No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
592 |
4. Check minimum number of eventsNone |
592 |
5. Include endpointsNone |
592 |
6. Filter based on genotype QC (FinnGen only) |
592 |
Control definitions (FinnGen only)
- Control exclude
- L12_DERMATITISECZEMA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L30
- Name in latin
- Pompholyx
Similar endpoints
↥List of similar endpoints to
Dyshidrosis [pompholyx]
based on the number of shared cases.
Similar with more cases:
- Dermatitis
- Dermatitis and eczema
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3645 | 2184 | 1440 |
| Only index persons | 3395 | 2092 | 1303 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 39.06 | 39.22 | 38.77 |
| Only index persons | 38.66 | 38.88 | 38.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 592 | 405 | 187 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.08 |
| Median age at first event (years) | 42.36 | 42.27 | 42.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 532
- Matched controls
- 5320
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L30.1
ICD-10 Finland
Dyshidrosis [pompholyx]
+∞
323.0
479
*
XQ802
NOMESCO Finland
Epicutan test
351.5
209.3
199
9
L20.0
ICD-10 Finland
Besnier prurigo
+∞
153.8
140
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
20.4
141.4
227
187
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
139.9
128
*
D07AC13
ATC
mometasone; topical
9.9
123.7
336
786
D07AC01
ATC
betamethasone; topical
8.4
109.4
343
947
E0000UV
ATC
NA
8.0
105.9
374
1211
D07AD01
ATC
clobetasol; topical
10.9
103.3
226
336
L30.9
ICD-10 Finland
Dermatitis, unspecified
11.9
102.2
210
276
XQ800
NOMESCO Finland
Prick test
16.6
97.2
165
140
L30.3
ICD-10 Finland
Infective dermatitis
48.2
73.5
89
22
D07BC01
ATC
betamethasone and antiseptics; topical
8.8
68.3
162
251
E000001
ATC
NA
5.4
56.0
205
553
69283
ICD-8 Finland
Other eczema and dermatitis, Dysidroticum (pompholyx)
+∞
55.2
52
*
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
50.8
48
*
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
535.4
50.3
49
*
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
263.0
47.8
48
*
D02AE01
ATC
carbamide; topical
9.2
42.2
93
120
D07CC01
ATC
betamethasone and antibiotics; topical
5.5
41.4
138
319
D07AB02
ATC
hydrocortisone butyrate; topical
3.7
37.0
210
801
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
5.2
36.8
126
297
L30.0
ICD-10 Finland
Nummular dermatitis
19.2
35.3
54
31
D11AH01
ATC
tacrolimus; topical
+∞
34.8
33
*
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
347.4
33.3
33
*
L20
ICD-10 Finland
Atopic dermatitis
+∞
30.5
29
*
L30.8
ICD-10 Finland
Other specified dermatitis
18.8
29.3
45
26
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
28.4
27
*
H02AB06
ATC
prednisolone; systemic
2.8
28.1
288
1573
TQW80
NOMESCO Finland
Local dermatologic skincare
17.2
27.2
43
27
D07AB08
ATC
desonide; topical
4.9
26.9
94
221
D07CB01
ATC
triamcinolone and antibiotics; topical
17.4
26.7
42
26
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
3.2
25.3
162
640
E000002
ATC
NA
4.4
25.0
99
264
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
5.0
22.4
76
172
H02AB04
ATC
methylprednisolone; systemic
3.6
22.0
111
364
R06AE07
ATC
cetirizine; oral
2.4
21.4
281
1671
L24.0
ICD-10 Finland
Irritant contact dermatitis due to detergents
+∞
21.0
20
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
20.3
100
321
L25.9
ICD-10 Finland
Unspecified contact dermatitis, unspecified cause
47.9
19.3
23
5
J01DB01
ATC
cefalexin; oral
2.9
18.9
460
3657
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
19.6
18.8
28
15
WQ021
NOMESCO Finland
NA
196.5
18.6
19
*
D07XC01
ATC
betamethasone, combinations; topical
3.6
17.6
84
261
E000004
ATC
NA
11.7
17.5
32
29
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.6
17.4
63
152
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
+∞
16.7
16
*
E000007
ATC
NA
5.4
16.6
51
103
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
175.2
16.6
17
*
R06AE09
ATC
levocetirizine; oral
2.8
15.7
110
448
SPAT1263
SPAT
Sampling
2.2
15.6
250
1552
D02AX
ATC
Other emollients and protectives
7.6
14.7
34
47
WQ007
NOMESCO Finland
NA
+∞
14.6
14
*
S87
ICPC
Dermatitis/atopic eczema
10.5
14.1
27
27
R06AX27
ATC
desloratadine; oral
2.2
13.8
177
983
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
5.2
13.7
43
89
WQ020
NOMESCO Finland
NA
143.4
13.5
14
*
D07XB05
ATC
dexamethasone, combinations; topical
8.9
13.4
28
33
D09AB01
ATC
zinc bandage without supplements; topical
14.3
13.3
22
16
L23
ICD-10 Finland
Allergic contact dermatitis
41.2
13.2
16
*
A46
ICD-10 Finland
Erysipelas
3.2
12.9
71
243
R06AX22
ATC
ebastine; oral
2.4
12.7
117
553
L24.8
ICD-10 Finland
Irritant contact dermatitis due to other agents
+∞
12.5
12
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
12.2
198
1203
N05BB01
ATC
hydroxyzine; systemic
3.9
12.1
51
142
H02AB07
ATC
prednisone; oral
2.9
11.9
77
296
E000006
ATC
NA
4.1
11.9
46
119
SPAT1310
SPAT
Counselling related to known health issue
2.0
11.7
188
1133
M01AE02
ATC
naproxen; oral, rectal
1.9
11.5
318
2336
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
11.5
11
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
5.3
11.1
33
65
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.6
10.9
49
145
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
22.0
10.7
15
7
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
10.7
229
1524
J01AA04
ATC
lymecycline; systemic
2.3
10.5
101
483
D11AX14
ATC
[U] tacrolimus; topical
+∞
10.4
10
*
S76
ICPC
Skin infection other
4.7
10.2
34
76
E000003
ATC
NA
4.6
10.1
34
77
R03AC02
ATC
salbutamol; inhalant
1.8
10.1
282
2037
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
14.9
10.0
16
11
Z01.2
ICD-10 Finland
Dental examination
1.8
10.0
244
1682
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
17.1
9.9
15
9
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
17.1
9.9
15
9
J01DA01
ATC
[U] cefalexin; systemic
1.8
9.8
336
2586
Z2221
NOMESCO Finland
Medical doctor
0.4
9.8
42
959
ND1BA
NOMESCO Finland
Wrist extensive X-ray examination
5.4
9.7
28
54
T78.4
ICD-10 Finland
Allergy, unspecified
4.1
9.6
37
96
S88
ICPC
Dermatitis contact/allergic
7.8
9.5
21
28
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.5
9.5
78
344
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
101.7
9.4
10
*
M03BX02
ATC
tizanidine; oral
1.8
9.4
336
2602
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
9.4
9
*
D07AA02
ATC
hydrocortisone; topical
2.4
9.3
80
361
XG410
NOMESCO Finland
Flow-volume spirometry
4.9
9.2
29
62
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.8
9.1
61
239
S21
ICPC
Skin texture symptom/complaint
2.6
8.8
65
269
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
8.8
74
330
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
8.8
259
1874
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
50.8
8.7
10
*
D05BB02
ATC
acitretin; oral
7.1
8.6
20
29
ZXX03
NOMESCO Finland
Extent of procedure, 3 units
16.6
8.6
13
8
N03AX16
ATC
pregabalin; oral
2.0
8.5
126
720
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.7
8.5
36
102
L17
ICPC
Foot/toe symptom/complaint
2.0
8.5
124
708
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
91.4
8.4
9
*
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
+∞
8.4
8
*
R03BA05
ATC
fluticasone; inhalant
2.1
8.3
103
547
L08.0
ICD-10 Finland
Pyoderma
14.8
8.2
13
9
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.9
8.2
146
891
Z04.3
ICD-10 Finland
Examination and observation following other accident
5.5
8.2
23
43
N02BE01
ATC
paracetamol; systemic, rectal
1.9
8.0
441
3810
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.1
8.0
93
480
C01CA24
ATC
epinephrine; parenteral
3.2
8.0
40
130
J01FF01
ATC
clindamycin; systemic
1.9
8.0
138
836
R01AD09
ATC
mometasone; nasal
1.7
7.9
249
1819
L12
ICPC
Hand/finger symptom/complaint
2.2
7.8
81
398
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
7.7
283
2151
F17.20
ICD-10 Finland
Addiction relationship caused by tobacco addiction relationship currently independent
18.7
7.6
11
6
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.5
7.6
34
102
B35.3
ICD-10 Finland
Tinea pedis
3.9
7.5
29
77
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.5
7.4
55
230
H25.8
ICD-10 Finland
Other senile cataract
3.0
7.3
41
143
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
7.3
88
463
G47.3
ICD-10 Finland
Sleep apnoea
2.0
7.2
104
588
PA7BD
NOMESCO Finland
CT angiography of neck and brain
8.1
7.1
15
19
N02AX02
ATC
tramadol; systemic, rectal
1.7
7.1
196
1365
L03
ICPC
Low back symptom/complaint
1.9
7.1
122
735
J01MA12
ATC
levofloxacin; systemic
2.1
7.1
85
448
SPAT1311
SPAT
Counselling and guidance related to occupational health
3.5
6.9
30
88
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.1
6.8
35
117
R01AD08
ATC
fluticasone; nasal
1.7
6.7
157
1041
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
6.6
209
1506
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.8
6.6
136
867
ZXE00
NOMESCO Finland
One hour or less
0.6
6.6
94
1473
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.8
6.6
131
824
XQ848
NOMESCO Finland
Dermatological photography
5.4
6.5
18
34
SPAT1312
SPAT
General health counselling
1.7
6.5
179
1240
L01
ICPC
Neck symptom/complaint
2.1
6.5
77
403
XQ899
NOMESCO Finland
Other assessment of skin
70.6
6.4
7
*
L27.2
ICD-10 Finland
Dermatitis due to ingested food
70.6
6.4
7
*
A02BC02
ATC
pantoprazole; systemic
1.6
6.4
301
2395
L16
ICPC
Ankle symptom/complaint
2.3
6.4
59
276
Z00.0
ICD-10 Finland
General medical examination
1.9
6.3
101
589
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
6.3
68
342
WX402
NOMESCO Finland
General anaesthesia
0.4
6.3
23
566
D82
ICPC
Teeth/gum disease
1.6
6.3
197
1412
D11AH04
ATC
alitretinoin; oral
+∞
6.3
6
*
L24.9
ICD-10 Finland
Irritant contact dermatitis, unspecified cause
+∞
6.3
6
*
D11AH02
ATC
pimecrolimus; topical
+∞
6.3
6
*
WQ055
NOMESCO Finland
NA
+∞
6.3
6
*
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
+∞
6.3
6
*
Z75.1
ICD-10 Finland
Person awaiting admission to adequate facility elsewhere
7.2
6.3
14
20
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
6.2
140
912
J20
ICD-10 Finland
Acute bronchitis
2.3
6.2
55
251
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
6.2
229
1710
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
6.2
57
264
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
6.4
6.2
15
24
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.3
6.2
55
254
S06
ICPC
Rash localized
3.1
6.1
31
104
B86
ICD-10 Finland
Scabies
5.7
6.0
16
29
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.6
6.0
43
177
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
6.0
125
795
Mortality – FinRegistry
↥Association
Association between endpoint L12_DYSHIDROSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DYSHIDROSIS | 1.254 [0.92, 1.71] | 0.15 |
| Birth year | 0.999 [0.99, 1.01] | 0.788 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 1569 females with L12_DYSHIDROSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DYSHIDROSIS | 1.603 [1.25, 2.06] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 941 males with L12_DYSHIDROSIS died.
Mortality risk
Mortality risk for people of age
years, who have L12_DYSHIDROSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.215% |
| 5 | 0.884% | 1.593% |
| 10 | 2.169% | 4.084% |
| 15 | 3.959% | 7.696% |
| 20 | 7.136% | 13.227% |
Relationships between endpoints
↥Index endpoint: L12_DYSHIDROSIS – Dyshidrosis [pompholyx]
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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