Risteys · L12_PILONIDALCYST

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L05 Hospital discharge: ICD-9 — 685 Cause of death: ICD-10 — L05 Cause of death: ICD-9 — 685 2 out of 7 registries used, show all original rules.	3930
4. Check minimum number of events None	3930
5. Include endpoints None	3930
6. Filter based on genotype QC (FinnGen only)	3930

	All	Female	Male
Number of individuals
Whole population	37426	10491	26770
Only index persons	36039	10189	25850
Unadjusted period prevalence (%)
Whole population	0.62	0.30	0.75
Only index persons	0.81	0.37	0.99
Median age at first event (years)
Whole population	26.92	24.70	27.76
Only index persons	26.75	24.65	27.58

	All	Female	Male
Number of individuals	3930	1503	2427
Unadjusted period prevalence (%)	0.86	0.51	1.07
Median age at first event (years)	29.25	26.14	31.17

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
3555: Matched controls
35549

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L05.9

ICD-10 Finland

Pilonidal cyst without abscess

10649.7

323.0

2029

QBE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin of trunk

21.5

323.0

1232

853

L02.3

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of buttock

33.2

323.0

474

164

L05.0

ICD-10 Finland

Pilonidal cyst with abscess

1020.6

323.0

1262

6851A

ICD-9 Finland

Pilonidal cyst, Without mention of abscess

+∞

323.0

738

6850A

ICD-9 Finland

Pilonidal cyst, With abscess

+∞

288.5

273

S10

ICPC

Boil/carbuncle

9.8

251.6

543

645

QBE99

NOMESCO Finland

Other excision or repair of lesion of skin of trunk

23.4

241.6

354

167

9736

FHL

Subcutaneous tumor removal in operating room or anesthesia

40.8

239.2

303

QBA10

NOMESCO Finland

Incision of skin of trunk

62.7

205.2

240

9733

FHL

Excision of skin change in operating room or anesthesia

23.2

152.5

223

102

P01AB01

ATC

metronidazole; oral, rectal

2.7

150.0

1512

7741

J01DB01

ATC

cefalexin; oral

3.2

146.5

3098

24047

J01FF01

ATC

clindamycin; systemic

2.7

133.4

1165

5392

SPAT1148

SPAT

Treatment of chronic ulcer or burn

4.4

133.0

539

1397

J01DA01

ATC

[U] cefalexin; systemic

2.4

131.4

2376

16161

L05

ICD-10 Finland

Pilonidal cyst

137.0

124.0

132

9749

FHL

Other measure in this category

67.2

117.7

136

L02.2

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of trunk

7.9

111.7

267

360

S85

ICPC

Pilonidal cyst/fistula

70.8

96.0

110

D95

ICPC

Anal fissure/perianal abscess

17.1

95.2

154

L73.2

ICD-10 Finland

Hidradenitis suppurativa

14.2

93.5

163

120

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

4.7

89.2

327

753

L02.9

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle, unspecified

10.1

87.0

179

186

K61.0

ICD-10 Finland

Anal abscess

9.1

85.9

187

215

QBB10

NOMESCO Finland

Major dressing of wound of skin of trunk

6.4

80.1

220

360

L02.4

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of limb

8.4

78.4

179

223

QBE40

NOMESCO Finland

Repair of anomaly or lesion after disease of skin of trunk

81.9

71.3

L02

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle

5.4

70.3

221

428

S18

ICPC

Laceration/cut

2.0

67.7

1280

7946

K60.3

ICD-10 Finland

Anal fistula

6.8

64.2

168

257

WX320

NOMESCO Finland

Spinalanesthesy

2.2

60.0

710

3602

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.9

54.9

992

5954

9731

FHL

Opening and channeling of the inflammatory site in the operating room or anesthesia

