No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
722 |
4. Check minimum number of eventsNone |
722 |
5. Include endpointsNone |
722 |
6. Filter based on genotype QC (FinnGen only) |
722 |
Control definitions (FinnGen only)
- Control exclude
- L12_INFECT_SKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L08
- Name in latin
- Pyoderma
Similar endpoints
↥List of similar endpoints to
Pyoderma
based on the number of shared cases.
Similar with more cases:
- Other local infections of skin and subcutaneous tissue
- Infections of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7378 | 3141 | 4153 |
| Only index persons | 5683 | 2533 | 3150 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.09 | 0.12 |
| Only index persons | 0.11 | 0.09 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 39.59 | 39.40 | 39.51 |
| Only index persons | 37.57 | 38.25 | 37.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 722 | 373 | 349 |
| Unadjusted period prevalence (%) | 0.14 | 0.13 | 0.15 |
| Median age at first event (years) | 43.51 | 41.75 | 45.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 662
- Matched controls
- 6621
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L08.0
ICD-10 Finland
Pyoderma
1499.8
323.0
460
10
68600
ICD-8 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
+∞
170.3
156
*
6860A
ICD-9 Finland
Other local infections of skin and subcutaneous tissue, Pyoderma
+∞
53.9
51
*
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
18.6
44.4
69
41
A46
ICD-10 Finland
Erysipelas
4.6
40.8
162
439
J01FF01
ATC
clindamycin; systemic
3.3
38.7
255
1055
E0000UV
ATC
NA
2.9
35.8
339
1771
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.8
31.1
147
458
L20.0
ICD-10 Finland
Besnier prurigo
5.5
30.8
97
201
E000001
ATC
NA
3.1
29.4
202
832
D07AC01
ATC
betamethasone; topical
2.6
28.2
279
1435
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.2
26.7
167
638
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
14.4
24.8
42
31
D07AB08
ATC
desonide; topical
3.7
24.8
118
365
J01DB01
ATC
cefalexin; oral
2.9
24.6
563
4393
D07CC01
ATC
betamethasone and antibiotics; topical
3.4
23.7
129
442
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.4
23.5
124
415
S97
ICPC
Chronic ulcer skin
5.9
23.0
66
121
D07BC01
ATC
betamethasone and antiseptics; topical
3.4
22.2
120
405
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.5
21.9
111
359
D07AC13
ATC
mometasone; topical
2.4
21.0
226
1168
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.6
19.4
95
298
H02AB06
ATC
prednisolone; systemic
2.1
19.3
335
2149
L30.3
ICD-10 Finland
Infective dermatitis
6.6
19.2
50
81
D07AA02
ATC
hydrocortisone; topical
2.9
19.0
130
517
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
72.0
18.8
21
*
D07AD01
ATC
clobetasol; topical
2.8
18.7
134
546
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
12.3
18.5
33
28
D07AB02
ATC
hydrocortisone butyrate; topical
2.3
18.1
223
1218
TQW80
NOMESCO Finland
Local dermatologic skincare
7.4
17.6
42
60
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
8.6
17.2
37
45
E000002
ATC
NA
3.1
17.1
104
380
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
12.5
17.0
30
25
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
3.2
16.7
94
326
J01DA01
ATC
[U] cefalexin; systemic
2.0
16.6
430
3162
D09AB01
ATC
zinc bandage without supplements; topical
9.1
16.4
34
39
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
15.9
86
290
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
8.1
15.8
35
45
XQ802
NOMESCO Finland
Epicutan test
5.6
15.7
46
87
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
15.7
297
1913
N05BB01
ATC
hydroxyzine; systemic
3.8
15.5
68
194
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.2
15.4
202
1120
E000003
ATC
NA
4.3
15.3
58
145
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.8
14.8
106
428
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.9
14.7
41
73
R06AE07
ATC
cetirizine; oral
1.9
14.7
303
2005
J01MA12
ATC
levofloxacin; systemic
2.3
14.2
143
697
J01MA02
ATC
ciprofloxacin; systemic
1.9
13.1
256
1639
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.8
12.7
85
329
-
ICD-10 Finland
NA
6.9
12.3
30
45
C03CA01
ATC
furosemide; systemic
2.0
12.3
191
1118
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.1
12.2
47
120
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
12.7
12.2
21
17
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.9
12.1
39
83
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.4
12.1
107
486
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.3
12.0
36
71
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
12.0
163
901
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.3
11.9
60
192
D07XC01
ATC
betamethasone, combinations; topical
2.5
11.9
96
416
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
11.7
103
466
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
11.6
104
473
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.1
11.4
64
221
D02AX
ATC
Other emollients and protectives
5.1
11.3
35
72
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
10.9
81
335
ZXD05
NOMESCO Finland
Urgent procedure
1.9
10.8
208
1305
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
4.4
10.6
38
91
L03.9
ICD-10 Finland
Cellulitis, unspecified
9.4
10.6
21
23
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
7.5
10.5
24
33
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
10.5
197
1225
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.9
10.1
41
111
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
10.1
51
165
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
10.1
99
471
D05BB02
ATC
acitretin; oral
5.4
9.9
29
56
NHQ40
NOMESCO Finland
Amputation of toe
8.3
9.9
21
26
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
8.3
9.9
21
26
D07XB05
ATC
dexamethasone, combinations; topical
5.1
9.8
30
61
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
20.4
9.8
14
7
D11AX14
ATC
[U] tacrolimus; topical
13.6
9.7
16
12
N06AB04
ATC
citalopram; systemic
1.9
9.7
152
884
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.6
268
1880
B18.2
ICD-10 Finland
Chronic viral hepatitis C
9.3
9.6
19
21
L73.2
ICD-10 Finland
Hidradenitis suppurativa
15.3
9.5
15
10
D02AE01
ATC
carbamide; topical
2.8
9.4
59
220
L04AA01
ATC
[U] ciclosporin; systemic
8.2
9.4
20
25
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
6.9
9.2
22
33
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
9.2
89
421
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.5
9.1
26
49
D11AH01
ATC
tacrolimus; topical
11.7
9.1
16
14
SPAT1254
SPAT
Administration of medicine
2.2
9.1
98
489
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
6.7
9.0
22
34
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
7.6
9.0
20
27
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.4
9.0
43
134
H02AB07
ATC
prednisone; oral
2.1
9.0
103
527
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
8.7
77
349
S18
ICPC
Laceration/cut
1.7
8.7
255
1801
L88
ICD-10 Finland
Pyoderma gangrenosum
50.6
8.7
10
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.7
8.7
61
242
N03AX16
ATC
pregabalin; oral
1.9
8.5
149
895
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
8.4
224
1537
N03AX12
ATC
gabapentin; oral
2.1
8.3
100
522
S76
ICPC
Skin infection other
3.2
8.2
41
132
D01AC02
ATC
miconazole; topical
2.5
8.2
65
278
ZZA00
NOMESCO Finland
Split skin graft
4.2
8.1
29
71
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
8.0
178
1151
J01CF05
ATC
flucloxacillin; systemic
4.3
8.0
28
67
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
7.9
118
669
R60.0
ICD-10 Finland
Localized oedema
2.3
7.9
76
360
R03AC02
ATC
salbutamol; inhalant
1.6
7.9
323
2474
J01AA07
ATC
tetracycline; systemic
2.0
7.8
108
593
SPAT1255
SPAT
Intravenous administration of medicine
2.8
7.8
49
183
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
7.8
113
633
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
6.0
7.7
20
34
D11AH02
ATC
pimecrolimus; topical
45.5
7.7
9
*
D11AX15
ATC
[U] pimecrolimus; topical
45.5
7.7
9
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.4
7.7
36
111
L04AX01
ATC
azathioprine; systemic
3.4
7.7
36
111
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
7.7
82
407
R50.9
ICD-10 Finland
Fever, unspecified
2.0
7.7
96
509
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
25.3
7.6
10
*
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
25.3
7.6
10
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
6.3
7.6
19
31
N05BA04
ATC
oxazepam; oral
1.8
7.5
158
1005
P01AB01
ATC
metronidazole; oral, rectal
1.6
7.5
236
1681
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
7.5
153
961
E000006
ATC
NA
2.5
7.4
55
228
B00.10
ICD-10 Finland
Herpes simplex facialis
13.5
7.4
12
9
K05.31
ICD-10 Finland
Periodontitis pronounced
2.3
7.4
65
293
69240
ICD-8 Finland
Other eczema and dermatitis, Due to other chemicals
+∞
7.3
7
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
7.3
81
408
A02BC02
ATC
pantoprazole; systemic
1.6
7.3
387
3133
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
15.9
7.2
11
7
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.5
7.2
24
55
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.6
7.2
51
207
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
7.2
41
144
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
7.2
112
642
H02AB04
ATC
methylprednisolone; systemic
2.0
7.2
98
537
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.3
7.2
66
304
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
7.1
172
1138
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
7.1
49
194
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.7
7.1
169
1114
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.8
7.0
28
76
L28
ICPC
Limited function/disability (L)
2.0
7.0
91
489
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
7.0
124
744
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
7.0
85
446
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
3.6
7.0
29
82
F10.24
ICD-10 Finland
Alcohol depence active use
5.9
7.0
18
31
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.3
6.9
63
291
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
6.9
85
448
M79.6
ICD-10 Finland
Pain in limb
1.6
6.9
207
1452
J02AC01
ATC
fluconazole; systemic
1.6
6.8
233
1687
SPAT1172
SPAT
Guidance concerning hydration
5.7
6.8
18
32
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.7
6.7
43
163
SPAT1216
SPAT
Assessment of functional ability
1.9
6.6
92
508
N05CD07
ATC
temazepam; oral
2.0
6.6
86
461
M05BA04
ATC
alendronic acid; oral
2.5
6.6
50
211
S87
ICPC
Dermatitis/atopic eczema
4.9
6.6
20
42
N06AB03
ATC
fluoxetine; oral
2.0
6.5
82
436
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
6.5
93
519
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.6
6.5
45
179
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
7.5
6.4
14
19
134
Kela drug reimbursment
General erythroderma
14.5
6.4
10
7
N05AH04
ATC
quetiapine; oral
1.9
6.4
101
583
SPAT1229
SPAT
Assessment of need for aid
2.3
6.4
54
241
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.1
6.3
23
58
X59
ICD-10 Finland
Exposure to unspecified factor
1.8
6.3
114
689
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
6.3
128
802
N02AA05
ATC
oxycodone; systemic
1.9
6.3
86
473
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.2
6.3
61
292
A10AE04
ATC
insulin glargine; parenteral
2.2
6.2
63
306
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
6.2
162
1088
J45
ICD-10 Finland
Asthma
2.2
6.2
63
307
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
6.2
77
407
S10
ICPC
Boil/carbuncle
2.9
6.2
35
123
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.1
97
558
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.6
6.1
41
162
D05AX52
ATC
calcipotriol, combinations; topical
2.6
6.1
41
162
L20
ICD-10 Finland
Atopic dermatitis
3.8
6.1
24
65
N05BA01
ATC
diazepam; systemic, rectal
1.9
6.1
90
507
XQ800
NOMESCO Finland
Prick test
2.4
6.1
49
212
N05BA02
ATC
chlordiazepoxide; systemic
4.0
6.0
22
56
Mortality – FinRegistry
↥Association
Association between endpoint L12_PYODERMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYODERMA | 2.971 [2.44, 3.62] | < 0.001 |
| Birth year | 0.996 [0.99, 1.01] | 0.409 |
During the follow-up period (1.1.1998 — 31.12.2019), 506 out of 2065 females with L12_PYODERMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PYODERMA | 3.025 [2.54, 3.61] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 688 out of 2431 males with L12_PYODERMA died.
Mortality risk
Mortality risk for people of age
years, who have L12_PYODERMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.308% | 0.658% |
| 5 | 1.762% | 3.384% |
| 10 | 4.729% | 8.653% |
| 15 | 8.484% | 16.462% |
| 20 | 14.789% | 26.195% |
Relationships between endpoints
↥Index endpoint: L12_PYODERMA – Pyoderma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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