cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).
Other specified/unspecified disorders of bone/cartilage
DOID EFO Endpoint Browser PheWeb
M13_BONEDISNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1052 |
4. Check minimum number of eventsNone |
1052 |
5. Include endpointsNone |
1052 |
6. Filter based on genotype QC (FinnGen only) |
1052 |
Control definitions (FinnGen only)
- Control exclude
- M13_OSTEOCHONDRO
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified disorders of bone/cartilage
based on the number of shared cases.
Similar with more cases:
- Other disorders of bone
- Osteopathies and chondropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8627 | 3501 | 5069 |
| Only index persons | 7527 | 3030 | 4497 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.10 | 0.14 |
| Only index persons | 0.15 | 0.11 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 30.25 | 43.37 | 20.93 |
| Only index persons | 28.79 | 40.76 | 20.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1052 | 476 | 576 |
| Unadjusted period prevalence (%) | 0.21 | 0.16 | 0.25 |
| Median age at first event (years) | 32.17 | 42.28 | 23.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 953
- Matched controls
- 9530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
72398
ICD-8 Finland
Other diseases of bone, Alii definiti
+∞
323.0
326
*
M89.9
ICD-10 Finland
Disorder of bone, unspecified
+∞
147.8
138
*
M94.9
ICD-10 Finland
Disorder of cartilage, unspecified
556.1
147.8
143
*
72399
ICD-8 Finland
Other diseases of bone
+∞
103.0
97
*
M94.8
ICD-10 Finland
Other specified disorders of cartilage
358.7
96.8
96
*
7339X
ICD-9 Finland
Other disorders of bone and cartilage, Other and unspecified disorders of bone and cartilage
+∞
95.4
90
*
M89.88
ICD-10 Finland
Other specified disorders of bone, other
+∞
64.3
61
*
9102
FHL
Trepanation or removal of the local bone process
28.7
32.7
44
16
M89.0
ICD-10 Finland
Algoneurodystrophy
+∞
29.3
28
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.7
23.2
108
320
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
21.3
21.3
31
15
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
5.3
21.0
65
129
M25.5
ICD-10 Finland
Pain in joint
2.1
20.1
286
1616
N02AX02
ATC
tramadol; systemic, rectal
1.9
18.5
414
2766
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.6
18.4
147
624
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.1
15.7
205
1100
M54.5
ICD-10 Finland
Low back pain
1.8
14.6
302
1925
N03AX16
ATC
pregabalin; oral
1.9
13.8
229
1348
M03BX02
ATC
tizanidine; oral
1.7
13.6
581
4578
N06AX21
ATC
duloxetine; oral
2.5
13.4
110
473
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.4
13.1
111
487
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.2
12.8
144
723
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
12.4
255
1605
M81.9
ICD-10 Finland
Osteoporosis, unspecified
7.3
12.4
29
41
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.4
12.2
112
510
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.4
12.0
108
486
M01AH05
ATC
etoricoxib; oral
1.6
11.9
558
4427
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
11.8
256
1638
R51.80
ICD-10 Finland
Headache
2.1
11.5
135
691
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
5.1
11.2
34
68
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
11.0
82
333
M02AA07
ATC
piroxicam; topical
1.6
10.7
327
2300
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
7.1
10.6
25
36
1220
FHL
Arthroscopy
3.2
10.5
54
175
M79.6
ICD-10 Finland
Pain in limb
1.7
10.5
302
2088
M54.4
ICD-10 Finland
Lumbago with sciatica
2.0
10.4
152
844
9476
FHL
Splitting of fascia or aponeurosis
8.9
10.3
21
24
N03AX12
ATC
gabapentin; oral
1.9
9.9
145
807
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
9.9
93
429
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
9.8
426
3254
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
9.7
343
2486
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
9.7
98
467
M01AB05
ATC
diclofenac; systemic, rectal
1.5
9.3
614
5141
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.2
361
2677
N06AX16
ATC
venlafaxine; oral
1.9
8.8
125
687
A03FA02
ATC
cisapride; oral, rectal
2.4
8.8
72
311
J01FF01
ATC
clindamycin; systemic
1.6
8.7
243
1652
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.7
288
2046
R03DC03
ATC
montelukast; oral
1.9
8.6
141
816
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
5.4
8.5
24
45
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.2
8.4
90
440
M89.81
ICD-10 Finland
Other specified disorders of bone, shoulder region
+∞
8.3
8
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
8.3
233
1583
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.1
8.3
93
464
M01AH01
ATC
celecoxib; oral (coxibs)
1.8
8.2
163
1001
J01AA02
ATC
doxycycline; systemic
1.5
8.2
700
6112
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
2.6
8.2
57
226
M23.8
ICD-10 Finland
Other internal derangements of knee
3.0
8.2
44
149
N06AA09
ATC
amitriptyline; systemic
2.1
8.1
88
434
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
8.1
332
2472
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
2.2
8.1
85
412
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
8.1
152
919
M01AE02
ATC
naproxen; oral, rectal
1.5
8.0
499
4061
A02BC01
ATC
omeprazole; systemic
1.6
8.0
232
1587
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.9
177
1129
9101
FHL
Bone biopsy
45.3
7.7
9
*
H02AB06
ATC
prednisolone; systemic
1.5
7.7
401
3132
WX002
NOMESCO Finland
Sedation and analgesia
1.7
7.7
169
1073
T92.3
ICD-10 Finland
Sequelae of dislocation, sprain and strain of upper limb
8.9
7.6
15
17
R05FB02
ATC
cough suppressants and expectorants
1.5
7.5
314
2338
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
7.4
206
1390
SPAT1312
SPAT
General health counselling
1.6
7.4
252
1790
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
80.7
7.4
8
*
M01AX05
ATC
glucosamine; oral
1.7
7.3
161
1017
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.4
7.3
58
248
M93.2
ICD-10 Finland
Osteochondritis dissecans
+∞
7.3
7
*
M94.2
ICD-10 Finland
Chondromalacia
30.2
7.2
9
*
N02AA05
ATC
oxycodone; systemic
1.9
7.1
110
621
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
5.1
7.1
21
42
R96
ICPC
Asthma
2.1
7.1
76
373
A02BA02
ATC
ranitidine; systemic
1.7
7.0
167
1085
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
7.0
223
1559
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
6.9
137
840
M01AC06
ATC
meloxicam; systemic, rectal
1.5
6.8
310
2341
Y0899
ICD-8 Finland
Investigation of musculoskeletal system
9.4
6.8
13
14
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
2.1
6.8
78
393
B01AB05
ATC
enoxaparin; parenteral
1.5
6.6
248
1794
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
6.6
79
406
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
6.6
89
481
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.5
161
1052
UKC02
NOMESCO Finland
Cystoscopy
1.8
6.5
122
736
M84.1
ICD-10 Finland
Nonunion of fracture [pseudarthrosis]
70.3
6.4
7
*
S93.2
ICD-10 Finland
Rupture of ligaments at ankle and foot level
4.9
6.4
19
39
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
4.2
6.3
22
53
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.8
6.3
112
665
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
9.3
6.3
12
13
R03AC02
ATC
salbutamol; inhalant
1.4
6.3
436
3564
M84.8
ICD-10 Finland
Other disorders of continuity of bone
+∞
6.3
6
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
6.3
85
462
WX320
NOMESCO Finland
Spinalanesthesy
1.6
6.2
179
1218
M01AE01
ATC
ibuprofen; systemic, rectal
1.6
6.1
820
7577
X58
ICD-10 Finland
Exposure to other specified factors
1.7
6.1
125
772
J01DA01
ATC
[U] cefalexin; systemic
1.4
6.1
534
4536
J01DB01
ATC
cefalexin; oral
1.5
6.1
725
6523
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.9
6.0
92
517
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
6.0
236
1721
Mortality – FinRegistry
↥Association
Association between endpoint M13_BONEDISNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.434 [1.18, 1.74] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.203 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 1536 females with M13_BONEDISNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_BONEDISNAS | 1.396 [1.14, 1.7] | 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 1231 males with M13_BONEDISNAS died.
Mortality risk
Mortality risk for people of age
years, who have M13_BONEDISNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.111% | 0.265% |
| 5 | 0.864% | 1.517% |
| 10 | 2.15% | 3.733% |
| 15 | 3.897% | 7.014% |
| 20 | 7.024% | 12.433% |
Relationships between endpoints
↥Index endpoint: M13_BONEDISNAS – Other specified/unspecified disorders of bone/cartilage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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