rosacea: a chronic skin condition characterized by facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
799 |
4. Check minimum number of eventsNone |
799 |
5. Include endpointsNone |
799 |
6. Filter based on genotype QC (FinnGen only) |
799 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L71
- Name in latin
- Dermatitis perioralis
Similar endpoints
↥List of similar endpoints to
Perioral dermatitis
based on the number of shared cases.
Similar with more cases:
- Rosacea
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4435 | 3704 | 720 |
| Only index persons | 4253 | 3606 | 647 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.02 |
| Only index persons | 0.12 | 0.13 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 40.59 | 40.25 | 42.27 |
| Only index persons | 40.98 | 40.43 | 44.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 799 | 713 | 86 |
| Unadjusted period prevalence (%) | 0.22 | 0.24 | 0.04 |
| Median age at first event (years) | 45.70 | 44.68 | 54.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 700
- Matched controls
- 7001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L71.0
ICD-10 Finland
Perioral dermatitis
4503599627370496.0
323.0
698
45
D06BX01
ATC
metronidazole; topical
24.4
263.9
421
407
J01AA04
ATC
lymecycline; systemic
9.3
131.0
325
594
J01AA07
ATC
tetracycline; systemic
6.6
95.6
301
714
L71.9
ICD-10 Finland
Rosacea, unspecified
27.3
55.0
76
31
L71.8
ICD-10 Finland
Other rosacea
54.0
54.0
64
13
E0000UV
ATC
NA
3.3
49.3
406
2059
D10AX03
ATC
azelaic acid; topical
4.6
35.8
136
347
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.3
35.1
145
401
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.3
31.3
183
672
XQ802
NOMESCO Finland
Epicutan test
6.3
30.9
86
152
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.9
29.3
102
235
D10BA01
ATC
isotretinoin; oral
4.7
28.3
103
248
L70.0
ICD-10 Finland
Acne vulgaris
9.7
24.9
51
56
XQ800
NOMESCO Finland
Prick test
3.9
24.8
110
319
E000001
ATC
NA
2.5
20.8
199
962
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
19.7
96
299
L71
ICD-10 Finland
Rosacea
8.4
19.5
43
54
D07AC13
ATC
mometasone; topical
2.2
17.3
236
1337
H02AB06
ATC
prednisolone; systemic
2.0
17.0
336
2207
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
17.0
299
1880
D07AC01
ATC
betamethasone; topical
2.1
16.6
250
1471
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
16.4
228
1296
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
16.1
180
924
L20.0
ICD-10 Finland
Besnier prurigo
3.1
15.5
91
323
R06AE07
ATC
cetirizine; oral
1.9
14.9
355
2458
D07AD01
ATC
clobetasol; topical
2.5
14.9
129
579
S01GX01
ATC
cromoglicic acid; ophthalmic
2.1
14.8
191
1043
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
14.4
193
1070
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
13.4
110
479
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
4.3
12.8
48
119
J02AC01
ATC
fluconazole; systemic
1.8
12.8
359
2579
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
12.6
165
898
D10AF01
ATC
clindamycin; topical
3.4
12.3
61
193
R06AE09
ATC
levocetirizine; oral
2.2
12.0
140
723
D02AE01
ATC
carbamide; topical
3.0
11.7
69
247
P01BA02
ATC
hydroxychloroquine; oral
2.8
11.7
77
296
D07AB08
ATC
desonide; topical
2.5
11.2
92
400
UJF32
NOMESCO Finland
Coloscopy
2.0
11.1
163
921
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.5
11.0
93
409
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.9
10.8
44
119
R06AX27
ATC
desloratadine; oral
1.8
10.7
240
1574
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
9.4
10.6
21
23
L71.1
ICD-10 Finland
Rhinophyma
+∞
10.4
10
*
L57.0
ICD-10 Finland
Actinic keratosis
3.1
10.1
57
196
L04AX01
ATC
azathioprine; systemic
3.5
10.1
47
142
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.7
9.6
41
116
J01DB01
ATC
cefalexin; oral
1.8
9.5
566
4889
J02AC02
ATC
itraconazole; systemic
2.0
9.4
137
771
R01AD08
ATC
fluticasone; nasal
1.8
9.4
215
1411
R03BA02
ATC
budesonide; inhalant
2.0
9.3
136
767
L70
ICD-10 Finland
Acne
5.7
9.1
25
45
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
9.0
108
562
C01CA24
ATC
epinephrine; parenteral
2.7
9.0
63
249
E000006
ATC
NA
2.7
9.0
63
250
D02AX
ATC
Other emollients and protectives
3.6
8.9
39
113
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
8.7
54
200
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.6
200
1310
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
8.5
78
358
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
8.5
94
473
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.7
8.4
58
230
E0001A1
ATC
NA
4.4
8.4
29
68
L43.8
ICD-10 Finland
Other lichen planus
5.9
8.3
22
38
J01DA01
ATC
[U] cefalexin; systemic
1.6
8.2
427
3465
H02AB07
ATC
prednisone; oral
2.1
8.1
95
487
S18
ICPC
Laceration/cut
1.6
8.0
254
1812
L21.0
ICD-10 Finland
Seborrhoea capitis
8.6
7.8
16
19
L30.8
ICD-10 Finland
Other specified dermatitis
4.3
7.8
27
64
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
6.0
7.7
20
34
D07XC01
ATC
betamethasone, combinations; topical
2.3
7.7
73
344
S21
ICPC
Skin texture symptom/complaint
2.1
7.6
88
450
D11AH02
ATC
pimecrolimus; topical
12.0
7.6
13
11
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.7
7.6
24
52
S01AD03
ATC
aciclovir; ophthalmic
3.5
7.5
34
102
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.4
574
5082
R05
ICD-10 Finland
Cough
1.8
7.3
132
795
D11AH01
ATC
tacrolimus; topical
6.9
7.3
17
25
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
7.4
7.2
16
22
D07AA02
ATC
hydrocortisone; topical
1.9
7.1
110
628
A07EC01
ATC
sulfasalazine; oral, rectal
2.4
7.1
61
273
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.5
7.1
347
2732
L30.3
ICD-10 Finland
Infective dermatitis
3.6
7.0
30
87
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
6.4
7.0
17
27
ZXC50
NOMESCO Finland
Cryotherapy
5.5
7.0
19
35
R01AD12
ATC
fluticasone furoate; nasal
1.6
6.9
236
1706
S29
ICPC
Skin symptom/complaint other
1.9
6.8
108
620
R03AC02
ATC
salbutamol; inhalant
1.5
6.8
366
2930
Z3231
NOMESCO Finland
Registered nurse
1.7
6.8
171
1139
L21
ICD-10 Finland
Seborrhoeic dermatitis
6.2
6.8
17
28
L70.1
ICD-10 Finland
Acne conglobata
40.4
6.8
8
*
D07XB05
ATC
dexamethasone, combinations; topical
3.8
6.7
27
74
N03AX16
ATC
pregabalin; oral
1.7
6.7
141
889
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.0
6.7
38
133
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
6.5
6.7
16
25
J01AA02
ATC
doxycycline; systemic
1.6
6.6
507
4389
SPAT1153
SPAT
Removal of sutures
1.6
6.6
188
1293
L82
ICD-10 Finland
Seborrhoeic keratosis
1.9
6.5
93
516
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.3
6.5
30
93
L50.3
ICD-10 Finland
Dermatographic urticaria
4.1
6.3
23
58
L04AA01
ATC
[U] ciclosporin; systemic
5.6
6.3
17
31
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.6
6.3
44
176
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
5.8
6.2
16
28
A02BC05
ATC
esomeprazole; systemic
1.5
6.1
253
1898
TQW99
NOMESCO Finland
Other minor procedure on skin
3.0
6.1
33
114
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
6.1
58
274
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.3
6.1
28
87
R06AX22
ATC
ebastine; oral
1.7
6.1
135
867
WZA10
NOMESCO Finland
Long statement of health and health related matters
5.3
6.0
17
33
Mortality – FinRegistry
↥Association
Association between endpoint L12_PERIORALDERM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PERIORALDERM | 0.904 [0.74, 1.1] | 0.316 |
| Birth year | 0.996 [0.99, 1.0] | 0.35 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 2529 females with L12_PERIORALDERM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PERIORALDERM | 1.434 [1.09, 1.89] | 0.011 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 585 males with L12_PERIORALDERM died.
Mortality risk
Mortality risk for people of age
years, who have L12_PERIORALDERM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.089% | 0.262% |
| 5 | 0.583% | 1.442% |
| 10 | 1.383% | 3.6% |
| 15 | 2.476% | 7.047% |
| 20 | 4.8% | 12.19% |
Relationships between endpoints
↥Index endpoint: L12_PERIORALDERM – Perioral dermatitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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