No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
230 |
4. Check minimum number of eventsNone |
230 |
5. Include endpointsNone |
230 |
6. Filter based on genotype QC (FinnGen only) |
230 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Onycholysis
Similar endpoints
↥List of similar endpoints to
Onycholysis
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1667 | 990 | 666 |
| Only index persons | 1526 | 920 | 606 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.88 | 48.31 | 39.98 |
| Only index persons | 46.36 | 49.26 | 41.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 230 | 159 | 71 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.03 |
| Median age at first event (years) | 52.56 | 50.80 | 56.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 198
- Matched controls
- 1978
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.1
ICD-10 Finland
Onycholysis
4503599627370496.0
272.5
196
*
L60.9
ICD-10 Finland
Nail disorder, unspecified
16.8
11.0
17
11
QDH01
NOMESCO Finland
Excision of nail bed in toe
+∞
10.5
10
*
L60.0
ICD-10 Finland
Ingrowing nail
7.4
10.3
24
36
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
8.4
96
548
D01BA02
ATC
terbinafine; oral; topical
2.6
7.1
61
294
L60.3
ICD-10 Finland
Nail dystrophy
72.1
6.5
7
*
S22
ICPC
Nail symptom/complaint
4.8
6.4
20
45
L60.8
ICD-10 Finland
Other nail disorders
18.8
6.3
9
5
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_LYSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_LYSIS | 1.582 [1.07, 2.33] | 0.02 |
| Birth year | 0.995 [0.99, 1.0] | 0.282 |
During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 827 females with L12_NAIL_LYSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_LYSIS | 1.692 [1.09, 2.62] | 0.018 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 543 males with L12_NAIL_LYSIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_LYSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.308% |
| 5 | 0.914% | 1.598% |
| 10 | 2.268% | 4.152% |
| 15 | 4.445% | 7.92% |
| 20 | 7.88% | 13.34% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_LYSIS – Onycholysis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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