No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3888 |
4. Check minimum number of eventsNone |
3888 |
5. Include endpointsNone |
3888 |
6. Filter based on genotype QC (FinnGen only) |
3888 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L90
- Name in latin
- Lichen sclerosus et atrophicus
Similar endpoints
↥List of similar endpoints to
Lichen sclerosus et atrophicus
based on the number of shared cases.
Similar with more cases:
- Atrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 21817 | 18224 | 3552 |
| Only index persons | 21007 | 17541 | 3466 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.52 | 0.10 |
| Only index persons | 0.56 | 0.64 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 60.38 | 64.39 | 39.87 |
| Only index persons | 60.31 | 64.36 | 39.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3888 | 3385 | 503 |
| Unadjusted period prevalence (%) | 1.03 | 1.15 | 0.22 |
| Median age at first event (years) | 62.64 | 64.07 | 53.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3361
- Matched controls
- 33608
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
62.9
323.0
1208
297
ULA02
NOMESCO Finland
Kolposcopy
12.0
323.0
1347
1770
D07AD01
ATC
clobetasol; topical
21.7
323.0
2324
3147
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
16384.0
323.0
3335
134
D07AC01
ATC
betamethasone; topical
3.3
223.7
1676
7740
E0000UV
ATC
NA
2.8
173.8
1764
9440
D07AB02
ATC
hydrocortisone butyrate; topical
3.0
170.2
1376
6339
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.8
162.2
821
2657
N90.4
ICD-10 Finland
Leukoplakia of vulva
39.3
135.1
172
46
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.4
112.7
1321
7096
KGH10
NOMESCO Finland
Operation for phimosis
17.7
106.3
170
101
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
103.4
1032
5040
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
13.0
90.5
164
132
L29.2
ICD-10 Finland
Pruritus vulvae
9.3
82.7
178
201
J02AC01
ATC
fluconazole; systemic
2.0
74.9
1700
11529
D07AC13
ATC
mometasone; topical
2.1
73.4
1117
6450
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.2
70.0
403
1364
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.9
68.4
2245
17166
E000006
ATC
NA
3.2
67.3
396
1360
LEB00
NOMESCO Finland
Biopsy of vagina
6.5
64.9
176
283
N76.3
ICD-10 Finland
Subacute and chronic vulvitis
11.2
61.5
119
110
N76.6
ICD-10 Finland
Ulceration of vulva
12.8
59.2
107
86
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
196.6
56.2
58
*
N48.1
ICD-10 Finland
Balanoposthitis
12.5
54.8
100
82
LFC00
NOMESCO Finland
Partial excision of vulva
27.6
53.1
73
27
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
11.0
53.1
103
96
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.5
52.6
480
2137
L43.9
ICD-10 Finland
Lichen planus, unspecified
6.0
52.4
150
259
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
10.6
51.0
101
98
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
13.4
50.9
90
69
N90.0
ICD-10 Finland
Mild vulvar dysplasia
19.9
48.8
74
38
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.1
47.9
652
3488
E000001
ATC
NA
2.0
47.7
746
4221
L43.8
ICD-10 Finland
Other lichen planus
5.7
46.9
139
251
D07AB01
ATC
clobetasone; topical
3.8
43.8
193
524
X16
ICPC
Vulval symptom/complaint
6.9
42.5
109
163
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
26.1
38.9
54
21
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
38.3
500
2608
L90.9
ICD-10 Finland
Atrophic disorder of skin, unspecified
+∞
35.5
34
*
7010B
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Circumscribed scleroderma[LICHEN SCLEROSUS ET ATROPHICUS]
+∞
33.4
32
*
D05BB02
ATC
acitretin; oral
4.5
31.7
116
266
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.1
31.6
409
2111
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
27.6
30.2
41
15
UJF32
NOMESCO Finland
Coloscopy
1.6
28.0
865
5925
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
33.1
27.8
36
11
D07BC01
ATC
betamethasone and antiseptics; topical
2.0
27.7
399
2144
LCA06
NOMESCO Finland
Biopsy of endometrium
1.8
26.8
520
3104
UKC02
NOMESCO Finland
Cystoscopy
1.9
25.9
410
2278
G04BD12
ATC
mirabegron; oral
1.9
25.0
382
2094
G01AA10
ATC
clindamycin; vaginal
1.7
24.6
598
3815
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
13.7
24.5
42
31
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
28.4
23.1
31
11
N77.8*L43.9
ICD-10 Finland
Vulvovaginal ulceration and inflammation caused by lichen ruber planus
17.3
23.1
36
21
KGB00
NOMESCO Finland
Biopsy of penis
84.0
22.7
25
*
D07AB08
ATC
desonide; topical
1.9
22.4
331
1791
J01DB01
ATC
cefalexin; oral
1.5
22.2
2614
23467
LDA20
NOMESCO Finland
Biopsy of vaginal cervix
2.3
22.0
221
1019
N39.3
ICD-10 Finland
Stress incontinence
1.9
22.0
336
1843
N48.0
ICD-10 Finland
Leukoplakia of penis
110.7
20.6
22
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
20.2
904
6663
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
4.1
20.1
80
201
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
16.1
20.1
32
20
G03CA04
ATC
estriol; systemic, vaginal
1.8
20.1
365
2123
N48.6
ICD-10 Finland
Induratio penis plastica
27.2
20.0
27
10
L43
ICD-10 Finland
Lichen planus
4.8
19.7
66
140
D07AA02
ATC
hydrocortisone; topical
1.7
19.6
416
2540
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
19.4
2184
19100
J01EA01
ATC
trimethoprim; systemic
1.5
19.3
942
7059
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
18.9
848
6240
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
7.2
18.7
45
63
L80
ICD-10 Finland
Vitiligo
18.1
17.8
27
15
H03AA01
ATC
levothyroxine sodium; systemic
1.4
17.5
888
6684
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
17.4
1233
9868
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
17.3
956
7309
LFA00
NOMESCO Finland
Incision of vulva or perineum
12.0
17.3
31
26
X15
ICPC
Vaginal symptom/complaint other
2.7
17.0
121
466
T90
ICPC
Diabetes non-insulin dependent
1.5
16.8
646
4581
N76.2
ICD-10 Finland
Acute vulvitis
7.2
16.7
40
56
A02BC03
ATC
lansoprazole; oral
1.4
16.7
940
7203
A63.0
ICD-10 Finland
Anogenital (venereal) warts
2.7
16.6
114
428
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
16.5
1089
8585
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
170.8
16.5
17
*
N94.1
ICD-10 Finland
Dyspareunia
4.8
16.5
54
113
8077/2-C51.9
ICD-O-3
Squamous intraepithelial neoplasia, high grade of vulva, NOS
20.1
16.4
24
12
L90
ICD-10 Finland
Atrophic disorders of skin
40.3
16.3
20
5
A02BC02
ATC
pantoprazole; systemic
1.4
16.2
2082
18301
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
16.1
669
4816
M79.6
ICD-10 Finland
Pain in limb
1.4
16.1
1135
9040
Z01.2
ICD-10 Finland
Dental examination
1.4
16.1
1247
10094
XKD00
NOMESCO Finland
Uroflowmetry
1.9
16.1
235
1267
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
21.0
16.0
23
11
R05
ICD-10 Finland
Cough
1.5
15.9
613
4341
XQ848
NOMESCO Finland
Dermatological photography
3.1
15.8
86
280
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
15.8
361
2246
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
13.0
15.6
27
21
N81.6
ICD-10 Finland
Rectocele
1.8
15.4
300
1779
R06AX27
ATC
desloratadine; oral
1.4
15.4
820
6203
L93.0
ICD-10 Finland
Discoid lupus erythematosus
38.2
15.4
19
5
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
15.4
653
4723
J02AC02
ATC
itraconazole; systemic
1.5
15.2
597
4243
N35.9
ICD-10 Finland
Urethral stricture, unspecified
7.3
15.2
36
50
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.8
15.1
287
1687
WX110
NOMESCO Finland
Local anesthesy
1.3
15.1
2098
18561
N02BE01
ATC
paracetamol; systemic, rectal
1.5
15.0
2820
26254
SPAT1310
SPAT
Counselling related to known health issue
1.4
14.8
978
7675
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.6
14.8
460
3097
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
14.8
1948
17058
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
14.8
927
7213
N95.0
ICD-10 Finland
Postmenopausal bleeding
1.6
14.7
377
2419
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.9
14.6
209
1116
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
14.4
458
3104
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
14.3
1657
14206
C05AA08
ATC
fluocortolone; rectal, topical
1.6
14.0
441
2978
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
2.5
13.9
112
463
D07CC01
ATC
betamethasone and antibiotics; topical
1.6
13.9
375
2439
R87.6
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal cytological findings
1.7
13.9
301
1845
TQW80
NOMESCO Finland
Local dermatologic skincare
3.0
13.8
79
265
R06AE07
ATC
cetirizine; oral
1.3
13.8
1377
11516
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
3.3
13.8
69
213
M54.5
ICD-10 Finland
Low back pain
1.4
13.6
1002
7989
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.7
13.6
45
96
G47.3
ICD-10 Finland
Sleep apnoea
1.5
13.6
524
3703
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
13.5
806
6204
N48.5
ICD-10 Finland
Ulcer of penis
140.5
13.5
14
*
D02AX
ATC
Other emollients and protectives
2.5
13.4
103
418
WX320
NOMESCO Finland
Spinalanesthesy
1.4
13.3
670
4996
L29.0
ICD-10 Finland
Pruritus ani
5.4
13.3
39
73
L08
ICPC
Shoulder symptom/complaint
1.4
13.1
589
4296
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
13.1
689
5177
TKD00
NOMESCO Finland
Dilatation of urethra
4.3
13.0
47
110
D02AE01
ATC
carbamide; topical
1.9
13.0
202
1115
WX240
NOMESCO Finland
Penis blockade
28.5
12.9
17
6
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
28.5
12.9
17
6
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.6
12.9
352
2297
L43.0
ICD-10 Finland
Hypertrophic lichen planus
5.2
12.8
39
76
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
12.8
805
6238
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
12.8
2874
27021
N90.5
ICD-10 Finland
Atrophy of vulva
10.5
12.7
24
23
N95.2
ICD-10 Finland
Postmenopausal atrophic vaginitis
1.7
12.7
243
1435
SPAT1263
SPAT
Sampling
1.3
12.7
1287
10752
K59.1
ICD-10 Finland
Functional diarrhoea
2.0
12.6
163
839
A02BC05
ATC
esomeprazole; systemic
1.3
12.6
1276
10648
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.2
12.5
131
618
L30.4
ICD-10 Finland
Erythema intertrigo
3.8
12.5
51
134
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
12.5
1254
10452
L91.0
ICD-10 Finland
Hypertrophic scar
10.1
12.5
24
24
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
20.1
12.4
18
9
S29
ICPC
Skin symptom/complaint other
1.5
12.4
499
3551
P01AB01
ATC
metronidazole; oral, rectal
1.3
12.3
1259
10516
J01MA02
ATC
ciprofloxacin; systemic
1.3
12.2
1073
8759
D01AA02
ATC
natamycin; topical
2.8
12.1
76
274
A10BA02
ATC
metformin; oral
1.4
12.1
725
5565
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.7
12.1
251
1518
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
12.1
1410
11985
S18
ICPC
Laceration/cut
1.3
12.1
1194
9918
KDH10
NOMESCO Finland
Meatoplasty of urethra
18.1
12.0
18
10
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
12.0
1180
9786
R03AC02
ATC
salbutamol; inhalant
1.3
12.0
1606
13904
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.2
12.0
28
39
D07XC01
ATC
betamethasone, combinations; topical
1.6
12.0
315
2034
A10BH01
ATC
sitagliptin; oral
1.7
11.9
249
1507
EKA10
NOMESCO Finland
Biopsy of cheek
2.8
11.9
76
278
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
11.7
1097
9026
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
11.6
814
6405
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.4
11.6
692
5303
LFD00
NOMESCO Finland
Vulvectomy
65.2
11.6
13
*
N77.1*B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
3.2
11.6
59
186
L29.3
ICD-10 Finland
Anogenital pruritus, unspecified
23.0
11.6
16
7
H02AB06
ATC
prednisolone; systemic
1.3
11.3
1370
11668
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.7
11.2
231
1392
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
11.2
441
3121
A98
ICPC
Health maint/preventive medicine
1.7
11.1
3196
30900
M01AH05
ATC
etoricoxib; oral
1.3
11.1
1803
15947
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.4
11.0
730
5692
SPAT1153
SPAT
Removal of sutures
1.3
10.9
940
7626
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.7
10.9
254
1585
SPAT1301
SPAT
No procedures
1.3
10.9
944
7666
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
10.9
955
7771
G04BD08
ATC
solifenacin; oral
1.7
10.8
218
1308
N76.0
ICD-10 Finland
Acute vaginitis
1.9
10.7
148
782
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
2.1
10.7
120
584
SPAT1262
SPAT
Handing over of treatment supplies
1.4
10.6
476
3461
K03.64
ICD-10 Finland
Dental calculus supragingival
1.3
10.5
782
6201
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.9
10.5
156
849
L28.0
ICD-10 Finland
Lichen simplex chronicus
3.8
10.4
43
115
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.4
10.3
539
4026
G03CC04
ATC
estrone; systemic
1.9
10.3
155
847
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
10.6
10.3
19
18
E66.01
ICD-10 Finland
Obesity due to excess calories
1.7
10.3
217
1322
D07AC14
ATC
methylprednisolone aceponate; topical
1.9
10.2
142
751
R01AD09
ATC
mometasone; nasal
1.3
10.2
1353
11610
Z2221
NOMESCO Finland
Medical doctor
1.3
10.2
796
6350
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
10.2
688
5365
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.8
10.1
172
982
N84.0
ICD-10 Finland
Polyp of corpus uteri
1.6
10.0
287
1890
L90.5
ICD-10 Finland
Scar conditions and fibrosis of skin
11.3
10.0
18
16
M70.6
ICD-10 Finland
Trochanteric bursitis
1.4
10.0
450
3271
R06.0
ICD-10 Finland
Dyspnoea
1.3
9.9
711
5599
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
1.6
9.8
251
1606
L30.8
ICD-10 Finland
Other specified dermatitis
2.7
9.8
64
239
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
9.8
524
3930
K02.1
ICD-10 Finland
Caries of dentine
1.3
9.8
1599
14059
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
9.7
349
2423
R42
ICD-10 Finland
Dizziness and giddiness
1.3
9.7
663
5183
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
9.7
1545
13539
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
9.6
1349
11636
K60.1
ICD-10 Finland
Chronic anal fissure
2.5
9.6
72
291
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
2.6
9.5
66
256
ULC02
NOMESCO Finland
Hysteroscopy
1.7
9.4
192
1157
L90.4
ICD-10 Finland
Acrodermatitis chronica atrophicans
+∞
9.4
9
*
E000007
ATC
NA
1.8
9.3
150
839
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
9.3
1657
14686
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
9.3
575
4418
L01
ICPC
Neck symptom/complaint
1.4
9.2
409
2966
A60.0
ICD-10 Finland
Herpesviral infection of genitalia and urogenital tract
3.2
9.1
45
140
L17
ICPC
Foot/toe symptom/complaint
1.3
9.1
730
5835
J01CA04
ATC
amoxicillin; systemic
1.3
9.1
2487
23166
G03CB01
ATC
dienestrol; oral, vaginal
1.9
9.1
129
693
R53
ICD-10 Finland
Malaise and fatigue
1.4
9.1
572
4407
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
36.8
9.0
11
*
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
1.9
8.9
118
617
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
8.9
483
3624
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
8.9
604
4705
N30.0
ICD-10 Finland
Acute cystitis
1.4
8.9
462
3446
D01AC02
ATC
miconazole; topical
1.7
8.9
195
1198
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.3
8.8
763
6163
H01
ICPC
Ear pain/earache
1.5
8.8
283
1920
SPAT1312
SPAT
General health counselling
1.3
8.7
919
7618
S21
ICPC
Skin texture symptom/complaint
1.5
8.7
349
2476
M25.5
ICD-10 Finland
Pain in joint
1.3
8.7
835
6837
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
3.7
8.7
36
98
SPAT1260
SPAT
Consultation of another employee
1.4
8.7
506
3845
LEF03
NOMESCO Finland
Posterior colporrpahy with sutures for primary rectocele
1.7
8.7
168
999
Z70.8
ICD-10 Finland
Other sex counselling
7.6
8.6
19
25
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
8.6
1034
8721
A02BA02
ATC
ranitidine; systemic
1.3
8.6
577
4490
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
8.5
520
3985
D11
ICPC
Diarrhoea
1.5
8.4
291
2003
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
6.0
8.4
22
37
L90.8
ICD-10 Finland
Other atrophic disorders of skin
90.3
8.4
9
*
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.5
8.4
321
2259
A01AB09
ATC
miconazole; local oral
1.5
8.4
281
1921
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
1.9
8.3
109
570
R05
ICPC
Cough
1.3
8.2
642
5102
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.3
8.2
569
4443
R35
ICD-10 Finland
Polyuria
1.8
8.2
144
832
N81.1
ICD-10 Finland
Cystocele
1.5
8.2
276
1890
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
6.5
8.2
20
31
N76.8
ICD-10 Finland
Other specified inflammation of vagina and vulva
3.1
8.2
42
136
ZXE00
NOMESCO Finland
One hour or less
1.3
8.1
1131
9695
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
8.1
302
2112
R30.0
ICD-10 Finland
Dysuria
1.9
8.1
105
547
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.7
8.1
169
1027
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.4
8.1
432
3236
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
17.2
8.1
12
7
J05AB11
ATC
valaciclovir; oral
1.4
8.0
375
2742
X01
ICPC
Genital pain female
3.7
8.0
33
90
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
8.0
1727
15523
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.5
8.0
295
2063
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.4
7.9
376
2756
Y04
ICPC
Penis symptom/complaint other
7.8
7.9
17
22
J01CA08
ATC
pivmecillinam; oral
1.2
7.8
1512
13418
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
7.8
1160
10008
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.4
7.8
374
2752
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
7.8
1294
11302
L90.6
ICD-10 Finland
Striae atrophicae
45.1
7.7
9
*
SBA00
NOMESCO Finland
Microbiological examinations
2.2
7.7
75
348
H13
ICPC
Plugged feeling ear
1.4
7.7
471
3605
L82
ICD-10 Finland
Seborrhoeic keratosis
1.4
7.7
399
2970
D06BB10
ATC
imiquimod; topical
1.8
7.7
121
674
R32
ICD-10 Finland
Unspecified urinary incontinence
2.0
7.7
99
513
D01
ICPC
Abdominal pain/cramps general
1.5
7.7
294
2072
E000002
ATC
NA
1.5
7.6
288
2019
M01AE02
ATC
naproxen; oral, rectal
1.2
7.6
1677
15072
M03BX02
ATC
tizanidine; oral
1.2
7.6
1892
17221
J01FF01
ATC
clindamycin; systemic
1.3
7.6
715
5825
J05AB01
ATC
aciclovir; systemic
1.3
7.5
619
4954
QBA99
NOMESCO Finland
Other local destruction of skin of trunk
4.6
7.5
24
52
L03
ICPC
Low back symptom/complaint
1.3
7.5
717
5858
A46
ICD-10 Finland
Erysipelas
1.4
7.4
317
2280
N77.8
ICD-10 Finland
Vulvovaginal ulceration and inflammation in other diseases classified elsewhere
13.4
7.4
12
9
R01AD12
ATC
fluticasone furoate; nasal
1.3
7.4
813
6758
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
7.3
280
1967
Z00.0
ICD-10 Finland
General medical examination
1.3
7.3
492
3825
ZXC50
NOMESCO Finland
Cryotherapy
2.2
7.3
69
317
U02
ICPC
Urinary frequency/urgency
1.4
7.2
424
3224
L57.0
ICD-10 Finland
Actinic keratosis
1.5
7.2
240
1642
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
1.6
7.2
164
1025
N02AX02
ATC
tramadol; systemic, rectal
1.2
7.2
1172
10188
8070/3-C51.1
ICD-O-3
Squamous cell carcinoma, NOS, of labium minus
30.1
7.1
9
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.4
7.1
283
2009
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
7.1
1083
9340
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
6.6
7.1
17
26
B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
2.8
7.1
42
150
E66.00
ICD-10 Finland
Metabolic syndrome
1.8
7.1
125
723
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
7.0
1989
18273
G04BD07
ATC
tolterodine; oral
1.6
7.0
165
1039
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.4
7.0
291
2083
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.4
7.0
280
1990
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
2.2
7.0
65
297
N06AB04
ATC
citalopram; systemic
1.3
7.0
633
5131
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
4.9
7.0
21
43
H29
ICPC
Ear symptom/complaint other
1.4
6.9
286
2040
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.4
6.9
283
2020
R07.0
ICD-10 Finland
Pain in throat
1.6
6.9
151
934
N06AX21
ATC
duloxetine; oral
1.4
6.9
308
2234
T86
ICPC
Hypothyroidism/myxoedema
1.7
6.8
132
788
B37.4
ICD-10 Finland
Candidiasis of other urogenital sites
8.3
6.8
14
17
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
6.8
814
6827
104
Kela drug reimbursment
Thyroid insufficiency
1.5
6.8
260
1830
T82
ICPC
Obesity
1.9
6.8
98
532
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.8
6.7
113
643
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
6.7
613
4967
M79.1
ICD-10 Finland
Myalgia
1.4
6.7
354
2645
SPAT1240
SPAT
Therapeutic discussion
1.5
6.7
254
1784
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.3
6.7
628
5108
A04
ICPC
Weakness/tiredness general
1.4
6.7
335
2482
R21
ICPC
Throat symptom/complaint
1.3
6.7
498
3927
A02BDXX
ATC
NA
1.8
6.7
107
603
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.3
6.7
407
3116
TKC22
NOMESCO Finland
Catheterisation instruction
2.6
6.6
44
169
A02BC01
ATC
omeprazole; systemic
1.3
6.6
792
6634
G04BD04
ATC
oxybutynin; oral, transdermal
1.6
6.6
172
1109
R10.2
ICD-10 Finland
Pelvic and perineal pain
2.3
6.6
56
243
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.4
6.6
295
2140
N03AX16
ATC
pregabalin; oral
1.3
6.6
675
5552
A10BK03
ATC
empagliflozin; oral
1.6
6.6
159
1006
L40.0
ICD-10 Finland
Psoriasis vulgaris
1.8
6.6
99
547
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.5
6.5
249
1753
R5140
NOMESCO Finland
Monitoring the use of the aid
1.5
6.5
242
1695
A06AC51
ATC
ispaghula, combinations; systemic
1.6
6.5
149
932
L29.9
ICD-10 Finland
Pruritus, unspecified
2.2
6.5
62
287
P03
ICPC
Feeling depressed
1.5
6.5
213
1452
R06AE09
ATC
levocetirizine; oral
1.4
6.5
391
2985
WZA90
NOMESCO Finland
Other doctors statement
1.3
6.4
615
5013
DHB50
NOMESCO Finland
Turbinoplasty
2.3
6.4
56
249
G01AF01
ATC
metronidazole; vaginal
1.4
6.4
356
2680
L98.1
ICD-10 Finland
Factitial dermatitis
70.0
6.4
7
*
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
1.8
6.4
112
647
R13
ICD-10 Finland
Dysphagia
1.6
6.4
162
1040
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.3
6.4
55
242
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.4
6.4
382
2914
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
6.4
638
5231
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
3.1
6.4
32
104
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.4
6.3
320
2375
U01
ICPC
Dysuria/painful urination
1.5
6.3
233
1633
TLC02
NOMESCO Finland
Simple extraction of IUD
1.8
6.3
104
595
D29.0
ICD-10 Finland
Benign neoplasm: Penis
+∞
6.2
6
*
L90.3
ICD-10 Finland
Atrophoderma of Pasini and Pierini
+∞
6.2
6
*
8070/3-C51.0
ICD-O-3
Squamous cell carcinoma, NOS, of labium majus
26.7
6.2
8
*
LFE00
NOMESCO Finland
Suture of vulva
26.7
6.2
8
*
L13
ICPC
Hip symptom/complaint
1.3
6.2
489
3884
L98.88
ICD-10 Finland
Other specified disorders of skin and subcutaneous tissue
7.0
6.2
14
20
D01AC03
ATC
econazole; topical
1.6
6.2
155
991
R51.80
ICD-10 Finland
Headache
1.3
6.2
387
2970
S76
ICPC
Skin infection other
1.7
6.2
122
733
XQ802
NOMESCO Finland
Epicutan test
1.7
6.1
111
650
K05.08
ICD-10 Finland
Another acute gingivitis
2.2
6.1
59
276
B07.9
ICD-10 Finland
Verruca simplex
2.0
6.1
73
373
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.3
6.1
471
3733
R06.5
ICD-10 Finland
Mouth breathing
1.5
6.1
189
1275
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.3
6.1
536
4321
R01AD08
ATC
fluticasone; nasal
1.2
6.1
795
6721
KMAK
NOMESCO Finland
NA
1.2
6.1
1462
13145
XKC03
NOMESCO Finland
Water cystometry
1.8
6.1
96
538
LDA10
NOMESCO Finland
Curettage of cervix uteri
1.7
6.0
114
677
R33
ICD-10 Finland
Retention of urine
1.7
6.0
107
624
D06BB03
ATC
aciclovir; topical
1.6
6.0
147
936
M01AB05
ATC
diclofenac; systemic, rectal
1.2
6.0
1989
18409
R06AX22
ATC
ebastine; oral
1.3
6.0
484
3858
Mortality – FinRegistry
↥Association
Association between endpoint L12_LICHENSCLERATROPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHENSCLERATROPH | 0.833 [0.75, 0.92] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1814 out of 13288 females with L12_LICHENSCLERATROPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_LICHENSCLERATROPH | 0.786 [0.64, 0.97] | 0.023 |
| Birth year | 0.992 [0.98, 1.0] | 0.134 |
During the follow-up period (1.1.1998 — 31.12.2019), 145 out of 2735 males with L12_LICHENSCLERATROPH died.
Mortality risk
Mortality risk for people of age
years, who have L12_LICHENSCLERATROPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.13% |
| 5 | 0.44% | 0.996% |
| 10 | 0.985% | 2.672% |
| 15 | 1.926% | 5.039% |
| 20 | 3.252% | 8.678% |
Relationships between endpoints
↥Index endpoint: L12_LICHENSCLERATROPH – Lichen sclerosus et atrophicus
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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