No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
227 |
4. Check minimum number of eventsNone |
227 |
5. Include endpointsNone |
227 |
6. Filter based on genotype QC (FinnGen only) |
227 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60
- Name in latin
- Dystrophia unguium
Similar endpoints
↥List of similar endpoints to
Nail dystrophy
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1588 | 915 | 667 |
| Only index persons | 1462 | 851 | 611 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 45.42 | 50.45 | 38.41 |
| Only index persons | 45.88 | 50.41 | 39.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 227 | 134 | 93 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | 53.57 | 53.41 | 53.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 203
- Matched controls
- 2028
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.3
ICD-10 Finland
Nail dystrophy
+∞
256.3
188
*
L60.9
ICD-10 Finland
Nail disorder, unspecified
46.1
14.3
17
*
QDH00
NOMESCO Finland
Avulsion of toe nail
80.7
13.8
15
*
QCH00
NOMESCO Finland
Avulsion of finger nail
126.8
11.5
12
*
D01BA02
ATC
terbinafine; oral; topical
3.1
11.4
76
325
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.5
11.0
33
69
RJ421
NOMESCO Finland
NA
+∞
10.5
10
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
10.5
37
93
L60.0
ICD-10 Finland
Ingrowing nail
7.7
10.1
23
33
RJ420
NOMESCO Finland
NA
+∞
9.4
9
*
B35.1
ICD-10 Finland
Tinea unguium
5.5
9.2
27
55
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.2
9.1
53
202
Z3226
NOMESCO Finland
Physiotherapist
3.2
9.0
52
195
S22
ICPC
Nail symptom/complaint
5.7
8.0
22
42
RJ411
NOMESCO Finland
NA
46.8
7.8
9
*
D01AE16
ATC
amorolfine; topical
3.4
7.6
38
129
L60.1
ICD-10 Finland
Onycholysis
83.0
7.5
8
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.3
7.4
27
70
70300
ICD-8 Finland
Diseases of nail, Dystrophia unguium
+∞
7.3
7
*
L17
ICPC
Foot/toe symptom/complaint
2.5
6.7
63
314
Z3231
NOMESCO Finland
Registered nurse
2.4
6.7
67
346
Z2221
NOMESCO Finland
Medical doctor
2.4
6.7
67
346
R4110
NOMESCO Finland
Physiotherapy
2.4
6.6
63
317
7038A
ICD-9 Finland
Diseases of nail, Other specified diseases of nail[DYSTROPHIA UNGUIUM]
+∞
6.3
6
*
R53
ICD-10 Finland
Malaise and fatigue
2.6
6.1
49
223
L03.0
ICD-10 Finland
Cellulitis of finger and toe
4.0
6.1
23
62
R03AC02
ATC
salbutamol; inhalant
2.1
6.1
114
770
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
4.0
6.0
23
63
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAIL_DYSTROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.491 [1.13, 1.97] | 0.005 |
| Birth year | 0.99 [0.98, 1.0] | 0.034 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 782 females with L12_NAIL_DYSTROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAIL_DYSTROPHY | 1.187 [0.87, 1.62] | 0.285 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 524 males with L12_NAIL_DYSTROPHY died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAIL_DYSTROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.129% | 0.238% |
| 5 | 0.734% | 1.34% |
| 10 | 1.892% | 3.472% |
| 15 | 3.565% | 6.6% |
| 20 | 6.123% | 11.305% |
Relationships between endpoints
↥Index endpoint: L12_NAIL_DYSTROPHY – Nail dystrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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