No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
300 |
4. Check minimum number of eventsNone |
300 |
5. Include endpointsNone |
300 |
6. Filter based on genotype QC (FinnGen only) |
300 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M21
- Name in latin
- Aliae deformitates acquisitae tarsi et pedis
Similar endpoints
↥List of similar endpoints to
Other acquired deformities of ankle and foot
based on the number of shared cases.
Similar with more cases:
- Other joint disorders
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2070 | 1328 | 732 |
| Only index persons | 1951 | 1272 | 679 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 49.53 | 52.51 | 44.04 |
| Only index persons | 49.39 | 52.17 | 44.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 300 | 211 | 89 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.04 |
| Median age at first event (years) | 52.07 | 51.52 | 53.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 258
- Matched controls
- 2579
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M21.6
ICD-10 Finland
Other acquired deformities of ankle and foot
10820.0
268.6
210
*
M19.0
ICD-10 Finland
Primary arthrosis of other joints
70.5
53.4
60
11
M17.1
ICD-10 Finland
Other primary gonarthrosis
26.1
52.3
74
39
7367A
ICD-9 Finland
Other acquired deformities of limbs, Other acquired deformities of ankle and foot
+∞
51.8
48
*
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
270.9
45.5
45
*
M20.1
ICD-10 Finland
Hallux valgus (acquired)
40.3
41.7
52
16
NHK30
NOMESCO Finland
Osteotomy or rotation osteotomy of first metatarsal or tarsal bone
+∞
37.4
35
*
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
34.1
32
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
15.2
31.8
54
44
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
29.8
28
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
116.9
29.3
31
*
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
112.6
28.3
30
*
M25.5
ICD-10 Finland
Pain in joint
5.5
27.8
98
259
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
84.2
27.4
30
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
19.0
27.4
42
26
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
18.3
27.0
42
27
WX320
NOMESCO Finland
Spinalanesthesy
6.2
27.0
82
180
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
+∞
26.5
25
*
N02AX02
ATC
tramadol; systemic, rectal
3.9
22.7
132
547
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
21.1
20
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.6
20.9
143
663
N03AX12
ATC
gabapentin; oral
5.4
20.2
66
153
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
31.9
20.1
26
9
M20.2
ICD-10 Finland
Hallux rigidus
+∞
20.0
19
*
L17
ICPC
Foot/toe symptom/complaint
4.0
19.4
95
330
M16.1
ICD-10 Finland
Other primary coxarthrosis
59.8
19.2
22
*
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
23.0
19.1
27
13
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
15.1
18.8
31
23
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
204.1
18.8
19
*
M01AX05
ATC
glucosamine; oral
4.9
18.6
68
177
NHL68
NOMESCO Finland
Tenodesis, shortening or lengthening of tendon of foot
102.1
17.8
19
*
NHK10
NOMESCO Finland
Incision or excision of metatarsal or tarsal bone
192.5
17.7
18
*
M22.4
ICD-10 Finland
Chondromalacia patellae
+∞
16.8
16
*
M01AH05
ATC
etoricoxib; oral
3.1
16.6
161
901
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
14.1
16.6
28
22
M79.6
ICD-10 Finland
Pain in limb
3.3
16.4
112
491
L15
ICPC
Knee symptom/complaint
4.3
16.2
67
195
9271
FHL
Hallux surgery
169.7
15.7
16
*
N03AX16
ATC
pregabalin; oral
3.7
15.5
80
279
M77.4
ICD-10 Finland
Metatarsalgia
9.1
14.8
31
38
M09AX01
ATC
hyaluronic acid; parenteral
16.7
14.7
23
15
N02AJ06
ATC
codeine and paracetamol; systemic
3.0
14.7
109
499
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
