Risteys · L12_SCARCONDITIONS

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L90.5 Hospital discharge: ICD-9 — 7092 Hospital discharge: ICD-8 — 7090[6-7] Cause of death: ICD-10 — L90.5 Cause of death: ICD-9 — 7092 Cause of death: ICD-8 — 7090[6-7] 2 out of 7 registries used, show all original rules.	1551
4. Check minimum number of events None	1551
5. Include endpoints None	1551
6. Filter based on genotype QC (FinnGen only)	1551

	All	Female	Male
Number of individuals
Whole population	10628	7098	3457
Only index persons	9929	6769	3160
Unadjusted period prevalence (%)
Whole population	0.17	0.20	0.10
Only index persons	0.21	0.25	0.12
Median age at first event (years)
Whole population	39.03	40.91	35.05
Only index persons	38.45	40.47	34.13

	All	Female	Male
Number of individuals	1551	1168	383
Unadjusted period prevalence (%)	0.34	0.40	0.17
Median age at first event (years)	45.90	45.81	46.18

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
1386: Matched controls
13861

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L90.5

ICD-10 Finland

Scar conditions and fibrosis of skin

13416.9

323.0

1191

L91.0

ICD-10 Finland

Hypertrophic scar

163.0

140.3

146

QAE20

NOMESCO Finland

Excision and repair of scar or web of skin of head or neck

170.0

119.4

124

7092A

ICD-9 Finland

Other disorders of skin and subcutaneous tissue, Scar conditions and fibrosis of skin

