Livedoid vasculitis

L12_LIVEDOIDVASC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L95.0 Cause of death: ICD-10 — L95.0 2 out of 7 registries used, show all original rules.	123
4. Check minimum number of events None	123
5. Include endpoints None	123
6. Filter based on genotype QC (FinnGen only)	123

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L95
Name in latin: Vasculitis lividoides

NAME	L12_LIVEDOIDVASC
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L950
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L950
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Livedoid vasculitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	736	442	289
Only index persons	645	394	251
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	62.30	64.34	59.28
Only index persons	60.70	62.60	57.71

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	123	73	50
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	61.66	62.75	60.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
111: Matched controls
1109

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L95.0

ICD-10 Finland

Livedoid vasculitis

+∞

160.1

111

L95.9

ICD-10 Finland

Vasculitis limited to skin, unspecified

+∞

48.5

L97

ICD-10 Finland

Ulcer of lower limb, not elsewhere classified

628.1

44.5

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

22.5

34.6

L95.8

ICD-10 Finland

Other vasculitis limited to skin

+∞

34.1

S97

ICPC

Chronic ulcer skin

27.3

26.1

L98.4

ICD-10 Finland

Chronic ulcer of skin, not elsewhere classified

302.4

24.7

I83.0

ICD-10 Finland

Varicose veins of lower extremities with ulcer

47.6

19.4

H02AB06

ATC

prednisolone; systemic

7.2

19.3

372

D69.0

ICD-10 Finland

Allergic purpura

212.3

18.1

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

20.8

17.6

L04AX01

ATC

azathioprine; systemic

19.5

17.2

A46

ICD-10 Finland

Erysipelas

7.5

16.0

J01FF01

ATC

clindamycin; systemic

5.4

14.9

186

J01MA02

ATC

ciprofloxacin; systemic

5.0

14.3

289

ZZA00

NOMESCO Finland

Split skin graft

26.4

13.4

QDG20

NOMESCO Finland

Operation for chronic ulcer or fistula of skin of lower limb

145.7

12.7

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

9.6

11.6

SPAT1148

SPAT

Treatment of chronic ulcer or burn

5.4

11.0

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

10.5

10.9

C03CA01

ATC

furosemide; systemic

4.0

10.4

219

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.8

10.0

262

E0000UV

ATC

3.7

9.8

283

QXB99

NOMESCO Finland

Other procedure to treat skin wound, unspecified location

33.2

9.6

I87.2

ICD-10 Finland

Venous insufficiency (chronic)(peripheral)

5.6

9.0

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.4

8.8

371

N02AX02

ATC

tramadol; systemic, rectal

3.4

8.8

325

H02AB07

ATC

prednisone; oral

4.7

8.6

D07AC01

ATC

betamethasone; topical

3.4

8.4

249

D07AD01

ATC

clobetasol; topical

4.4

8.4

J01CF05

ATC

flucloxacillin; systemic

13.1

8.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.6

8.3

L04AD01

ATC

ciclosporin; systemic

24.1

8.2

R60.0

ICD-10 Finland

Localized oedema

5.1

8.0

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.2

8.0

102

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

6.5

7.8

S76

ICPC

Skin infection other

8.7

7.7

XF400

NOMESCO Finland

ECG with 12 standard connections

4.1

7.6

100

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

4.7

7.4

N02AJ06

ATC

codeine and paracetamol; systemic

3.1

7.3

260

PD4BC

NOMESCO Finland

Extensive arterigography of lower extremity with X-ray

32.3

7.3

WX408

NOMESCO Finland

General anesthesy, balanced

3.3

7.2

185

N02AA05

ATC

oxycodone; systemic

4.0

7.0

A41.9

ICD-10 Finland

Sepsis, unspecified

10.3

7.0

A28

ICPC

Limited function/disability NOS

3.8

6.9

103

TPH04

NOMESCO Finland

Cathetrisation of vein

3.5

6.7

129

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

5.3

6.7

I83.1

ICD-10 Finland

Varicose veins of lower extremities with inflammation

12.0

6.4

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

7.0

6.4

J01DA01

ATC

[U] cefalexin; systemic

2.9

6.4

521

J01MA12

ATC

levofloxacin; systemic

3.5

6.3

120

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

4.7

6.3

M30.0

ICD-10 Finland

Polyarteritis nodosa

+∞

6.3

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.6

6.3

TQW80

NOMESCO Finland

Local dermatologic skincare

10.9

6.2

S91.3

ICD-10 Finland

Open wound of other parts of foot

16.1

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(40768443) Skin Pathology biopsy report

14.72

38.11

1.5

1.2

—

(4306422)

