obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1584 |
4. Check minimum number of eventsNone |
1584 |
5. Include endpoints |
1618 |
6. Filter based on genotype QC (FinnGen only) |
1618 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Aliae perturbationes pigmentationis cutis
Similar endpoints
↥List of similar endpoints to
Other disorders of pigmentation
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11936 | 7478 | 4395 |
| Only index persons | 10675 | 6915 | 3760 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.12 |
| Only index persons | 0.22 | 0.25 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 54.72 | 57.66 | 49.93 |
| Only index persons | 57.01 | 58.69 | 53.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1618 | 1061 | 557 |
| Unadjusted period prevalence (%) | 0.32 | 0.36 | 0.25 |
| Median age at first event (years) | 59.69 | 57.97 | 62.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1427
- Matched controls
- 14281
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
946.3
323.0
669
13
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
944.8
317.4
300
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
13.7
265.4
502
543
L81.1
ICD-10 Finland
Chloasma
694.0
130.7
127
*
L57.0
ICD-10 Finland
Actinic keratosis
6.9
128.4
360
668
L81.9
ICD-10 Finland
Disorder of pigmentation, unspecified
345.1
125.5
125
*
L81.8
ICD-10 Finland
Other specified disorders of pigmentation
1072.8
103.6
100
*
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
5.9
63.6
190
360
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
10.0
55.2
114
123
L81.0
ICD-10 Finland
Postinflammatory hyperpigmentation
504.7
49.7
49
*
L82
ICD-10 Finland
Seborrhoeic keratosis
3.2
49.5
296
1068
XQ848
NOMESCO Finland
Dermatological photography
9.2
47.8
103
120
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
8.7
43.6
97
119
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
18.4
43.1
67
38
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.7
41.9
199
595
L81.3
ICD-10 Finland
Café au lait spots
+∞
41.9
40
*
ZXC50
NOMESCO Finland
Cryotherapy
7.3
40.4
100
145
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
8.9
39.5
86
102
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.7
38.8
306
1303
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
36.5
315
1408
XQ845
NOMESCO Finland
Dermatoscopy
12.6
35.4
64
53
E0000UV
ATC
NA
2.0
31.5
602
3836
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
3.7
29.8
138
401
D07AC01
ATC
betamethasone; topical
2.0
27.7
509
3154
S18
ICPC
Laceration/cut
1.8
23.6
610
4191
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
3.2
23.5
132
444
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
7.9
23.1
53
69
TQW99
NOMESCO Finland
Other minor procedure on skin
3.6
22.4
104
303
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
19.8
22.2
33
17
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
4.9
22.1
74
158
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
4.0
21.6
89
234
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
5.4
21.5
65
124
SPAT1153
SPAT
Removal of sutures
1.8
21.2
476
3094
D06BB10
ATC
imiquimod; topical
3.8
21.2
93
258
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
21.0
324
1842
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
6.2
20.7
56
93
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
17.6
20.1
31
18
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.8
19.9
40
42
D07AD01
ATC
clobetasol; topical
2.1
19.2
233
1198
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
19.1
410
2610
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
16.1
18.8
30
19
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
18.0
407
2622
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
17.7
17
*
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
3.1
17.2
95
316
L04AD01
ATC
ciclosporin; systemic
6.5
15.9
41
65
D69.0
ICD-10 Finland
Allergic purpura
14.7
15.9
26
18
J01DB01
ATC
cefalexin; oral
1.7
15.8
1121
9737
ZXC20
NOMESCO Finland
Use of chemical agents
5.0
15.8
50
102
L91.0
ICD-10 Finland
Hypertrophic scar
26.6
15.6
21
8
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
26.6
15.6
21
8
L04AA01
ATC
[U] ciclosporin; systemic
6.5
15.6
40
63
E000006
ATC
NA
2.6
15.4
118
483
E000001
ATC
NA
1.8
15.3
287
1731
A02BC05
ATC
esomeprazole; systemic
1.6
15.1
559
4094
H02AB06
ATC
prednisolone; systemic
1.6
15.0
624
4705
L04AA06
ATC
mycophenolic acid; systemic
6.2
14.3
38
63
TQW80
NOMESCO Finland
Local dermatologic skincare
4.4
14.2
51
119
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
5.9
14.1
39
68
ZXC15
NOMESCO Finland
Use of photodynamic technique
5.5
14.0
41
77
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.9
13.9
57
151
127
Kela drug reimbursment
Transplant complication
6.7
13.6
34
52
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
13.2
469
3371
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
13.2
472
3399
R51.80
ICD-10 Finland
Headache
1.9
13.2
200
1112
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
13.1
185
1005
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
7.2
13.1
31
44
Z94.0
ICD-10 Finland
Kidney transplant status
8.4
13.0
28
34
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
9.4
13.0
26
28
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
14.2
12.8
21
15
A02BC03
ATC
lansoprazole; oral
1.6
12.7
394
2731
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.0
12.6
74
258
M54.5
ICD-10 Finland
Low back pain
1.6
12.6
432
3071
L81.2
ICD-10 Finland
Freckles
+∞
12.5
12
*
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
8.5
12.3
26
31
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
14.5
12.3
20
14
UJF32
NOMESCO Finland
Coloscopy
1.6
12.3
347
2345
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
4.3
12.2
44
104
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
3.4
12.2
59
180
M79.6
ICD-10 Finland
Pain in limb
1.5
12.1
473
3464
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
12.1
566
4322
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
3.6
11.9
53
152
D07AB08
ATC
desonide; topical
2.0
11.8
150
780
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
11.8
562
4296
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
11.8
840
6998
A98
ICPC
Health maint/preventive medicine
2.2
11.7
1358
12806
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
11.4
280
1820
SPAT1301
SPAT
No procedures
1.5
11.2
430
3123
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
10.8
360
2526
G44.2
ICD-10 Finland
Tension-type headache
1.8
10.6
178
1023
S21
ICPC
Skin texture symptom/complaint
1.8
10.5
177
1018
L04AX01
ATC
azathioprine; systemic
2.7
10.5
69
259
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
110.8
10.4
11
*
L81.6
ICD-10 Finland
Other disorders of diminished melanin formation
+∞
10.4
10
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
2.4
10.4
91
399
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
7.2
10.3
24
34
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
5.8
10.3
28
49
Z3231
NOMESCO Finland
Registered nurse
1.6
10.3
351
2472
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
10.2
349
2460
S08
ICPC
Skin colour change
2.4
10.2
85
367
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.1
537
4167
D02AE01
ATC
carbamide; topical
2.3
10.0
94
428
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
9.9
331
2317
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
9.9
499
3826
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
9.8
914
7882
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.4
9.7
558
4386
S29
ICPC
Skin symptom/complaint other
1.7
9.6
236
1529
D07AC13
ATC
mometasone; topical
1.5
9.5
365
2633
F16
ICPC
Eyelid symptom/complaint
2.6
9.5
69
277
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
9.5
136
742
ZXA00
NOMESCO Finland
Right side
1.5
9.5
355
2547
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
100.7
9.4
10
*
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
30.2
9.4
12
*
P01BA02
ATC
hydroxychloroquine; oral
2.0
9.4
117
605
SPAT1263
SPAT
Sampling
1.4
9.3
557
4404
N03AX12
ATC
gabapentin; oral
1.7
9.3
204
1277
SBB10
NOMESCO Finland
Teeth copy
2.3
9.3
87
398
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
9.3
290
1995
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
6.8
9.1
22
33
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.8
9.1
20
26
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
7.8
9.1
20
26
SPAT1325
SPAT
Vaccination
1.5
9.1
460
3514
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
6.1
8.9
23
38
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
12.6
8.9
15
12
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
12.6
8.9
15
12
WX110
NOMESCO Finland
Local anesthesy
1.4
8.8
893
7741
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
8.7
55
202
A02BC02
ATC
pantoprazole; systemic
1.4
8.7
846
7270
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
8.7
214
1380
J01MA02
ATC
ciprofloxacin; systemic
1.4
8.6
485
3775
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.5
8.5
65
268
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
20.1
8.5
12
6
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
8.3
155
923
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
8.2
605
4931
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.3
8.2
77
351
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.5
8.1
346
2543
D05BB02
ATC
acitretin; oral
3.6
7.9
33
92
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
7.9
710
5976
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
7.8
666
5550
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.9
7.8
107
575
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
7.8
174
1092
R50.9
ICD-10 Finland
Fever, unspecified
1.7
7.7
169
1054
L85.89
ICD-10 Finland
Other specified epidermal thickening
45.2
7.7
9
*
B07.9
ICD-10 Finland
Verruca simplex
3.0
7.7
44
152
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
5.9
7.7
20
34
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.9
7.7
118
661
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
7.7
125
713
M25.5
ICD-10 Finland
Pain in joint
1.4
7.5
355
2655
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.7
7.5
148
897
ZZR00
NOMESCO Finland
Flap of skin
3.1
7.5
38
123
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
7.5
178
1139
ZX120
NOMESCO Finland
Intravenous
1.8
7.5
118
666
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.8
7.4
132
776
N03AX16
ATC
pregabalin; oral
1.5
7.4
295
2132
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.5
7.4
33
97
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
7.4
140
837
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
2.9
7.4
43
152
L30.0
ICD-10 Finland
Nummular dermatitis
2.6
7.4
49
189
L30.8
ICD-10 Finland
Other specified dermatitis
3.3
7.3
35
109
7090A
ICD-9 Finland
Other disorders of skin and subcutaneous tissue, Dyschromia[CHLOASMA]
+∞
7.3
7
*
B03XA01
ATC
erythropoietin; parenteral
5.8
7.2
19
33
D10AX03
ATC
azelaic acid; topical
2.1
7.2
78
383
R06AX27
ATC
desloratadine; oral
1.5
7.2
319
2359
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.3
7.2
60
262
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.9
7.2
42
150
A01
ICPC
Pain general/multiple sites
1.9
7.1
106
589
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
7.1
157
985
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
7.1
234
1623
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.3
7.0
64
289
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
7.0
413
3217
ZZA00
NOMESCO Finland
Split skin graft
3.0
7.0
38
130
R03BA08
ATC
ciclesonide; inhalant
1.8
7.0
110
621
J01MA14
ATC
moxifloxacin; systemic
1.8
6.9
106
593
R06AE07
ATC
cetirizine; oral
1.4
6.9
544
4446
L50.3
ICD-10 Finland
Dermatographic urticaria
3.9
6.9
26
67
Z2446
NOMESCO Finland
Social worker
2.0
6.9
86
448
-
ICD-10 Finland
NA
3.1
6.8
35
115
KMAK
NOMESCO Finland
NA
1.3
6.8
642
5393
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.8
6.8
114
656
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
4.5
6.8
22
49
ZXA05
NOMESCO Finland
Left side
1.4
6.8
320
2393
E000002
ATC
NA
1.7
6.7
145
901
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
6.6
118
695
C10AA03
ATC
pravastatin; oral
1.9
6.6
98
543
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.4
6.6
309
2301
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.6
269
1949
K02.1
ICD-10 Finland
Caries of dentine
1.3
6.6
699
5975
D06BX01
ATC
metronidazole; topical
1.7
6.6
134
822
J04BA02
ATC
dapsone; oral
8.7
6.6
13
15
N05CF02
ATC
zolpidem; oral
1.5
6.5
220
1533
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
6.5
568
4709
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.8
6.5
99
554
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.8
6.5
113
658
L03
ICPC
Low back symptom/complaint
1.4
6.5
300
2228
D02AX
ATC
Other emollients and protectives
2.4
6.5
50
211
B01AB05
ATC
enoxaparin; parenteral
1.4
6.4
376
2917
J01DA01
ATC
[U] cefalexin; systemic
1.3
6.4
797
6961
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
7.4
6.4
14
19
N02BE01
ATC
paracetamol; systemic, rectal
1.4
6.4
1149
10634
S97
ICPC
Chronic ulcer skin
2.3
6.4
57
255
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.8
6.4
112
657
137
Kela drug reimbursment
Uraemia requiring dialysis
5.5
6.3
17
31
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
6.3
88
479
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.7
6.3
39
146
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.4
6.3
49
208
R42
ICD-10 Finland
Dizziness and giddiness
1.5
6.3
269
1967
XF404
NOMESCO Finland
Ambulatory ECG
1.7
6.3
115
685
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
18.1
6.3
9
5
L90.6
ICD-10 Finland
Striae atrophicae
+∞
6.3
6
*
L81.5
ICD-10 Finland
Leukoderma, not elsewhere classified
+∞
6.3
6
*
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.4
6.2
438
3500
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
6.2
504
4123
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
26.8
6.2
8
*
C43.51
ICD-10 Finland
Malignant melanoma of the trunk originating in lentigo maligna
26.8
6.2
8
*
D06BX02
ATC
ingenol mebutate; topical
3.6
6.2
26
74
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
6.2
669
5709
Z2221
NOMESCO Finland
Medical doctor
1.4
6.2
341
2618
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
3.8
6.2
24
64
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.1
6.1
65
315
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.0
6.1
74
380
D07AA02
ATC
hydrocortisone; topical
1.6
6.1
161
1059
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.4
6.1
300
2255
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
12.6
6.1
10
8
L80
ICD-10 Finland
Vitiligo
12.6
6.1
10
8
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
6.0
427
3415
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
6.0
134
843
M03BX02
ATC
tizanidine; oral
1.3
6.0
758
6603
L85.3
ICD-10 Finland
Xerosis cutis
5.2
6.0
17
33
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHPIGMENTATION and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHPIGMENTATION | 0.759 [0.68, 0.85] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.564 |
During the follow-up period (1.1.1998 — 31.12.2019), 828 out of 6273 females with L12_OTHPIGMENTATION died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHPIGMENTATION | 0.914 [0.79, 1.06] | 0.229 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 538 out of 3664 males with L12_OTHPIGMENTATION died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHPIGMENTATION.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.162% |
| 5 | 0.515% | 1.012% |
| 10 | 1.222% | 2.626% |
| 15 | 2.343% | 5.337% |
| 20 | 4.204% | 9.004% |
Relationships between endpoints
↥Index endpoint: L12_OTHPIGMENTATION – Other disorders of pigmentation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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