29.8

54.2

N02BE01

ATC

paracetamol; systemic, rectal

1.8

51.2

2776

23438

103

Kela drug reimbursment

Diabetes, insulin-treated

2.0

50.9

733

4009

SPAT1146

SPAT

Puncture of abscess or incision of skin

6.9

49.8

128

191

S97

ICPC

Chronic ulcer skin

4.7

49.4

176

390

215

Kela drug reimbursment

Diabetes, non-insulin-treated

2.0

48.4

704

3856

L02.8

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of other sites

10.1

48.0

JHA00

NOMESCO Finland

Anal or perianal incision

7.1

47.1

118

170

QBE00

NOMESCO Finland

Excision of loose skin or fold of skin from trunk

24.5

45.9

N02AX02

ATC

tramadol; systemic, rectal

1.7

43.5

1246

8548

SPAT1149

SPAT

Suture or treatment of traumatic wound

2.4

42.4

391

1735

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

2.5

41.9

345

1439

QBG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of trunk

67.9

41.1

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.6

40.8

1515

11117

A10BA02

ATC

metformin; oral

1.9

40.6

684

3934

J01MA02

ATC

ciprofloxacin; systemic

1.7

40.5

1107

7454

WX110

NOMESCO Finland

Local anesthesy

1.6

39.8

2445

20395

E66.01

ICD-10 Finland

Obesity due to excess calories

2.4

37.3

331

1434

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.0

36.6

510

2717

L72.1

ICD-10 Finland

Trichilemmal cyst

2.8

35.1

245

928

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

2.6

34.7

279

1145

QBG99

NOMESCO Finland

Other operation for chronic ulcer or fistula of skin

340.3

34.0

JHW96

NOMESCO Finland

Other operation on anus or perianal tissue

15.9

33.8

M01AE01

ATC

ibuprofen; systemic, rectal

1.9

32.9

3200

29323

9734

FHL

Excision and local plastic or associated free skin grafting

11.9

32.6

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

2.4

31.1

278

1208

WX002

NOMESCO Finland

Sedation and analgesia

1.9

30.1

508

2895

SPAT1262

SPAT

Handing over of treatment supplies

1.9

29.0

485

2753

J01MA12

ATC

levofloxacin; systemic

1.9

28.3

463

2607

JHA20

NOMESCO Finland

Excision of lesion of anal canal or perianal tissue

6.9

28.1

105

SPAT1250

SPAT

Comprehensive monitoring of chronic illness

1.7

27.2

588

3626

M01AE03

ATC

ketoprofen; systemic, rectal

1.6

27.0

1037

7461

A10AE04

ATC

insulin glargine; parenteral

2.2

27.0

303

1467

T90

ICPC

Diabetes non-insulin dependent

1.8

26.1

508

3029

9759

FHL

Other measure in this category

60.5

26.0

N02AJ06

ATC

codeine and paracetamol; systemic

1.5

25.2

1189

8930

G47.3

ICD-10 Finland

Sleep apnoea

1.6

25.2

688

4529

N07BA03

ATC

varenicline; oral

2.3

24.9

236

1056

A10AB01

ATC

insulin (human); parenteral (insulins and analog. for injection, fast-acting)

2.7

24.8

179

692

68599

ICD-8 Finland

Pilonidal cyst

11.1

24.3

E10.3

ICD-10 Finland

Type 1 diabetes mellitus, With ophthalmic complications

2.7

24.2

168

635

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

2.4

24.0

219

962

QBE05

NOMESCO Finland

Excision of sweat glands or sweat gland bearing skin from trunk

67.9

23.8

L02.0

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of face

5.8

23.5

117

J01AA07

ATC

tetracycline; systemic

1.7

23.2

566

3602

A02BC02

ATC

pantoprazole; systemic

1.4

23.1

1765

14523

ABE30

NOMESCO Finland

Excision of dermal sinus

+∞

22.9

M79.6

ICD-10 Finland

Pain in limb

1.5

22.8

957

6969

M01AE02

ATC

naproxen; oral, rectal

1.4

22.8

1769

14578

M01AB05

ATC

diclofenac; systemic, rectal

1.4

22.7

2115

18041

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

22.5

1829

15193

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.4

22.4

1684

13782

T89

ICPC

Diabetes insulin dependent

2.4

22.3

188

792

E66.8

ICD-10 Finland

Other obesity

2.4

22.2

196

848

6459

FHL

Other measure in this category

18.1

22.1

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.5

21.2

942

6927

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.5

21.1

1035

7767

J01AA02

ATC

doxycycline; systemic

1.4

21.0

2316

20220

A10AE05

ATC

insulin detemir; parenteral

2.4

21.0

187

810

L08.8

ICD-10 Finland

Other specified local infections of skin and subcutaneous tissue

3.9

20.7

224

N03AX16

ATC

pregabalin; oral

1.6

20.5

594

3952

I10

ICD-10 Finland

Essential (primary) hypertension

1.4

20.4

1135

8722

QBB99

NOMESCO Finland

Other procedure for wound of skin of trunk

25.6

20.4

TPH04

NOMESCO Finland

Cathetrisation of vein

1.6

20.1

527

3411

QXA05

NOMESCO Finland

Skin division, unspecified location

18.9

19.9

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.4

19.8

166

700

SAA01

NOMESCO Finland

Simple examination of mouth

1.4

19.3

2416

21385

JHD20

NOMESCO Finland

Incision of fistula-in-ano

5.1

19.1

119

SPAT1153

SPAT

Removal of sutures

1.5

18.9

770

5536

L03.9

ICD-10 Finland

Cellulitis, unspecified

5.1

18.8

117

TNX30

NOMESCO Finland

Soft bandage, unspecified region

4.9

18.6

127

A10AA02

ATC

2.6

18.5

137

538

H04AA01

ATC

glucagon; nasal, parenteral

2.6

18.4

138

548

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

1.9

18.3

291

1614

EBA05

NOMESCO Finland

Complicated extraction of tooth

1.5

18.2

622

4295

J01CF05

ATC

flucloxacillin; systemic

2.8

18.2

121

447

N05BA01

ATC

diazepam; systemic, rectal

1.8

18.2

354

2099

K04.5

ICD-10 Finland

Chronic apical periodontitis

1.5

18.1

717

5117

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.5

18.1

804

5879

J01DB05

ATC

cefadroxil; oral

2.4

18.0

159

686

A10AB04

ATC

insulin lispro; parenteral (insulins and analog. for injection, fast-acting)

2.4

17.8

149

624

WX290

NOMESCO Finland

Other blockade of nerve

1.4

17.8

1653

13822

S04

ICPC

Lump/swelling localized

1.9

17.7

259

1393

H02AB06

ATC

prednisolone; systemic

1.4

17.5

1223

9735

XCK10

NOMESCO Finland

Photography of fundus of eye

2.0

17.5

238

1246

6455

FHL

Perianal fistula surgery

11.5

17.5

M03BC01

ATC

orphenadrine (citrate); systemic

1.5

17.1

763

5577

UJF32

NOMESCO Finland

Coloscopy

1.5

16.9

557

3807

A10BK03

ATC

empagliflozin; oral

2.1

16.8

187

902

N03AX12

ATC

gabapentin; oral

1.7

16.7

379

2350

SPAT1263

SPAT

Sampling

1.4

16.6

1218

9751

N06AB04

ATC

citalopram; systemic

1.5

16.5

573

3963

T82

ICPC

Obesity

2.5

16.4

131

537

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.4

16.3

1257

10146

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.7

16.0

338

2049

QWC00

NOMESCO Finland

Reoperation for superficial infection in surgery of skin

10.1

15.9

J01CA04

ATC

amoxicillin; systemic

1.4

15.8

2711

24790

SGA01

NOMESCO Finland

Tooth opening as first aid

1.5

15.8

586

4108

SPAT1156

SPAT

Guidance concerning treatment of rash and skin

1.8

15.8

285

1649

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.3

15.6

1575

13234

L02.1

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of neck

9.2

15.6

N05AH02

ATC

clozapine; systemic

2.7

15.6

109

417

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

2.3

15.5

151

685

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.6

15.5

445

2939

SPAT1310

SPAT

Counselling related to known health issue

1.4

15.5

857

6516

C08CA01

ATC

amlodipine; oral

1.5

15.4

639

4588

A10AA01

ATC

2.5

15.4

125

520

E11

ICD-10 Finland

Type 2 diabetes mellitus

1.7

15.3

320

1935

2500B

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]

2.6

15.3

114

451

M03BX02

ATC

tizanidine; oral

1.3

15.3

1980

17261

QBA99

NOMESCO Finland

Other local destruction of skin of trunk

8.3

15.2

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.2

15.1

161

761

K61

ICD-10 Finland

Abscess of anal and rectal regions

20.1

15.1

QBA25

NOMESCO Finland

Destruction of lesion of skin of trunk

4.9

15.0

M54.5

ICD-10 Finland

Low back pain

1.4

15.0

960

7483

F29

ICD-10 Finland

Unspecified nonorganic psychosis

2.1

14.9

176

871

N05AH04

ATC

quetiapine; oral

1.5

14.9

548

3830

J01CE02

ATC

phenoxymethylpenicillin; oral

1.3

14.9

2399

21572

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.5

14.9

627

4513

S29

ICPC

Skin symptom/complaint other

1.6

14.7

385

2479

L03

ICPC

Low back symptom/complaint

1.5

14.6

630

4557

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.3

14.4

1928

16817

ZZR00

NOMESCO Finland

Flap of skin

3.9

14.3

150

JH1CG

NOMESCO Finland

Extensive MRI of perianal area

6.3

14.2

D06AX01

ATC

fusidic acid; topical (antibiotics for topical use)

1.7

14.2

296

1789

QBB05

NOMESCO Finland

Revision of wound of skin of trunk

5.2

14.2

L08.9

ICD-10 Finland

Local infection of skin and subcutaneous tissue, unspecified

3.2

14.1

230

EBA00

NOMESCO Finland

Extraction of tooth

1.4

14.1

1036

8250

8201

FHL

Ovarian preservation exploration and related procedures, eg resection, enucleation or ovariolysis

6.2

14.1

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.5

14.0

616

4470

N05AA02

ATC

levomepromazine; systemic

2.3

14.0

135

611

N05BA04

ATC

oxazepam; oral

1.5

13.9

626

4561

A46

ICD-10 Finland

Erysipelas

1.7

13.9

288

1740

S76

ICPC

Skin infection other

2.3

13.8

124

544

J02AC01

ATC

fluconazole; systemic

1.4

13.8

968

7644

E66

ICD-10 Finland

Obesity

2.2

13.6

143

672

N03AG01

ATC

valproic acid; systemic, rectal

1.9

13.6

203

1102

K02.1

ICD-10 Finland

Caries of dentine

1.3

13.6

1966

17277

E66.00

ICD-10 Finland

Metabolic syndrome

2.1

13.5

152

737

WX408

NOMESCO Finland

General anesthesy, balanced

1.4

13.5

702

5256

SPAT1301

SPAT

No procedures

1.4

13.5

773

5891

L03.1

ICD-10 Finland

Cellulitis of other parts of limb

3.9

13.5

139

E10.7

ICD-10 Finland

Type 1 diabetes mellitus, With multiple complications

2.6

13.3

357

SGA02

NOMESCO Finland

Opening and dilatation of root canal of tooth

1.6

13.3

390

2586

QDA10

NOMESCO Finland

Incision of skin of lower limb

9.7

13.2

M25.5

ICD-10 Finland

Pain in joint

1.4

13.1

766

5854

K61.2

ICD-10 Finland

Anorectal abscess

13.0

12.9

N03AX09

ATC

lamotrigine; oral

1.9

12.9

179

945

Z01.8

ICD-10 Finland

Other specified special examinations

1.5

12.8

546

3931

QXB99

NOMESCO Finland

Other procedure to treat skin wound, unspecified location

4.0

12.7

127

SPAT1211

SPAT

Application of soft bandage

1.8

12.7

216

1227

F32.9

ICD-10 Finland

Depressive episode, unspecified

1.5

12.6

414

2817

6804

FHL

Removal of sacrococcygeal teratoma

130.4

12.4

E66.9

ICD-10 Finland

Obesity, unspecified

2.4

12.4

108

465

G56.0

ICD-10 Finland

Carpal tunnel syndrome

1.6

12.3

308

1961

R5140

NOMESCO Finland

Monitoring the use of the aid

1.6

12.2

288

1806

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.3

12.1

985

7932

C07AB07

ATC

bisoprolol; oral

1.3

12.1

884

7002

A06AD11

ATC

lactulose; oral

1.7

12.1

239

1423

K04.0

ICD-10 Finland

Pulpitis

1.6

12.0

366

2447

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.4

12.0

810

6329

F17.29

ICD-10 Finland

Addiction caused by tobacco UNS

2.9

11.8

238

C03CA01

ATC

furosemide; systemic

1.6

11.7

358

2391

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

1.8

11.7

186

1034

N06AX16

ATC

venlafaxine; oral

1.5

11.7

415

2871

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

1.5

11.6

392

2681

B01AB05

ATC

enoxaparin; parenteral

1.4

11.4

610

4580

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

1.6

11.4

317

2074

C09AA05

ATC

ramipril; oral

1.5

11.3

420

2936

UJH02

NOMESCO Finland

Anoscopy

2.2

11.2

112

520

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.7

11.1

240

1466

D10BA01

ATC

isotretinoin; oral

1.6

11.1

283

1812

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.4

11.1

546

4036

E10.1

ICD-10 Finland

Type 1 diabetes mellitus, With ketoacidosis

2.9

11.0

227

N06AB06

ATC

sertraline; oral

1.6

11.0

323

2141

M01AX17

ATC

nimesulide; oral

1.4

10.8

477

3449

E10.8

ICD-10 Finland

Type 1 diabetes mellitus, With unspecified complications

3.2

10.7

169

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

2.3

10.7

427

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

2.1

10.7

113

538

Z72.0

ICD-10 Finland

Tobacco use

2.5

10.7

351

N05CF01

ATC

zopiclone; oral

1.4

10.6

694

5382

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

3.7

10.6

123

QDE10

NOMESCO Finland

Excision of other lesion extending through all layers of skin in lower limb

2.7

10.6

256

L72.0

ICD-10 Finland

Epidermal cyst

3.7

10.5

119

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

1.6

10.5

279

1803

SPAT1216

SPAT

Assessment of functional ability

1.6

10.5

244

1521

SPAT1249

SPAT

Treatment-related counselling outside office

1.3

10.5

1067

8833

Z71.8

ICD-10 Finland

Other specified counselling

1.4

10.5

666

5141

TQW11

NOMESCO Finland

Vacuum treatment of wound

3.3

10.4

157

ZXA05

NOMESCO Finland

Left side

1.4

10.4

511

3774

L15

ICPC

Knee symptom/complaint

1.4

10.3

442

3176

JHD33

NOMESCO Finland

Completing incision of fistula-in-ano

9.6

10.2

SPAT1254

SPAT

Administration of medicine

1.5

10.2

313

2097

N05AX12

ATC

aripiprazole; systemic

1.8

10.2

167

939

J01FA06

ATC

roxithromycin; oral

1.3

10.1

1050

8704

J18.9

ICD-10 Finland

Pneumonia, unspecified

1.4

10.1

441

3179

N05AF03

ATC

chlorprothixene; systemic

2.3

10.1

413

177

Kela drug reimbursment

Insulin glargine 300 U / ml

2.5

10.1

299

Z01.0

ICD-10 Finland

Examination of eyes and vision

1.5

10.0

388

2731

E11.7

ICD-10 Finland

Type 2 diabetes mellitus, with multiple complications

2.4

10.0

328

J01AA04

ATC

lymecycline; systemic

1.5

10.0

394

2786

A02BC05

ATC

esomeprazole; systemic

1.3

10.0

987

8132

M01AH05

ATC

etoricoxib; oral

1.3

10.0

1720

15188

E11.8

ICD-10 Finland

Type 2 diabetes mellitus, with unspecified complications

1.8

9.9

156

865

H36.09*E10.3

ICD-10 Finland

Insulin-dependent diabetes mellitus - Diabetic retinopathy

3.5

9.9

126

L17

ICPC

Foot/toe symptom/complaint

1.4

9.9

550

4147

285

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

2.0

9.9

121

613

R03AC02

ATC

salbutamol; inhalant

1.3

9.9

1493

12976

A10BB12

ATC

glimepiride; oral

2.2

9.9

447

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.3

9.8

1701

15013

N05AH03

ATC

olanzapine; systemic

1.7

9.8

217

1336

A28

ICPC

Limited function/disability NOS

1.7

9.8

180

1052

N06AX11

ATC

mirtazapine; oral

1.3

9.8

832

6709

A03

ICPC

Fever

1.4

9.7

521

3903

N05CD07

ATC

temazepam; oral

1.7

9.7

195

1170

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.6

9.6

227

1425

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.5

9.6

288

1919

SPAT1255

SPAT

Intravenous administration of medicine

1.9

9.5

141

766

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.5

9.5

304

2054

A02BC03

ATC

lansoprazole; oral

1.4

9.5

623

4826

R06.0

ICD-10 Finland

Dyspnoea

1.4

9.4

498

3726

L72.9

ICD-10 Finland

Follicular cyst of skin and subcutaneous tissue, unspecified

5.8

9.3

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.3

9.3

783

6295

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.5

9.3

285

1909

WX404

NOMESCO Finland

Intravenous generell anesthesy

1.4

9.3

494

3696

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.4

9.2

479

3565

SGB10

NOMESCO Finland

Fiiling of rooth of tooth with one root channel

1.5

9.2

326

2254

N05AN01

ATC

lithium; oral

2.2

9.1

384

L70.0

ICD-10 Finland

Acne vulgaris

2.0

9.1

117

604

L68.0

ICD-10 Finland

Hirsutism

4.6

9.1

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.3

9.0

1142

9680

J01DA06

ATC

[U] cefuroxime; systemic

1.4

9.0

382

2741

L03.0

ICD-10 Finland

Cellulitis of finger and toe

1.8

9.0

159

918

S93.4

ICD-10 Finland

Sprain and strain of ankle

1.5

9.0

333

2323

AA1AD

NOMESCO Finland

CT of head and brain

1.4

9.0

452

3349

WX722

NOMESCO Finland

PEEP

2.0

8.9

109

551

N06AX21

ATC

duloxetine; oral

1.5

8.9

273

1826

C10AA01

ATC

simvastatin; oral

1.3

8.9

665

5250

E11.2

ICD-10 Finland

Type 2 diabetes mellitus, with renal complications

2.8

8.9

188

J01XC01

ATC

fusidic acid; systemic

3.3

8.9

127

N05AX08

ATC

risperidone; systemic

1.6

8.9

202

1256

E10

ICD-10 Finland

Type 1 diabetes mellitus

2.2

8.8

377

5651A

ICD-9 Finland

Anal fissure and fistula, Anal fistula[FISTULA ANI]

8.0

8.8

-1

NOMESCO Finland

1.3

8.8

1076

9075

C07AA05

ATC

propranolol; systemic

1.4

8.8

513

3896

G56.2

ICD-10 Finland

Lesion of ulnar nerve

2.1

8.8

471

QBE20

NOMESCO Finland

Excision and repair of scar or web of skin of trunk

5.1

8.8

C10AA05

ATC

atorvastatin; oral

1.3

8.7

674

5346

S21

ICPC

Skin texture symptom/complaint

1.5

8.7

260

1732

E10.00

ICD-10 Finland

Insulin-dependent diabetes diabetic hypoglycemic coma

2.9

8.6

180

F32.3

ICD-10 Finland

Severe depressive episode with psychotic symptoms

2.3

8.6

347

ACC51

NOMESCO Finland

Release of median nerve

1.7

8.6

162

951

L84

ICD-10 Finland

Corns and callosities

2.3

8.5

322

J04BA02

ATC

dapsone; oral

6.4

8.5

SPAT1033

SPAT

Irrigation or wax removal of outer auditory canal

1.5

8.4

329

2323

SGC00

NOMESCO Finland

Local medication of root channels of tooth

1.4

8.4

340

2417

K04.4

ICD-10 Finland

Acute apical periodontitis of pulpal origin

1.5

8.4

251

1669

N05BA12

ATC

alprazolam; oral

1.5

8.4

242

1600

M75.0

ICD-10 Finland

Adhesive capsulitis of shoulder

1.9

8.4

121

653

K08.3

ICD-10 Finland

Retained dental root

1.7

8.3

161

958

SFA40

NOMESCO Finland

Replacement of krone of tooth

1.4

8.3

488

3714

M17.1

ICD-10 Finland

Other primary gonarthrosis

1.5

8.2

304

2124

A10BH01

ATC

sitagliptin; oral

1.7

8.2

160

951

L02

ICPC

Back symptom/complaint

1.6

8.1

232

1529

IGY02

NOMESCO Finland

Psychiatric monitoring contact

2.2

8.1

379

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.4

8.1

413

3064

M03BC51

ATC

orphenadrine, combinations; systemic

1.3

8.1

766

6248

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

1.6

8.1

214

1385

K61.1

ICD-10 Finland

Rectal abscess

6.8

8.0

N76.4

ICD-10 Finland

Abscess of vulva

6.8

8.0

T81.3

ICD-10 Finland

Disruption of operation wound, not elsewhere classified

2.5

8.0

226

346

Kela drug reimbursment

Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)

1.9

8.0

106

553

QX2XE

NOMESCO Finland

Ultrsound examination of soft tissue not elsewhere classified

2.5

8.0

255

K59.1

ICD-10 Finland

Functional diarrhoea

1.9

7.9

104

544

L14

ICPC

Leg/thigh symptom/complaint

1.8

7.9

140

810

M01AC06

ATC

meloxicam; systemic, rectal

1.3

7.9

847

7017

1413

FHL

Laparoscopy and other therapeutic procedure

3.2

7.9

123

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.3

7.8

549

4288

SPAT1260

SPAT

Consultation of another employee

1.4

7.8

391

2891

N06AA09

ATC

amitriptyline; systemic

1.6

7.8

178

1106

R60.0

ICD-10 Finland

Localized oedema

1.6

7.8

178

1110

IGY01

NOMESCO Finland

Accelerated psychiatric treatment contact

2.2

7.7

325

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

2.4

7.7

255

H03AA01

ATC

levothyroxine sodium; systemic

1.4

7.7

425

3195

A10AD01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)

2.4

7.7

256

TQW99

NOMESCO Finland

Other minor procedure on skin

2.0

7.7

430

M48.0

ICD-10 Finland

Spinal stenosis

1.7

7.7

167

1024

QDB05

NOMESCO Finland

Revision of wound of skin of lower limb

2.7

7.7

188

R51.80

ICD-10 Finland

Headache

1.4

7.6

404

3015

N05AB03

ATC

perphenazine; systemic, rectal

1.9

7.6

107

572

J45.9

ICD-10 Finland

Asthma, unspecified

1.4

7.6

376

2773

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

1.4

7.6

307

2181

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.4

7.6

369

2719

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

1.4

7.5

355

2596

IGY99

NOMESCO Finland

Other psychiatric treatment contact

2.3

7.5

284

R06.5

ICD-10 Finland

Mouth breathing

1.5

7.5

244

1659

SGB20

NOMESCO Finland

Filling of root of tooth with 2 root channels

1.6

7.5

200

1296

A10AE06

ATC

insulin degludec; parenteral

1.9

7.5

100

527

IER04

NOMESCO Finland

Rehabilitative psychiatric group intervention, functional

3.5

7.4

F31.9

ICD-10 Finland

Bipolar affective disorder, unspecified

2.0

7.4

463

M54.4

ICD-10 Finland

Lumbago with sciatica

1.4

7.4

410

3083

A02BC01

ATC

omeprazole; systemic

1.3

7.4

565

4464

H3600, E103

ICD-10 Finland

2.5

7.4

222

380

Kela drug reimbursment

Adalimumab (hidradenitis suppurativa)

13.4

7.4

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.3

7.4

645

5199

F25.9

ICD-10 Finland

Schizoaffective disorder, unspecified

2.7

7.4

181

F20.30

ICD-10 Finland

Undifferentiated schizophrenia continuous

2.3

7.4

289

L03.3

ICD-10 Finland

Cellulitis of trunk

5.6

7.4

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

1.7

7.3

160

985

C05.9

ICD-10 Finland

Malignant neoplasm: Palate, unspecified

+∞

7.3

6463

FHL

Perineal or sacroperineal plastics

+∞

7.3

6805A

ICD-9 Finland

Carbuncle and furuncle, Buttock

+∞

7.3

R53

ICD-10 Finland

Malaise and fatigue

1.3

7.3

449

3439

SPAT1283

SPAT

Restricted health certificate

1.3

7.3

669

5424

SGA03

NOMESCO Finland

Demanding opening and dilatation of root canal of tooth

1.4

7.3

292

2073

P99

ICPC

Psychological disorders other

1.9

7.3

517

S01

ICPC

Pain/tenderness of skin

2.0

7.2

476

E66.2

ICD-10 Finland

Extreme obesity with alveolar hypoventilation

3.7

7.2

XF600

NOMESCO Finland

Bloodpressure measurement

1.7

7.2

132

774

R50.9

ICD-10 Finland

Fever, unspecified

1.4

7.2

340

2488

H3601, E103

ICD-10 Finland

2.6

7.1

180

F19.29

ICD-10 Finland

Addiction caused by several drugs in combination and by other psychoactive substances UNS

3.4

7.1

J01MA01

ATC

ofloxacin; systemic

1.6

7.1

161

1005

F60.9

ICD-10 Finland

Personality disorder, unspecified

2.4

7.1

224

2500A

ICD-9 Finland

Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]

3.6

7.0

G40.9

ICD-10 Finland

Epilepsy, unspecified

2.0

7.0

427

F20.00

ICD-10 Finland

Paranoid schizophrenia continuous

2.1

7.0

378

R07.4

ICD-10 Finland

Chest pain, unspecified

1.3

7.0

554

4405

SPAT1240

SPAT

Therapeutic discussion

1.4

6.9

339

2498

N03AF01

ATC

carbamazepine; oral, rectal

1.8

6.9

111

625

TQW40

NOMESCO Finland

Remowal of suture of skin

1.6

6.9

154

956

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

2.7

6.9

171

R03BB04

ATC

tiotropium bromide; inhalant

1.7

6.9

144

878

N30.9

ICD-10 Finland

Cystitis, unspecified

1.9

6.8

480

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

1.5

6.8

217

1470

QBB10

SPAT

6.7

6.8

ICB03

NOMESCO Finland

Psychiatric treatment plan, monitoring

2.5

6.8

190

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

1.6

6.8

177

1142

T36

ICD-10 Finland

Poisoning by systemic antibiotics

1.7

6.8

140

851

L16

ICPC

Ankle symptom/complaint

1.5

6.8

228

1564

D07AC01

ATC

betamethasone; topical

1.2

6.8

827

6940

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

1.5

6.7

195

1291

C09AA02

ATC

enalapril; systemic

1.4

6.7

312

2274

N05AA01

ATC

chlorpromazine; systemic, rectal

2.7

6.7

167

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.2

6.7

975

8342

R01BA52

ATC

pseudoephedrine, combinations; oral

1.3

6.7

718

5931

WZC30

NOMESCO Finland

Teaching

1.4

6.7

272

1934

CKC12

NOMESCO Finland

Photocoagulation of retina

1.8

6.7

537

7058C

ICD-9 Finland

Disorders of sweat glands, Other specified disorders of sweat glands[HIDRADENITIS SUPPURATIVA]

22.5

6.7

R74

ICPC

Upper respiratory infection acute

1.2

6.7

917

7796

H13

ICPC

Plugged feeling ear

1.4

6.7

335

2481

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

1.4

6.7

284

2042

J01DC02

ATC

cefuroxime; systemic

1.6

6.6

150

932

ICZ03

NOMESCO Finland

Participation in compiling a psychiatric treatment plan

1.9

6.6

441

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

1.8

6.6

116

671

SGA04

NOMESCO Finland

Very demanding opening and dilatation of root canal of tooth

1.4

6.6

353

2639

M04AA01

ATC

allopurinol; systemic

1.5

6.6

192

1272

IFA01

NOMESCO Finland

Psychiatric pharmacotherapy plan, not specified

2.4

6.6

223

D10AF01

ATC

clindamycin; topical

1.6

6.6

169

1087

BEF00

NOMESCO Finland

Continuous subcutaneous glucose monitoring

3.1

6.6

112

J44.0

ICD-10 Finland

Chronic obstructive pulmonary disease with acute lower respiratory infection

2.3

6.6

244

QXB10

NOMESCO Finland

Exchange of dressing for large skin wound, unspecified location

12.3

6.6

Z76.9

ICD-10 Finland

Person encountering health services in unspecified circumstances

1.6

6.6

175

1139

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

1.6

6.6

173

1119

K04.08

ICD-10 Finland

Other specified pulpit

1.5

6.5

222

1524

SPAT1225

SPAT

Implementation of podiatry rehabilitation plan

2.3

6.5

246

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

1.3

6.5

396

3025

ZXA00

NOMESCO Finland

Right side

1.3

6.5

515

4089

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.2

6.5

845

7140

L03.8

ICD-10 Finland

Cellulitis of other sites

6.2

6.5

L73.8

ICD-10 Finland

Other specified follicular disorders

3.1

6.4

103

Z50.1

ICD-10 Finland

Other physical therapy

1.8

6.4

105

596

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

1.5

6.4

206

1396

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

1.6

6.4

167

1081

H36.01

ICD-10 Finland

Diabetic maculopathy

2.8

6.4

137

SPAT1222

SPAT

Counselling/guidance promoting independent living

1.4

6.4

250

1766

9473

FHL

Local soft tissue removal or exploration (eg Bursa)

4.1

6.4

J01CA08

ATC

pivmecillinam; oral

1.3

6.4

716

5947

KMAK

NOMESCO Finland

1.2

6.4

1699

15414

NA1AA

NOMESCO Finland

Cervical spine X-ray examination without contrast

2.0

6.4

394

SPAT1229

SPAT

Assessment of need for aid

1.7

6.3

110

637

A10BD07

ATC

metformin and sitagliptin; systemic

1.9

6.2

445

SGC10

NOMESCO Finland

Covering pulpa of tooth

1.4

6.2

313

2315

ZZA00

NOMESCO Finland

Split skin graft

2.3

6.2

227

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

1.5

6.2

174

1147

D07BC01

ATC

betamethasone and antiseptics; topical

1.4

6.2

271

1960

P72

ICPC

Schizophrenia

2.1

6.2

333

SFA00

NOMESCO Finland

Small filling

1.4

6.1

330

2469

QWA00

NOMESCO Finland

Repair of wound dehiscence in surgery of skin

5.3

6.1

N30.0

ICD-10 Finland

Acute cystitis

1.5

6.1

223

1554

ZXC10

NOMESCO Finland

Use of laser

2.3

6.1

233

WX702

NOMESCO Finland

Supraglottic ventilation device

1.7

6.1

127

774

SPAT1234

SPAT

Support of social functional capacity

1.9

6.1

441

H36.00

ICD-10 Finland

Diabetic background retinopathy

2.5

6.1

177

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

1.5

6.1

195

1320

E10.6

ICD-10 Finland

Type 1 diabetes mellitus, With other specified complications

3.5

6.1

L28

ICPC

Limited function/disability (L)

1.5

6.1

221

1542

C07AB03

ATC

atenolol; systemic

2.0

6.1

365

K60

ICD-10 Finland

Fissure and fistula of anal and rectal regions

8.6

6.0

N49.9

ICD-10 Finland

Inflammatory disorder of unspecified male genital organ

10.0

6.0

C03EA01

ATC

hydrochlorothiazide and potassium-sparing agents; oral

1.6

6.0

164

1071

NAME	L12_PILONIDALCYST
CONTROL_EXCLUDE	L12_INFECT_SKIN
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L05
HD_ICD_9	685
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L05
COD_ICD_9	685
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
L12_PILONIDALCYST	1.434 [1.18, 1.74]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.013

Parameter	HR [95% CI]	p-value
L12_PILONIDALCYST	1.341 [1.19, 1.51]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.011

N-year risk	Females	Males
1	0.127%	0.249%
5	0.809%	1.604%
10	1.803%	3.91%
15	3.667%	7.756%
20	5.968%	12.828%

Pilonidal cyst

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints