No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
734 |
4. Check minimum number of eventsNone |
734 |
5. Include endpointsNone |
734 |
6. Filter based on genotype QC (FinnGen only) |
734 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified nail disorders
based on the number of shared cases.
Similar with more cases:
- Nail disorders
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4733 | 2702 | 2009 |
| Only index persons | 4307 | 2489 | 1818 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.06 |
| Only index persons | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 51.51 | 52.58 | 50.15 |
| Only index persons | 52.27 | 53.11 | 51.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 734 | 475 | 259 |
| Unadjusted period prevalence (%) | 0.15 | 0.16 | 0.11 |
| Median age at first event (years) | 58.17 | 57.58 | 59.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 642
- Matched controls
- 6419
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L60.9
ICD-10 Finland
Nail disorder, unspecified
692.5
323.0
422
18
L60.8
ICD-10 Finland
Other nail disorders
337.9
231.8
222
10
RJ410
NOMESCO Finland
NA
122.4
52.7
56
5
RJ421
NOMESCO Finland
NA
120.0
51.7
55
5
RJ190
NOMESCO Finland
NA
180.3
48.6
50
*
RJ411
NOMESCO Finland
NA
57.5
45.3
53
10
RJ422
NOMESCO Finland
NA
+∞
43.2
41
*
QDH00
NOMESCO Finland
Avulsion of toe nail
+∞
42.1
40
*
L60.0
ICD-10 Finland
Ingrowing nail
9.0
34.3
75
93
B35.1
ICD-10 Finland
Tinea unguium
6.7
34.0
91
154
S22
ICPC
Nail symptom/complaint
5.8
28.1
83
159
L03.0
ICD-10 Finland
Cellulitis of finger and toe
5.0
27.5
94
213
E0000UV
ATC
NA
2.5
25.3
308
1750
QDH01
NOMESCO Finland
Excision of nail bed in toe
129.8
23.7
25
*
D01AE16
ATC
amorolfine; topical
3.6
23.6
119
386
RJ511
NOMESCO Finland
NA
83.0
21.8
24
*
XQ848
NOMESCO Finland
Dermatological photography
9.7
21.1
43
47
TQW80
NOMESCO Finland
Local dermatologic skincare
8.0
21.0
48
64
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.7
20.4
94
281
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.4
20.4
78
197
L60.1
ICD-10 Finland
Onycholysis
21.6
20.1
29
14
L84
ICD-10 Finland
Corns and callosities
6.8
19.6
50
79
D01BA02
ATC
terbinafine; oral; topical
2.4
19.3
202
1024
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.7
19.1
145
617
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.8
18.2
39
47
RJ420
NOMESCO Finland
NA
34.0
18.1
23
7
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
6.9
17.5
44
68
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.3
17.4
54
109
L60.3
ICD-10 Finland
Nail dystrophy
51.5
17.1
20
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
16.8
85
273
RJ414
NOMESCO Finland
NA
92.5
16.6
18
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
23.8
16.5
23
10
D07AD01
ATC
clobetasol; topical
2.6
15.9
127
552
127
Kela drug reimbursment
Transplant complication
10.8
15.8
30
29
A46
ICD-10 Finland
Erysipelas
2.8
15.6
112
456
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.8
15.5
44
80
J01DB01
ATC
cefalexin; oral
2.3
15.2
543
4506
D07AC01
ATC
betamethasone; topical
2.1
15.1
243
1468
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.7
14.5
64
184
Z94.0
ICD-10 Finland
Kidney transplant status
13.8
14.3
24
18
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
14.2
103
420
A10AE05
ATC
insulin detemir; parenteral
4.1
14.2
56
146
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.3
13.8
73
242
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.2
13.2
29
37
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
6.0
13.2
36
63
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
13.1
127
607
XQ845
NOMESCO Finland
Dermatoscopy
9.6
12.6
25
27
A10AA02
ATC
NA
5.4
12.5
37
72
A10AE04
ATC
insulin glargine; parenteral
3.0
12.3
75
274
J01MA02
ATC
ciprofloxacin; systemic
1.9
12.1
250
1625
L04AA06
ATC
mycophenolic acid; systemic
7.5
12.1
28
39
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.2
12.0
64
214
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.7
11.9
87
357
S18
ICPC
Laceration/cut
1.8
11.7
273
1844
J01FF01
ATC
clindamycin; systemic
2.0
11.6
185
1089
C03CA01
ATC
furosemide; systemic
2.0
11.6
165
931
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
13.9
11.5
19
14
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.5
11.5
29
46
RJ425
NOMESCO Finland
NA
+∞
11.5
11
*
Z3231
NOMESCO Finland
Registered nurse
2.0
11.4
182
1073
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
20.5
11.2
16
8
L04AD01
ATC
ciclosporin; systemic
7.3
11.1
26
37
SPAT1260
SPAT
Consultation of another employee
2.1
10.9
134
709
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.5
10.6
50
153
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
10.5
45
127
L57.0
ICD-10 Finland
Actinic keratosis
2.9
10.5
66
247
J02AC02
ATC
itraconazole; systemic
2.1
10.5
133
714
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
6.6
10.4
26
41
SPAT1310
SPAT
Counselling related to known health issue
1.8
10.4
220
1426
RJ210
NOMESCO Finland
NA
33.1
10.4
13
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
10.2
82
352
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.7
150
864
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
9.7
118
620
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.7
9.7
41
115
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.5
9.6
76
325
TQW99
NOMESCO Finland
Other minor procedure on skin
3.6
9.5
42
122
L17
ICPC
Foot/toe symptom/complaint
1.9
9.5
168
1020
A02BC02
ATC
pantoprazole; systemic
1.7
9.5
404
3204
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
9.5
207
1350
RJ412
NOMESCO Finland
NA
101.4
9.4
10
*
RJ521
NOMESCO Finland
NA
101.4
9.4
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
9.4
265
1863
H04AA01
ATC
glucagon; nasal, parenteral
5.2
9.3
28
56
H02AB06
ATC
prednisolone; systemic
1.7
9.3
291
2109
Z71.8
ICD-10 Finland
Other specified counselling
1.9
9.3
160
961
SPAT1263
SPAT
Sampling
1.7
9.2
273
1945
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
6.9
9.2
22
33
N02BE01
ATC
paracetamol; systemic, rectal
1.9
9.1
541
4723
A11CC03
ATC
alfacalcidol; systemic
5.7
9.1
25
45
TNX92
NOMESCO Finland
Supporting bandage or orthosis of lower limb
5.7
9.1
25
45
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.5
9.1
19
23
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.7
9.1
16
14
Z49.2
ICD-10 Finland
Other dialysis
11.7
9.1
16
14
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.6
9.1
30
67
WZC30
NOMESCO Finland
Teaching
2.2
9.0
95
470
A10AA01
ATC
NA
4.9
9.0
28
59
UJF32
NOMESCO Finland
Coloscopy
1.8
8.8
161
984
137
Kela drug reimbursment
Uraemia requiring dialysis
10.9
8.8
16
15
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
8.8
153
920
RD211
NOMESCO Finland
NA
3.3
8.8
44
142
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
14.3
8.7
14
10
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.2
8.7
45
149
NHQ40
NOMESCO Finland
Amputation of toe
7.1
8.6
20
29
E000001
ATC
NA
1.9
8.6
133
768
TK800
NOMESCO Finland
Hemodialysis
5.3
8.5
25
49
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.1
8.5
106
561
SPAT1262
SPAT
Handing over of treatment supplies
2.0
8.5
122
682
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.8
8.5
54
205
ZXC50
NOMESCO Finland
Cryotherapy
4.6
8.5
28
63
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
91.2
8.4
9
*
V03AE01
ATC
polystyrene sulfonate; oral
8.0
8.4
18
23
L40.8
ICD-10 Finland
Other psoriasis
13.0
8.4
14
11
70309
ICD-8 Finland
Diseases of nail, Unspecified
+∞
8.3
8
*
RJ520
NOMESCO Finland
NA
+∞
8.3
8
*
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
10.9
8.3
15
14
H3603, E103
ICD-10 Finland
NA
9.6
8.3
16
17
D07AB02
ATC
hydrocortisone butyrate; topical
1.8
8.3
179
1155
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
8.2
115
638
SPAT1153
SPAT
Removal of sutures
1.7
8.2
208
1405
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
8.1
46
161
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
10.2
8.1
15
15
N18.0
ICD-10 Finland
End-stage renal disease
10.2
8.1
15
15
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
10.2
8.1
15
15
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
8.0
92
470
A12AA04
ATC
calcium carbonate; oral
7.4
8.0
18
25
R50.9
ICD-10 Finland
Fever, unspecified
2.1
8.0
92
471
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
2.7
8.0
54
212
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
8.0
152
938
D07AB08
ATC
desonide; topical
2.3
7.9
76
357
S09
ICPC
Infected finger/toe
4.4
7.9
27
63
B05DA
ATC
Isotonic solutions
11.0
7.8
14
13
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
7.7
248
1787
Z00.0
ICD-10 Finland
General medical examination
1.9
7.6
126
743
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
18.6
7.6
11
6
L60
ICD-10 Finland
Nail disorders
12.0
7.6
13
11
QDH05
NOMESCO Finland
Correction of deformity of toe nail
25.3
7.6
10
*
D02AE01
ATC
carbamide; topical
2.7
7.6
52
206
K65.0
ICD-10 Finland
Acute peritonitis
9.0
7.6
15
17
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
10.2
7.6
14
14
SPAT1301
SPAT
No procedures
1.7
7.5
201
1371
J01EA01
ATC
trimethoprim; systemic
1.8
7.5
156
992
S29
ICPC
Skin symptom/complaint other
1.9
7.4
107
598
SPAT1255
SPAT
Intravenous administration of medicine
2.8
7.4
47
177
QCH00
NOMESCO Finland
Avulsion of finger nail
81.0
7.4
8
*
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
4.1
7.4
27
68
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.3
251
1828
B37.2
ICD-10 Finland
Candidiasis of skin and nail
11.0
7.3
13
12
70308
ICD-8 Finland
Diseases of nail, Alii definiti
+∞
7.3
7
*
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.3
7.2
35
111
V03AE02
ATC
sevelamer; oral
15.9
7.2
11
7
T89
ICPC
Diabetes insulin dependent
3.3
7.2
34
106
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
7.2
110
628
XCK10
NOMESCO Finland
Photography of fundus of eye
2.3
7.1
67
315
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
5.4
7.1
20
38
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.6
7.1
50
202
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
7.1
182
1229
L28
ICPC
Limited function/disability (L)
2.0
7.0
95
520
M79.6
ICD-10 Finland
Pain in limb
1.6
7.0
224
1604
H02AB04
ATC
methylprednisolone; systemic
2.0
6.9
96
528
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
6.9
85
448
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
14.0
6.9
11
8
N30.0
ICD-10 Finland
Acute cystitis
2.0
6.9
94
515
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.5
6.9
23
53
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
6.9
60
272
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
6.8
196
1360
SPAT1079
SPAT
Echocardiography
6.8
6.8
16
24
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
6.8
192
1325
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.1
6.8
80
414
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
6.8
76
386
-1
NOMESCO Finland
NA
1.6
6.8
207
1460
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.1
6.8
79
405
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.6
6.7
48
196
RD210
NOMESCO Finland
NA
5.6
6.6
18
33
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
6.6
60
276
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
6.6
76
391
ZY010
NOMESCO Finland
Hospital outpatient
3.0
6.6
35
120
A10AE06
ATC
insulin degludec; parenteral
3.7
6.6
27
76
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.5
6.6
47
193
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
10.2
6.6
12
12
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
6.5
65
314
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.5
6.5
28
82
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
2.7
6.5
43
169
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
6.5
69
343
S97
ICPC
Chronic ulcer skin
2.8
6.5
39
145
S94
ICPC
Ingrowing nail
7.5
6.4
14
19
J02AC01
ATC
fluconazole; systemic
1.6
6.4
257
1931
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.2
6.4
64
310
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
6.4
77
404
H3600, E103
ICD-10 Finland
NA
6.6
6.4
15
23
A02BC03
ATC
lansoprazole; oral
1.6
6.3
178
1225
WZA90
NOMESCO Finland
Other doctors statement
1.7
6.3
147
959
D01AE15
ATC
terbinafine; topical
2.5
6.3
48
203
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
11.2
6.3
11
10
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
11.2
6.3
11
10
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
6.3
76
397
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.8
6.3
37
135
K59.1
ICD-10 Finland
Functional diarrhoea
2.9
6.3
36
128
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
18.2
6.3
9
5
QCH01
NOMESCO Finland
Excision of nail bed in finger
+∞
6.3
6
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.1
6.2
67
333
H13
ICPC
Plugged feeling ear
1.8
6.2
106
629
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.6
6.2
20
45
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.2
249
1868
D05AX52
ATC
calcipotriol, combinations; topical
2.7
6.2
41
161
RS221
NOMESCO Finland
NA
5.4
6.2
17
32
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.8
6.2
37
137
H36.00
ICD-10 Finland
Diabetic background retinopathy
5.8
6.2
16
28
H3601, E103
ICD-10 Finland
NA
7.8
6.1
13
17
Z49.0
ICD-10 Finland
Preparatory care for dialysis
7.8
6.1
13
17
C09CA01
ATC
losartan; oral
1.7
6.1
132
845
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.6
6.1
41
163
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
6.8
6.1
14
21
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.0
168
1148
S21
ICPC
Skin texture symptom/complaint
2.0
6.0
76
405
Mortality – FinRegistry
↥Association
Association between endpoint L12_NAILNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAILNAS | 1.733 [1.42, 2.12] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 1906 females with L12_NAILNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_NAILNAS | 2.137 [1.7, 2.68] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 258 out of 1445 males with L12_NAILNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_NAILNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.197% | 0.395% |
| 5 | 1.018% | 2.492% |
| 10 | 2.49% | 6.655% |
| 15 | 4.702% | 11.997% |
| 20 | 8.331% | 19.587% |
Relationships between endpoints
↥Index endpoint: L12_NAILNAS – Other and unspecified nail disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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