Vitiligo

L12_VITILIGO

Vitiligo: Generalized well circumscribed patches of leukoderma that are generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L80
  • Hospital discharge: ICD-9 7090F
  • Hospital discharge: ICD-8 70905
  • Cause of death: ICD-10 L80
  • Cause of death: ICD-9 7090F
  • Cause of death: ICD-8 70905

2 out of 7 registries used, show all original rules.

359

4. Check minimum number of events

None

359

5. Include endpoints

None

359

6. Filter based on genotype QC (FinnGen only)

339

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L80-L99
Name in latin
Vitiligo

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3372 1868 1488
Only index persons 3076 1720 1356
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.04
Only index persons 0.06 0.06 0.05
Median age at first event (years)
Whole population 36.14 37.31 34.62
Only index persons 36.81 38.02 35.29

-FinnGen-

Key figures

All Female Male
Number of individuals 339 205 134
Unadjusted period prevalence (%) 0.08 0.08 0.07
Median age at first event (years) 46.03 44.98 47.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
359
Matched controls
3588
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L80
ICD-10 Finland
Vitiligo
4503599627370496.0
323.0
346
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.4
21.4
59
107
E0000UV
ATC
NA
2.9
19.9
178
908
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.6
19.0
101
356
D07AD01
ATC
clobetasol; topical
3.8
17.4
82
261
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
19.1
16.7
25
14
D07AC01
ATC
betamethasone; topical
2.6
15.3
148
759
70905
ICD-8 Finland
Other diseases of skin, Vitiligo
+∞
14.7
14
*
D05AX02
ATC
calcipotriol; topical
6.2
12.0
32
56
H03AA01
ATC
levothyroxine sodium; systemic
2.5
10.8
100
486
D07AC13
ATC
mometasone; topical
2.2
8.9
109
597
107
Kela drug reimbursment
Pernicious anaemia
11.1
8.4
15
14
TQW80
NOMESCO Finland
Local dermatologic skincare
7.2
7.9
18
26
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
6.6
7.8
19
30
104
Kela drug reimbursment
Thyroid insufficiency
3.4
7.7
36
113
L63.8
ICD-10 Finland
Other alopecia areata
81.7
7.4
8
*
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
8.6
7.4
15
18
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
20.5
7.2
10
5
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.8
7.1
45
175
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.6
6.8
22
50
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
6.6
105
627
H02AB07
ATC
prednisone; oral
2.4
6.6
57
262
D07AB08
ATC
desonide; topical
2.6
6.6
46
189
E000001
ATC
NA
2.1
6.6
83
453
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.8
6.4
40
153
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
6.3
6
*
D05BA02
ATC
methoxsalen; oral
+∞
6.3
6
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
12.8
6.1
10
8

Mortality – FinRegistry

Association

Association between endpoint L12_VITILIGO and mortality.

Females

Parameter HR [95% CI] p-value
L12_VITILIGO 1.203 [0.93, 1.55] 0.156
Birth year 0.994 [0.99, 1.0] 0.165

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1518 females with L12_VITILIGO died.

Males

Parameter HR [95% CI] p-value
L12_VITILIGO 1.183 [0.94, 1.49] 0.157
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 1189 males with L12_VITILIGO died.

Mortality risk

Mortality risk for people of age

years, who have L12_VITILIGO.

N-year risk Females Males
1 0.11% 0.247%
5 0.704% 1.539%
10 1.552% 3.646%
15 3.01% 6.626%
20 5.436% 10.822%

Relationships between endpoints

Index endpoint: L12_VITILIGO – Vitiligo

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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