urticaria: A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
116 |
4. Check minimum number of eventsNone |
116 |
5. Include endpointsNone |
116 |
6. Filter based on genotype QC (FinnGen only) |
116 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria ex contactu
Similar endpoints
↥List of similar endpoints to
Contact urticaria
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 756 | 481 | 272 |
| Only index persons | 681 | 448 | 233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 33.99 | 36.01 | 30.25 |
| Only index persons | 36.48 | 36.75 | 35.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 116 | 87 | 29 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | 42.95 | 40.42 | 50.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 100
- Matched controls
- 1001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.60
ICD-10 Finland
Allergic contact urticaria
1035.4
59.0
52
*
L50.6
ICD-10 Finland
Contact urticaria
+∞
30.8
28
*
L50.69
ICD-10 Finland
Other (non-immunological) contact urticaria
+∞
22.8
21
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
9.1
14.0
31
47
L50.8
ICD-10 Finland
Other urticaria
+∞
13.9
13
*
R06AE07
ATC
cetirizine; oral
3.9
9.6
63
303
L50.9
ICD-10 Finland
Urticaria, unspecified
22.4
8.7
12
6
L50.3
ICD-10 Finland
Dermatographic urticaria
86.2
7.5
8
*
XQ800
NOMESCO Finland
Prick test
5.3
6.4
19
42
J31.0
ICD-10 Finland
Chronic rhinitis
5.9
6.0
16
31
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTIGA_CONTACT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_URTIGA_CONTACT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_URTIGA_CONTACT – Contact urticaria
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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