skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
399 |
4. Check minimum number of eventsNone |
399 |
5. Include endpointsNone |
399 |
6. Filter based on genotype QC (FinnGen only) |
399 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L90
- Name in latin
- Striae atrophicae
Similar endpoints
↥List of similar endpoints to
Striae atrophicae
based on the number of shared cases.
Similar with more cases:
- Atrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2553 | 1773 | 764 |
| Only index persons | 2451 | 1722 | 729 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 34.96 | 37.84 | 28.31 |
| Only index persons | 35.09 | 37.92 | 28.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 399 | 316 | 83 |
| Unadjusted period prevalence (%) | 0.09 | 0.11 | 0.04 |
| Median age at first event (years) | 42.74 | 42.67 | 42.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 355
- Matched controls
- 3548
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L90.6
ICD-10 Finland
Striae atrophicae
4503599627370496.0
323.0
350
*
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
138.2
46.0
48
*
ZXE10
NOMESCO Finland
More than one and less than three hours
5.0
44.0
208
780
QAE20
NOMESCO Finland
Excision and repair of scar or web of skin of head or neck
+∞
43.6
41
*
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
50.0
36.9
44
10
ZXE00
NOMESCO Finland
One hour or less
4.2
36.1
224
1022
ZZF00
NOMESCO Finland
Graft of adipose tissue
84.5
34.6
38
5
WX408
NOMESCO Finland
General anesthesy, balanced
4.2
30.8
153
546
QBJ00
NOMESCO Finland
Liposuction in trunk
108.9
28.1
30
*
L91.0
ICD-10 Finland
Hypertrophic scar
58.3
27.7
32
6
ZXE20
NOMESCO Finland
More than three and less than five hours
5.3
27.0
91
215
QBJ30
NOMESCO Finland
Correction of abdominal apron
28.4
26.8
36
14
ZXD10
NOMESCO Finland
Scheduled procedure
3.3
24.9
184
869
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
24.1
129
471
ZZA00
NOMESCO Finland
Split skin graft
22.5
21.7
31
15
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
6.8
21.4
56
95
R4110
NOMESCO Finland
Physiotherapy
3.3
21.3
133
539
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
9.7
20.0
41
47
Z3226
NOMESCO Finland
Physiotherapist
3.6
19.6
105
374
ZXD05
NOMESCO Finland
Urgent procedure
2.9
18.6
155
750
R4120
NOMESCO Finland
Occupational therapy
6.1
17.4
49
91
X59
ICD-10 Finland
Exposure to unspecified factor
3.3
16.7
95
350
Z3231
NOMESCO Finland
Registered nurse
2.8
15.5
127
592
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
4.2
15.2
62
172
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.4
14.3
44
91
Z2221
NOMESCO Finland
Medical doctor
2.6
14.3
135
679
QCE20
NOMESCO Finland
Excision and repair of scar or web of skin of upper limb
145.3
13.5
14
*
N02BE01
ATC
paracetamol; systemic, rectal
3.2
13.5
316
2541
TQW99
NOMESCO Finland
Other minor procedure on skin
8.1
13.5
30
40
QBE30
NOMESCO Finland
Excision and repair of surgical scar in trunk
41.8
13.3
16
*
N02AX02
ATC
tramadol; systemic, rectal
2.4
13.2
156
873
ZXA10
NOMESCO Finland
Bilateral
3.1
13.1
83
322
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
12.5
117
576
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
5.8
12.3
35
66
WX110
NOMESCO Finland
Local anesthesy
2.5
12.1
280
2133
N03AX16
ATC
pregabalin; oral
2.7
12.1
96
430
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
12.0
42
100
J01FF01
ATC
clindamycin; systemic
2.5
11.9
114
564
N62
ICD-10 Finland
Hypertrophy of breast
5.2
11.9
37
78
WX002
NOMESCO Finland
Sedation and analgesia
2.8
11.7
86
367
S18
ICPC
Laceration/cut
2.3
11.5
149
859
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
17.8
11.3
17
10
J01DB01
ATC
cefalexin; oral
2.7
11.0
309
2523
E0000UV
ATC
NA
2.2
10.9
163
994
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.8
10.9
36
81
ZXA05
NOMESCO Finland
Left side
2.5
10.6
96
456
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.2
10.6
141
814
N06AX16
ATC
venlafaxine; oral
2.8
10.5
74
307
N05BA04
ATC
oxazepam; oral
2.4
10.4
103
515
P01AB01
ATC
metronidazole; oral, rectal
2.1
10.2
165
1033
WX402
NOMESCO Finland
General anaesthesia
2.6
10.0
81
361
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
41.3
10.0
12
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
10.0
58
212
TQW40
NOMESCO Finland
Remowal of suture of skin
4.0
9.9
39
105
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.1
9.9
38
100
N05CF01
ATC
zopiclone; oral
2.3
9.8
113
605
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.0
9.7
26
46
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.7
9.6
43
129
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
10.5
9.6
18
18
ZZR00
NOMESCO Finland
Flap of skin
12.8
9.4
16
13
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.0
9.3
173
1134
J01MA12
ATC
levofloxacin; systemic
2.8
9.3
66
271
A46
ICD-10 Finland
Erysipelas
3.3
9.1
47
158
B01AB05
ATC
enoxaparin; parenteral
2.2
9.1
105
563
N06AB04
ATC
citalopram; systemic
2.3
8.9
92
466
M79.6
ICD-10 Finland
Pain in limb
2.1
8.9
140
855
Z2446
NOMESCO Finland
Social worker
3.7
8.9
39
116
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
7.5
8.9
20
28
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
8.8
51
187
L28
ICPC
Limited function/disability (L)
3.0
8.8
51
187
R03AC02
ATC
salbutamol; inhalant
2.0
8.6
203
1442
HAE99
NOMESCO Finland
Other reconstruction of breast
20.6
8.5
12
6
QDE20
NOMESCO Finland
Excision and repair of scar or web of skin of lower limb
92.1
8.4
9
*
QDE30
NOMESCO Finland
Excision and repair of surgical scar in lower limb
+∞
8.4
8
*
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
9.8
8.4
16
17
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
8.3
67
298
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
8.3
132
804
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
7.8
8.3
18
24
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
34.2
8.1
10
*
J01DA01
ATC
[U] cefalexin; systemic
1.9
8.1
232
1752
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.4
7.9
69
319
N06AX11
ATC
mirtazapine; oral
2.0
7.9
117
690
SAA04
NOMESCO Finland
Special inverstigation of mouth
3.6
7.8
35
106
A01
ICPC
Pain general/multiple sites
3.3
7.7
38
124
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.2
7.7
39
130
A08
ICPC
Swelling
5.4
7.7
22
43
E000002
ATC
NA
2.6
7.6
57
244
H02AB06
ATC
prednisolone; systemic
1.9
7.5
160
1073
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.9
7.5
16
21
ZZR10
NOMESCO Finland
Flap of skin and muscle
13.7
7.4
12
9
H02AB09
ATC
hydrocortisone; systemic
7.1
7.4
17
25
N06AB10
ATC
escitalopram; oral
2.1
7.2
91
499
R52.2
ICD-10 Finland
Other chronic pain
5.2
7.2
21
42
N05BA01
ATC
diazepam; systemic, rectal
2.6
7.2
55
237
D06
ICPC
Abdominal pain localized other
3.0
7.2
41
148
TQW20
NOMESCO Finland
Tatoe
8.2
7.2
15
19
A06AD11
ATC
lactulose; oral
2.9
7.1
44
166
S29
ICPC
Skin symptom/complaint other
2.3
7.1
67
324
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
4.8
7.0
22
48
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.5
7.0
31
94
N05AH04
ATC
quetiapine; oral
2.2
7.0
74
376
E66.8
ICD-10 Finland
Other obesity
3.3
6.9
34
111
E000001
ATC
NA
2.1
6.9
89
491
GBB00
NOMESCO Finland
Tracheostomy
14.1
6.9
11
8
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
6.9
122
764
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.3
6.8
33
107
R05
ICD-10 Finland
Cough
2.2
6.8
71
359
X58
ICD-10 Finland
Exposure to other specified factors
2.4
6.8
62
293
A02BC02
ATC
pantoprazole; systemic
1.8
6.7
217
1655
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.5
6.7
30
92
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.4
6.6
55
249
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.8
6.6
208
1568
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
6.6
95
548
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.6
6.6
48
202
R06AE07
ATC
cetirizine; oral
1.8
6.5
169
1196
AA1AD
NOMESCO Finland
CT of head and brain
2.2
6.5
69
351
N03AE01
ATC
clonazepam; systemic
3.7
6.5
27
78
QDE35
NOMESCO Finland
Repair of skin defect in lower limb after surgery or injury
71.1
6.4
7
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.4
6.4
30
95
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.9
6.4
38
142
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
6.8
6.4
15
23
D07AC13
ATC
mometasone; topical
1.9
6.4
103
618
A02BC01
ATC
omeprazole; systemic
2.0
6.3
95
558
ZXA00
NOMESCO Finland
Right side
2.0
6.3
85
479
D07AA02
ATC
hydrocortisone; topical
2.3
6.3
62
305
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
6.3
199
1494
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.6
6.3
46
192
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.3
154
1066
QBE00
NOMESCO Finland
Excision of loose skin or fold of skin from trunk
+∞
6.3
6
*
EDC38
NOMESCO Finland
Open reduction and fixation of fracture of body of mandible
+∞
6.3
6
*
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.7
6.3
26
75
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
27.2
6.3
8
*
UKC02
NOMESCO Finland
Cystoscopy
2.7
6.2
41
164
R60.0
ICD-10 Finland
Localized oedema
2.8
6.2
39
149
A02BC05
ATC
esomeprazole; systemic
1.8
6.1
138
930
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
6.1
71
376
QAB00
NOMESCO Finland
Suture of skin of head or neck
8.8
6.1
12
14
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.5
6.1
46
198
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
10.3
6.1
11
11
HA1AA
NOMESCO Finland
X-ray mammography
2.8
6.0
38
146
D07AD01
ATC
clobetasol; topical
2.3
6.0
58
283
TKC20
NOMESCO Finland
Catheterisation of bladder
3.9
6.0
23
62
Mortality – FinRegistry
↥Association
Association between endpoint L12_STRIAEATROPHICAE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_STRIAEATROPHICAE | 1.328 [1.01, 1.75] | 0.045 |
| Birth year | 0.996 [0.99, 1.0] | 0.317 |
During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 1519 females with L12_STRIAEATROPHICAE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_STRIAEATROPHICAE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | No data |
| 5 | 0.764% | No data |
| 10 | 1.961% | No data |
| 15 | 3.999% | No data |
| 20 | 7.169% | No data |
Relationships between endpoints
↥Index endpoint: L12_STRIAEATROPHICAE – Striae atrophicae
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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