No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
202 |
4. Check minimum number of eventsNone |
202 |
5. Include endpointsNone |
202 |
6. Filter based on genotype QC (FinnGen only) |
202 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L71
- Name in latin
- Rhinophyma
Similar endpoints
↥List of similar endpoints to
Rhinophyma
based on the number of shared cases.
Similar with more cases:
- Rosacea
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1418 | 326 | 1079 |
| Only index persons | 1182 | 258 | 924 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.01 | 0.03 |
| Only index persons | 0.03 | 0.01 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 62.67 | 49.47 | 66.72 |
| Only index persons | 62.60 | 47.46 | 66.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 202 | 32 | 170 |
| Unadjusted period prevalence (%) | 0.06 | 0.01 | 0.07 |
| Median age at first event (years) | 64.36 | 47.43 | 67.55 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 179
- Matched controls
- 1788
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L71.1
ICD-10 Finland
Rhinophyma
15961.6
220.0
164
*
D06BX01
ATC
metronidazole; topical
78.2
106.5
120
45
D10BA01
ATC
isotretinoin; oral
99.9
83.2
88
17
L71.9
ICD-10 Finland
Rosacea, unspecified
186.4
53.1
53
*
J01AA07
ATC
tetracycline; systemic
16.8
49.4
87
95
L71.8
ICD-10 Finland
Other rosacea
128.9
30.8
32
*
J01AA04
ATC
lymecycline; systemic
9.7
28.0
62
92
D10AX03
ATC
azelaic acid; topical
44.9
22.4
27
7
L71
ICD-10 Finland
Rosacea
59.0
18.4
21
*
69530
ICD-8 Finland
Erythematous condition, Rosacea
+∞
15.9
15
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
9.6
12.8
26
31
D10AF01
ATC
clindamycin; topical
20.7
11.8
17
9
ZXC10
NOMESCO Finland
Use of laser
13.3
10.1
17
14
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
105.3
9.5
10
*
DHB00
NOMESCO Finland
Excision of lesion of external nose
19.9
9.1
13
7
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
4.3
8.8
33
89
I10
ICD-10 Finland
Essential (primary) hypertension
2.8
8.7
136
947
L71.0
ICD-10 Finland
Perioral dermatitis
94.2
8.5
9
*
ZXC12
NOMESCO Finland
Pulse colorlaser
83.3
7.5
8
*
DLW99
NOMESCO Finland
Other plastic operations on nose
41.6
6.8
8
*
E000001
ATC
NA
2.8
6.5
44
185
E0000UV
ATC
NA
2.4
6.5
73
405
205
Kela drug reimbursment
Chronic hypertension
2.3
6.4
77
440
Mortality – FinRegistry
↥Association
Association between endpoint L12_RHINOPHYMA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_RHINOPHYMA | 1.076 [0.9, 1.29] | 0.435 |
| Birth year | 0.991 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 223 out of 774 males with L12_RHINOPHYMA died.
Mortality risk
Mortality risk for people of age
years, who have L12_RHINOPHYMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.243% |
| 5 | No data | 1.406% |
| 10 | No data | 3.532% |
| 15 | No data | 6.807% |
| 20 | No data | 11.741% |
Relationships between endpoints
↥Index endpoint: L12_RHINOPHYMA – Rhinophyma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data