No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
92 |
4. Check minimum number of eventsNone |
92 |
5. Include endpointsNone |
92 |
6. Filter based on genotype QC (FinnGen only) |
92 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Onychogryposis
Similar endpoints
↥List of similar endpoints to
Onychogryphosis
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1009 | 654 | 347 |
| Only index persons | 760 | 483 | 277 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.13 | 56.57 | 52.13 |
| Only index persons | 52.59 | 53.62 | 50.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 92 | 59 | 33 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 49.23 | 48.61 | 50.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 84
- Matched controls
- 840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.2
ICD-10 Finland
Onychogryphosis
+∞
82.3
65
*
70305
ICD-8 Finland
Diseases of nail, Onychogryphosis
+∞
15.0
14
*
QDH00
NOMESCO Finland
Avulsion of toe nail
+∞
15.0
14
*
L84
ICD-10 Finland
Corns and callosities
16.1
10.2
16
12
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
13.7
7.9
13
11
L60.0
ICD-10 Finland
Ingrowing nail
11.6
7.3
13
13
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
10.7
7.1
13
14
V03AE01
ATC
polystyrene sulfonate; oral
43.7
6.9
8
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
43.7
6.9
8
*
B35.1
ICD-10 Finland
Tinea unguium
7.3
6.9
16
26
L03.0
ICD-10 Finland
Cellulitis of finger and toe
6.8
6.5
16
28
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
75.3
6.5
7
*
E000001
ATC
NA
3.9
6.2
27
90
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
4.9
6.1
20
50
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.5
6.1
22
61
SPAT1229
SPAT
Assessment of need for aid
6.1
6.1
16
31
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_GRYPHOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_GRYPHOSIS | 1.729 [1.08, 2.77] | 0.023 |
| Birth year | 0.996 [0.99, 1.0] | 0.325 |
During the follow-up period (1.1.1998 — 31.12.2019), 85 out of 308 females with L12_NAIL_GRYPHOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_GRYPHOSIS | 1.993 [1.26, 3.15] | 0.003 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 60 out of 199 males with L12_NAIL_GRYPHOSIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_GRYPHOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.15% | 0.353% |
| 5 | 0.942% | 2.183% |
| 10 | 2.462% | 5.526% |
| 15 | 4.902% | 10.297% |
| 20 | 8.73% | 16.677% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_GRYPHOSIS – Onychogryphosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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