+∞

101.3

70907

ICD-8 Finland

Other diseases of skin, Cicatrix NUD

+∞

99.2

QBE20

NOMESCO Finland

Excision and repair of scar or web of skin of trunk

38.4

86.3

110

QBE30

NOMESCO Finland

Excision and repair of surgical scar in trunk

40.5

72.3

ZZF00

NOMESCO Finland

Graft of adipose tissue

25.0

61.4

ZXE10

NOMESCO Finland

More than one and less than three hours

2.5

53.4

614

3351

WX408

NOMESCO Finland

General anesthesy, balanced

2.6

50.7

480

2336

ZXE00

NOMESCO Finland

One hour or less

2.3

48.6

662

3883

ZXD10

NOMESCO Finland

Scheduled procedure

2.4

48.2

638

3681

L90.6

ICD-10 Finland

Striae atrophicae

462.3

45.5

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.6

45.2

401

1857

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

4.5

44.5

168

409

QBJ00

NOMESCO Finland

Liposuction in trunk

28.2

41.9

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

3.5

41.7

217

701

HAD30

NOMESCO Finland

Reduction mammoplasty with transposition of areola

5.5

41.3

129

255

QAE30

NOMESCO Finland

Excision and repair of surgical scar in head or neck

69.3

41.3

QDE20

NOMESCO Finland

Excision and repair of scar or web of skin of lower limb

113.5

41.0

Z3226

NOMESCO Finland

Physiotherapist

2.6

39.2

334

1494

HAD99

NOMESCO Finland

Other plastic operation on breast

24.4

38.2

ZZA00

NOMESCO Finland

Split skin graft

8.4

37.7

107

Z3231

NOMESCO Finland

Registered nurse

2.3

36.6

440

2344

Z2221

NOMESCO Finland

Medical doctor

2.2

35.4

472

2630

QCE20

NOMESCO Finland

Excision and repair of scar or web of skin of upper limb

78.2

34.0

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

3.8

33.6

154

445

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

3.6

33.5

160

479

9734

FHL

Excision and local plastic or associated free skin grafting

34.1

33.3

R4110

NOMESCO Finland

Physiotherapy

2.2

33.0

421

2283

QAE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in head or neck

3.7

32.5

150

436

N62

ICD-10 Finland

Hypertrophy of breast

4.4

32.1

122

297

QBB10

NOMESCO Finland

Major dressing of wound of skin of trunk

5.4

30.8

189

QBJ30

NOMESCO Finland

Correction of abdominal apron

14.8

29.8

R4120

NOMESCO Finland

Occupational therapy

3.8

29.6

133

377

WX402

NOMESCO Finland

General anaesthesia

2.4

28.4

285

1364

ZXA00

NOMESCO Finland

Right side

2.1

27.9

394

2201

S18

ICPC

Laceration/cut

1.9

27.4

574

3738

ZXD20

NOMESCO Finland

Day surgery

2.5

26.0

237

1076

X59

ICD-10 Finland

Exposure to unspecified factor

2.3

26.0

286

1426

WX110

NOMESCO Finland

Local anesthesy

1.9

25.8

1002

8015

ZXA05

NOMESCO Finland

Left side

2.1

25.7

367

2051

N02AX02

ATC

tramadol; systemic, rectal

1.8

24.4

564

3761

N02AJ06

ATC

codeine and paracetamol; systemic

1.8

23.7

535

3523

HA1AA

NOMESCO Finland

X-ray mammography

2.9

23.5

152

563

TQW99

NOMESCO Finland

Other minor procedure on skin

4.3

23.4

217

ZXA10

NOMESCO Finland

Bilateral

2.2

22.8

271

1392

N02BE01

ATC

paracetamol; systemic, rectal

2.1

22.4

1181

10207

J01DB01

ATC

cefalexin; oral

2.0

22.4

1141

9729

J02AC01

ATC

fluconazole; systemic

1.8

22.3

622

4366

WX002

NOMESCO Finland

Sedation and analgesia

2.1

22.2

294

1576

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

7.4

22.2

HA1AE

NOMESCO Finland

Ultrasound examination of mammary glands

2.9

21.9

138

501

Z42.1

ICD-10 Finland

Follow-up care involving plastic surgery of breast

13.5

21.5

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

19.8

20.9

J01FF01

ATC

clindamycin; systemic

1.9

20.9

386

2352

ZXE20

NOMESCO Finland

More than three and less than five hours

2.3

20.5

200

934

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.8

20.0

520

3537

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.7

19.6

626

4516

N05CF01

ATC

zopiclone; oral

1.8

19.6

419

2669

HAE99

NOMESCO Finland

Other reconstruction of breast

10.8

19.5

N03AX16

ATC

pregabalin; oral

1.9

19.1

330

1953

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.8

18.9

369

2276

PJA12

NOMESCO Finland

Sentinel node biopsy

2.7

18.9

140

562

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.8

18.8

426

2762

N06AX11

ATC

mirtazapine; oral

1.8

18.6

439

2878

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

4.2

18.6

174

P01AB01

ATC

metronidazole; oral, rectal

1.7

18.3

567

4031

115

Kela drug reimbursment

Breast cancer

2.6

18.1

143

596

B01AB05

ATC

enoxaparin; parenteral

1.8

17.9

392

2504

TQW40

NOMESCO Finland

Remowal of suture of skin

2.8

17.9

118

442

ZZR00

NOMESCO Finland

Flap of skin

6.4

17.8

J01MA02

ATC

ciprofloxacin; systemic

1.7

17.8

483

3299

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.7

17.6

472

3208

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

2.1

17.6

219

1135

QDE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in lower limb

4.8

17.5

128

A06AC01

ATC

ispaghula (psylla seeds); oral

1.8

17.0

324

1973

QDE30

NOMESCO Finland

Excision and repair of surgical scar in lower limb

91.2

16.6

N05BA04

ATC

oxazepam; oral

1.8

16.2

348

2199

J01DA01

ATC

[U] cefalexin; systemic

1.6

16.1

834

6712

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.7

15.9

110

424

9733

FHL

Excision of skin change in operating room or anesthesia

6.5

15.9

THW99

NOMESCO Finland

Other minor procedure in surgery of mammary gland

4.8

15.8

115

ZXD05

NOMESCO Finland

Urgent procedure

1.7

15.6

419

2825

QBB05

NOMESCO Finland

Revision of wound of skin of trunk

9.1

15.5

M01AE03

ATC

ketoprofen; systemic, rectal

1.6

15.4

479

3366

A02BC02

ATC

pantoprazole; systemic

1.6

15.4

832

6734

X58

ICD-10 Finland

Exposure to other specified factors

2.1

15.3

195

1016

PJD52

NOMESCO Finland

Block dissection of axillary lymph nodes

3.4

15.1

226

A02BC05

ATC

esomeprazole; systemic

1.6

15.1

533

3866

ZXE30

NOMESCO Finland

More than five and less than seven hours

3.1

14.9

273

N05AH04

ATC

quetiapine; oral

1.9

14.7

241

1386

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

13.4

14.7

TPH04

NOMESCO Finland

Cathetrisation of vein

1.8

14.4

258

1531

L02BG04

ATC

letrozole; oral

2.6

14.3

110

451

J01FA10

ATC

azithromycin; systemic

1.6

14.2

813

6609

N06AX16

ATC

venlafaxine; oral

1.9

14.0

217

1223

ZXE03

NOMESCO Finland

Procedure duration 20 to 29 minutes

2.7

14.0

382

C44.31

ICD-10 Finland

