Cholinergic urticaria

L12_URTICA_CHOLINERG

cholinergic urticaria: a type of physical urticarias (or hives) that appears when a person is sweating.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L50.5 Hospital discharge: ICD-9 — 7085 Cause of death: ICD-10 — L50.5 Cause of death: ICD-9 — 7085 2 out of 7 registries used, show all original rules.	183
4. Check minimum number of events None	183
5. Include endpoints None	183
6. Filter based on genotype QC (FinnGen only)	183

Control definitions (FinnGen only)

Control exclude: L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L50
Name in latin: Urticaria cholinergica

NAME	L12_URTICA_CHOLINERG
CONTROL_EXCLUDE	L12_URTICARIAERYTHEMA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L505
HD_ICD_9	7085
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L505
COD_ICD_9	7085
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Cholinergic urticaria based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1274	625	643
Only index persons	1222	606	616
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	28.90	35.86	22.06
Only index persons	28.80	35.69	22.03

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	183	113	70
Unadjusted period prevalence (%)	0.04	0.04	0.03
Median age at first event (years)	37.77	43.73	28.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
170: Matched controls
1701

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L50.5

ICD-10 Finland

Cholinergic urticaria

+∞

201.6

151

L50.3

ICD-10 Finland

Dermatographic urticaria

156.4

36.3

L50.0

ICD-10 Finland

Allergic urticaria

60.2

26.2

R06AE09

ATC

levocetirizine; oral

6.8

23.5

155

C01CA24

ATC

epinephrine; parenteral

13.9

23.3

XQ800

NOMESCO Finland

Prick test

9.4

21.5

L50.8

ICD-10 Finland

Other urticaria

87.8

21.3

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

8.4

21.2

L50.9

ICD-10 Finland

Urticaria, unspecified

24.7

20.8

L50.2

ICD-10 Finland

Urticaria due to cold and heat

+∞

20.2

R06AE07

ATC

cetirizine; oral

4.7

19.8

120

573

R03DC03

ATC

montelukast; oral

5.6

18.6

162

7085A

ICD-9 Finland

Urticaria, Cholinergic urticaria

+∞

18.0

L50.1

ICD-10 Finland

Idiopathic urticaria

+∞

17.0

R06AX27

ATC

desloratadine; oral

4.2

16.5

341

H02AB06

ATC

prednisolone; systemic

3.7

14.8

101

481

R06AX22

ATC

ebastine; oral

4.2

13.5

189

T78.4

ICD-10 Finland

Allergy, unspecified

9.3

11.2

XQ810

NOMESCO Finland

Physical test for urticaria

+∞

10.5

R06AX13

ATC

loratadine; oral

3.7

10.0

163

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

3.6

10.0

187

J45.0

ICD-10 Finland

Predominantly allergic asthma

5.0

9.2

D07AB02

ATC

hydrocortisone butyrate; topical

3.0

9.0

293

L20.0

ICD-10 Finland

Besnier prurigo

5.5

8.8

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

21.4

8.6

D07AB08

ATC

desonide; topical

4.5

8.5

E0000UV

ATC

2.6

8.3

461

N05BB01

ATC

hydroxyzine; systemic

5.3

8.0

E000001

ATC

3.0

7.8

207

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

3.4

7.2

124

L50

ICD-10 Finland

Urticaria

14.6

7.0

J45

ICD-10 Finland

Asthma

3.9

6.9

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.4

6.4

395

317

Kela drug reimbursment

Topical pimecrolimus and tacrolimus

18.9

6.3

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.4

6.2

375

R06AX26

ATC

fexofenadine; oral

4.2

6.1

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3018418) pH of Serum or Plasma

378

2.44

7.49

3.8

3.7

7.4

0.25

(4010399)

3.26

6.78

1.5

1.4

—

(42870588) Differential panel, method unspecified - Blood

445

2.16

5.85

7.3

5.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

557

2.07

5.47

4.2

6.3

mmol/l

1.2

0.73

516

(3000492) Spirometry study

156

2.54

5.24

1.3

1.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

4.81

4.85

1.9

4.8

50.9

59.1

0.86

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

443

1.98

4.63

2.5

2.8

—

(3013707) Erythrocyte sedimentation rate by Westergren method

141

1118

2.14

4.52

5.7

3.7

mm/h

10.7

9.7

0.27

133

1039

(3030467) Casts [#/volume] in Urine by Automated count

348

2.03

4.48

2.8

2.6

e6/l

0.1

0.2

1.32

250

(3001604) Monocytes [#/volume] in Blood

104

746

1.91

4.42

7.0

5.6

e9/l

0.5

0.07

660

(3006315) Basophils [#/volume] in Blood

104

748

1.90

4.36

7.0

5.6

e9/l

0.0

0.39

663

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.81

4.33

1.3

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

495

1.92

4.30

2.0

1.8

pmol/l

94.6

96.3

0.13

259

(3012095) Magnesium [Moles/volume] in Serum or Plasma

185

2.25

4.27

2.2

3.9

mmol/l

0.8

0.23

174

(3013115) Eosinophils [#/volume] in Blood

106

771

1.89

4.25

7.1

6.2

e9/l

0.2

0.79

693

(36304419) Bacteria [Presence] in Urine

348

1.98

4.16

2.8

2.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

382

1.94

4.11

1.8

1.6

—

(3048689) Calprotectin [Mass/mass] in Stool

196

2.18

4.06

2.7

2.2

ug/g

73.0

123.8

0.73

152

(3019198) Lymphocytes [#/volume] in Blood

105

772

1.84

3.97

6.8

5.6

e9/l

2.0

2.1

0.14

697

(3030905) Polymorphonuclear cells [#/volume] in Blood

4.35

3.94

1.9

4.6

e9/l

3.7

4.1

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

102

2.56

3.94

1.2

iu/ml

95.3

144.4

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

614

1.83

3.93

5.0

7.2

mmol/l

1.2

0.36

522

(3018095) Leukocytes [#/volume] in Urine

464

1.87

3.91

3.3

3.1

e6/l

196.5

36.2

0.51

307

(3037522) Nuclear Ab [Titer] in Serum

218

2.07

3.70

1.7

1.3

titre

1354.3

425.3

—

(3002582) Erythrocytes [#/volume] in Urine

380

1.86

3.60

3.0

2.7

e6/l

421.7

52.2

0.43

278

(3037467) Urinalysis macro (dipstick) panel - Urine

125

987

1.84

3.58

4.5

3.8

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

662

1.75

3.39

3.0

2.6

ug/l

148.2

93.6

0.47

623

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

182

2.07

3.29

2.0

2.5

e6/l

2.8

3.3

0.11

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

138

1147

1.83

3.07

5.1

3.8

pmol/l

15.0

14.5

1.66

128

1054

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

202

1.97

3.06

1.9

2.4

e6/l

0.3

0.9

2.46

107

(3021960) Folate [Moles/volume] in Serum or Plasma

274

1.85

3.00

1.5

1.4

nmol/l

21.8

0.00

241

(3026782) Osmolality of Urine

233

1.86

2.75

2.7

2.4

mosm/kgh2o

604.7

568.8

0.44

201

(3013650) Neutrophils [#/volume] in Blood by Automated count

110

873

1.65

2.75

9.3

9.5

e9/l

3.6

4.0

1.29

103

765

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

550

1.65

2.73

2.8

2.2

nmol/l

74.9

75.1

0.02

506

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

275

1.79

2.68

1.3

iu/ml

12.0

24.8

1.62

100

(3004789) Transferrin [Mass/volume] in Serum or Plasma

183

1.91

2.57

1.7

2.2

g/l

2.3

2.5

1.04

169

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

2.94

2.52

1.0

1.2

mmol/l

3.4

3.8

1.23

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

3.59

2.52

1.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

314

1.72

2.49

1.8

1.6

mg/l

0.8

1.0

0.47

242

(3007164) IgA [Mass/volume] in Serum or Plasma

340

1.69

2.47

2.3

1.4

g/l

3.6

2.2

0.53

209

(3023419) Bacteria identified in Sputum by Culture

5.13

2.42

3.2

2.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

156

1380

1.88

2.42

6.0

4.4

mu/l

1.6

2.7

0.66

149

1277

(3021589) Normoblasts [#/volume] in Blood

638

1.59

2.41

10.9

8.2

e9/l

0.0

0.50

517

(3000850) Epithelial cells [#/volume] in Urine

259

1.75

2.40

2.6

2.2

e6/l

4.3

4.9

0.21

232

(44813793)

6.39

2.38

1.0

—

(21491868) Cryoglobulin [Mass/volume] in Serum

6.39

2.38

1.2

1.0

g/l

—

(36660697) Celiac disease serology panel - Serum

128

2.01

2.35

1.2

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

168

1531

2.19

2.27

13.9

11.7

mg/l

13.3

20.5

3.57

124

1171

(3023420) DNA double strand Ab [Units/volume] in Serum

4.00

2.27

1.1

1.5

—

(3032080) INR in Blood by Coagulation assay

481

1.58

2.22

7.7

6.9

inr

1.2

0.01

145

(3044290) Cell count panel - Cerebral spinal fluid

3.10

2.18

1.0

1.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

448

1.58

2.16

4.0

3.3

mmol/l

2.4

0.03

396

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.13

2.14

1.1

1.0

—

(42529406) Shigella sp [Presence] in Stool by Culture

2.66

2.14

1.2

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

2.66

2.14

1.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

485

1.56

2.13

3.3

3.4

ng/l

29.2

22.4

0.23

286

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

370

1.61

2.12

1.6

1.2

u/ml

3.1

1.5

—

107

(40768797) Stomach Pathology biopsy report

179

1.81

2.12

1.2

—

(3015736) pH of Urine

568

1.54

2.12

2.6

3.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.24

2.04

4.5

3.4

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.73

2.04

1.4

1.3

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

175

1.78

1.98

1.9

2.2

21.9

24.3

0.54

147

(3044889) 12 lead EKG panel

116

974

1.52

1.97

4.0

3.3

—

(1002224) Polysomnography panel

2.08

1.92

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

267

1.64

1.91

1.4

1.2

u/ml

1.2

10.3

2.12

110

(4306422)

3.27

1.90

1.1

—

(3037756) Immunofixation for Serum or Plasma

3.27

1.90

1.4

2.0

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

362

1.57

1.89

1.7

mmol/l

1.2

1.4

1.59

313

(3003327) Ova and parasites identified in Stool by Light microscopy

2.48

1.89

2.3

1.5

—

(40758558) Short blood count panel - Blood

363

1.56

1.87

7.0

7.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

2.65

1.83

2.2

2.4

147.8

166.7

—

(3002385) Erythrocyte distribution width [Ratio]

147

1311

1.62

1.81

17.8

14.1

13.3

13.5

2.04

147

1292

(3013512) EKG study

359

1.54

1.75

2.5

3.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

369

1.53

1.73

2.1

2.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

2.46

1.71

1.2

—

(4268621)

3.23

1.67

3.0

2.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

499

1.47

1.65

3.1

3.0

u/l

32.3

32.0

0.02

472

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

226

1.62

1.65

3.2

ng/l

265.8

513.3

0.27

150

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

3.40

1.53

1.2

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

3.40

1.53

1.2

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

3.40

1.53

1.2

1.1

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

3.40

1.53

1.2

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

3.40

1.53

1.2

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

3.40

1.53

1.2

1.1

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

552

1.43

1.53

4.5

4.6

g/l

37.9

36.7

1.45

524

(3021601) Nitrite [Presence] in Urine by Test strip

705

1.41

1.51

4.6

estimate

0.0

0.00

136

(3035350) Ketones [Presence] in Urine by Test strip

705

1.41

1.51

3.3

3.2

estimate

0.0

0.00

135

(3052851) Hemolysis interference index of Serum or Plasma

2.50

1.50

2.3

3.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

257

1.55

1.50

2.4

2.3

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.19

1.47

1.8

1.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

312

1.49

1.43

2.6

3.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

131

1164

1.44

1.41

3.2

3.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

2.99

1.37

1.4

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

2.19

1.36

1.1

1.2

—

3.0

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

1.36

0.0

1.6

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

1.36

0.0

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

160

1486

1.61

1.32

16.6

12.1

40.4

40.8

0.27

127

1176

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.15

1.32

4.2

2.9

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.41

1.31

1.4

1.2

—

(40768443) Skin Pathology biopsy report

2.06

1.30

1.1

1.2

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

567

1.38

1.27

3.2

3.3

—

(21494755) Public health laboratory ask at order entry panel

234

0.57

1.24

1.1

1.4

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

2.68

1.22

1.0

1.1

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

278

1.46

1.21

2.3

1.9

mg/l

2.5

3.2

1.49

246

(3042936) Bacteria identified in Isolate by Culture

175

1.57

1.21

1.5

2.1

—

(3009261) Glucose [Presence] in Urine by Test strip

715

1.35

1.21

3.3

estimate

0.0

0.00

131

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

171

1622

1.83

1.21

12.4

9.3

u/l

25.2

27.6

1.74

165

1575

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

307

1.43

1.16

1.7

2.3

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

2.54

1.16

1.0

1.1

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

2.54

1.16

3.8

5.5

umol/l

367.8

360.9

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.99

1.10

1.1

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.42

1.10

1.6

2.8

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

2.42

1.10

1.0

1.1

—

(40761536) Microorganisms panel - Urine sediment

122

1.62

1.07

4.1

2.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

376

1.37

1.05

4.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.74

1.05

1.1

1.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

787

1.31

1.02

3.8

4.8

mmol/l

6.4

0.07

714

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

123

1110

1.33

1.01

3.3

2.9

u/l

37.8

41.9

0.42

116

1060

(3026008) Bacteria identified in Urine by Culture

370

1.36

1.00

3.0

2.6

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.21

0.98

9.4

5.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.21

0.98

1.2

1.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.84

0.98

1.3

2.3

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.97

0.0

4.8

—

(3026493) Urate [Moles/volume] in Serum or Plasma

345

1.36

0.96

2.8

2.7

umol/l

335.1

2255.7

0.80

306

(3029937) Albumin [Presence] in Urine by Test strip

382

1.35

0.95

3.3

estimate

0.0

0.00

135

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

127

1.55

0.93

2.6

4.2

u/l

258.3

236.8

0.18

121

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.18

0.92

1.0

1.7

—

(3003694) ABO and Rh group [Type] in Blood

423

1.32

0.89

1.5

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.85

0.87

1.0

1.1

—

1.2

—

(3027944) Amphetamines [Presence] in Urine

112

0.52

0.86

1.7

2.3

—

(3028300) Cannabinoids [Presence] in Urine

113

0.52

0.86

1.7

2.6

—

(3027008) Opiates [Presence] in Urine

113

0.52

0.86

1.7

2.6

—

(3000764) Benzodiazepines [Presence] in Urine

113

0.52

0.86

1.7

2.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

1.97

0.85

1.0

1.2

—

(40761511) CBC panel - Blood by Automated count

168

1608

1.55

0.84

13.9

10.9

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

210

1.39

0.80

2.0

2.7

mmol/l

2.4

0.40

180

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.85

0.80

1.8

2.5

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.79

0.0

1.4

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.78

0.0

1.6

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.79

0.77

1.0

1.1

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.76

0.0

1.4

—

(3016879) Cocaine [Presence] in Urine

106

0.55

0.75

1.7

2.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

195

1.39

0.75

2.3

1.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

204

0.66

0.73

1.5

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

416

1.28

0.72

2.8

2.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

232

1.35

0.72

2.2

2.1

—

(3024928) Oxygen saturation in Venous blood

1.87

0.69

2.0

3.1

—

(3027315) Oxygen [Partial pressure] in Blood

1.81

0.66

5.4

2.0

kpa

8.5

8.9

—

(3013290) Carbon dioxide [Partial pressure] in Blood

1.81

0.66

5.4

2.0

kpa

5.5

5.2

—

(3012501) Base excess in Blood by calculation

1.81

0.66

5.4

2.0

mmol/l

2.3

2.8

—

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

1.81

0.66

2.2

1.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

318

1.29

0.66

2.5

3.0

ng/l

743.4

881.8

0.22

263

(3019309) Folate [Moles/volume] in Red Blood Cells

209

1.34

0.65

2.0

1.6

nmol/l

1120.5

1215.4

0.26

161

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

1.68

0.62

1.4

1.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.4

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.60

0.0

1.5

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.56

0.60

1.9

1.5

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.60

0.0

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.60

0.60

4.0

4.8

mmol/l

25.5

25.6

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.53

0.59

1.8

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.50

0.58

1.4

1.1

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.64

0.56

1.0

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.53

0.55

1.6

2.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

420

1.23

0.55

3.3

2.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

147

1403

1.24

0.52

15.0

10.1

ml/min/173m2

90.2

88.2

0.49

122

1117

(40768804) Tissue Pathology biopsy report

567

1.20

0.52

2.1

1.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

145

1.35

0.51

1.3

1.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

143

0.68

0.50

1.5

1.7

—

(3049717) Cytology report of Urine Cyto stain

1.58

0.49

2.1

2.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.51

0.48

2.0

1.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

294

1.24

0.47

1.6

1.7

—

(3000494) Fungus identified in Specimen by Culture

156

1.32

0.47

1.7

1.6

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.58

0.46

3.4

12.3

mmol/l

25.3

24.5

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.45

0.46

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

140

0.70

0.45

1.5

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

1.53

0.41

2.2

1.5

—

(44806118)

0.00

0.41

0.0

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(44790048)

0.00

0.41

0.0

1.5

—

(44790047)

0.00

0.41

0.0

1.5

—

(44790049)

0.00

0.41

0.0

1.5

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.3

—

(3019150) Specific gravity of Urine by Refractometry

337

1.20

0.41

2.5

3.4

kg/l

1.0

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

2.0

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

244

1.22

0.39

5.0

4.2

19.0

21.3

0.40

(4035726)

115

0.68

0.38

1.0

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

162

1.26

0.37

1.5

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

1.41

0.35

1.8

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

127

1.28

0.35

4.3

2.9

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

1.38

0.35

1.3

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.66

0.33

1.5

2.8

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.29

0.32

1.7

1.6

—

(3022145) Colonoscopy Study observation

147

1.25

0.32

1.9

1.3

—

(40761535) Cells panel - Urine sediment

0.71

0.31

1.9

3.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

186

1.21

0.29

1.3

1.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.24

0.29

2.3

18.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.30

0.24

1.4

1.6

—

(3012516) Albumin [Mass/volume] in Urine

353

1.13

0.24

3.8

3.4

mg/l

1347.2

243.8

0.39

229

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

153

1494

1.15

0.24

4.3

3.9

mmol/l

1.4

1.5

0.69

145

1393

(3027801) Oxygen [Partial pressure] in Arterial blood

125

0.79

0.23

3.1

10.6

kpa

14.5

12.5

—

118

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

125

0.79

0.23

3.1

10.6

kpa

5.0

5.1

—

118

(3022621) pH of Urine by Test strip

0.73

0.23

2.6

2.2

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

219

0.85

0.22

1.5

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.21

0.0

2.2

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.3

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

106.1

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.21

0.0

1.4

—

(3051014) Leukocytes [#/area] in Urine sediment by Automated count

0.00

0.21

0.0

2.3

—

3.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(4281824)

0.00

0.21

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

23.6

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.20

0.0

3.4

—

875.1

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

1.23

0.20

2.3

1.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

148

1448

1.12

0.19

3.7

3.6

mmol/l

1.3

0.14

139

1345

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

153

1500

1.12

0.19

4.2

4.0

mmol/l

4.8

0.02

146

1408

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

141

0.84

0.17

4.3

2.0

—

(3025941) Bacteria identified in Stool by Culture

1.21

0.16

1.2

—

(3012544) pH of Venous blood

111

1.18

0.16

2.9

3.6

—

(3002256) Pathology report gross observation

161

0.86

0.16

1.4

1.2

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.75

0.16

3.0

3.4

kpa

5.4

5.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

155

1525

1.11

0.15

4.8

4.3

mmol/l

2.9

2.8

0.48

146

1423

(3021879) Hepatitis B virus core Ab [Presence] in Serum

131

1.16

0.15

1.5

—

(3019225) pH of Specimen

112

1.17

0.15

2.7

5.3

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

170

0.87

0.14

4.3

6.1

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

137

1344

1.08

0.13

5.3

5.0

mmol/mol

38.4

38.8

0.22

129

1277

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

664

1.06

0.12

3.0

4.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

309

1.08

0.11

1.3

1.4

—

(4094501)

1.14

0.10

1.4

1.1

—

(40768793) Breast Pathology biopsy report

1.07

0.09

1.0

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

145

1432

1.06

0.08

4.8

3.9

mmol/l

5.7

5.8

0.41

133

1339

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.08

0.08

1.6

1.7

—

(3009508) Creatinine [Moles/volume] in Urine

422

1.06

0.08

2.9

3.3

mmol/l

9.0

8.1

0.40

364

(3017143) Hepatitis C virus Ab [Presence] in Serum

225

1.08

0.08

2.0

1.6

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.85

0.08

2.0

1.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

137

1.10

0.07

1.1

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

108

1.12

0.07

3.8

2.0

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.03

0.07

1.8

3.6

g/l

132.9

131.5

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

151

0.92

0.05

3.4

4.2

33.1

30.8

—

103

(3003338) MCHC [Mass/volume]

141

1396

1.04

0.05

19.1

14.7

g/l

332.7

333.4

0.50

141

1384

(3036481) Cortisol [Moles/volume] in Serum or Plasma

131

1.07

0.03

3.4

1.8

nmol/l

370.1

387.7

0.19

118

(1761868) Lipid panel - Serum or Plasma

591

1.02

0.02

2.1

2.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

116

1.04

0.00

1.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

371

1.00

0.00

3.7

4.2

mg/mmol

8.9

8.0

0.06

238

(3016502) Oxygen saturation in Arterial blood

113

0.97

0.00

2.8

11.3

96.4

96.0

0.11

107

(3027945) Reticulocytes/100 erythrocytes in Blood

127

1.03

0.00

1.4

2.6

1.5

1.7

0.64

117

(3002173) Hemoglobin [Mass/volume] in Arterial blood

108

1.02

0.00

2.9

11.8

g/l

129.0

124.8

0.33

103

(3000991) Gas panel - Venous blood

1.06

0.00

3.7

6.8

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.86

0.00

1.0

1.5

—

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.0

37.0

—

86.0

—

(40758990) Choriogonadotropin.beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3006462) Nitrate [Presence] in Urine

0.00

0.0

1.4

—

(3002619) Bacteria identified in Specimen by Culture

0.00

0.0

1.2

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

3.1

—

(3011288) Drugs identified in Urine by Screen method

0.99

0.00

1.6

4.2

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.4

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.1

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.2

—

(3007463) Buprenorphine [Presence] in Urine

0.00

0.0

5.8

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

4.6

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3023368) Bacteria identified in Blood by Culture

320

1.00

0.00

2.9

4.1

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.3

—

9.2

—

(3028679) Herpes simplex virus Ab [Presence] in Serum

0.00

0.0

1.0

—

(3008898) HLA-B27 [Presence]

0.98

0.00

1.2

1.0

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.5

—

(3004451) EKG impression Narrative

0.00

0.0

1.5

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.87

0.00

1.4

3.6

55.0

51.2

—

(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.3

—

(3020779) Urea [Moles/volume] in Serum or Plasma

0.98

0.00

4.4

8.4

mmol/l

9.2

8.4

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.7

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.98

0.00

2.0

1.5

—

(3014300) Beta 2 glycoprotein 1 IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.89

0.00

1.7

1.4

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.9

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3034988) Calcium [Moles/volume] in Capillary blood

0.00

0.0

1.2

—

1.2

—

(40758292) HTLV I+II Ab panel - Serum

0.00

0.0

1.6

—

(4024509)

0.00

0.0

1.3

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

5.6

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

2.8

—

49.2

—

(4211845)

0.00

0.0

1.3

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.84

0.00

1.6

1.4

—

(3000034) Microalbumin [Mass/volume] in Urine

0.00

0.0

2.7

—

42.6

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.6

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.00

0.00

1.6

2.2

g/l

1.2

1.4

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.4

—

(3035544) Cardiolipin IgG Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.00

0.00

1.2

1.5

—

(3000012) Reticulocyte production index

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_URTICA_CHOLINERG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_CHOLINERG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_URTICA_CHOLINERG – Cholinergic urticaria

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Cholinergic urticaria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints