No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
313 |
4. Check minimum number of eventsNone |
313 |
5. Include endpointsNone |
313 |
6. Filter based on genotype QC (FinnGen only) |
313 |
Control definitions (FinnGen only)
- Control exclude
- L12_URTICARIAERYTHEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L50
- Name in latin
- Urticaria ex calore
Similar endpoints
↥List of similar endpoints to
Urticaria due to cold and heat
based on the number of shared cases.
Similar with more cases:
- Urticaria
- Urticaria and erythema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2310 | 1500 | 804 |
| Only index persons | 2168 | 1431 | 737 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 28.24 | 32.69 | 19.84 |
| Only index persons | 29.01 | 33.50 | 20.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 313 | 235 | 78 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.03 |
| Median age at first event (years) | 38.60 | 39.73 | 35.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 282
- Matched controls
- 2821
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.2
ICD-10 Finland
Urticaria due to cold and heat
+∞
323.0
272
*
L50.3
ICD-10 Finland
Dermatographic urticaria
389.0
63.1
61
*
L50.9
ICD-10 Finland
Urticaria, unspecified
30.7
42.7
57
23
R06AE09
ATC
levocetirizine; oral
7.0
40.4
120
271
L50.8
ICD-10 Finland
Other urticaria
+∞
38.4
36
*
C01CA24
ATC
epinephrine; parenteral
9.1
32.5
73
104
R06AX27
ATC
desloratadine; oral
4.4
30.1
156
614
XQ800
NOMESCO Finland
Prick test
7.0
28.9
78
145
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
27.5
26
*
R06AE07
ATC
cetirizine; oral
3.5
22.2
185
989
H02AB06
ATC
prednisolone; systemic
3.4
21.7
167
837
R03DC03
ATC
montelukast; oral
4.2
20.6
92
292
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
20.0
19
*
L50.0
ICD-10 Finland
Allergic urticaria
23.8
19.9
28
13
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
5.0
18.7
65
159
R06AX22
ATC
ebastine; oral
3.8
17.7
88
302
L50.1
ICD-10 Finland
Idiopathic urticaria
135.8
12.5
13
*
7082A
ICD-9 Finland
Urticaria due to cold and heat[URTICARIA E FRIGORE]
+∞
11.5
11
*
A02BC02
ATC
pantoprazole; systemic
2.4
11.1
183
1228
R06AX13
ATC
loratadine; oral
2.9
11.0
74
304
D07AA02
ATC
hydrocortisone; topical
3.1
10.7
64
243
R03AC02
ATC
salbutamol; inhalant
2.2
9.8
169
1126
H02AB07
ATC
prednisone; oral
3.2
9.8
54
193
L20.0
ICD-10 Finland
Besnier prurigo
3.8
9.8
42
124
E000003
ATC
NA
5.2
9.3
28
58
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.8
9.3
63
259
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
9.2
63
261
R01AD09
ATC
mometasone; nasal
2.2
9.0
149
959
M79.6
ICD-10 Finland
Pain in limb
2.2
8.3
109
629
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.1
8.2
119
717
T78.4
ICD-10 Finland
Allergy, unspecified
4.5
8.1
28
68
R06AX26
ATC
fexofenadine; oral
3.6
8.0
36
111
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.6
7.9
35
106
D07AC13
ATC
mometasone; topical
2.2
7.9
95
526
J45.0
ICD-10 Finland
Predominantly allergic asthma
3.2
7.7
41
143
R01AD12
ATC
fluticasone furoate; nasal
2.1
7.6
113
683
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
7.5
70
341
E000002
ATC
NA
2.8
7.3
49
198
344
Kela drug reimbursment
Omalizumab
+∞
7.3
7
*
T78.3
ICD-10 Finland
Angioneurotic oedema
16.3
7.3
11
7
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
16.3
7.3
11
7
M79.1
ICD-10 Finland
Myalgia
2.7
7.2
49
201
R06.0
ICD-10 Finland
Dyspnoea
2.4
7.2
64
304
L50
ICD-10 Finland
Urticaria
9.1
7.1
14
16
E0000UV
ATC
NA
2.0
7.0
131
856
E000001
ATC
NA
2.2
6.8
74
386
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
6.8
64
313
D07AB08
ATC
desonide; topical
2.9
6.7
40
151
R06AX18
ATC
acrivastine; oral
5.8
6.7
18
33
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
6.5
33
112
R03BA02
ATC
budesonide; inhalant
2.3
6.5
62
306
G44.2
ICD-10 Finland
Tension-type headache
2.6
6.4
47
201
XQ802
NOMESCO Finland
Epicutan test
4.3
6.4
22
54
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.6
6.2
20
46
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.1
6.2
77
427
Mortality – FinRegistry
↥Association
Association between endpoint L12_URTICA_COLDHEAT and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_URTICA_COLDHEAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_URTICA_COLDHEAT – Urticaria due to cold and heat
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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