD-10 Finland
Pain in thoracic spine
2.5
6.3
48
202
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.3
54
242
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.3
288
2183
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
+∞
6.3
6
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
+∞
6.3
6
*
7183F
ICD-9 Finland
Other derangement of joint, Recurrent dislocation of joint[LUXATIO HABITUALIS, POLVI]
+∞
6.3
6
*
NG2CA
NOMESCO Finland
X-ray of patella with specialised projection
+∞
6.3
6
*
7176A
ICD-9 Finland
Internal derangement of knee, Loose body in knee
+∞
6.3
6
*
NBC40
NOMESCO Finland
Secondary implantation of prosthesis in humeroscapular joint, both parts
+∞
6.3
6
*
NDG30
NOMESCO Finland
Fusion of wrist, total
+∞
6.3
6
*
7152F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, secondary[OSTEORTHROSIS SECUNDARIA,POLVI]
+∞
6.3
6
*
7180E
ICD-9 Finland
Other derangement of joint, Articular cartilage disorder[NIVELRUSTON SAIRAUS,LONKKANIVEL]
+∞
6.3
6
*
NB1BG
NOMESCO Finland
Shoulder and humerus MRI examination with high intensity magnet
4.8
6.2
19
40
M94.2
ICD-10 Finland
Chondromalacia
26.9
6.2
8
*
NBB10
NOMESCO Finland
Primary partial prosthetic replacement of humero-scapular joint not using cement, other or unspecified
26.9
6.2
8
*
D07AC13
ATC
mometasone; topical
1.5
6.1
209
1483
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
2.0
6.1
79
422
R09
ICPC
Sinus symptom/complaint
2.4
6.0
49
212
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
6.1
6.0
15
25
SPAT1203
SPAT
Injection therapy, other than intramuscular or subcutaneous
3.1
6.0
31
104
Mortality – FinRegistry
↥Association
Association between endpoint M13_CARTILAGE and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_CARTILAGE | 1.362 [1.0, 1.85] | 0.05 |
| Birth year | 0.98 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 796 males with M13_CARTILAGE died.
Mortality risk
Mortality risk for people of age
years, who have M13_CARTILAGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.249% |
| 5 | No data | 1.259% |
| 10 | No data | 3.205% |
| 15 | No data | 5.826% |
| 20 | No data | 9.971% |
Relationships between endpoints
↥Index endpoint: M13_CARTILAGE – Other articular cartilage disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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