Cholinergic urticaria

L12_URTICA_CHOLINERG

cholinergic urticaria: a type of physical urticarias (or hives) that appears when a person is sweating.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L50.5
  • Hospital discharge: ICD-9 7085
  • Cause of death: ICD-10 L50.5
  • Cause of death: ICD-9 7085

2 out of 7 registries used, show all original rules.

170

4. Check minimum number of events

None

170

5. Include endpoints

None

170

6. Filter based on genotype QC (FinnGen only)

164

Control definitions (FinnGen only)

Control exclude
L12_URTICARIAERYTHEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L50
Name in latin
Urticaria cholinergica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1274 625 643
Only index persons 1222 606 616
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 28.90 35.86 22.06
Only index persons 28.80 35.69 22.03

-FinnGen-

Key figures

All Female Male
Number of individuals 164 100 64
Unadjusted period prevalence (%) 0.04 0.04 0.03
Median age at first event (years) 39.22 43.44 32.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
170
Matched controls
1701
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L50.5
ICD-10 Finland
Cholinergic urticaria
+∞
201.6
151
*
L50.3
ICD-10 Finland
Dermatographic urticaria
156.4
36.3
37
*
L50.0
ICD-10 Finland
Allergic urticaria
60.2
26.2
30
6
R06AE09
ATC
levocetirizine; oral
6.8
23.5
69
155
C01CA24
ATC
epinephrine; parenteral
13.9
23.3
41
38
XQ800
NOMESCO Finland
Prick test
9.4
21.5
47
66
L50.8
ICD-10 Finland
Other urticaria
87.8
21.3
23
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
8.4
21.2
50
80
L50.9
ICD-10 Finland
Urticaria, unspecified
24.7
20.8
29
14
L50.2
ICD-10 Finland
Urticaria due to cold and heat
+∞
20.2
19
*
R06AE07
ATC
cetirizine; oral
4.7
19.8
120
573
R03DC03
ATC
montelukast; oral
5.6
18.6
63
162
7085A
ICD-9 Finland
Urticaria, Cholinergic urticaria
+∞
18.0
17
*
L50.1
ICD-10 Finland
Idiopathic urticaria
+∞
17.0
16
*
R06AX27
ATC
desloratadine; oral
4.2
16.5
87
341
H02AB06
ATC
prednisolone; systemic
3.7
14.8
101
481
R06AX22
ATC
ebastine; oral
4.2
13.5
59
189
T78.4
ICD-10 Finland
Allergy, unspecified
9.3
11.2
23
28
XQ810
NOMESCO Finland
Physical test for urticaria
+∞
10.5
10
*
R06AX13
ATC
loratadine; oral
3.7
10.0
48
163
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.6
10.0
52
187
J45.0
ICD-10 Finland
Predominantly allergic asthma
5.0
9.2
30
70
D07AB02
ATC
hydrocortisone butyrate; topical
3.0
9.0
65
293
L20.0
ICD-10 Finland
Besnier prurigo
5.5
8.8
26
54
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
21.4
8.6
12
6
D07AB08
ATC
desonide; topical
4.5
8.5
31
81
E0000UV
ATC
NA
2.6
8.3
84
461
N05BB01
ATC
hydroxyzine; systemic
5.3
8.0
24
51
E000001
ATC
NA
3.0
7.8
50
207
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.4
7.2
36
124
L50
ICD-10 Finland
Urticaria
14.6
7.0
11
8
J45
ICD-10 Finland
Asthma
3.9
6.9
28
81
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
6.4
71
395
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
18.9
6.3
9
5
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
6.2
68
375
R06AX26
ATC
fexofenadine; oral
4.2
6.1
22
58

Mortality – FinRegistry

Association

Association between endpoint L12_URTICA_CHOLINERG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_URTICA_CHOLINERG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_URTICA_CHOLINERG – Cholinergic urticaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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