No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
880 |
4. Check minimum number of eventsNone |
880 |
5. Include endpointsNone |
880 |
6. Filter based on genotype QC (FinnGen only) |
880 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L80-L99
- Name in latin
- Lupus erythematosus
Similar endpoints
↥List of similar endpoints to
Lupus erythematosus
based on the number of shared cases.
Similar with more cases:
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5703 | 4197 | 1469 |
| Only index persons | 5048 | 3789 | 1259 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.12 | 0.04 |
| Only index persons | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 54.73 | 55.76 | 51.68 |
| Only index persons | 53.96 | 55.11 | 50.50 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 880 | 671 | 209 |
| Unadjusted period prevalence (%) | 0.20 | 0.23 | 0.09 |
| Median age at first event (years) | 54.21 | 53.16 | 57.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 805
- Matched controls
- 8050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L93.0
ICD-10 Finland
Discoid lupus erythematosus
+∞
323.0
631
*
P01BA02
ATC
hydroxychloroquine; oral
34.5
323.0
498
361
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
23.3
254.8
397
323
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
148.7
177.9
184
16
L93.1
ICD-10 Finland
Subacute cutaneous lupus erythematosus
+∞
133.1
124
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.2
100.8
332
816
L93.2
ICD-10 Finland
Other local lupus erythematosus
+∞
95.8
90
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
7.3
94.6
259
489
D07AC01
ATC
betamethasone; topical
4.6
88.1
465
1852
D07AC13
ATC
mometasone; topical
4.6
84.5
415
1519
D07AB08
ATC
desonide; topical
6.8
80.9
231
451
D07AD01
ATC
clobetasol; topical
5.0
68.7
260
696
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
23.7
64.4
93
44
D07AB02
ATC
hydrocortisone butyrate; topical
3.8
63.4
374
1501
E0000UV
ATC
NA
3.5
62.6
465
2241
L93
ICD-10 Finland
Lupus erythematosus
+∞
60.2
57
*
H02AB06
ATC
prednisolone; systemic
3.4
58.7
516
2772
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
147.3
52.5
55
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
4.7
43.1
162
408
L04AX01
ATC
azathioprine; systemic
7.6
42.7
105
156
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
107.9
38.1
41
*
E000001
ATC
NA
3.1
36.2
245
998
69540
ICD-8 Finland
Erythematous condition, Lupus erythematosus
+∞
35.7
34
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
5.1
35.5
121
272
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
15.9
35.4
58
39
L04AA06
ATC
mycophenolic acid; systemic
20.5
34.8
52
27
P01BA01
ATC
chloroquine; systemic
34.8
33.5
43
13
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
340.4
33.1
33
*
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
114.6
30.9
33
*
M32
ICD-10 Finland
Systemic lupus erythematosus
302.3
29.0
29
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
28.7
362
2059
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.7
27.9
83
158
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
31.3
27.4
36
12
D06BX01
ATC
metronidazole; topical
3.3
26.2
150
529
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
9.4
25.9
54
61
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
25.3
393
2421
XQ848
NOMESCO Finland
Dermatological photography
9.6
24.8
51
56
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.8
21.5
95
271
L71.8
ICD-10 Finland
Other rosacea
10.7
21.3
41
40
TQW80
NOMESCO Finland
Local dermatologic skincare
8.6
21.2
46
56
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
59.1
20.0
23
*
C08CA05
ATC
nifedipine; systemic
3.8
19.2
86
248
SBA10
NOMESCO Finland
Measurement of excretion of saliva
18.6
17.9
27
15
D07XC01
ATC
betamethasone, combinations; topical
2.8
17.8
128
516
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
183.9
17.6
18
*
H02AB07
ATC
prednisone; oral
2.5
17.3
155
708
L88
ICPC
Rheumatoid/seropositive arthritis
4.6
17.2
61
142
D07AA02
ATC
hydrocortisone; topical
2.6
16.8
139
607
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.7
16.7
124
509
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
16.6
112
435
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.0
16.1
100
367
J04BA02
ATC
dapsone; oral
48.5
16.1
19
*
R50.9
ICD-10 Finland
Fever, unspecified
2.6
15.8
128
552
6954A
ICD-9 Finland
Erythematous conditions, Lupus erythematosus[LUPUS ERYTHEMATOSUS DISCOIDES]
+∞
15.7
15
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.0
15.1
91
328
E000002
ATC
NA
2.6
15.0
115
481
L71.9
ICD-10 Finland
Rosacea, unspecified
5.4
14.7
44
85
M05BA04
ATC
alendronic acid; oral
2.7
14.3
102
408
L56.4
ICD-10 Finland
Polymorphous light eruption
22.7
14.3
20
9
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
14.2
158
798
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
13.9
84
303
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
24.3
13.8
19
8
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
9.9
13.8
27
28
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
13.6
360
2512
D02BB01
ATC
betacarotene; oral
26.2
13.4
18
7
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
13.2
206
1194
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.0
13.0
52
137
J01DB01
ATC
cefalexin; oral
1.9
12.9
647
5484
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.5
12.2
43
100
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
9.8
11.8
23
24
N02AX02
ATC
tramadol; systemic, rectal
1.7
11.8
331
2322
J01FF01
ATC
clindamycin; systemic
1.8
11.5
221
1369
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.6
11.5
89
373
D02AX
ATC
Other emollients and protectives
4.1
11.4
44
112
XQ802
NOMESCO Finland
Epicutan test
3.6
11.2
50
145
SPAT1153
SPAT
Removal of sutures
1.8
11.2
261
1720
J01DA01
ATC
[U] cefalexin; systemic
1.7
11.2
503
4008
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.0
10.9
34
70
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.4
10.6
95
431
B07.9
ICD-10 Finland
Verruca simplex
4.1
10.5
40
101
L43.9
ICD-10 Finland
Lichen planus, unspecified
5.3
10.5
31
60
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
10.5
241
1576
R06AX27
ATC
desloratadine; oral
1.8
10.4
221
1410
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.2
10.4
114
568
E000007
ATC
NA
3.0
10.4
61
217
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
10.4
88
388
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.0
10.3
60
212
R06AE07
ATC
cetirizine; oral
1.6
10.2
357
2630
XX9XE
NOMESCO Finland
Other ultrasound examination
9.3
10.1
20
22
D05BB02
ATC
acitretin; oral
4.8
9.9
32
69
L43.8
ICD-10 Finland
Other lichen planus
5.5
9.9
28
52
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.8
9.9
65
248
L30.8
ICD-10 Finland
Other specified dermatitis
4.8
9.6
31
67
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
9.6
83
370
L04AD01
ATC
ciclosporin; systemic
5.8
9.6
26
46
ZXC12
NOMESCO Finland
Pulse colorlaser
15.2
9.5
15
10
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
9.4
115
597
6954B
ICD-9 Finland
Erythematous conditions, Lupus erythematosus[LUPUS ERYTHEMATOSUS DISCOIDES DISSEMINATUS]
+∞
9.4
9
*
XPX04
NOMESCO Finland
Angioscopy
22.0
9.4
13
6
J01AA07
ATC
tetracycline; systemic
2.0
9.1
130
717
D07AC14
ATC
methylprednisolone aceponate; topical
2.9
9.1
54
194
A02BC05
ATC
esomeprazole; systemic
1.6
9.0
322
2364
A02BC02
ATC
pantoprazole; systemic
1.6
8.9
513
4236
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.8
8.8
28
60
M35.1
ICD-10 Finland
Other overlap syndromes
10.2
8.6
16
16
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
8.5
221
1484
N03AX16
ATC
pregabalin; oral
1.7
8.5
189
1213
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
91.0
8.4
9
*
J01MA12
ATC
levofloxacin; systemic
1.9
8.3
141
828
D02AE01
ATC
carbamide; topical
2.5
8.3
63
263
L04AA13
ATC
leflunomide; oral
4.0
8.2
31
79
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.7
8.1
53
203
S18
ICPC
Laceration/cut
1.6
8.1
311
2306
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
17.4
8.1
12
7
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
22.3
8.0
11
5
D10BA01
ATC
isotretinoin; oral
2.8
8.0
51
193
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.6
7.9
57
230
S97
ICPC
Chronic ulcer skin
3.1
7.9
41
136
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
7.8
313
2338
H02AB04
ATC
methylprednisolone; systemic
1.9
7.8
127
737
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
15.2
7.7
12
8
M33.1
ICD-10 Finland
Other dermatomyositis
45.4
7.7
9
*
I78.9
ICD-10 Finland
Disease of capillaries, unspecified
45.4
7.7
9
*
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.5
7.6
57
237
S99
ICPC
Skin disease other
4.7
7.6
24
52
E000006
ATC
NA
2.3
7.5
70
325
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.1
7.5
39
130
A07AA02
ATC
nystatin; oral
2.5
7.5
56
233
J05AB11
ATC
valaciclovir; oral
1.9
7.4
111
625
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
7.3
94
497
L98.64
ICD-10 Finland
Benign lymphocyte infiltration into the skin [Jessner-Kanof]
+∞
7.3
7
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
7.3
72
342
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.3
168
1088
M25.5
ICD-10 Finland
Pain in joint
1.6
7.2
227
1593
B02.9
ICD-10 Finland
Zoster without complication
2.5
7.1
53
219
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
8.0
7.1
15
19
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
12.2
7.1
12
10
A02BC03
ATC
lansoprazole; oral
1.6
7.1
228
1610
EKA10
NOMESCO Finland
Biopsy of cheek
4.8
7.1
22
47
ZX120
NOMESCO Finland
Intravenous
2.1
6.9
77
386
A01AB04
ATC
amphotericin B; local oral
2.6
6.9
49
199
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
4.9
6.9
21
44
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.3
6.9
63
291
S06
ICPC
Rash localized
2.5
6.8
52
219
WZA10
NOMESCO Finland
Long statement of health and health related matters
5.7
6.8
18
32
SBA00
NOMESCO Finland
Microbiological examinations
3.6
6.7
28
79
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
22.7
6.7
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
6.6
155
1006
S01
ICPC
Pain/tenderness of skin
2.8
6.6
40
149
N07BA03
ATC
varenicline; oral
2.7
6.5
42
160
NF1AA
NOMESCO Finland
Hip X-ray examination
2.1
6.5
72
361
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.4
6.5
29
87
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
6.5
74
377
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
4.0
6.4
24
62
M05BA07
ATC
risedronic acid; oral
2.9
6.4
37
132
E000003
ATC
NA
2.6
6.4
43
170
NH3EA
NOMESCO Finland
Feet X-ray examination with load
4.1
6.3
23
58
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
5.6
6.3
17
31
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
6.3
88
482
R06AE09
ATC
levocetirizine; oral
1.8
6.3
119
722
D07CC01
ATC
betamethasone and antibiotics; topical
1.8
6.3
104
605
G73.7*M32.1
ICD-10 Finland
Myopathy in systemic lupus erythematosus
+∞
6.3
6
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
6.3
88
485
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
3.7
6.2
25
69
A01AC01
ATC
triamcinolone; local oral
4.0
6.2
23
59
SPAT1263
SPAT
Sampling
1.5
6.2
316
2459
N03AX12
ATC
gabapentin; oral
1.7
6.2
120
733
XQ845
NOMESCO Finland
Dermatoscopy
5.8
6.2
16
28
J01AA02
ATC
doxycycline; systemic
1.5
6.1
608
5403
L57.0
ICD-10 Finland
Actinic keratosis
2.1
6.1
69
348
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.0
6.1
79
420
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.3
6.1
52
231
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
3.5
6.1
26
76
A02BA02
ATC
ranitidine; systemic
1.6
6.0
155
1029
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.1
6.0
31
104
M13.9
ICD-10 Finland
Arthritis, unspecified
2.2
6.0
55
255
C03CA01
ATC
furosemide; systemic
1.6
6.0
196
1382
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint L12_LUPUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LUPUS | 1.429 [1.27, 1.61] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 3420 females with L12_LUPUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LUPUS | 1.68 [1.43, 1.98] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 1146 males with L12_LUPUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_LUPUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.121% | 0.312% |
| 5 | 0.794% | 1.697% |
| 10 | 2.072% | 4.409% |
| 15 | 3.835% | 8.15% |
| 20 | 6.609% | 13.991% |
Relationships between endpoints
↥Index endpoint: L12_LUPUS – Lupus erythematosus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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