No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
869 |
4. Check minimum number of eventsNone |
869 |
5. Include endpointsNone |
869 |
6. Filter based on genotype QC (FinnGen only) |
869 |
Control definitions (FinnGen only)
- Control exclude
- L12_DERMATITISECZEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L28
- Name in latin
- Prurigo nodularis
Similar endpoints
↥List of similar endpoints to
Prurigo nodularis
based on the number of shared cases.
Similar with more cases:
- Lichen simplex chronicus and prurigo
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6005 | 3529 | 2437 |
| Only index persons | 5439 | 3242 | 2197 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.07 |
| Only index persons | 0.10 | 0.12 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 62.03 | 62.76 | 60.90 |
| Only index persons | 61.16 | 61.95 | 59.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 869 | 538 | 331 |
| Unadjusted period prevalence (%) | 0.17 | 0.18 | 0.15 |
| Median age at first event (years) | 61.00 | 59.86 | 62.84 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 771
- Matched controls
- 7710
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L28.1
ICD-10 Finland
Prurigo nodularis
4503599627370496.0
323.0
760
*
D07AD01
ATC
clobetasol; topical
20.0
270.5
477
578
D07AC01
ATC
betamethasone; topical
15.2
241.5
608
1518
E0000UV
ATC
NA
14.0
224.1
622
1769
D09AB01
ATC
zinc bandage without supplements; topical
89.7
213.6
233
37
L30.9
ICD-10 Finland
Dermatitis, unspecified
17.3
213.6
378
406
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
19.1
194.7
321
277
D07AC13
ATC
mometasone; topical
10.6
192.4
529
1314
E000001
ATC
NA
9.1
149.5
388
773
L20.0
ICD-10 Finland
Besnier prurigo
+∞
139.9
130
*
TQW80
NOMESCO Finland
Local dermatologic skincare
42.3
127.2
159
47
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
116.7
119.2
127
13
D07BC01
ATC
betamethasone and antiseptics; topical
9.4
117.8
276
432
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
115.6
108
*
L30.3
ICD-10 Finland
Infective dermatitis
68.3
114.7
131
23
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
8.9
111.8
270
439
D07AB08
ATC
desonide; topical
9.5
95.5
215
301
D07AB02
ATC
hydrocortisone butyrate; topical
5.3
93.2
386
1233
D07BA04
ATC
hydrocortisone and antiseptics; topical
9.2
91.1
208
296
R06AE07
ATC
cetirizine; oral
4.6
84.9
499
2212
L28.0
ICD-10 Finland
Lichen simplex chronicus
111.6
82.9
89
9
L29.9
ICD-10 Finland
Pruritus, unspecified
33.0
80.3
106
37
H02AB06
ATC
prednisolone; systemic
4.3
79.4
522
2507
D02AX
ATC
Other emollients and protectives
22.2
78.2
116
61
D07CC01
ATC
betamethasone and antibiotics; topical
6.5
77.8
232
480
E000002
ATC
NA
7.6
76.6
199
339
A46
ICD-10 Finland
Erysipelas
5.5
66.4
229
554
XQ802
NOMESCO Finland
Epicutan test
31.0
64.3
86
31
R06AX27
ATC
desloratadine; oral
4.0
61.5
318
1143
D02AE01
ATC
carbamide; topical
8.1
58.9
141
206
E000003
ATC
NA
13.0
58.8
107
94
L30.0
ICD-10 Finland
Nummular dermatitis
17.3
56.6
91
59
N05BB01
ATC
hydroxyzine; systemic
8.0
54.7
132
194
L28.2
ICD-10 Finland
Other prurigo
+∞
51.6
49
*
R06AE09
ATC
levocetirizine; oral
4.7
48.9
190
504
J01DB01
ATC
cefalexin; oral
4.8
48.7
701
5208
E000007
ATC
NA
8.7
47.1
106
138
D07AA02
ATC
hydrocortisone; topical
4.7
45.6
175
455
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
45.2
43
*
J01FF01
ATC
clindamycin; systemic
3.2
44.4
302
1275
D07XC01
ATC
betamethasone, combinations; topical
4.4
39.2
158
426
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.6
38.5
146
370
L29.8
ICD-10 Finland
Other pruritus
26.6
36.3
50
20
XQ848
NOMESCO Finland
Dermatological photography
11.2
34.8
67
65
D11AH01
ATC
tacrolimus; topical
340.9
33.1
33
*
R06AX22
ATC
ebastine; oral
3.3
32.6
190
691
S97
ICPC
Chronic ulcer skin
5.8
31.8
95
183
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
31.6
412
2442
XQ800
NOMESCO Finland
Prick test
6.2
31.1
88
158
C03CA01
ATC
furosemide; systemic
2.6
30.3
291
1449
L04AD01
ATC
ciclosporin; systemic
13.9
30.1
52
40
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.9
30.1
105
241
E000006
ATC
NA
4.8
28.6
102
239
L50.3
ICD-10 Finland
Dermatographic urticaria
20.1
28.1
42
22
J01DA01
ATC
[U] cefalexin; systemic
2.4
27.8
531
3711
S76
ICPC
Skin infection other
5.6
27.1
82
160
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.5
26.8
102
255
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
26.2
187
769
Z3231
NOMESCO Finland
Registered nurse
2.5
26.1
264
1329
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.8
25.4
199
865
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.0
24.5
158
606
L20
ICD-10 Finland
Atopic dermatitis
+∞
24.1
23
*
D07AC14
ATC
methylprednisolone aceponate; topical
5.7
23.3
69
131
A10AE04
ATC
insulin glargine; parenteral
3.5
22.9
117
378
S18
ICPC
Laceration/cut
2.2
22.7
366
2272
N06AA12
ATC
doxepin; systemic
4.6
22.5
82
196
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
22.4
271
1471
Z2221
NOMESCO Finland
Medical doctor
2.3
22.2
261
1395
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
22.0
21
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.0
21.8
61
108
J04BA02
ATC
dapsone; oral
27.3
21.5
29
11
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
11.0
21.1
40
38
R03AC02
ATC
salbutamol; inhalant
2.1
20.9
422
2845
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
79.0
20.8
23
*
D05BB02
ATC
acitretin; oral
8.0
20.6
47
62
S02
ICPC
Pruritus
6.7
20.6
53
84
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.9
20.3
69
153
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
20.2
234
1231
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
20.2
322
1958
Z2446
NOMESCO Finland
Social worker
4.2
20.0
80
209
L30.8
ICD-10 Finland
Other specified dermatitis
14.3
19.7
33
24
L43.0
ICD-10 Finland
Hypertrophic lichen planus
32.2
19.4
25
8
Z3226
NOMESCO Finland
Physiotherapist
2.4
19.3
183
870
ZXE00
NOMESCO Finland
One hour or less
2.0
19.1
341
2160
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
18.8
18
*
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
5.8
18.6
53
96
103
Kela drug reimbursment
Diabetes, insulin-treated
2.2
18.5
248
1385
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
18.5
137
564
J01CF05
ATC
flucloxacillin; systemic
5.5
18.4
55
106
S29
ICPC
Skin symptom/complaint other
2.5
18.2
163
750
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
17.9
330
2097
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.1
17.8
57
119
H02AB07
ATC
prednisone; oral
2.6
17.7
141
605
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
17.4
148
658
H02AB04
ATC
methylprednisolone; systemic
2.6
17.4
145
637
S87
ICPC
Dermatitis/atopic eczema
10.1
17.3
34
35
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.8
17.0
75
214
J01MA02
ATC
ciprofloxacin; systemic
2.0
16.9
319
2036
N03AX16
ATC
pregabalin; oral
2.1
16.8
220
1208
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
+∞
16.7
16
*
6983A
ICD-9 Finland
Pruritus and related conditions, Lichenification and lichen simplex chronicus[PRURIGO NODULARIS HYDE]
+∞
16.7
16
*
R03DC03
ATC
montelukast; oral
2.5
16.7
141
624
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
173.5
16.6
17
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
16.6
133
574
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
16.5
301
1892
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
16.4
481
3588
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.6
16.2
130
560
ZY010
NOMESCO Finland
Hospital outpatient
4.6
16.2
57
132
R50.9
ICD-10 Finland
Fever, unspecified
2.6
16.1
129
553
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.9
15.9
100
372
S21
ICPC
Skin texture symptom/complaint
2.6
15.7
120
502
D11AX14
ATC
[U] tacrolimus; topical
+∞
15.7
15
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.5
15.7
133
591
N02AX02
ATC
tramadol; systemic, rectal
1.9
15.6
351
2363
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.6
15.6
124
531
R06.0
ICD-10 Finland
Dyspnoea
2.1
15.3
215
1211
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.1
15.2
202
1106
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.5
15.2
74
229
R06AX13
ATC
loratadine; oral
2.5
15.1
131
586
R4110
NOMESCO Finland
Physiotherapy
2.0
15.0
229
1328
J45
ICD-10 Finland
Asthma
2.9
14.9
97
367
C03DA01
ATC
spironolactone; oral
2.8
14.8
104
412
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
14.8
83
285
A02BC02
ATC
pantoprazole; systemic
1.9
14.8
517
4022
WW200
NOMESCO Finland
Immunization
6.1
14.7
40
69
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.7
14.6
106
428
L04AX01
ATC
azathioprine; systemic
4.6
14.6
51
117
J01CE08
ATC
benzathine benzylpenicillin; parenteral
14.5
14.6
24
17
N06AX16
ATC
venlafaxine; oral
2.5
14.6
123
542
L43.9
ICD-10 Finland
Lichen planus, unspecified
7.8
14.5
33
44
R60.0
ICD-10 Finland
Localized oedema
2.6
14.5
112
470
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
14.5
209
1181
L28
ICD-10 Finland
Lichen simplex chronicus and prurigo
15.8
14.5
23
15
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.8
14.4
95
363
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
14.2
197
1098
N02BE01
ATC
paracetamol; systemic, rectal
2.2
14.1
671
5793
Z71.8
ICD-10 Finland
Other specified counselling
2.1
14.1
192
1060
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
14.0
89
332
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
14.0
106
440
ZXD05
NOMESCO Finland
Urgent procedure
1.9
13.9
249
1530
Z3229
NOMESCO Finland
Other healthcare associate professional
2.9
13.9
88
328
N06AB04
ATC
citalopram; systemic
2.1
13.9
189
1043
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.8
13.8
46
101
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.8
13.8
46
101
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
13.7
135
643
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.2
13.7
52
130
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
13.7
315
2111
L04AA06
ATC
mycophenolic acid; systemic
8.6
13.6
29
35
L13.0
ICD-10 Finland
Dermatitis herpetiformis
34.7
13.5
17
5
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.4
13.4
124
575
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.3
13.3
35
58
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
5.4
13.2
39
75
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
13.2
145
730
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.2
13.1
35
59
D07XB05
ATC
dexamethasone, combinations; topical
5.9
13.1
36
63
E000004
ATC
NA
7.6
13.1
30
41
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.2
13.0
143
716
WX110
NOMESCO Finland
Local anesthesy
1.8
12.9
513
4059
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
12.9
149
765
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.9
12.7
79
291
T90
ICPC
Diabetes non-insulin dependent
2.0
12.7
198
1147
I50.0
ICD-10 Finland
Congestive heart failure
3.2
12.7
69
232
D05AX02
ATC
calcipotriol; topical
4.2
12.7
48
120
N06AX11
ATC
mirtazapine; oral
1.8
12.7
258
1648
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
71.0
12.6
14
*
L08.0
ICD-10 Finland
Pyoderma
11.2
12.6
23
21
C08CA01
ATC
amlodipine; oral
1.8
12.6
306
2074
L26
ICD-10 Finland
Exfoliative dermatitis
+∞
12.5
12
*
TK800
NOMESCO Finland
Hemodialysis
6.2
12.5
33
55
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
12.5
364
2609
TKC20
NOMESCO Finland
Catheterisation of bladder
3.0
12.4
73
260
L98.1
ICD-10 Finland
Factitial dermatitis
38.2
12.2
15
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
12.2
83
323
R03BA02
ATC
budesonide; inhalant
2.1
12.2
148
774
R03BB04
ATC
tiotropium bromide; inhalant
2.7
12.2
89
361
N06AX21
ATC
duloxetine; oral
2.5
12.1
100
433
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.7
12.1
52
146
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.7
12.1
34
62
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
12.0
218
1332
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
12.0
141
726
ZXA00
NOMESCO Finland
Right side
1.9
12.0
230
1433
M54.5
ICD-10 Finland
Low back pain
1.8
12.0
260
1689
Z49.1
ICD-10 Finland
Extracorporeal dialysis
9.1
11.8
24
27
C08CA13
ATC
lercanidipine; oral
2.2
11.8
125
615
D07AC03
ATC
desoximetasone; topical
7.5
11.8
27
37
J01AA07
ATC
tetracycline; systemic
2.3
11.7
122
594
L12.0
ICD-10 Finland
Bullous pemphigoid
16.7
11.7
18
11
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
11.6
76
289
N18.8
ICD-10 Finland
Other chronic renal failure
5.1
11.6
36
74
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.0
11.5
67
237
UJF32
NOMESCO Finland
Coloscopy
1.9
11.5
218
1349
SPAT1262
SPAT
Handing over of treatment supplies
2.0
11.5
160
886
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
11.4
98
434
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
11.3
138
722
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
11.3
119
582
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.7
11.3
305
2113
C07AB07
ATC
bisoprolol; oral
1.7
11.2
381
2822
A10BA02
ATC
metformin; oral
1.8
11.2
231
1469
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
17.3
11.2
17
10
J01FA06
ATC
roxithromycin; oral
1.7
11.2
312
2181
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
11.2
404
3046
RJ411
NOMESCO Finland
NA
20.4
11.2
16
8
M79.6
ICD-10 Finland
Pain in limb
1.7
11.1
286
1950
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.7
11.1
76
297
205
Kela drug reimbursment
Chronic hypertension
1.8
11.1
237
1527
N05CF01
ATC
zopiclone; oral
1.8
11.1
267
1784
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
11.0
219
1374
D05AX52
ATC
calcipotriol, combinations; topical
3.3
11.0
55
175
K08.3
ICD-10 Finland
Retained dental root
2.8
11.0
72
275
P01AB01
ATC
metronidazole; oral, rectal
1.7
10.9
302
2103
A02BC01
ATC
omeprazole; systemic
1.8
10.9
225
1431
RD210
NOMESCO Finland
NA
6.6
10.9
27
42
L04AA01
ATC
[U] ciclosporin; systemic
7.3
10.8
25
35
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.7
10.8
36
80
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
28.5
10.7
14
5
A06AD11
ATC
lactulose; oral
2.1
10.7
128
661
S99
ICPC
Skin disease other
6.5
10.7
27
43
L73.8
ICD-10 Finland
Other specified follicular disorders
13.1
10.7
18
14
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
10.7
168
972
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.9
10.6
43
115
EBA30
NOMESCO Finland
Excision of root of tooth
3.0
10.5
61
215
A11CC03
ATC
alfacalcidol; systemic
5.3
10.5
31
60
WZC30
NOMESCO Finland
Teaching
2.2
10.5
115
574
L28
ICPC
Limited function/disability (L)
2.1
10.5
133
707
J01FA01
ATC
erythromycin; systemic
2.2
10.5
110
538
A10BH01
ATC
sitagliptin; oral
2.4
10.5
91
407
N03AX12
ATC
gabapentin; oral
2.0
10.5
136
729
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
4.5
10.4
36
83
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
10.4
95
435
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
10.4
97
448
XCK10
NOMESCO Finland
Photography of fundus of eye
2.4
10.4
93
423
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
5.9
10.3
28
49
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
10.8
10.3
19
18
Z94.0
ICD-10 Finland
Kidney transplant status
9.7
10.3
20
21
D01AE15
ATC
terbinafine; topical
2.8
10.3
67
253
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
10.3
59
207
R4120
NOMESCO Finland
Occupational therapy
2.9
10.1
62
227
EBA00
NOMESCO Finland
Extraction of tooth
1.7
10.0
240
1591
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
40.6
10.0
12
*
N05BA04
ATC
oxazepam; oral
1.8
9.9
195
1215
L43.8
ICD-10 Finland
Other lichen planus
6.1
9.9
26
44
J01AA02
ATC
doxycycline; systemic
1.7
9.8
589
5024
RJ410
NOMESCO Finland
NA
26.4
9.8
13
5
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.0
9.8
56
195
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
10.8
9.8
18
17
J01MA12
ATC
levofloxacin; systemic
1.9
9.8
149
850
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
9.7
225
1476
D07AB01
ATC
clobetasone; topical
3.9
9.6
38
100
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
11.6
9.6
17
15
A02BC05
ATC
esomeprazole; systemic
1.6
9.6
312
2251
E66.9
ICD-10 Finland
Obesity, unspecified
4.2
9.6
35
86
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
9.5
90
420
R53
ICD-10 Finland
Malaise and fatigue
1.9
9.5
160
944
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.8
9.4
197
1247
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
101.2
9.4
10
*
G47.3
ICD-10 Finland
Sleep apnoea
1.9
9.4
161
953
L17
ICPC
Foot/toe symptom/complaint
1.8
9.4
201
1282
D11AH02
ATC
pimecrolimus; topical
+∞
9.4
9
*
395
Kela drug reimbursment
Dupilumab
+∞
9.4
9
*
D01AC02
ATC
miconazole; topical
2.6
9.4
70
289
B35.3
ICD-10 Finland
Tinea pedis
3.7
9.4
40
113
J01AA04
ATC
lymecycline; systemic
2.2
9.3
95
456
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
6.5
9.3
23
36
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.6
9.3
338
2508
J45.8
ICD-10 Finland
Mixed asthma
4.3
9.3
33
79
S01GX01
ATC
cromoglicic acid; ophthalmic
1.9
9.3
142
811
127
Kela drug reimbursment
Transplant complication
7.4
9.3
21
29
B86
ICD-10 Finland
Scabies
7.4
9.3
21
29
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.3
9.2
46
147
WX002
NOMESCO Finland
Sedation and analgesia
1.8
9.2
167
1009
SAA01
NOMESCO Finland
Simple examination of mouth
1.6
9.1
496
4067
K02.1
ICD-10 Finland
Caries of dentine
1.6
9.1
390
3010
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.9
9.1
56
205
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
9.0
253
1745
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
9.0
70
293
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
9.0
57
213
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.4
9.0
77
342
ZXA05
NOMESCO Finland
Left side
1.7
9.0
205
1331
A10AE06
ATC
insulin degludec; parenteral
4.4
9.0
31
72
ZX120
NOMESCO Finland
Intravenous
2.3
9.0
83
380
M10.9
ICD-10 Finland
Gout, unspecified
2.8
8.9
56
209
A10BH05
ATC
linagliptin; oral
3.2
8.9
45
146
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.7
8.8
255
1771
E66.01
ICD-10 Finland
Obesity due to excess calories
2.6
8.8
63
253
E66.8
ICD-10 Finland
Other obesity
3.0
8.8
51
180
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.8
8.8
57
217
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.7
8.8
213
1405
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.3
8.8
20
28
R03AK07
ATC
formoterol and budesonide; inhalant
1.9
8.8
141
816
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.2
8.7
44
142
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
4.1
8.7
33
84
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.7
8.7
58
222
A10AE05
ATC
insulin detemir; parenteral
2.9
8.7
54
198
E66.00
ICD-10 Finland
Metabolic syndrome
2.9
8.7
51
183
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.8
8.6
55
207
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.3
8.6
42
132
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
8.6
82
384
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.6
8.6
61
242
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.6
8.6
400
3133
TQW99
NOMESCO Finland
Other minor procedure on skin
2.9
8.6
50
178
M25.5
ICD-10 Finland
Pain in joint
1.7
8.6
204
1342
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.2
8.6
16
16
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.2
8.6
31
76
R52.2
ICD-10 Finland
Other chronic pain
3.7
8.5
36
101
L30
ICD-10 Finland
Other dermatitis
5.5
8.5
24
45
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
6.1
8.5
22
37
N05BA01
ATC
diazepam; systemic, rectal
2.0
8.5
112
602
J45.1
ICD-10 Finland
Nonallergic asthma
2.6
8.5
62
254
N06AB03
ATC
fluoxetine; oral
2.0
8.4
106
559
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
+∞
8.3
8
*
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
+∞
8.3
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
8.3
91
454
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.5
8.3
64
270
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
8.3
97
497
F34.1
ICD-10 Finland
Dysthymia
3.6
8.3
36
104
SAA02
NOMESCO Finland
Basic examination of mouth
1.6
8.2
440
3552
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.3
8.2
73
329
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.0
8.2
46
158
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.8
8.2
138
813
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
8.1
275
1984
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
8.2
8.1
17
21
L29
ICD-10 Finland
Pruritus
8.2
8.1
17
21
RJ421
NOMESCO Finland
NA
33.7
8.1
10
*
SPAT1255
SPAT
Intravenous administration of medicine
2.5
8.1
64
271
N18.0
ICD-10 Finland
End-stage renal disease
6.4
8.0
20
32
L02.9
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle, unspecified
4.2
8.0
29
71
RJ414
NOMESCO Finland
NA
22.3
8.0
11
5
RS221
NOMESCO Finland
NA
6.0
8.0
21
36
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
8.0
62
262
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
7.9
227
1566
R03BA05
ATC
fluticasone; inhalant
1.8
7.9
136
805
D07CB01
ATC
triamcinolone and antibiotics; topical
5.5
7.9
22
41
C09AA02
ATC
enalapril; systemic
1.7
7.8
165
1042
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.5
7.8
26
59
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
3.5
7.8
35
104
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.8
7.8
138
823
C10AA05
ATC
atorvastatin; oral
1.6
7.7
300
2230
P01BA02
ATC
hydroxychloroquine; oral
2.3
7.7
71
327
PD4CG
NOMESCO Finland
Extensive MRI examination of abdominal aortta and vasculature of lower extremities with high intensity magnet
6.5
7.7
19
30
D72.1
ICD-10 Finland
Eosinophilia
15.2
7.7
12
8
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
45.4
7.7
9
*
R42
ICD-10 Finland
Dizziness and giddiness
1.7
7.7
173
1111
N06AA09
ATC
amitriptyline; systemic
2.1
7.7
91
470
C02AC05
ATC
moxonidine; oral
2.9
7.7
44
155
J01DA06
ATC
[U] cefuroxime; systemic
1.9
7.7
110
612
H04.10
ICD-10 Finland
Dry eye syndrome
2.2
7.6
80
392
KMAK
NOMESCO Finland
NA
1.5
7.6
353
2735
D01BA02
ATC
terbinafine; oral; topical
1.7
7.6
181
1182
R03BA01
ATC
beclometasone; inhalant
1.9
7.6
111
617
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
7.6
266
1927
H3603, E103
ICD-10 Finland
NA
8.1
7.6
16
20
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
12.0
7.6
13
11
A12AA04
ATC
calcium carbonate; oral
5.5
7.6
21
39
N30.0
ICD-10 Finland
Acute cystitis
2.0
7.6
105
574
R02
ICPC
Shortness of breath/dyspnoea
2.0
7.5
92
481
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.7
7.5
186
1230
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
7.5
94
496
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
7.5
62
272
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
7.5
208
1421
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.8
7.5
45
165
W19
ICD-10 Finland
Unspecified fall
2.2
7.4
78
381
R06AX18
ATC
acrivastine; oral
3.9
7.4
29
77
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
7.4
42
146
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.0
7.4
40
137
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.5
7.4
32
93
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.1
7.4
38
126
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.4
7.4
60
260
M04AA01
ATC
allopurinol; systemic
2.0
7.3
98
530
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.8
7.3
29
78
N06AB05
ATC
paroxetine; oral
2.5
7.3
55
230
QXA70
NOMESCO Finland
Guidance related to rash and skin care
+∞
7.3
7
*
6918C
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[DIATHESIS (CONSTITUTIO) ATOPICA]
+∞
7.3
7
*
D11AH05
ATC
dupilumab; topical
+∞
7.3
7
*
A04
ICPC
Weakness/tiredness general
2.0
7.3
96
517
P76
ICPC
Depressive disorder
2.8
7.3
46
172
AA1AD
NOMESCO Finland
CT of head and brain
1.7
7.3
185
1234
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.9
7.3
110
621
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.4
7.3
60
263
L50.9
ICD-10 Finland
Urticaria, unspecified
3.6
7.3
31
89
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
7.2
163
1049
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
7.2
101
557
R03AC13
ATC
formoterol; inhalant
2.7
7.2
46
174
S88
ICPC
Dermatitis contact/allergic
5.1
7.1
21
42
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
7.1
38
129
Z49.0
ICD-10 Finland
Preparatory care for dialysis
6.7
7.1
17
26
A01AB09
ATC
miconazole; local oral
2.2
7.1
71
339
RJ420
NOMESCO Finland
NA
12.2
7.1
12
10
SPAT1301
SPAT
No procedures
1.6
7.1
239
1710
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
7.0
114
661
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
10.1
7.0
13
13
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.2
7.0
25
61
RS220
NOMESCO Finland
NA
7.1
7.0
16
23
L02
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle
3.2
7.0
35
114
F60.9
ICD-10 Finland
Personality disorder, unspecified
7.6
6.9
15
20
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.1
6.9
35
115
TQW40
NOMESCO Finland
Remowal of suture of skin
2.4
6.9
58
257
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
6.9
126
761
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.3
6.9
63
291
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.9
350
2748
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.9
234
1675
3AC01
NOMESCO Finland
NA
8.4
6.8
14
17
R03AC03
ATC
terbutaline; inhalant
1.9
6.8
105
596
SPAT1254
SPAT
Administration of medicine
1.8
6.8
112
651
K90.0
ICD-10 Finland
Coeliac disease
3.7
6.8
28
78
A41.9
ICD-10 Finland
Sepsis, unspecified
3.4
6.8
31
94
N05AH04
ATC
quetiapine; oral
1.8
6.8
117
691
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
9.4
6.8
13
14
E10
ICD-10 Finland
Type 1 diabetes mellitus
5.4
6.8
19
36
X57
ICD-10 Finland
Unspecified privation
4.4
6.8
23
54
N02AA05
ATC
oxycodone; systemic
1.8
6.8
110
639
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
6.8
59
265
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.0
6.7
82
428
L03
ICPC
Low back symptom/complaint
1.6
6.7
174
1160
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
4.0
6.7
25
64
137
Kela drug reimbursment
Uraemia requiring dialysis
7.3
6.7
15
21
B01AB05
ATC
enoxaparin; parenteral
1.6
6.7
230
1647
AN1
HP
Coronary angiography
1.9
6.7
95
525
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
6.7
73
364
-1
NOMESCO Finland
NA
1.6
6.7
217
1536
134
Kela drug reimbursment
General erythroderma
22.7
6.7
9
*
R51.80
ICD-10 Finland
Headache
1.9
6.7
102
579
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
6.5
6.7
16
25
WX203
NOMESCO Finland
Infraclavicular plexus blockade
3.6
6.6
28
80
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
4.1
6.6
24
60
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.5
6.6
366
2915
SPF40
NOMESCO Finland
Removal and reattachment with cement of tooth crone or short bridge
3.9
6.6
25
65
WX290
NOMESCO Finland
Other blockade of nerve
1.5
6.6
283
2132
J01MA14
ATC
moxifloxacin; systemic
2.1
6.6
68
332
CKC15
NOMESCO Finland
Panretinal photocoagulation
8.8
6.6
13
15
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
4.9
6.6
20
42
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.9
6.6
90
490
A28
ICPC
Limited function/disability NOS
1.8
6.6
115
685
T89
ICPC
Diabetes insulin dependent
3.1
6.6
34
114
Z49.2
ICD-10 Finland
Other dialysis
10.1
6.5
12
12
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.5
123
749
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.9
6.5
101
576
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
6.9
6.5
15
22
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
6.9
6.5
15
22
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.0
6.5
24
61
S01
ICPC
Pain/tenderness of skin
2.9
6.5
38
137
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.4
6.5
50
213
J02AC01
ATC
fluconazole; systemic
1.5
6.5
279
2107
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.3
6.4
30
93
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
70.4
6.4
7
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.7
6.4
26
72
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
6.4
171
1152
N06AB10
ATC
escitalopram; oral
1.7
6.4
131
820
J46
ICD-10 Finland
Status asthmaticus
3.5
6.4
27
78
R03DA04
ATC
theophylline; systemic, rectal
2.6
6.4
42
164
J01CE02
ATC
phenoxymethylpenicillin; oral
1.5
6.3
478
4046
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.6
6.3
159
1052
R06AX26
ATC
fexofenadine; oral
2.3
6.3
54
242
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.9
6.3
36
127
A10BK03
ATC
empagliflozin; oral
2.3
6.3
57
263
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.7
6.3
144
929
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
18.2
6.3
9
5
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.9
6.3
88
485
WXQ24
NOMESCO Finland
UVB/UVA light therapy
+∞
6.3
6
*
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
+∞
6.3
6
*
WXQ20
NOMESCO Finland
UVA broad spectrum light therapy
+∞
6.3
6
*
Z50.1
ICD-10 Finland
Other physical therapy
2.5
6.3
47
195
N19
ICD-10 Finland
Unspecified kidney failure
3.1
6.2
32
107
H02AB09
ATC
hydrocortisone; systemic
3.8
6.2
24
64
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.6
6.2
41
160
A07EC01
ATC
sulfasalazine; oral, rectal
2.2
6.2
63
306
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
5.4
6.2
17
32
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.1
6.2
31
102
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.2
6.1
62
297
C09BA02
ATC
enalapril and diuretics; systemic
2.1
6.1
71
362
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
3.3
6.1
28
86
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
4.4
6.1
20
46
D01AC03
ATC
econazole; topical
2.4
6.1
49
212
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.7
6.1
39
148
B05DA
ATC
Isotonic solutions
8.7
6.1
12
14
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
6.1
146
952
SPAT1240
SPAT
Therapeutic discussion
2.1
6.1
66
328
L85.3
ICD-10 Finland
Xerosis cutis
6.8
6.1
14
21
H3601, E103
ICD-10 Finland
NA
6.8
6.1
14
21
J01CF02
ATC
cloxacillin; systemic
3.6
6.0
25
71
A03
ICPC
Fever
1.8
6.0
100
583
Mortality – FinRegistry
↥Association
Association between endpoint L12_PRURIGONOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONOD | 1.628 [1.43, 1.85] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.366 |
During the follow-up period (1.1.1998 — 31.12.2019), 716 out of 2849 females with L12_PRURIGONOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PRURIGONOD | 1.578 [1.36, 1.83] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 1993 males with L12_PRURIGONOD died.
Mortality risk
Mortality risk for people of age
years, who have L12_PRURIGONOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.343% |
| 5 | 1.021% | 1.905% |
| 10 | 2.627% | 4.714% |
| 15 | 4.688% | 9.11% |
| 20 | 8.065% | 14.938% |
Relationships between endpoints
↥Index endpoint: L12_PRURIGONOD – Prurigo nodularis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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