No definition available.
Localized skin eruption due to drugs and medicaments
LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
401 |
4. Check minimum number of eventsNone |
401 |
5. Include endpointsNone |
401 |
6. Filter based on genotype QC (FinnGen only) |
401 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Localized skin eruption due to drugs and medicaments
based on the number of shared cases.
Similar with more cases:
- Dermatitis due to substances taken internally
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2626 | 1498 | 1115 |
| Only index persons | 2347 | 1368 | 979 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 51.43 | 54.02 | 47.91 |
| Only index persons | 52.21 | 54.10 | 49.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 401 | 257 | 144 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.06 |
| Median age at first event (years) | 54.76 | 52.84 | 58.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 347
- Matched controls
- 3469
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L27.1
ICD-10 Finland
Localized skin eruption due to drugs and medicaments
4503599627370496.0
323.0
346
*
H02AB06
ATC
prednisolone; systemic
4.6
38.8
239
1126
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.3
23.1
77
178
XQ800
NOMESCO Finland
Prick test
4.8
17.9
63
152
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.5
17.9
99
359
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.4
15.1
57
147
R06AE07
ATC
cetirizine; oral
2.5
14.5
184
1089
D07AC01
ATC
betamethasone; topical
2.5
14.3
149
792
E0000UV
ATC
NA
2.4
13.5
169
982
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
12.9
167
981
XQ820
NOMESCO Finland
Exposure to medicinal substance
72.5
12.7
14
*
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
13.1
12.3
21
17
H02AB02
ATC
dexamethasone; systemic
3.6
11.9
56
176
N02AX02
ATC
tramadol; systemic, rectal
2.2
11.3
162
976
R06AX27
ATC
desloratadine; oral
2.4
11.0
118
616
R06AE09
ATC
levocetirizine; oral
2.8
10.0
68
275
J01AA02
ATC
doxycycline; systemic
2.3
9.7
274
2155
XQ802
NOMESCO Finland
Epicutan test
4.5
9.7
34
82
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
9.7
89
429
A02BC02
ATC
pantoprazole; systemic
2.1
9.5
231
1696
J01MA02
ATC
ciprofloxacin; systemic
2.1
9.5
145
879
J01DB01
ATC
cefalexin; oral
2.4
9.2
296
2441
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
8.9
115
645
A02BC05
ATC
esomeprazole; systemic
2.0
8.8
153
969
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.5
8.8
77
359
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
8.7
48
168
J01FF01
ATC
clindamycin; systemic
2.1
8.1
105
585
UJF32
NOMESCO Finland
Coloscopy
2.1
7.7
101
564
XQ801
NOMESCO Finland
Intracutantest
18.9
7.6
11
6
R50.9
ICD-10 Finland
Fever, unspecified
2.5
7.6
62
277
UDC00
NOMESCO Finland
Ear microscopy
3.3
7.6
38
126
XX3DW
NOMESCO Finland
Time consuming IT work
3.0
7.4
42
152
L03AA13
ATC
pegfilgrastim; parenteral
4.8
7.3
23
50
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
7.2
107
631
J01MA12
ATC
levofloxacin; systemic
2.2
7.1
75
380
A04AA02
ATC
granisetron; systemic, transdermal
3.7
7.1
30
87
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
7.0
140
915
T78.4
ICD-10 Finland
Allergy, unspecified
4.0
6.9
26
68
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.5
6.9
53
230
J02AC01
ATC
fluconazole; systemic
1.9
6.9
152
1027
J01FA09
ATC
clarithromycin; systemic
1.9
6.6
122
771
L50.9
ICD-10 Finland
Urticaria, unspecified
4.2
6.5
23
57
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.6
6.4
47
198
N03AX16
ATC
pregabalin; oral
2.0
6.4
90
516
K12.00
ICD-10 Finland
Recurrent oral aphthae
9.5
6.3
12
13
ZX120
NOMESCO Finland
Intravenous
2.8
6.3
40
156
D07AD01
ATC
clobetasol; topical
2.2
6.2
63
313
N48.1
ICD-10 Finland
Balanoposthitis
5.9
6.2
16
28
D07AC13
ATC
mometasone; topical
1.9
6.2
106
652
D70.82
ICD-10 Finland
Drug-induced neutropenia
7.9
6.2
13
17
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.0
6.1
23
61
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
6.1
105
645
L50.0
ICD-10 Finland
Allergic urticaria
5.7
6.1
16
29
J01DA01
ATC
[U] cefalexin; systemic
1.8
6.1
216
1678
Mortality – FinRegistry
↥Association
Association between endpoint LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM | 1.557 [1.26, 1.93] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.626 |
During the follow-up period (1.1.1998 — 31.12.2019), 246 out of 1248 females with LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM | 1.561 [1.26, 1.93] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 969 males with LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM died.
Mortality risk
Mortality risk for people of age
years, who have LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.415% |
| 5 | 1.089% | 2.227% |
| 10 | 2.717% | 5.267% |
| 15 | 4.883% | 9.734% |
| 20 | 8.541% | 15.853% |
Relationships between endpoints
↥Index endpoint: LOCALIZED_SKIN_ERUPT_DRUGS_MEDICAM – Localized skin eruption due to drugs and medicaments
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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