Basocellular carcinoma of the skin on another or unspecified part of the face

3.1

14.0

252

SPAT1153

SPAT

Removal of sutures

1.7

13.9

391

2654

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.6

13.9

503

3654

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.1

13.6

171

886

QAE40

NOMESCO Finland

Repair of anomaly or lesion after disease of skin of head or neck

18.4

13.4

A02BC03

ATC

lansoprazole; oral

1.7

13.2

368

2485

C50.41

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor

2.6

13.2

395

HAC20

NOMESCO Finland

Total mastectomy

3.0

13.1

256

ZX012

NOMESCO Finland

Radiotherapy with large shaped fields - isocentric therapy

2.8

12.8

315

R03AC02

ATC

salbutamol; inhalant

1.5

12.8

702

5590

C50.40

ICD-10 Finland

Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication

4.3

12.7

109

Z2446

NOMESCO Finland

Social worker

2.5

12.5

102

431

HAD20

NOMESCO Finland

Liposuction of breast

24.5

12.5

TQW11

NOMESCO Finland

Vacuum treatment of wound

5.7

12.4

M79.6

ICD-10 Finland

Pain in limb

1.6

12.4

460

3341

ZZR10

NOMESCO Finland

Flap of skin and muscle

9.1

12.3

HAE10

NOMESCO Finland

Reconstruction of breast using graft or flap

5.2

12.2

Z2445

NOMESCO Finland

Psychologist

2.9

12.1

263

J01MA12

ATC

levofloxacin; systemic

1.8

12.0

215

1269

UJF32

NOMESCO Finland

Coloscopy

1.7

12.0

300

1962

Z71.8

ICD-10 Finland

Other specified counselling

1.6

11.9

332

2237

Z01.8

ICD-10 Finland

Other specified special examinations

1.7

11.7

275

1767

WX320

NOMESCO Finland

Spinalanesthesy

1.7

11.6

282

1827

T81.0

ICD-10 Finland

Haemorrhage and haematoma complicating a procedure, not elsewhere classified

2.5

11.5

373

E0000UV

ATC

1.5

11.5

517

3906

L82

ICD-10 Finland

Seborrhoeic keratosis

1.9

11.5

165

902

N63

ICD-10 Finland

Unspecified lump in breast

2.4

11.4

101

447

T81.3

ICD-10 Finland

Disruption of operation wound, not elsewhere classified

4.4

11.3

N05CF02

ATC

zolpidem; oral

1.7

11.3

235

1453

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.5

11.1

642

5108

H02.3

ICD-10 Finland

Blepharochalasis

2.5

11.1

350

QAB10

NOMESCO Finland

Major dressing of wound of skin of head or neck

11.3

11.1

HAB50

NOMESCO Finland

Partial excision of mammary gland with reconstructive operation

3.7

11.0

130

A02BA02

ATC

ranitidine; systemic

1.7

11.0

237

1479

L28

ICPC

Limited function/disability (L)

1.9

11.0

174

983

Z41.1

ICD-10 Finland

Other plastic surgery for unacceptable cosmetic appearance

9.3

11.0

HA1CG

NOMESCO Finland

Extensive MRI examination of mammary gland with high intensity magnet

4.6

11.0

SPAT1148

SPAT

Treatment of chronic ulcer or burn

2.0

11.0

144

760

UDH02

NOMESCO Finland

Rhinopharyngoscopy

2.4

10.9

429

M01AE01

ATC

ibuprofen; systemic, rectal

1.7

10.8

1220

11222

J02AC02

ATC

itraconazole; systemic

1.7

10.8

247

1573

EP1AE

NOMESCO Finland

Neck ultrasound examination

2.5

10.8

355

SAA01

NOMESCO Finland

Simple examination of mouth

1.5

10.7

960

8333

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.6

10.7

337

2335

C50.90

ICD-10 Finland

Malignant tumor in other or unspecified location in mammary gland without histology

4.0

10.6

104

ZZS45

NOMESCO Finland

Z-plasty

60.5

10.6

YG1BD

NOMESCO Finland

Extensive CT examination of thorax for dose design of radiotherapy

3.0

10.5

207

H04.10

ICD-10 Finland

Dry eye syndrome

2.0

10.4

145

780

QCE30

NOMESCO Finland

Excision and repair of surgical scar in upper limb

+∞

10.4

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.5

10.4

495

3763

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

2.5

10.3

351

A03FA01

ATC

metoclopramide; systemic, rectal

1.6

10.3

275

1820

W00

ICD-10 Finland

Fall on same level involving ice and snow

2.0

10.3

138

733

L02BA01

ATC

tamoxifen; oral

2.7

10.3

264

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.0

10.3

132

691

RD210

NOMESCO Finland

4.0

10.2

103

D48.5

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Skin

2.6

10.2

300

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

10.2

728

6005

ZXE04

NOMESCO Finland

Procedure duration 30 to 39 minutes

2.3

10.2

398

L70.0

ICD-10 Finland

Acne vulgaris

3.1

10.1

173

QB2S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in chest

7.0

10.1

J01AA02

ATC

doxycycline; systemic

1.5

10.1

993

8726

HAD60

NOMESCO Finland

Replacement of prosthetic implant in breast

11.4

10.1

F43.22

ICD-10 Finland

Adaptation disorder with mixed anxiety and depression

2.6

10.1

297

D10BA01

ATC

isotretinoin; oral

2.2

10.0

105

505

N06CA01

ATC

amitriptyline and psycholeptics; systemic

2.0

10.0

138

741

J45.9

ICD-10 Finland

Asthma, unspecified

1.7

10.0

227

1438

ZXB10

NOMESCO Finland

Medial

9.6

9.8

WX290

NOMESCO Finland

Other blockade of nerve

1.4

9.7

593

4730

R01AD09

ATC

mometasone; nasal

1.4

9.7

605

4841

R06AE07

ATC

cetirizine; oral

1.4

9.7

585

4652

ZXE06

NOMESCO Finland

Procedure duration 50 to 59 minutes

2.4

9.7

369

V49.9

ICD-10 Finland

Car occupant [any] injured in unspecified traffic accident

2.9

9.6

196

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.5

9.5

351

2517

J05AB01

ATC

aciclovir; systemic

1.6

9.5

271

1826

M03BC51

ATC

orphenadrine, combinations; systemic

1.5

9.4

371

2696

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

9.4

669

5477

XQ848

NOMESCO Finland

Dermatological photography

3.8

9.4

101

ZQX00

NOMESCO Finland

0-4% of the skin

30.2

9.4

QDE35

NOMESCO Finland

Repair of skin defect in lower limb after surgery or injury

17.7

9.4

ZXC12

NOMESCO Finland

Pulse colorlaser

17.7

9.4

M19.0

ICD-10 Finland

Primary arthrosis of other joints

2.0

9.4

117

603

R51.80

ICD-10 Finland

Headache

1.7

9.4

206

1291

Z87.1

ICD-10 Finland

Personal history of diseases of the digestive system

1.4

9.3

558

4418

N03AX12

ATC

gabapentin; oral

1.7

9.3

190

1166

HAD50

NOMESCO Finland

Removal of prosthetic implant from breast

8.7

9.3

HA6AA

NOMESCO Finland

Extra corporeal mammography of operated mammary gland

3.0

9.2

184

M25.5

ICD-10 Finland

Pain in joint

1.5

9.2

364

2645

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

2.2

9.2

426

N06AB06

ATC

sertraline; oral

1.8

9.1

153

880

N06AB04

ATC

citalopram; systemic

1.6

9.1

276

1886

N06AA09

ATC

amitriptyline; systemic

1.9

9.1

131

715

QXA25

NOMESCO Finland

Destruction of lesion of skin, site unspecified

4.6

9.1

XF400

NOMESCO Finland

ECG with 12 standard connections

1.8

9.1

175

1054

WX702

NOMESCO Finland

Supraglottic ventilation device

2.4

9.1

342

AA1AD

NOMESCO Finland

CT of head and brain

1.6

9.1

251

1673

R01AD08

ATC

fluticasone; nasal

1.5

9.1

369

2700

N06AX21

ATC

duloxetine; oral

1.8

9.1

147

837

M01AB05

ATC

diclofenac; systemic, rectal

1.4

9.0

855

7365

C07AA05

ATC

propranolol; systemic

1.6

9.0

266

1804

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.8

9.0

162

954

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.7

8.9

213

1368

Z3229

NOMESCO Finland

Other healthcare associate professional

2.0

8.9

107

545

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.9

8.9

131

723

R23.8

ICD-10 Finland

Other and unspecified skin changes

1.7

8.9

184

1133

G44.2

ICD-10 Finland

Tension-type headache

1.7

8.8

187

1159

N06AB10

ATC

escitalopram; oral

1.6

8.8

275

1890

L57.0

ICD-10 Finland

Actinic keratosis

2.2

8.8

423

JN4BD

NOMESCO Finland

Extensive body CT

1.9

8.8

128

701

A46

ICD-10 Finland

Erysipelas

1.9

8.7

139

787

ZXE11

NOMESCO Finland

Procedure duration 60 to 89 minutes

2.2

8.7

428

J01FA06

ATC

roxithromycin; oral

1.4

8.7

501

3922

Z42.2

ICD-10 Finland

Follow-up care involving plastic surgery of other parts of trunk

50.3

8.7

QAE99

NOMESCO Finland

Other excision or repair surgery of skin and subcutaneous tissue in head and neck

3.9

8.7

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.6

8.6

213

1376

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.4

8.6

749

6320

WZC10

NOMESCO Finland

Extensive specialist consultion with written report

2.4

8.6

323

H03AA01

ATC

levothyroxine sodium; systemic

1.5

8.6

304

2149

D07AB08

ATC

desonide; topical

1.9

8.6

127

702

TQW20

NOMESCO Finland

Tatoe

4.8

8.6

D07AC01

ATC

betamethasone; topical

1.5

8.5

404

3045

QXB99

NOMESCO Finland

Other procedure to treat skin wound, unspecified location

5.0

8.5

D07AB02

ATC

hydrocortisone butyrate; topical

1.5

8.4

344

2513

D06BB10

ATC

imiquimod; topical

2.5

8.4

262

H02AB06

ATC

prednisolone; systemic

1.4

8.4

553

4435

NGU20

NOMESCO Finland

Removal of internal fixation device from knee or lower leg

4.2

8.4

R52.2

ICD-10 Finland

Other chronic pain

2.8

8.4

196

ZX120

NOMESCO Finland

Intravenous

1.9

8.4

121

660

A02BC01

ATC

omeprazole; systemic

1.5

8.4

325

2346

M54.5

ICD-10 Finland

Low back pain

1.5

8.4

414

3146

TQB05

NOMESCO Finland

Puncture of skin of trunk

5.1

8.3

70906

ICD-8 Finland

Other diseases of skin, Cicatrix atrophica

+∞

8.3

QBE99

NOMESCO Finland

Other excision or repair of lesion of skin of trunk

3.5

8.3

108

QAA05

NOMESCO Finland

Incision for biopsy of skin of head or neck

4.2

8.3

N39.3

ICD-10 Finland

Stress incontinence

2.0

8.3

505

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

9.5

8.3

H02AB07

ATC

prednisone; oral

1.7

8.2

178

1108

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.4

8.2

516

4099

T81.8

ICD-10 Finland

Other complications of procedures, not elsewhere classified

3.6

8.2

KMAK

NOMESCO Finland

1.4

8.2

686

5734

HAD40

NOMESCO Finland

Mastopexy

7.6

8.2

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.4

8.2

695

5823

8500/3-C50.9

ICD-O-3

Infiltrating duct carcinoma, NOS, of breast, NOS

2.4

8.1

293

K02.1

ICD-10 Finland

Caries of dentine

1.4

8.1

747

6343

ZZA50

NOMESCO Finland

Full thickness skin graft

11.8

8.1

RF210

NOMESCO Finland

3.0

7.9

146

LC2AE

NOMESCO Finland

Ultrasound examination of uterus and parametria

1.7

7.9

159

970

J04AB02

ATC

rifampicin; systemic

6.1

7.9

8090/3-C44.3

ICD-O-3

Basal cell carcinoma, NOS, of skin of other and unspecified parts of face

3.4

7.9

108

ZY010

NOMESCO Finland

Hospital outpatient

2.3

7.8

327

QAA40

NOMESCO Finland

Laser therapy or photocoagulation of skin of head or neck

8.5

7.8

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.7

7.8

180

1142

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.3

7.8

309

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

2.2

7.7

330

J01AA07

ATC

tetracycline; systemic

1.6

7.7

198

1294

TDM10

NOMESCO Finland

Puncture of maxillary antrum

2.6

7.7

214

M01AX17

ATC

nimesulide; oral

1.5

7.7

274

1938

UJD02

NOMESCO Finland

Gastroscopy

2.5

7.7

233

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

1.5

7.6

289

2068

SPAT1149

SPAT

Suture or treatment of traumatic wound

1.8

7.6

135

792

N64.9

ICD-10 Finland

Disorder of breast, unspecified

5.0

7.6

A03FA02

ATC

cisapride; oral, rectal

2.0

7.6

502

N06AX18

ATC

reboxetine; oral

5.2

7.6

L17

ICPC

Foot/toe symptom/complaint

1.5

7.5

292

2104

L90.0

ICD-10 Finland

Lichen sclerosus et atrophicus

5.5

7.5

Y84

ICD-10 Finland

Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

5.8

7.5

N06AB03

ATC

fluoxetine; oral

1.7

7.5

170

1071

ZXD31

NOMESCO Finland

Major difficulties in performing procedure

2.6

7.5

212

K02.0

ICD-10 Finland

Caries limited to enamel

1.6

7.5

188

1221

GD1BD

NOMESCO Finland

Thorax extensive CT-examination

2.4

7.5

260

N30.0

ICD-10 Finland

Acute cystitis

1.7

7.5

173

1101

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

2.1

7.5

418

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.5

7.5

300

2175

QA4S1

NOMESCO Finland

Photography of skin or subcutaneous tissue in face

7.7

7.4

R60.0

ICD-10 Finland

Localized oedema

1.8

7.4

119

678

S01GX01

ATC

cromoglicic acid; ophthalmic

1.5

7.4

266

1883

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

1.7

7.4

167

1056

K21.0

ICD-10 Finland

Gastro-oesophageal reflux disease with oesophagitis

1.8

7.4

119

680

S29

ICPC

Skin symptom/complaint other

1.6

7.3

203

1351

L08.8

ICD-10 Finland

Other specified local infections of skin and subcutaneous tissue

3.1

7.3

120

R03AC03

ATC

terbutaline; inhalant

1.6

7.3

176

1132

QCD00

NOMESCO Finland

Dressing of major burn of upper limb

15.8

7.2

C50

ICD-10 Finland

Malignant neoplasm of breast

3.0

7.2

127

ZXE02

NOMESCO Finland

Procedure duration 10 to 19 minutes

2.2

7.2

302

R50.9

ICD-10 Finland

Fever, unspecified

1.7

7.2

164

1040

N02AA05

ATC

oxycodone; systemic

1.7

7.2

141

855

N06AA10

ATC

nortriptyline; systemic

3.1

7.1

117

J01CE02

ATC

phenoxymethylpenicillin; oral

1.4

7.1

892

7887

D06AX01

ATC

fusidic acid; topical (antibiotics for topical use)

1.8

7.1

122

712

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

2.0

7.1

433

ZZQ00

NOMESCO Finland

Free microvascular graft of skin

8.8

7.1

M01AH05

ATC

etoricoxib; oral

1.4

7.1

732

6276

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.7

7.0

138

836

N05BA01

ATC

diazepam; systemic, rectal

1.7

7.0

162

1028

HAC15

NOMESCO Finland

Subcutaneous mastectomy with excision of mamilla

7.0

UKC02

NOMESCO Finland

Cystoscopy

1.7

7.0

146

903

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

1.9

7.0

526

C50.99

ICD-10 Finland

Breast, unspecified

2.8

7.0

147

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

1.9

6.9

104

576

WB113

NOMESCO Finland

Multiple adjuvant cytostatic therapy

2.1

6.9

352

C50.82

ICD-10 Finland

Overall malignant tumor of the mammary gland, lobular tumor

5.5

6.9

HAE00

NOMESCO Finland

Reconstruction of breast using prosthesis

7.6

6.9

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.9

6.9

100

549

XF600

NOMESCO Finland

Bloodpressure measurement

2.1

6.9

367

R06.0

ICD-10 Finland

Dyspnoea

1.5

6.9

267

1921

R05

ICD-10 Finland

Cough

1.5

6.9

233

1627

R07.4

ICD-10 Finland

Chest pain, unspecified

1.5

6.9

285

2080

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

1.9

6.8

508

H02AB02

ATC

dexamethasone; systemic

1.8

6.8

126

748

R42

ICD-10 Finland

Dizziness and giddiness

1.5

6.8

231

1611

QCE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in upper limb

3.1

6.8

110

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.6

6.8

204

1384

G04BD04

ATC

oxybutynin; oral, transdermal

2.2

6.7

291

H53.1

ICD-10 Finland

Subjective visual disturbances

2.0

6.7

388

Z31.5

ICD-10 Finland

Genetic counselling

2.2

6.7

304

WZC30

NOMESCO Finland

Teaching

1.7

6.7

142

879

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

2.4

6.7

231

NG4AA

NOMESCO Finland

Lower leg X-ray examination

2.9

6.7

139

SFA40

NOMESCO Finland

Replacement of krone of tooth

1.5

6.7

231

1620

X00

ICD-10 Finland

Exposure to uncontrolled fire in building or structure

22.6

6.7

QAB05

NOMESCO Finland

Revision of wound of skin of head or neck

22.6

6.7

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

3.5

6.6

ZXD30

NOMESCO Finland

Difficulties in perfomrming procedure

2.3

6.6

254

ZXE05

NOMESCO Finland

Procedure duration 40 to 49 minutes

2.1

6.6

360

N06AX12

ATC

bupropion; oral

1.9

6.6

470

C50.81

ICD-10 Finland

Overall malignant tumor of the mammary gland, ductal tumor

3.7

6.6

HA003

NOMESCO Finland

Radiotherapy after partial ablation of mammary gland

2.2

6.6

280

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

1.7

6.6

145

908

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

1.7

6.5

122

727

QAB00

NOMESCO Finland

Suture of skin of head or neck

4.8

6.5

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

1.7

6.5

140

870

Y83.8

ICD-10 Finland

Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.9

6.5

125

J01MA14

ATC

moxifloxacin; systemic

1.9

6.5

539

L02BG06

ATC

exemestane; oral

3.8

6.5

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.3

6.5

593

4962

EBB15

NOMESCO Finland

Insertion of dental implant abutment

5.7

6.5

T21.3

ICD-10 Finland

Burn of third degree of trunk

70.2

6.4

QAE35

NOMESCO Finland

Repair of skin defect in head or neck after surgery or injury

70.2

6.4

N06AX03

ATC

mianserin; oral

2.2

6.4

276

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.7

6.4

119

708

HAE20

NOMESCO Finland

Reconstruction of areola and mamilla using graft or flap

4.1

6.4

J01MA06

ATC

norfloxacin; oral

1.6

6.4

162

1054

F32.9

ICD-10 Finland

Depressive episode, unspecified

1.6

6.4

165

1081

A04.7

ICD-10 Finland

Enterocolitis due to Clostridium difficile

3.3

6.4

E03.9

ICD-10 Finland

Hypothyroidism, unspecified

1.6

6.4

151

967

HA1AT

NOMESCO Finland

Biopsy of mammary glands with ultrasound guidance

2.9

6.4

132

SBB00

NOMESCO Finland

Fotograf of mouth and teeth

2.3

6.3

258

HWA00

NOMESCO Finland

Repair of wound dehiscence in surgery of mammary gland

8.2

6.3

R03DC03

ATC

montelukast; oral

1.5

6.3

205

1417

K58.0

ICD-10 Finland

Irritable bowel syndrome with diarrhoea

2.0

6.3

391

D04.3

ICD-10 Finland

Carcinoma in situ: Skin of other and unspecified parts of face

4.2

6.3

WB103

NOMESCO Finland

Simple adjuvant cytostatic therapy

2.3

6.3

239

R22.4

ICD-10 Finland

Localized swelling, mass and lump, lower limb

3.0

6.3

111

D07CA01

ATC

hydrocortisone and antibiotics; topical

1.6

6.3

155

1002

QBA25

NOMESCO Finland

Destruction of lesion of skin of trunk

4.6

6.3

T90.5

ICD-10 Finland

Sequelae of intracranial injury

4.6

6.3

S01.9

ICD-10 Finland

Open wound of head, part unspecified

3.9

6.3

ZXE40

NOMESCO Finland

More than seven and less than nine hours

3.1

6.3

100

R01BA52

ATC

pseudoephedrine, combinations; oral

1.4

6.3

373

2904

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.5

6.3

200

1379

R03BA05

ATC

fluticasone; inhalant

1.5

6.3

226

1599

L91.8

ICD-10 Finland

Other hypertrophic disorders of skin

26.8

6.2

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

1.8

6.2

534

S81.8

ICD-10 Finland

Open wound of other parts of lower leg

2.8

6.2

135

CBB20

NOMESCO Finland

Correction of lax skin of eyelid and resection of herniated fat

3.9

6.2

S97

ICPC

Chronic ulcer skin

2.5

6.2

177

A03DA02

ATC

pitofenone and analgesics; systemic

3.3

6.2

HAE05

NOMESCO Finland

Reconstruction of breast using soft tissue and prosthesis

6.3

6.2

N31.9

ICD-10 Finland

Neuromuscular dysfunction of bladder, unspecified

6.3

6.2

L84

ICD-10 Finland

Corns and callosities

3.2

6.2

C44.51

ICD-10 Finland

Basocellular carcinoma of the skin on the torso

3.4

6.1

E000002

ATC

1.6

6.1

139

880

L89

ICD-10 Finland

Decubitus ulcer and pressure area

12.6

6.1

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.7

6.1

121

736

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.7

6.1

128

795

D02AE01

ATC

carbamide; topical

1.9

6.1

427

RS230

NOMESCO Finland

8.6

6.1

QDB99

NOMESCO Finland

Other procedure for wound of skin of lower limb

8.6

6.1

R22.3

ICD-10 Finland

Localized swelling, mass and lump, upper limb

3.4

6.1

K05.1

ICD-10 Finland

Chronic gingivitis

1.9

6.1

487

Z76.0

ICD-10 Finland

Issue of repeat prescription

1.5

6.0

182

1238

L98.9

ICD-10 Finland

Disorder of skin and subcutaneous tissue, unspecified

10.1

6.0

HAB40

NOMESCO Finland

Wedge excision of mammary gland

2.1

6.0

334

X21

ICPC

Breast sympt/compl female other

3.0

6.0

109

LFB00

NOMESCO Finland

Biopsy of vulva or perineum

3.1

6.0

Z01.4

ICD-10 Finland

Gynaecological examination (general)(routine)

1.5

6.0

227

1620

NAME	L12_SCARCONDITIONS
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L905
HD_ICD_9	7092
HD_ICD_8	7090[6-7]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L905
COD_ICD_9	7092
COD_ICD_8	7090[6-7]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
L12_SCARCONDITIONS	1.162 [1.0, 1.34]	0.043
Birth year	0.999 [0.99, 1.01]	0.85

Parameter	HR [95% CI]	p-value
L12_SCARCONDITIONS	1.13 [0.96, 1.34]	0.151
Birth year	0.987 [0.98, 1.0]	0.009

N-year risk	Females	Males
1	0.171%	0.243%
5	0.873%	1.446%
10	2.118%	3.502%
15	3.909%	6.488%
20	6.892%	10.721%

Scar conditions and fibrosis of skin

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints