phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
DOID EFO Endpoint Browser PheWeb
L12_NONIONRADISKINNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
458 |
4. Check minimum number of eventsNone |
458 |
5. Include endpointsNone |
458 |
6. Filter based on genotype QC (FinnGen only) |
458 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified skin changes due to chronic exposure to nonionizing radiation
based on the number of shared cases.
Similar with more cases:
- Skin changes due to chronic exposure to nonionizing radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3420 | 1992 | 1406 |
| Only index persons | 3066 | 1831 | 1235 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 71.86 | 71.91 | 71.77 |
| Only index persons | 71.03 | 71.15 | 70.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 458 | 235 | 223 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.10 |
| Median age at first event (years) | 67.92 | 66.13 | 69.80 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 427
- Matched controls
- 4271
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
3120.7
300.6
255
*
L57.0
ICD-10 Finland
Actinic keratosis
83.4
238.9
264
81
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
3326.5
208.1
184
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
21.6
125.5
199
166
ZXC50
NOMESCO Finland
Cryotherapy
131.9
96.9
101
10
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
97.2
85.2
92
12
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
58.9
76.4
89
19
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
223.0
73.7
74
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
10.1
64.3
141
198
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
11.2
58.7
119
142
TQW99
NOMESCO Finland
Other minor procedure on skin
16.3
52.8
88
67
ZXC15
NOMESCO Finland
Use of photodynamic technique
175.5
45.8
47
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
46.2
43.7
53
13
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
10.0
43.0
91
113
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
49.0
40.0
48
11
D06BB10
ATC
imiquimod; topical
12.9
38.4
70
64
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
21.0
35.0
52
28
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
34.0
33.3
43
14
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
10.6
32.0
64
70
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.3
28.7
122
361
XQ845
NOMESCO Finland
Dermatoscopy
26.9
27.1
37
15
XQ848
NOMESCO Finland
Dermatological photography
17.8
26.9
42
26
E0000UV
ATC
NA
3.1
26.3
215
1055
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
11.3
24.7
47
46
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
92.1
23.9
26
*
L56.8
ICD-10 Finland
Other specified acute skin changes due to ultraviolet radiation
+∞
22.1
21
*
SPAT1153
SPAT
Removal of sutures
2.8
20.5
190
963
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.4
20.4
114
412
TEA00
NOMESCO Finland
Biopsy of lip
22.9
19.8
28
13
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
42.3
19.7
24
6
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
5.2
19.1
62
135
ZZR00
NOMESCO Finland
Flap of skin
10.6
19.0
37
38
EAA10
NOMESCO Finland
Excision of lesion of lip
17.5
18.1
28
17
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
17.8
157
756
ZXC20
NOMESCO Finland
Use of chemical agents
11.4
17.8
33
31
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
52.3
17.1
20
*
E000001
ATC
NA
2.9
16.9
118
492
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
14.2
16.7
28
21
L82
ICD-10 Finland
Seborrhoeic keratosis
3.2
16.6
100
377
S18
ICPC
Laceration/cut
2.4
16.5
213
1250
D07AB08
ATC
desonide; topical
3.6
15.8
77
247
WXQ41
NOMESCO Finland
Photodynamic therapy of head and neck
+∞
15.7
15
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
10.0
15.7
31
33
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
165.8
15.6
16
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
9.5
15.2
31
35
D07AC13
ATC
mometasone; topical
2.5
15.2
151
765
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
83.0
14.7
16
*
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
83.0
14.7
16
*
D07AC01
ATC
betamethasone; topical
2.4
14.5
173
959
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
28.3
14.4
19
7
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
12.6
14.3
25
21
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
9.1
14.0
29
34
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
14.2
13.9
23
17
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
+∞
13.6
13
*
ZXC07
NOMESCO Finland
Carbon dioxide laser
+∞
13.6
13
*
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
35.3
13.6
17
5
K13.03
ICD-10 Finland
Keilit UNS
144.4
13.5
14
*
D07AA02
ATC
hydrocortisone; topical
3.2
13.3
77
277
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
41.5
13.2
16
*
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
51.7
12.9
15
*
D06BX02
ATC
ingenol mebutate; topical
14.7
12.9
21
15
L56.4
ICD-10 Finland
Polymorphous light eruption
72.1
12.7
14
*
EAA30
NOMESCO Finland
Partial excision of lower lip
133.8
12.5
13
*
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
133.8
12.5
13
*
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
133.8
12.5
13
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.4
11.4
41
100
ZQZ00
NOMESCO Finland
Treatment of several skin areas
36.1
11.3
14
*
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
22.1
10.7
15
7
P01BA02
ATC
hydroxychloroquine; oral
3.4
10.7
52
165
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.5
10.5
50
157
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
+∞
10.5
10
*
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
33.4
10.4
13
*
E000002
ATC
NA
2.9
10.1
62
233
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
15.1
10.1
16
11
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
41.1
10.0
12
*
QAA99
NOMESCO Finland
Other local destruction of skin of head or neck
41.1
10.0
12
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.8
9.8
27
49
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
30.8
9.4
12
*
A02BC05
ATC
esomeprazole; systemic
1.9
9.4
187
1229
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.7
9.3
68
284
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
3.3
9.3
47
155
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
16.0
9.1
14
9
DHB00
NOMESCO Finland
Excision of lesion of external nose
12.9
8.9
15
12
XQ802
NOMESCO Finland
Epicutan test
6.0
8.7
23
40
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
28.1
8.5
11
*
L56.9
ICD-10 Finland
Acute skin change due to ultraviolet radiation, unspecified
91.8
8.4
9
*
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
91.8
8.4
9
*
J01DB01
ATC
cefalexin; oral
2.0
8.3
334
2752
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
8.2
213
1510
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
12.0
8.1
14
12
S29
ICPC
Skin symptom/complaint other
2.2
8.1
85
427
C44.3
ICD-10 Finland
Malignant neoplasm: Skin of other and unspecified parts of face
34.0
8.1
10
*
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
34.0
8.1
10
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
7.8
72
340
B07.9
ICD-10 Finland
Verruca simplex
6.1
7.8
20
34
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
7.8
189
1307
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.0
7.7
30
80
ZXC10
NOMESCO Finland
Use of laser
5.9
7.6
20
35
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
25.5
7.6
10
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
7.6
295
2357
S21
ICPC
Skin texture symptom/complaint
2.4
7.4
62
279
J05AB01
ATC
aciclovir; systemic
2.1
7.3
95
522
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
7.3
49
192
K13.09
ICD-10 Finland
Disease of the lips UNS
+∞
7.3
7
*
C44.99
ICD-10 Finland
Unspecified localization of malignant tumor in skin other or unspecified histology
+∞
7.3
7
*
XF404
NOMESCO Finland
Ambulatory ECG
2.6
7.3
55
232
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
7.1
198
1412
DAB00
NOMESCO Finland
Excision of lesion of auricle
10.3
7.1
13
13
D02AX
ATC
Other emollients and protectives
4.6
7.1
23
52
H02AB06
ATC
prednisolone; systemic
1.7
7.0
208
1512
E000007
ATC
NA
3.4
7.0
32
99
L04AA01
ATC
[U] ciclosporin; systemic
8.5
6.9
14
17
S08
ICPC
Skin colour change
3.3
6.8
33
106
127
Kela drug reimbursment
Transplant complication
11.2
6.8
12
11
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.6
6.8
50
209
SPAT1301
SPAT
No procedures
1.8
6.8
154
1027
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
17.0
6.8
10
6
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
17.0
6.8
10
6
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
6.7
96
546
WX110
NOMESCO Finland
Local anesthesy
1.7
6.7
253
1963
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
6.7
191
1368
SDA02
NOMESCO Finland
Parodonthologic therapy
1.9
6.7
118
726
S77
ICPC
Malignant neoplasm of skin
8.0
6.7
14
18
L04AD01
ATC
ciclosporin; systemic
8.0
6.7
14
18
ZZA00
NOMESCO Finland
Split skin graft
3.8
6.6
26
71
SPAT1325
SPAT
Vaccination
1.7
6.6
178
1251
ZXE00
NOMESCO Finland
One hour or less
1.7
6.5
167
1154
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
70.9
6.4
7
*
8070/3-C44.5
ICD-O-3
Squamous cell carcinoma, NOS, of skin of trunk
70.9
6.4
7
*
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.3
6.4
58
270
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
6.4
34
118
TQW80
NOMESCO Finland
Local dermatologic skincare
5.7
6.4
17
31
SPAT1263
SPAT
Sampling
1.7
6.3
183
1306
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
11.3
6.3
11
10
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
6.3
109
664
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.5
6.3
50
219
L30.3
ICD-10 Finland
Infective dermatitis
3.9
6.2
24
65
L20.0
ICD-10 Finland
Besnier prurigo
4.0
6.2
23
60
D05BB02
ATC
acitretin; oral
5.0
6.1
18
37
C10AA01
ATC
simvastatin; oral
1.7
6.1
233
1792
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
3.1
6.1
32
110
J02AC01
ATC
fluconazole; systemic
1.8
6.0
137
907
Mortality – FinRegistry
↥Association
Association between endpoint L12_NONIONRADISKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.839 [0.75, 0.94] | 0.003 |
| Birth year | 0.995 [0.99, 1.0] | 0.298 |
During the follow-up period (1.1.1998 — 31.12.2019), 659 out of 1855 females with L12_NONIONRADISKINNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NONIONRADISKINNAS | 0.902 [0.79, 1.03] | 0.133 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 578 out of 1306 males with L12_NONIONRADISKINNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NONIONRADISKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.097% | 0.162% |
| 5 | 0.522% | 0.98% |
| 10 | 1.337% | 2.459% |
| 15 | 2.522% | 4.826% |
| 20 | 4.316% | 8.193% |
Relationships between endpoints
↥Index endpoint: L12_NONIONRADISKINNAS – Other and unspecified skin changes due to chronic exposure to nonionizing radiation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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