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Lichen simplex chronicus

DOID EFO Endpoint Browser PheWeb

L12_LICHENSIMPLEX

lichen disease: a long-term skin condition that mainly affects the skin of the genitals. It usually causes itching and white patches to appear on the affected skin.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L28.0
  • Hospital discharge: ICD-9 — 6983B|697X
  • Hospital discharge: ICD-8 — 6983
  • Cause of death: ICD-10 — L28.0
  • Cause of death: ICD-9 — 6983B|697X
  • Cause of death: ICD-8 — 6983

2 out of 7 registries used, show all original rules.

1285

4. Check minimum number of events

None

1285

5. Include endpoints

None

1285

6. Filter based on genotype QC (FinnGen only)

1285

Control definitions (FinnGen only)

Control exclude
L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L28
Name in latin
Lichen simplex chronicus

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8813 4491 4275
Only index persons 7913 4095 3818
Unadjusted period prevalence (%)
Whole population 0.12 0.13 0.12
Only index persons 0.15 0.15 0.15
Median age at first event (years)
Whole population 53.53 54.18 52.91
Only index persons 52.84 53.38 52.26

-FinnGen-

Key figures

All Female Male
Number of individuals 1285 702 583
Unadjusted period prevalence (%) 0.25 0.24 0.26
Median age at first event (years) 53.59 52.63 54.75

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1139
Matched controls
11390
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L28.0
ICD-10 Finland
Lichen simplex chronicus
13835.0
323.0
1063
13
D07AD01
ATC
clobetasol; topical
15.6
316.8
601
760
D07AC01
ATC
betamethasone; topical
9.6
262.4
784
2128
L30.9
ICD-10 Finland
Dermatitis, unspecified
12.4
221.8
449
569
D07AC13
ATC
mometasone; topical
7.8
212.2
668
1758
D09AB01
ATC
zinc bandage without supplements; topical
64.1
181.6
210
40
E0000UV
ATC
NA
6.0
170.3
709
2454
L20.0
ICD-10 Finland
Besnier prurigo
+∞
142.8
134
*
E000001
ATC
NA
5.8
119.9
404
979
D07BC01
ATC
betamethasone and antiseptics; topical
7.0
119.7
335
637
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.6
107.0
252
363
D07AB02
ATC
hydrocortisone butyrate; topical
4.3
100.1
481
1643
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
6.2
97.6
298
617
L28.1
ICD-10 Finland
Prurigo nodularis
323.5
89.1
89
*
XQ802
NOMESCO Finland
Epicutan test
36.0
85.9
111
34
TQW80
NOMESCO Finland
Local dermatologic skincare
24.7
81.2
116
52
L30.3
ICD-10 Finland
Infective dermatitis
32.7
80.9
107
36
D07CC01
ATC
betamethasone and antibiotics; topical
5.1
78.9
281
681
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
76.9
73
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
7.3
70.4
181
287
E000002
ATC
NA
5.3
62.3
208
458
D07AB08
ATC
desonide; topical
5.2
58.6
198
440
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
52.5
50
*
69830
ICD-8 Finland
Pruritus and related conditions, Lichenification and lichen simplex chronicus
+∞
51.4
49
*
D02AE01
ATC
carbamide; topical
6.3
50.1
141
249
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
42.9
49.3
61
15
A46
ICD-10 Finland
Erysipelas
3.7
49.0
245
785
L30.0
ICD-10 Finland
Nummular dermatitis
12.2
44.3
82
72
D07XC01
ATC
betamethasone, combinations; topical
3.8
43.8
206
622
R06AE07
ATC
cetirizine; oral
2.4
41.9
558
3263
N05BB01
ATC
hydroxyzine; systemic
6.0
41.5
121
222
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.3
41.5
167
437
6983B
ICD-9 Finland
Pruritus and related conditions, Lichenification and lichen simplex chronicus[NEURODERMATITIS CIRCUMSCRIPTA]
+∞
39.8
38
*
L28.2
ICD-10 Finland
Other prurigo
+∞
36.7
35
*
E000003
ATC
NA
7.2
36.6
92
138
H02AB06
ATC
prednisolone; systemic
2.2
35.3
575
3599
E000006
ATC
NA
4.8
34.9
124
285
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
34.5
33
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
33.6
317
1509
L20
ICD-10 Finland
Atopic dermatitis
+∞
33.5
32
*
D07AC14
ATC
methylprednisolone aceponate; topical
6.2
32.2
90
156
E000007
ATC
NA
5.9
31.9
92
166
L30.8
ICD-10 Finland
Other specified dermatitis
17.6
31.2
49
29
XQ800
NOMESCO Finland
Prick test
4.6
31.1
113
265
J01DB01
ATC
cefalexin; oral
2.4
30.7
953
7715
L28
ICD-10 Finland
Lichen simplex chronicus and prurigo
25.0
29.3
41
17
D07AA02
ATC
hydrocortisone; topical
3.1
29.1
176
631
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.9
28.5
193
746
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
9.4
28.2
59
66
D02AX
ATC
Other emollients and protectives
8.3
27.7
62
78
R06AX27
ATC
desloratadine; oral
2.3
27.3
323
1697
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
27.2
26
*
L29.9
ICD-10 Finland
Pruritus, unspecified
12.1
26.9
49
42
L43.9
ICD-10 Finland
Lichen planus, unspecified
9.1
26.5
56
64
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.2
26.4
85
175
J01DA01
ATC
[U] cefalexin; systemic
2.0
25.6
735
5479
XQ848
NOMESCO Finland
Dermatological photography
8.1
25.5
58
75
D11AH01
ATC
tacrolimus; topical
+∞
21.9
21
*
L43.8
ICD-10 Finland
Other lichen planus
8.4
21.8
48
59
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
224.0
21.7
22
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
20.2
331
1955
D05AX52
ATC
calcipotriol, combinations; topical
3.7
20.0
90
257
J01FF01
ATC
clindamycin; systemic
2.0
19.0
319
1893
D07XB05
ATC
dexamethasone, combinations; topical
6.0
18.5
51
88
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
18.4
173
798
D05BB02
ATC
acitretin; oral
6.5
18.4
48
77
C03CA01
ATC
furosemide; systemic
1.9
18.3
303
1785
R06AE09
ATC
levocetirizine; oral
2.3
18.2
179
844
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
18.0
451
3059
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
17.9
478
3305
L29.8
ICD-10 Finland
Other pruritus
15.3
16.7
27
18
S29
ICPC
Skin symptom/complaint other
2.2
16.3
190
963
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
16.2
384
2541
N02BE01
ATC
paracetamol; systemic, rectal
1.9
16.1
952
8267
L43.0
ICD-10 Finland
Hypertrophic lichen planus
18.8
16.0
24
13
H02AB04
ATC
methylprednisolone; systemic
2.2
15.8
172
845
SPAT1263
SPAT
Sampling
1.7
15.6
462
3258
N02AX02
ATC
tramadol; systemic, rectal
1.7
15.1
462
3279
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
14.2
15.1
25
18
UJF32
NOMESCO Finland
Coloscopy
1.8
14.9
289
1779
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
57.4
14.8
17
*
WQ020
NOMESCO Finland
NA
151.8
14.5
15
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
14.4
196
1060
S87
ICPC
Dermatitis/atopic eczema
7.4
14.1
33
46
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
5.2
14.1
43
85
D07CB01
ATC
triamcinolone and antibiotics; topical
5.8
14.0
39
69
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
13.8
237
1397
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
13.7
155
774
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
13.6
194
1066
R03AC02
ATC
salbutamol; inhalant
1.6
13.3
557
4254
R06.0
ICD-10 Finland
Dyspnoea
1.8
13.2
261
1610
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
12.9
152
771
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.4
12.9
117
525
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
12.9
135
653
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
12.7
200
1139
B35.3
ICD-10 Finland
Tinea pedis
3.7
12.7
56
159
WQ021
NOMESCO Finland
NA
70.6
12.6
14
*
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
32.4
12.6
16
5
L50.3
ICD-10 Finland
Dermatographic urticaria
8.8
12.5
26
30
D11AX14
ATC
[U] tacrolimus; topical
+∞
12.5
12
*
S02
ICPC
Pruritus
4.2
12.5
47
116
S18
ICPC
Laceration/cut
1.6
12.2
442
3228
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
2.2
12.1
127
614
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
12.1
504
3813
L17
ICPC
Foot/toe symptom/complaint
1.8
12.0
257
1620
J01MA02
ATC
ciprofloxacin; systemic
1.6
12.0
407
2924
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.4
11.9
58
179
S97
ICPC
Chronic ulcer skin
3.0
11.8
67
229
L13.0
ICD-10 Finland
Dermatitis herpetiformis
30.4
11.7
15
5
J02AC01
ATC
fluconazole; systemic
1.6
11.6
412
2987
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
11.5
113
527
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
11.1
127
639
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
11.0
122
604
M79.6
ICD-10 Finland
Pain in limb
1.6
10.9
368
2622
A02BC03
ATC
lansoprazole; oral
1.6
10.9
317
2175
L04AD01
ATC
ciclosporin; systemic
5.0
10.9
34
70
D01AE15
ATC
terbinafine; topical
2.4
10.9
91
393
R06AX13
ATC
loratadine; oral
1.9
10.8
163
911
A02BC02
ATC
pantoprazole; systemic
1.5
10.7
684
5651
WX110
NOMESCO Finland
Local anesthesy
1.5
10.7
732
6146
E66.8
ICD-10 Finland
Other obesity
2.8
10.6
66
242
H02AB07
ATC
prednisone; oral
2.0
10.5
150
819
E66.01
ICD-10 Finland
Obesity due to excess calories
2.3
10.5
94
420
S21
ICPC
Skin texture symptom/complaint
2.0
10.5
131
682
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
111.0
10.4
11
*
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
+∞
10.4
10
*
P01AB01
ATC
metronidazole; oral, rectal
1.5
10.4
412
3049
R50.9
ICD-10 Finland
Fever, unspecified
1.9
10.1
144
788
SAA02
NOMESCO Finland
Basic examination of mouth
1.5
10.1
670
5543
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
40.4
10.0
12
*
A10AE04
ATC
insulin glargine; parenteral
2.2
10.0
106
516
AA1AD
NOMESCO Finland
CT of head and brain
1.7
9.9
245
1602
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
16.9
9.9
15
9
J01AA02
ATC
doxycycline; systemic
1.6
9.8
839
7324
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.3
9.7
87
390
Z01.2
ICD-10 Finland
Dental examination
1.5
9.7
417
3131
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
4.5
9.7
33
75
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
6.9
9.6
23
34
J01CE08
ATC
benzathine benzylpenicillin; parenteral
6.9
9.6
23
34
SPAT1260
SPAT
Consultation of another employee
1.8
9.6
181
1089
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
9.6
138
759
R02
ICPC
Shortness of breath/dyspnoea
2.0
9.6
130
698
L29.2
ICD-10 Finland
Pruritus vulvae
8.5
9.6
20
24
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.3
9.6
88
399
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
9.5
297
2065
SPAT1153
SPAT
Removal of sutures
1.6
9.5
323
2292
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
9.5
279
1910
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
9.4
121
636
L24.9
ICD-10 Finland
Irritant contact dermatitis, unspecified cause
100.8
9.4
10
*
D11AH02
ATC
pimecrolimus; topical
+∞
9.4
9
*
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
9.2
389
2901
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.4
9.2
80
352
K13.29
ICD-10 Finland
Indefinite leukoplakia
6.3
9.1
23
37
N06AA09
ATC
amitriptyline; systemic
2.1
9.0
108
553
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.6
9.0
286
1991
S76
ICPC
Skin infection other
2.6
8.9
62
244
N03AX16
ATC
pregabalin; oral
1.6
8.9
241
1609
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.1
8.9
33
82
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
8.9
306
2172
H03AA01
ATC
levothyroxine sodium; systemic
1.6
8.9
228
1502
M79.7
ICD-10 Finland
Fibromyalgia
3.2
8.8
44
140
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
8.8
389
2923
Z49.1
ICD-10 Finland
Extracorporeal dialysis
5.4
8.8
25
47
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
8.8
88
417
J01CF05
ATC
flucloxacillin; systemic
3.0
8.8
50
173
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
8.7
234
1559
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
8.7
255
1738
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
8.7
42
130
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
50.4
8.7
10
*
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
50.4
8.7
10
*
R03BA05
ATC
fluticasone; inhalant
1.7
8.7
181
1124
D07AB01
ATC
clobetasone; topical
3.7
8.6
36
100
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
3.3
8.5
41
127
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.3
8.5
81
374
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
8.4
179
1116
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
3.5
8.4
38
112
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.7
8.4
55
210
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
8.3
124
690
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
10.8
8.3
15
14
WZA90
NOMESCO Finland
Other doctors statement
1.6
8.3
235
1588
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
8.3
145
854
K02.1
ICD-10 Finland
Caries of dentine
1.4
8.2
584
4814
5613
FHL
Conjunctival occlusion
14.6
8.2
13
9
G47.3
ICD-10 Finland
Sleep apnoea
1.6
8.2
231
1558
L40.9
ICD-10 Finland
Psoriasis, unspecified
5.4
8.2
23
43
E000004
ATC
NA
4.4
8.2
28
65
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
5.7
8.2
22
39
SPAT1301
SPAT
No procedures
1.5
8.1
305
2203
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
8.1
90
446
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
8.0
308
2237
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
7.9
730
6298
J45.1
ICD-10 Finland
Nonallergic asthma
2.3
7.9
72
324
D07AC03
ATC
desoximetasone; topical
5.0
7.9
24
49
N06AB03
ATC
fluoxetine; oral
1.8
7.8
131
758
S08
ICPC
Skin colour change
2.6
7.8
54
212
J01MA12
ATC
levofloxacin; systemic
1.7
7.7
180
1149
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
7.7
102
540
R06AX22
ATC
ebastine; oral
1.7
7.7
168
1055
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
4.3
7.7
27
64
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
3.5
7.7
34
99
R60.0
ICD-10 Finland
Localized oedema
1.9
7.7
110
603
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.9
7.7
30
79
SPAT1262
SPAT
Handing over of treatment supplies
1.7
7.7
184
1187
D05AX02
ATC
calcipotriol; topical
2.9
7.6
45
161
R53
ICD-10 Finland
Malaise and fatigue
1.6
7.6
192
1260
PHD99
NOMESCO Finland
Resection of other vein
2.2
7.5
75
355
R03DC03
ATC
montelukast; oral
1.7
7.5
153
945
EBA00
NOMESCO Finland
Extraction of tooth
1.5
7.4
330
2464
L26
ICD-10 Finland
Exfoliative dermatitis
80.6
7.4
8
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.1
7.4
27
67
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
5.6
7.4
20
36
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.9
7.4
100
539
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
4.8
7.3
23
49
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
7.3
264
1883
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
7.3
281
2034
KMAK
NOMESCO Finland
NA
1.4
7.3
531
4359
B05DA
ATC
Isotonic solutions
10.9
7.3
13
12
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
+∞
7.3
7
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.3
420
3302
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
7.3
287
2087
L04AX01
ATC
azathioprine; systemic
2.7
7.3
47
178
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
7.3
76
369
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
7.3
327
2447
A10AE05
ATC
insulin detemir; parenteral
2.3
7.3
65
291
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
7.2
98
525
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
7.4
7.2
16
22
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
7.2
211
1435
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.1
7.1
81
405
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.3
7.1
34
106
K59.09
ICD-10 Finland
Constipation, unspecified
2.3
7.1
60
264
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
7.1
118
682
137
Kela drug reimbursment
Uraemia requiring dialysis
8.0
7.1
15
19
EKA10
NOMESCO Finland
Biopsy of cheek
3.6
7.1
30
85
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
7.1
160
1014
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.0
7.1
87
450
M25.5
ICD-10 Finland
Pain in joint
1.5
7.1
273
1978
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.1
126
745
D07XB01
ATC
flumetasone, combinations; topical
8.8
7.1
14
16
H57.1
ICD-10 Finland
Ocular pain
3.2
7.1
34
107
S06
ICPC
Rash localized
2.4
7.0
58
250
A11CC03
ATC
alfacalcidol; systemic
3.6
7.0
30
86
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
6.9
269
1949
L43
ICD-10 Finland
Lichen planus
5.5
6.9
19
35
SPAT1097
SPAT
Recording of ECG
1.7
6.9
146
911
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.3
6.9
61
276
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.8
210
1444
L98.1
ICD-10 Finland
Factitial dermatitis
40.3
6.8
8
*
S01
ICPC
Pain/tenderness of skin
2.7
6.7
43
161
SPAT1216
SPAT
Assessment of functional ability
1.7
6.7
138
853
L73.8
ICD-10 Finland
Other specified follicular disorders
7.2
6.7
15
21
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
6.7
421
3350
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.7
6.7
131
798
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
6.6
251
1803
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
5.9
6.6
17
29
PH2DE
NOMESCO Finland
Ultrasound examination of bloodflow in veins of lower extremity with Doppler method
3.1
6.6
33
107
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.3
6.6
31
96
L04AA01
ATC
[U] ciclosporin; systemic
4.6
6.6
21
46
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.7
6.6
27
75
N03AX12
ATC
gabapentin; oral
1.6
6.6
155
995
J04BA02
ATC
dapsone; oral
10.1
6.5
12
12
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.1
6.5
68
330
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.0
6.5
34
114
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
6.5
81
423
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
5.7
6.5
17
30
N06AX21
ATC
duloxetine; oral
1.8
6.5
112
655
M54.5
ICD-10 Finland
Low back pain
1.4
6.4
313
2369
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.0
6.4
34
115
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.8
6.4
39
144
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
3.6
6.4
27
77
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.1
6.4
72
362
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
6.4
171
1137
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.4
6.3
51
218
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.6
6.3
42
163
R03BB04
ATC
tiotropium bromide; inhalant
1.9
6.3
93
514
L03
ICPC
Low back symptom/complaint
1.5
6.3
230
1638
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
6.3
154
998
TK800
NOMESCO Finland
Hemodialysis
3.3
6.3
29
89
N18.8
ICD-10 Finland
Other chronic renal failure
3.2
6.3
31
100
L24.0
ICD-10 Finland
Irritant contact dermatitis due to detergents
+∞
6.3
6
*
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
+∞
6.3
6
*
N06AB04
ATC
citalopram; systemic
1.5
6.2
212
1490
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.6
6.2
44
176
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.4
6.2
50
213
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
6.2
579
4907
H02AB09
ATC
hydrocortisone; systemic
3.4
6.1
27
80
SPAT1254
SPAT
Administration of medicine
1.7
6.1
129
800
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.1
209
1466
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
6.1
533
4465
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.2
6.0
55
252
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.5
6.0
43
174

Mortality – FinRegistry

↥

Association

Association between endpoint L12_LICHENSIMPLEX and mortality.

Females

Parameter HR [95% CI] p-value
L12_LICHENSIMPLEX 1.208 [1.06, 1.38] 0.004
Birth year 0.991 [0.98, 1.0] 0.044

During the follow-up period (1.1.1998 — 31.12.2019), 467 out of 3488 females with L12_LICHENSIMPLEX died.

Males

Parameter HR [95% CI] p-value
L12_LICHENSIMPLEX 1.41 [1.25, 1.59] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 651 out of 3285 males with L12_LICHENSIMPLEX died.

Mortality risk

Mortality risk for people of age

years, who have L12_LICHENSIMPLEX.

N-year risk Females Males
1 0.065% 0.25%
5 0.621% 1.792%
10 1.481% 4.38%
15 2.961% 8.242%
20 5.346% 13.364%

Relationships between endpoints

↥

Index endpoint: L12_LICHENSIMPLEX – Lichen simplex chronicus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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