28.55

37.77

1.3

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

29.70

36.99

1.2

1.1

—

(4268621)

24.14

29.09

2.8

1.7

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

18.20

28.77

1.4

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

107

7.43

25.72

4.8

1.4

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

14.67

22.70

2.5

2.7

g/l

3.6

4.6

0.87

(3037522) Nuclear Ab [Titer] in Serum

131

5.19

16.66

1.7

1.4

titre

706.7

661.3

0.04

(3017143) Hepatitis C virus Ab [Presence] in Serum

101

4.81

13.15

1.5

1.6

—

(3006315) Basophils [#/volume] in Blood

503

4.48

12.54

11.8

5.8

e9/l

0.1

0.0

0.69

440

(3001604) Monocytes [#/volume] in Blood

502

4.30

12.05

11.9

5.7

e9/l

0.7

0.6

0.78

438

(3019198) Lymphocytes [#/volume] in Blood

513

4.33

11.95

11.9

5.8

e9/l

1.8

0.05

458

(3023368) Bacteria identified in Blood by Culture

298

3.74

11.90

6.7

4.4

—

(3013115) Eosinophils [#/volume] in Blood

525

4.35

11.80

12.0

5.8

e9/l

0.2

0.38

466

(3004588) Protein electrophoresis panel - Serum or Plasma

4.97

11.76

3.0

3.1

—

(42870588) Differential panel, method unspecified - Blood

340

3.57

11.02

11.4

5.4

—

(3042936) Bacteria identified in Isolate by Culture

155

3.86

10.93

3.5

2.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

4.81

10.73

1.4

1.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

5.48

10.23

3.9

3.0

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

148

3.66

9.70

2.6

1.8

32.0

29.7

1.35

143

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

219

3.38

9.66

1.8

1.6

mg/l

1.0

1.4

0.87

177

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

229

3.31

9.40

3.5

2.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

608

3.82

9.07

16.6

9.3

e9/l

5.1

4.4

0.57

534

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

125

3.52

8.29

1.6

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

6.19

8.24

1.2

1.0

—

(3023520) Reticulocytes [#/volume] in Blood

3.99

8.23

2.8

3.5

e9/l

66.4

69.7

0.20

(40758558) Short blood count panel - Blood

260

2.82

7.16

10.0

7.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.84

7.13

1.9

1.4

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

204

2.90

7.02

4.6

3.5

ng/l

98.6

66.2

0.18

165

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

517

2.86

6.99

9.7

7.6

mmol/l

1.2

0.26

435

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

5.20

6.89

1.9

1.6

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

5.20

6.89

2.4

2.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

411

2.72

6.86

2.3

2.0

pmol/l

86.6

95.2

0.98

192

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

7.69

6.80

1.1

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

153

3.03

6.78

1.7

1.8

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

382

2.66

6.60

5.1

3.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.88

6.48

2.9

1.7

—

(3004616) Nuclear Ab [Presence] in Serum

7.17

6.41

1.4

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

180

2.81

6.24

2.8

1.9

—

(3044640) Blood type and Crossmatch panel - Blood

310

2.56

6.07

3.8

2.3

—

(3022217) INR in Platelet poor plasma by Coagulation assay

123

3.03

6.05

27.6

20.3

inr

1.5

1.2

0.63

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.61

6.01

2.5

2.2

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

476

2.56

5.96

9.1

6.8

mmol/l

1.2

0.22

433

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

5.94

5.92

1.7

—

(3019225) pH of Specimen

3.44

5.90

6.7

4.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

233

2.56

5.60

3.2

3.8

—

(3018095) Leukocytes [#/volume] in Urine

379

2.44

5.54

5.5

4.3

e6/l

50.7

65.0

0.22

284

(3037467) Urinalysis macro (dipstick) panel - Urine

691

2.77

5.36

8.1

4.6

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

437

2.40

5.32

2.9

2.3

nmol/l

75.9

77.0

0.09

380

(3015377) Calcium [Moles/volume] in Serum or Plasma

367

2.39

5.32

5.6

3.1

mmol/l

2.4

0.07

314

(3026493) Urate [Moles/volume] in Serum or Plasma

258

2.41

5.06

3.8

2.8

umol/l

352.1

7115.1

1.54

220

(3032080) INR in Blood by Coagulation assay

400

2.33

5.02

14.6

8.3

inr

1.3

1.2

0.37

129

(3048929) Epstein Barr virus Ab [Presence] in Serum

4.94

4.89

1.2

1.5

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

4.48

4.74

1.1

1.3

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

4.73

4.66

2.6

2.4

u/ml

0.3

0.5

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

123

2.65

4.45

3.5

2.7

umol/l

7.1

8.0

0.17

109

(3002582) Erythrocytes [#/volume] in Urine

337

2.21

4.42

4.9

3.5

e6/l

28.3

45.5

0.46

262

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

193

2.31

4.06

3.2

3.0

e6/l

0.9

0.03

110

