No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
114 |
4. Check minimum number of eventsNone |
114 |
5. Include endpointsNone |
114 |
6. Filter based on genotype QC (FinnGen only) |
114 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M89
- Name in latin
- Hypertrophia ossis
Similar endpoints
↥List of similar endpoints to
Hypertrophy of bone
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 932 | 474 | 453 |
| Only index persons | 900 | 464 | 436 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 41.88 | 43.81 | 40.03 |
| Only index persons | 41.76 | 43.39 | 40.02 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 114 | 69 | 45 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 42.27 | 38.91 | 47.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 101
- Matched controls
- 1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M89.3
ICD-10 Finland
Hypertrophy of bone
+∞
145.6
101
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
216.2
18.1
18
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
76.9
17.4
19
*
N02BE01
ATC
paracetamol; systemic, rectal
5.0
6.5
93
706
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEHYPERTRPH and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_BONEHYPERTRPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_BONEHYPERTRPH – Hypertrophy of bone
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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