29.1
14.5
19
7
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
21.5
14.0
20
10
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
9.4
13.7
28
33
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
19.6
13.6
20
11
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
147.3
13.6
14
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.6
12.8
64
217
M13.9
ICD-10 Finland
Arthritis, unspecified
18.5
12.7
19
11
NHG26
NOMESCO Finland
Fusion between bones of ankle or ankle and foot
+∞
12.6
12
*
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
12.6
12
*
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
+∞
12.6
12
*
N02BE01
ATC
paracetamol; systemic, rectal
3.5
12.3
227
1746
9102
FHL
Trepanation or removal of the local bone process
49.1
12.0
14
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
6.5
11.9
31
53
ZXA05
NOMESCO Finland
Left side
3.1
11.9
78
320
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
6.0
11.6
32
59
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
125.3
11.5
12
*
B01AB05
ATC
enoxaparin; parenteral
2.9
11.4
83
362
M01AE02
ATC
naproxen; oral, rectal
2.5
11.3
153
951
M01AX17
ATC
nimesulide; oral
3.1
11.3
72
287
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.6
10.9
52
169
L16
ICPC
Ankle symptom/complaint
4.2
10.5
41
111
NHG82
NOMESCO Finland
Fusion of other tarsal joint
114.4
10.5
11
*
NHG22
NOMESCO Finland
Fusion of subtalar joint
114.4
10.5
11
*
G57.6
ICD-10 Finland
Lesion of plantar nerve
16.9
10.5
16
10
9351
FHL
Metatarsus osteotomies
+∞
10.5
10
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
34.0
10.4
13
*
M01AH01
ATC
celecoxib; oral (coxibs)
3.3
10.3
56
200
L28
ICPC
Limited function/disability (L)
3.5
10.2
50
165
J01FF01
ATC
clindamycin; systemic
2.7
10.1
84
393
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
41.8
10.0
12
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
7.9
9.9
22
30
SPAT1229
SPAT
Assessment of need for aid
5.1
9.9
31
67
NG2AA
NOMESCO Finland
Patella X-ray examination
57.2
9.7
11
*
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
6.7
9.6
24
39
S18
ICPC
Laceration/cut
2.4
9.6
110
612
P01BA02
ATC
hydroxychloroquine; oral
8.6
9.5
20
25
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.3
9.5
35
90
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
31.3
9.5
12
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
103.6
9.5
10
*
L90
ICPC
Osteoarthrosis of knee
9.2
9.5
19
22
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.7
9.5
42
128
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
9.4
9
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
+∞
9.4
9
*
7350A
ICD-9 Finland
Acquired deformities of toe, Hallux valgus (acquired)
+∞
9.4
9
*
NHL14
NOMESCO Finland
Shortening or lengthening of achilles tendon
+∞
9.4
9
*
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
+∞
9.4
9
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.6
9.2
81
388
M19.9
ICD-10 Finland
Arthrosis, unspecified
13.2
9.0
15
12
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.6
8.9
20
28
ZXA00
NOMESCO Finland
Right side
2.6
8.9
71
324
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
5.1
8.7
27
58
TNX39
NOMESCO Finland
Other orthopedic bandage, unspecified region
20.9
8.5
12
6
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.3
8.4
15
14
NHK68
NOMESCO Finland
Shortening or lengthening osteotomy of ankle or foot
+∞
8.4
8
*
NF1DA
NOMESCO Finland
X-ray of hips
+∞
8.4
8
*
M01AE01
ATC
ibuprofen; systemic, rectal
3.1
8.3
234
1956
M02AA07
ATC
piroxicam; topical
2.3
8.1
95
523
M48.0
ICD-10 Finland
Spinal stenosis
3.9
8.1
33
94
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
7.0
8.0
19
29
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
7.9
80
410
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
11.3
7.9
14
13
L13
ICPC
Hip symptom/complaint
3.2
7.9
43
152
M54.5
ICD-10 Finland
Low back pain
2.3
7.8
88
473
X58
ICD-10 Finland
Exposure to other specified factors
3.3
7.8
39
131
A02BC05
ATC
esomeprazole; systemic
2.2
7.7
107
635
ACC51
NOMESCO Finland
Release of median nerve
4.7
7.7
25
57
J01MA02
ATC
ciprofloxacin; systemic
2.2
7.7
102
594
NH1AD
NOMESCO Finland
Ankle and foot CT
12.4
7.7
13
11
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
7.6
29
78
L03
ICPC
Low back symptom/complaint
2.4
7.5
69
335
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
13.9
7.5
12
9
WX111
NOMESCO Finland
Local infiltration anesthesia
82.3
7.5
8
*
NH3EA
NOMESCO Finland
Feet X-ray examination with load
82.3
7.5
8
*
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
7.3
7
*
73799
ICD-8 Finland
Hallux valgus and varus
+∞
7.3
7
*
M21.5
ICD-10 Finland
Acquired clawhand, clubhand, clawfoot and clubfoot
+∞
7.3
7
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
7.3
7
*
NHG70
NOMESCO Finland
Arthroplasty of first tarsometatarsal joint
+∞
7.3
7
*
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
16.3
7.3
11
7
L08
ICPC
Shoulder symptom/complaint
2.7
7.2
54
234
A02BC02
ATC
pantoprazole; systemic
2.1
7.2
161
1150
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
12.5
7.1
12
10
1220
FHL
Arthroscopy
10.5
7.1
13
13
L84
ICD-10 Finland
Corns and callosities
7.3
7.1
16
23
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.1
7.0
104
629
J01DA01
ATC
[U] cefalexin; systemic
2.0
7.0
165
1197
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
5.3
7.0
20
40
TQW40
NOMESCO Finland
Remowal of suture of skin
4.6
6.9
23
54
A07EC01
ATC
sulfasalazine; oral, rectal
7.0
6.9
16
24
XA402
NOMESCO Finland
ENMG
11.4
6.9
12
11
M01AH02
ATC
rofecoxib; oral
3.1
6.8
38
136
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
41.1
6.8
8
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
41.1
6.8
8
*
R03AC02
ATC
salbutamol; inhalant
2.0
6.8
136
924
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
23.2
6.7
9
*
H02AB06
ATC
prednisolone; systemic
2.0
6.5
112
714
J01DB01
ATC
cefalexin; oral
2.2
6.5
205
1651
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.2
6.5
23
58
Q66.7
ICD-10 Finland
Pes cavus
71.5
6.5
7
*
NHG20
NOMESCO Finland
Fusion of talocrural joint
71.5
6.5
7
*
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
71.5
6.5
7
*
NHL30
NOMESCO Finland
Suture or reinsertion of tendon of foot
14.8
6.4
10
7
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
11.4
6.4
11
10
B01AX06
ATC
[U] rivaroxaban; oral
+∞
6.3
6
*
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
6.3
6
*
NHA30
NOMESCO Finland
Exploration of joint of ankle or foot, arthroscopic
+∞
6.3
6
*
NDG60
NOMESCO Finland
Arthroplasty of first CMC joint
+∞
6.3
6
*
NHL99
NOMESCO Finland
Other operation on muscle or tendon of ankle or foot
+∞
6.3
6
*
WZA90
NOMESCO Finland
Other doctors statement
2.3
6.1
61
304
M01AC06
ATC
meloxicam; systemic, rectal
2.0
6.1
92
554
M01AB05
ATC
diclofenac; systemic, rectal
1.9
6.1
162
1201
M01AB55
ATC
diclofenac, combinations; oral
3.8
6.1
24
67
Mortality – FinRegistry
↥Association
Association between endpoint M13_ANKLEFOOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_ANKLEFOOT | 0.955 [0.74, 1.23] | 0.72 |
| Birth year | 0.996 [0.99, 1.0] | 0.354 |
During the follow-up period (1.1.1998 — 31.12.2019), 83 out of 876 females with M13_ANKLEFOOT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have M13_ANKLEFOOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.109% | No data |
| 5 | 0.579% | No data |
| 10 | 1.411% | No data |
| 15 | 2.842% | No data |
| 20 | 5.145% | No data |
Relationships between endpoints
↥Index endpoint: M13_ANKLEFOOT – Other acquired deformities of ankle and foot
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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