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

182

2.29

3.85

3.3

3.4

e6/l

2.0

2.4

0.13

100

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

9.19

3.82

1.1

1.3

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

12.51

3.80

1.3

1.2

umol/l

15.2

13.0

—

(3002256) Pathology report gross observation

113

2.52

3.73

1.5

1.2

—

(3015736) pH of Urine

399

2.05

3.72

3.2

3.5

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

2.70

3.41

1.8

2.4

ug/l

6.3

7.1

0.12

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

105

2.46

3.35

6.6

3.2

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

331

1.99

3.34

2.8

3.1

u/l

77.9

29.7

0.53

313

(3035947) Staphylolysin Ab [Units/volume] in Serum

8.93

3.30

1.2

1.3

—

(3018418) pH of Serum or Plasma

350

1.97

3.28

6.0

4.0

7.4

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

6.67

3.23

1.3

1.4

—

(40768804) Tissue Pathology biopsy report

390

1.92

3.12

3.1

2.0

—

(3026008) Bacteria identified in Urine by Culture

341

1.91

2.99

4.4

3.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

187

2.05

2.87

1.3

iu/ml

27.6

28.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.67

2.84

1.4

1.1

—

(3009508) Creatinine [Moles/volume] in Urine

294

1.90

2.83

4.4

3.1

mmol/l

7.1

7.4

0.24

236

(3000991) Gas panel - Venous blood

100

2.33

2.78

6.2

8.0

—

(3021589) Normoblasts [#/volume] in Blood

457

1.83

2.77

16.9

9.5

e9/l

0.0

0.71

366

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

129

2.18

2.75

2.9

1.8

—

(3000494) Fungus identified in Specimen by Culture

122

2.20

2.74

1.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

469

1.82

2.69

5.5

4.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

257

1.89

2.65

1.8

1.6

nmol/l

20.5

21.9

0.18

215

(36304419) Bacteria [Presence] in Urine

309

1.84

2.62

5.0

3.1

—

(3035350) Ketones [Presence] in Urine by Test strip

501

1.80

2.60

3.6

3.8

estimate

0.0

—

101

(1761868) Lipid panel - Serum or Plasma

352

0.46

2.59

2.3

2.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

295

1.83

2.52

5.4

4.0

mg/mmol

7.5

10.8

0.36

183

(3012516) Albumin [Mass/volume] in Urine

278

1.84

2.51

4.3

3.3

mg/l

37.4

297.6

0.59

178

(3026782) Osmolality of Urine

220

1.90

2.50

3.7

2.9

mosm/kgh2o

521.1

523.2

0.02

192

(3037756) Immunofixation for Serum or Plasma

3.51

2.44

1.3

2.0

—

(3030467) Casts [#/volume] in Urine by Automated count

315

1.80

2.43

5.1

3.2

e6/l

0.4

0.07

242

(40759836) Histone Ab [Presence] in Serum by Immunoblot

5.19

2.43

1.2

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

5.19

2.43

1.2

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

5.19

2.43

1.2

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

5.19

2.43

1.2

1.3

—

(3045142) Bone marrow Pathology biopsy report

5.19

2.43

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

5.19

2.43

1.2

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

5.19

2.43

1.2

1.3

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

4.30

2.39

1.3

1.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

130

2.05

2.33

3.0

1.8

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.79

2.30

1.0

—

(3045424) Erythrocytes [Presence] in Urine

4.79

2.30

1.7

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

107

926

2.20

2.29

5.3

4.7

mu/l

2.2

2.0

0.71

833

(3022313) Gas panel - Capillary blood

2.94

2.26

4.9

2.5

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

5.73

2.23

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

5.73

2.23

1.0

1.1

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.49

2.22

1.3

1.2

—

(3007164) IgA [Mass/volume] in Serum or Plasma

196

1.86

2.19

2.2

1.5

g/l

3.5

2.8

0.32

108

(3021601) Nitrite [Presence] in Urine by Test strip

509

1.69

2.16

5.1

5.2

estimate

0.0

—

(3052851) Hemolysis interference index of Serum or Plasma

2.85

2.16

2.8

—

(3012544) pH of Venous blood

112

2.06

2.12

3.2

3.7

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

5.16

2.09

1.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

4.15

2.06

1.2

1.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

665

1.70

2.01

4.4

3.0

u/l

73.0

49.5

0.81

621

(3051611) Lipemic interference index of Serum or Plasma

4.69

1.96

2.8

2.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

764

1.73

1.91

4.4

3.9

pmol/l

14.8

14.9

0.15

683

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.31

1.91

1.1

1.5

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.31

1.91

1.4

1.6

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.31

1.91

1.4

1.6

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

164

1.83

1.88

1.4

1.3

u/ml

40.4

12.4

0.57

(3030981) Hyaline casts [#/volume] in Urine by Automated count

2.40

1.87

2.7

3.5

e6/l

0.2

0.1

0.31

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.65

1.86

1.2

1.0

—

(3009261) Glucose [Presence] in Urine by Test strip

517

1.60

1.77

3.8

estimate

0.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

3.45

1.77

1.0

1.4

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.45

1.77

1.3

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.03

1.75

2.1

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

112

1013

2.18

1.70

36.6

15.0

mg/l

28.0

22.8

1.00

102

795

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.91

1.67

1.4

1.2

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

100

1.94

1.63

6.3

6.9

mmol/l

1.3

1.2

0.26

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.12

1.55

7.2

6.1

mmol/l

24.1

25.1

0.41

(4035726)

1.96

1.54

1.4

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

3.43

1.54

1.8

2.3

63.2

53.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.95

1.52

1.2

1.4

—

(3000492) Spirometry study

1.94

1.50

1.6

1.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

143

1.75

1.49

5.9

6.7

mmol/l

103.4

103.7

0.07

138

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

229

1.60

1.42

1.2

u/ml

1.1

0.9

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.50

1.41

2.7

2.3

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.14

1.37

2.8

2.5

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

3.02

1.37

1.8

1.4

—

(40761535) Cells panel - Urine sediment

1.92

1.31

3.9

4.0

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.47

1.26

1.3

2.0

—

(40768797) Stomach Pathology biopsy report

143

1.66

1.22

1.7

1.2

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

105

956

1.67

1.19

34.5

14.1

ml/min/173m2

78.3

79.3

0.17

773

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

1.17

0.0

4.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.95

1.11

1.5

1.1

—

(3021901) Oxygen saturation in Capillary blood

2.44

1.10

3.2

2.4

—

(3003396) Base excess in Arterial blood by calculation

131

1.63

1.08

9.2

11.1

mmol/l

0.3

1.3

0.47

108

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

335

1.44

1.06

3.5

3.4

ng/l

1368.8

1210.1

0.19

287

(1002224) Polysomnography panel

2.12

1.04

1.0

1.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.98

0.0

1.6

—

(3000764) Benzodiazepines [Presence] in Urine

2.20

0.93

2.8

1.3

—

(36660697) Celiac disease serology panel - Serum

1.72

0.92

1.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.12

0.90

1.3

—

(3045414) Leukocytes [Presence] in Urine

1.97

0.90

1.8

1.9

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.97

0.90

1.3

1.4

—

(3027008) Opiates [Presence] in Urine

2.05

0.88

2.8

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.05

0.88

2.8

1.3

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.76

0.85

14.5

15.9

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

107

1003

1.51

0.77

5.9

4.5

mmol/l

6.6

6.0

0.61

915

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.22

0.77

1.4

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.69

0.75

1.9

4.0

mmol/l

24.8

24.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.65

0.74

1.9

2.8

1.5

1.2

—

(3024928) Oxygen saturation in Venous blood

2.04

0.73

1.8

3.3

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

1.96

0.71

1.0

2.1

—

4.4

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.70

0.71

2.0

3.3

pmol/l

3.8

4.3

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

100

931

1.40

0.70

7.8

5.8

mmol/mol

42.3

40.1

1.17

861

(3003694) ABO and Rh group [Type] in Blood

275

0.71

0.67

1.4

—

(3009542) Hematocrit [Volume Fraction] of Blood

913

1.36

0.65

32.7

16.5

38.5

39.8

0.85

652

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.75

0.64

1.6

1.4

—

(3016879) Cocaine [Presence] in Urine

1.75

0.64

3.2

1.3

—

(3027944) Amphetamines [Presence] in Urine

1.75

0.64

3.0

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

267

1.32

0.63

4.4

4.0

estimate

0.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.61

0.0

3.0

—

3.9

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.61

0.0

3.0

—

107.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.61

0.60

1.5

1.4

—

(3013512) EKG study

290

1.29

0.56

4.9

4.0

—

(3020891) Body temperature

1.65

0.56

1.2

3.8

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

108

1029

1.41

0.54

5.1

5.0

mmol/l

2.5

2.7

1.80

100

938

(3049717) Cytology report of Urine Cyto stain

1.53

0.52

2.7

3.2

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

220

1.29

0.49

3.2

4.2

20.8

21.6

0.09

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.60

0.47

3.8

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

282

0.77

0.47

3.6

3.4

—

(4094501)

1.64

0.43

1.0

1.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

243

1.25

0.43

9.4

4.7

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.5

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.5

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.5

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.41

0.0

1.5

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.5

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.6

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

1.49

0.41

1.2

1.1

—

(3017181) Myelocytes/100 leukocytes in Blood

1.39

0.39

7.4

3.8

0.4

0.5

—

(3022145) Colonoscopy Study observation

125

1.32

0.39

1.4

1.2

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.39

0.0

3.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.39

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.5

—

(3008898) HLA-B27 [Presence]

1.49

0.36

1.3

1.1

—

(3019060) Gas panel - Arterial blood

1.40

0.36

7.8

10.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

110

1.31

0.33

6.1

4.9

34.8

31.9

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

1.36

0.33

2.9

3.3

ml/min/173m2

90.4

59.8

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.29

0.33

11.5

15.3

1.4

1.0

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.34

0.31

1.6

1.3

u/ml

135.4

194.5

—

(4010399)

1.36

0.31

1.5

1.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

121

1.27

0.30

5.1

4.2

ug/l

2.5

46.7

—

100

(3022621) pH of Urine by Test strip

0.68

0.27

2.0

2.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.66

0.27

3.8

1.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.70

0.25

1.5

1.3

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.37

0.24

1.2

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.37

0.24

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

101

0.78

0.22

1.4

1.7

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

2.2

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.21

0.0

1.8

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.20

0.0

1.7

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.26

0.19

8.0

3.9

0.0

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

402

1.11

0.17

4.9

4.1

ng/l

31.8

53.3

0.75

289

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.81

0.15

9.7

4.0

mmol/l

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

112

1.18

0.15

6.2

8.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

161

1.14

0.14

2.2

2.7

ug/l

0.6

0.7

0.50

(40761511) CBC panel - Blood by Automated count

104

1059

0.88

0.13

19.8

13.6

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.07

0.09

12.8

15.1

1.9

1.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.12

0.09

1.3

1.0

—

(40761536) Microorganisms panel - Urine sediment

0.86

0.07

6.4

3.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

388

1.05

0.04

3.9

3.8

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

971

1.00

0.00

4.2

4.0

mmol/l

1.3

0.01

884

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

617

1.01

0.00

2.9

—

(3044889) 12 lead EKG panel

735

1.02

0.00

4.2

3.9

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

155

0.96

0.00

1.3

1.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

165

1.04

0.00

2.0

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

101

1006

1.02

0.00

4.8

4.5

mmol/l

4.3

4.6

2.61

924

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

100

999

1.01

0.00

4.7

4.4

mmol/l

1.4

1.5

3.00

910

(4024509)

0.00

0.0

1.4

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

3.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.3

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.3

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.97

0.00

11.6

13.1

mmol/l

22.8

24.8

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

9.5

—

(3035880) pH of Pleural fluid

0.00

0.0

1.0

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.98

0.00

2.8

1.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.9

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.84

0.00

1.4

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.89

0.00

1.0

1.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.0

—

10.6

—

(3009550) Parvovirus B19 IgG Ab [Titer] in Serum

0.00

0.0

1.4

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

0.0

1.2

—

155.4

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(4211845)

0.00

0.0

1.6

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

35.3

—

(3037556) Urate [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.88

0.00

1.1

1.6

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

14.2

—

(3022192) Triglyceride [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

16.5

—

689.5

—

(44806420)

0.00

-0.00

0.0

1.8

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

22.5

—

921.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

-0.00

0.0

4.2

—

60.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LIVEDOIDVASC and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_LIVEDOIDVASC	2.31 [1.71, 3.12]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.057

During the follow-up period (1.1.1998 — 31.12.2019), 135 out of 387 females with L12_LIVEDOIDVASC died.

Males

Parameter	HR [95% CI]	p-value
L12_LIVEDOIDVASC	2.531 [1.81, 3.53]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.037

During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 258 males with L12_LIVEDOIDVASC died.

Mortality risk

Mortality risk for people of age

years, who have L12_LIVEDOIDVASC.

N-year risk	Females	Males
1	0.23%	0.457%
5	1.255%	2.884%
10	3.34%	7.557%
15	5.871%	13.411%
20	10.136%	22.15%

Relationships between endpoints

↥

Index endpoint: L12_LIVEDOIDVASC – Livedoid vasculitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Livedoid vasculitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints