Nummular dermatitis

L12_DERM_NUMMULAR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L30.0
  • Cause of death: ICD-10 L30.0

2 out of 7 registries used, show all original rules.

3201

4. Check minimum number of events

None

3201

5. Include endpoints

None

3201

6. Filter based on genotype QC (FinnGen only)

3201

Control definitions (FinnGen only)

Control exclude
L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L30
Name in latin
Eczema nummulare

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 24075 10311 13675
Only index persons 22125 9683 12442
Unadjusted period prevalence (%)
Whole population 0.34 0.30 0.38
Only index persons 0.42 0.36 0.47
Median age at first event (years)
Whole population 56.04 55.41 56.50
Only index persons 56.05 55.42 56.55

-FinnGen-

Key figures

All Female Male
Number of individuals 3201 1457 1744
Unadjusted period prevalence (%) 0.64 0.50 0.77
Median age at first event (years) 59.18 55.39 62.34

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2829
Matched controls
28290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E0000UV
ATC
NA
8.4
323.0
1972
6089
L30.3
ICD-10 Finland
Infective dermatitis
90.9
323.0
631
89
L30.9
ICD-10 Finland
Dermatitis, unspecified
12.9
323.0
1152
1427
D07AC13
ATC
mometasone; topical
6.1
323.0
1490
4360
L30.0
ICD-10 Finland
Nummular dermatitis
4503599627370496.0
323.0
2828
184
L20.0
ICD-10 Finland
Besnier prurigo
+∞
323.0
402
*
D07AC01
ATC
betamethasone; topical
9.3
323.0
1943
5388
E000001
ATC
NA
6.6
323.0
1146
2658
D07AD01
ATC
clobetasol; topical
6.4
293.6
909
1961
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
+∞
274.5
259
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.9
255.6
646
1025
D07AB02
ATC
hydrocortisone butyrate; topical
4.2
240.0
1221
4338
XQ802
NOMESCO Finland
Epicutan test
39.6
237.1
302
85
D07BC01
ATC
betamethasone and antiseptics; topical
5.9
222.8
704
1492
D07AB08
ATC
desonide; topical
7.0
222.0
607
1062
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
5.9
221.0
704
1505
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
8.5
220.0
522
737
E000002
ATC
NA
5.7
182.1
585
1235
TQW80
NOMESCO Finland
Local dermatologic skincare
19.1
164.3
257
147
D07CC01
ATC
betamethasone and antibiotics; topical
4.6
157.6
633
1683
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
41.4
156.3
197
51
D09AB01
ATC
zinc bandage without supplements; topical
25.0
153.7
220
95
H02AB06
ATC
prednisolone; systemic
2.8
146.9
1586
8831
D02AE01
ATC
carbamide; topical
6.3
130.4
374
667
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.6
112.7
434
1076
D07AA02
ATC
hydrocortisone; topical
3.8
108.1
516
1558
E000003
ATC
NA
7.6
105.3
259
368
E000007
ATC
NA
6.6
100.0
273
450
XQ800
NOMESCO Finland
Prick test
5.7
99.8
307
590
D02AX
ATC
Other emollients and protectives
9.7
99.6
210
231
D07XC01
ATC
betamethasone, combinations; topical
3.6
96.4
501
1610
R06AE07
ATC
cetirizine; oral
2.2
83.0
1269
7613
E000006
ATC
NA
4.5
82.7
314
756
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.5
80.9
778
3702
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
+∞
80.6
77
*
L20
ICD-10 Finland
Atopic dermatitis
+∞
78.5
75
*
J01DB01
ATC
cefalexin; oral
2.5
78.1
2363
19010
R06AX27
ATC
desloratadine; oral
2.5
77.7
795
3891
L23.2
ICD-10 Finland
Allergic contact dermatitis due to cosmetics
117.6
74.3
80
7
L28.1
ICD-10 Finland
Prurigo nodularis
114.5
72.2
78
7
D07AC14
ATC
methylprednisolone aceponate; topical
5.2
68.7
225
460
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.2
61.8
204
420
L23.0
ICD-10 Finland
Allergic contact dermatitis due to metals
130.9
60.1
64
5
R06AE09
ATC
levocetirizine; oral
2.7
59.8
453
1840
XQ848
NOMESCO Finland
Dermatological photography
7.3
59.0
147
211
S87
ICPC
Dermatitis/atopic eczema
9.1
57.8
125
143
L30.8
ICD-10 Finland
Other specified dermatitis
11.6
54.8
104
93
N05BB01
ATC
hydroxyzine; systemic
3.9
51.4
229
632
A46
ICD-10 Finland
Erysipelas
2.5
51.4
476
2153
L29.9
ICD-10 Finland
Pruritus, unspecified
10.1
50.8
103
105
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
59.2
49.6
58
10
L20.8
ICD-10 Finland
Other atopic dermatitis
+∞
48.0
46
*
D11AH01
ATC
tacrolimus; topical
233.7
45.1
46
*
L23.5
ICD-10 Finland
Allergic contact dermatitis due to other chemical products
159.2
44.9
47
*
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.4
44.5
408
1825
L28.0
ICD-10 Finland
Lichen simplex chronicus
25.3
44.2
62
25
S29
ICPC
Skin symptom/complaint other
2.2
43.8
507
2540
J01FF01
ATC
clindamycin; systemic
1.9
43.6
797
4806
D05BB02
ATC
acitretin; oral
6.2
43.1
120
201
J01DA01
ATC
[U] cefalexin; systemic
1.7
42.6
1700
13153
L30.1
ICD-10 Finland
Dyshidrosis [pompholyx]
93.5
41.9
46
5
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
+∞
41.8
40
*
S21
ICPC
Skin texture symptom/complaint
2.4
41.8
394
1786
L23.8
ICD-10 Finland
Allergic contact dermatitis due to other agents
213.0
41.0
42
*
E000004
ATC
NA
7.1
40.4
101
146
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
2.7
40.0
300
1196
L23.3
ICD-10 Finland
Allergic contact dermatitis due to drugs in contact with skin
34.1
36.3
47
14
D05AX52
ATC
calcipotriol, combinations; topical
3.2
35.3
198
651
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.1
33.6
412
2098
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.7
31.8
146
413
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
26.0
29.7
41
16
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
5.0
29.6
97
199
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
29.3
762
5034
B35.3
ICD-10 Finland
Tinea pedis
3.7
29.2
133
374
S18
ICPC
Laceration/cut
1.6
28.9
1125
8281
N02BE01
ATC
paracetamol; systemic, rectal
1.7
28.4
2310
20418
R03AC02
ATC
salbutamol; inhalant
1.6
27.8
1316
10138
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.7
27.0
704
4640
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
3.8
26.7
117
319
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
26.2
1158
8728
R06AX22
ATC
ebastine; oral
1.9
26.2
420
2359
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
25.9
801
5517
SPAT1301
SPAT
No procedures
1.6
25.8
841
5876
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
25.7
384
2102
L21.9
ICD-10 Finland
Seborrhoeic dermatitis, unspecified
6.3
25.6
69
112
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
6.7
24.8
64
98
H02AB04
ATC
methylprednisolone; systemic
1.9
24.7
385
2141
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
10.2
24.2
48
48
C03CA01
ATC
furosemide; systemic
1.6
24.1
728
4965
L23.1
ICD-10 Finland
Allergic contact dermatitis due to adhesives
241.9
23.7
24
*
L50.3
ICD-10 Finland
Dermatographic urticaria
6.3
23.5
63
102
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
23.1
450
2697
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
23.0
1036
7773
S99
ICPC
Skin disease other
4.8
23.0
78
167
D11AX14
ATC
[U] tacrolimus; topical
+∞
22.9
22
*
L04AX01
ATC
azathioprine; systemic
3.0
22.8
138
481
SPAT1263
SPAT
Sampling
1.5
22.6
1103
8416
L29.8
ICD-10 Finland
Other pruritus
10.4
22.5
44
43
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
2.1
22.0
255
1254
UJF32
NOMESCO Finland
Coloscopy
1.6
21.8
678
4644
D07XB05
ATC
dexamethasone, combinations; topical
4.1
21.7
86
215
D01AC02
ATC
miconazole; topical
2.2
21.7
230
1091
L24.0
ICD-10 Finland
Irritant contact dermatitis due to detergents
221.6
21.6
22
*
J01CF05
ATC
flucloxacillin; systemic
3.2
21.5
115
368
SPAT1153
SPAT
Removal of sutures
1.5
21.3
838
6072
L26
ICD-10 Finland
Exfoliative dermatitis
+∞
20.9
20
*
J01AA04
ATC
lymecycline; systemic
1.9
20.7
322
1784
L71.9
ICD-10 Finland
Rosacea, unspecified
4.6
20.7
72
159
J01AA07
ATC
tetracycline; systemic
1.8
20.6
371
2163
N03AX12
ATC
gabapentin; oral
1.8
20.2
389
2317
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
19.7
542
3579
SPAT1260
SPAT
Consultation of another employee
1.7
19.5
455
2873
R06AX13
ATC
loratadine; oral
1.8
19.1
346
2016
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
19.0
473
3037
M79.6
ICD-10 Finland
Pain in limb
1.5
18.5
855
6377
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
11.5
18.5
34
30
N02AX02
ATC
tramadol; systemic, rectal
1.4
18.4
1068
8348
S97
ICPC
Chronic ulcer skin
2.4
18.3
155
658
S06
ICPC
Rash localized
2.5
18.2
151
634
S76
ICPC
Skin infection other
2.5
18.2
143
585
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
18.0
536
3608
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
17.9
177
811
C08CA01
ATC
amlodipine; oral
1.5
17.9
901
6834
N03AX16
ATC
pregabalin; oral
1.6
17.6
567
3885
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
3.4
17.6
87
264
SPAT1310
SPAT
Counselling related to known health issue
1.5
17.5
800
5939
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
17.4
480
3159
L28.2
ICD-10 Finland
Other prurigo
42.2
17.3
21
5
S02
ICPC
Pruritus
3.0
17.3
99
333
R06.0
ICD-10 Finland
Dyspnoea
1.5
17.2
604
4226
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
3.4
17.1
83
248
L04AD01
ATC
ciclosporin; systemic
4.0
16.9
67
169
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
16.8
978
7606
S88
ICPC
Dermatitis contact/allergic
4.3
16.7
62
147
6918B
ICD-9 Finland
Atopic dermatitis and related conditions, Other atopic dermatitis and related conditions[ECZEMA ATOPICUM]
+∞
16.7
16
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
16.7
1478
12416
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
16.3
815
6142
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.1
16.3
64
160
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.1
16.3
194
965
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
16.3
423
2740
D01BA02
ATC
terbinafine; oral; topical
1.5
16.3
648
4656
B86
ICD-10 Finland
Scabies
5.2
16.0
49
95
6929B
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA INFECTIOSUM]
+∞
15.6
15
*
D11AH02
ATC
pimecrolimus; topical
+∞
15.6
15
*
D06BX01
ATC
metronidazole; topical
1.9
15.6
241
1327
L17
ICPC
Foot/toe symptom/complaint
1.5
15.5
602
4292
D07AB01
ATC
clobetasone; topical
2.9
15.5
92
319
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
15.5
1238
10161
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
15.4
160
751
A02BC02
ATC
pantoprazole; systemic
1.4
15.3
1629
14025
SPAT1312
SPAT
General health counselling
1.4
15.3
793
6010
A07EC01
ATC
sulfasalazine; oral, rectal
2.0
15.2
209
1100
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
15.2
686
5051
L50.9
ICD-10 Finland
Urticaria, unspecified
3.0
15.0
88
302
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
15.0
807
6151
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
15.0
701
5197
L30
ICD-10 Finland
Other dermatitis
4.0
15.0
59
149
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
14.9
101
380
J01MA02
ATC
ciprofloxacin; systemic
1.4
14.7
965
7622
L21.0
ICD-10 Finland
Seborrhoea capitis
7.5
14.7
34
46
WQ021
NOMESCO Finland
NA
27.3
14.3
19
7
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.2
14.3
53
127
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
9.7
14.2
28
29
L12.0
ICD-10 Finland
Bullous pemphigoid
10.9
14.0
26
24
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
13.9
758
5779
L30.4
ICD-10 Finland
Erythema intertrigo
5.9
13.9
38
65
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
13.9
1722
15080
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
13.9
657
4875
R60.0
ICD-10 Finland
Localized oedema
1.8
13.8
265
1571
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
13.7
269
1603
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
+∞
13.5
13
*
L04AA01
ATC
[U] ciclosporin; systemic
4.3
13.5
49
115
J02AC01
ATC
fluconazole; systemic
1.4
13.5
841
6563
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
13.4
1050
8523
L24.9
ICD-10 Finland
Irritant contact dermatitis, unspecified cause
25.9
13.4
18
7
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
13.3
387
2576
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
13.2
322
2045
C07AB07
ATC
bisoprolol; oral
1.4
13.2
1181
9785
S01
ICPC
Pain/tenderness of skin
2.4
13.2
114
492
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
13.1
276
1682
A02BC03
ATC
lansoprazole; oral
1.4
13.1
693
5242
J01FA06
ATC
roxithromycin; oral
1.4
13.1
938
7488
L57.0
ICD-10 Finland
Actinic keratosis
1.8
13.0
236
1371
J01AA02
ATC
doxycycline; systemic
1.4
13.0
1971
17725
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
13.0
268
1624
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
12.9
261
1570
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
3.0
12.9
74
250
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.2
12.8
132
617
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
12.8
574
4204
D01AE15
ATC
terbinafine; topical
1.9
12.7
178
947
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
12.7
224
1289
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
3.1
12.7
70
233
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
12.6
879
6975
D11AH04
ATC
alitretinoin; oral
+∞
12.5
12
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
12.5
1138
9434
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
12.5
394
2671
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.0
12.4
163
844
ZXC50
NOMESCO Finland
Cryotherapy
2.7
12.4
82
305
L03
ICPC
Low back symptom/complaint
1.5
12.4
540
3931
XQ845
NOMESCO Finland
Dermatoscopy
4.4
12.3
44
102
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.8
12.2
231
1361
J04BA02
ATC
dapsone; oral
9.0
12.2
25
28
N05CF01
ATC
zopiclone; oral
1.4
12.1
759
5902
L40.9
ICD-10 Finland
Psoriasis, unspecified
4.2
12.1
45
109
H02AB07
ATC
prednisone; oral
1.6
12.0
332
2175
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.4
12.0
672
5126
R96
ICPC
Asthma
1.8
12.0
204
1165
L71.8
ICD-10 Finland
Other rosacea
4.7
11.9
39
83
D05AX02
ATC
calcipotriol; topical
2.3
11.7
104
455
H25.1
ICD-10 Finland
Senile nuclear cataract
1.4
11.7
559
4133
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
11.7
1531
13343
K02.1
ICD-10 Finland
Caries of dentine
1.3
11.6
1347
11526
P01BA02
ATC
hydroxychloroquine; oral
1.8
11.6
186
1037
L85.3
ICD-10 Finland
Xerosis cutis
5.8
11.6
32
56
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.7
11.6
225
1336
ZY010
NOMESCO Finland
Hospital outpatient
2.3
11.6
109
492
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
11.6
1111
9247
T90
ICPC
Diabetes non-insulin dependent
1.4
11.5
569
4235
205
Kela drug reimbursment
Chronic hypertension
1.4
11.5
693
5351
M25.5
ICD-10 Finland
Pain in joint
1.4
11.5
624
4730
SPAT1262
SPAT
Handing over of treatment supplies
1.5
11.4
446
3165
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.3
11.3
104
462
R02
ICPC
Shortness of breath/dyspnoea
1.6
11.3
279
1776
T78.4
ICD-10 Finland
Allergy, unspecified
2.3
11.2
100
438
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
4.4
11.2
39
89
J01CE08
ATC
benzathine benzylpenicillin; parenteral
4.4
11.2
39
89
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
11.2
361
2456
L08.0
ICD-10 Finland
Pyoderma
5.7
11.2
31
55
E0001A1
ATC
NA
3.4
11.1
52
154
A02BC01
ATC
omeprazole; systemic
1.4
11.1
651
4998
L08
ICPC
Shoulder symptom/complaint
1.5
11.1
438
3115
D07CB01
ATC
triamcinolone and antibiotics; topical
3.0
11.1
64
219
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
11.0
779
6173
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
11.0
676
5230
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
11.0
211
1251
WX110
NOMESCO Finland
Local anesthesy
1.3
10.9
1691
15020
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
10.9
624
4766
L24.8
ICD-10 Finland
Irritant contact dermatitis due to other agents
43.5
10.9
13
*
SPAT1211
SPAT
Application of soft bandage
1.7
10.9
217
1302
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
10.8
887
7188
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
10.8
263
1671
B35.1
ICD-10 Finland
Tinea unguium
2.0
10.8
138
712
M04AA01
ATC
allopurinol; systemic
1.6
10.8
326
2184
R05
ICPC
Cough
1.4
10.7
490
3587
-1
NOMESCO Finland
NA
1.4
10.7
754
5967
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
10.7
1691
15048
134
Kela drug reimbursment
General erythroderma
12.9
10.6
18
14
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.8
10.6
178
1011
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
10.6
255
1614
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
10.6
234
1447
J01MA12
ATC
levofloxacin; systemic
1.5
10.6
446
3214
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.3
10.5
96
427
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
10.5
1244
10622
R03BA01
ATC
beclometasone; inhalant
1.6
10.4
302
2003
R50.9
ICD-10 Finland
Fever, unspecified
1.5
10.4
324
2186
6929X
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[DERMATITITIS ARTEFACTA NUD]
+∞
10.4
10
*
L85.89
ICD-10 Finland
Other specified epidermal thickening
16.1
10.3
16
10
M48.0
ICD-10 Finland
Spinal stenosis
1.6
10.3
277
1802
R01AD09
ATC
mometasone; nasal
1.3
10.3
999
8282
L85.9
ICD-10 Finland
Epidermal thickening, unspecified
8.8
10.3
21
24
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
10.2
342
2344
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
9.6
10.2
20
21
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
10.2
167
942
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
10.2
588
4493
G47.3
ICD-10 Finland
Sleep apnoea
1.4
10.2
501
3721
L50.0
ICD-10 Finland
Allergic urticaria
3.0
10.1
58
197
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.3
10.1
48
145
L04AB04
ATC
adalimumab; parenteral
3.3
10.0
49
151
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.6
10.0
244
1549
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
10.0
1303
11250
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.6
10.0
256
1645
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
10.0
901
7390
L40.8
ICD-10 Finland
Other psoriasis
5.8
9.9
27
47
N06AX21
ATC
duloxetine; oral
1.7
9.9
229
1430
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
9.9
182
1063
L50.8
ICD-10 Finland
Other urticaria
3.8
9.9
40
106
A02BC05
ATC
esomeprazole; systemic
1.3
9.8
937
7741
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.5
9.8
308
2081
R53
ICD-10 Finland
Malaise and fatigue
1.4
9.8
436
3175
R03DC03
ATC
montelukast; oral
1.5
9.7
329
2261
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
9.6
197
1191
R06AX26
ATC
fexofenadine; oral
1.9
9.6
129
679
M54.5
ICD-10 Finland
Low back pain
1.3
9.6
722
5756
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
9.6
889
7308
M10.9
ICD-10 Finland
Gout, unspecified
1.8
9.5
168
968
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
2.9
9.5
56
196
EBA00
NOMESCO Finland
Extraction of tooth
1.3
9.5
771
6211
R60.9
ICD-10 Finland
Oedema, unspecified
2.1
9.4
106
519
J02AC02
ATC
itraconazole; systemic
1.5
9.4
393
2823
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.5
9.4
302
2051
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.0
9.4
123
642
ZXA10
NOMESCO Finland
Bilateral
1.4
9.4
428
3131
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.1
9.3
49
160
R51.80
ICD-10 Finland
Headache
1.5
9.3
288
1937
M13.9
ICD-10 Finland
Arthritis, unspecified
1.8
9.3
163
941
L23
ICD-10 Finland
Allergic contact dermatitis
9.5
9.3
18
19
ZXA05
NOMESCO Finland
Left side
1.4
9.2
595
4626
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.3
9.2
82
363
L28
ICD-10 Finland
Lichen simplex chronicus and prurigo
5.5
9.2
26
48
L14
ICPC
Leg/thigh symptom/complaint
1.8
9.2
165
959
J05AB01
ATC
aciclovir; systemic
1.4
9.2
445
3292
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.6
9.2
66
261
K90.0
ICD-10 Finland
Coeliac disease
2.5
9.0
69
282
S08
ICPC
Skin colour change
2.0
9.0
112
574
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
9.0
880
7274
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.7
9.0
172
1022
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.9
8.9
133
726
SAA04
NOMESCO Finland
Special inverstigation of mouth
1.9
8.9
129
696
CBB30
NOMESCO Finland
Excision of lesion of eyelid
2.4
8.9
71
298
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.8
8.9
157
910
J01MA14
ATC
moxifloxacin; systemic
1.6
8.8
200
1247
L25.9
ICD-10 Finland
Unspecified contact dermatitis, unspecified cause
7.2
8.7
20
28
J01DB05
ATC
cefadroxil; oral
2.0
8.7
101
503
L04AA13
ATC
leflunomide; oral
2.6
8.7
61
239
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.1
8.7
100
494
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
8.7
391
2847
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
8.6
404
2965
KMAK
NOMESCO Finland
NA
1.3
8.6
1182
10203
R03BA05
ATC
fluticasone; inhalant
1.4
8.5
381
2770
AA1AD
NOMESCO Finland
CT of head and brain
1.4
8.5
533
4114
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.5
8.5
276
1878
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.5
8.5
354
2539
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.8
8.4
133
740
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.3
8.4
40
122
N07BA03
ATC
varenicline; oral
2.0
8.4
109
566
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.7
8.4
156
917
J01FA10
ATC
azithromycin; systemic
1.3
8.4
1316
11534
A08
ICPC
Swelling
2.1
8.4
91
441
69299
ICD-8 Finland
Other eczema and dermatitis, Due to other and unspecified cause
+∞
8.3
8
*
D11AX15
ATC
[U] pimecrolimus; topical
+∞
8.3
8
*
R01AD08
ATC
fluticasone; nasal
1.3
8.3
600
4738
A07AA02
ATC
nystatin; oral
1.8
8.2
137
780
UKC02
NOMESCO Finland
Cystoscopy
1.4
8.2
392
2890
WX290
NOMESCO Finland
Other blockade of nerve
1.3
8.1
962
8134
WQ007
NOMESCO Finland
NA
33.4
8.1
10
*
ZXD05
NOMESCO Finland
Urgent procedure
1.3
8.1
712
5784
H02AB09
ATC
hydrocortisone; systemic
2.7
8.1
53
201
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
8.0
299
2096
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
2.0
8.0
102
530
GD1AD
NOMESCO Finland
Thorax CT examination
2.0
7.9
97
493
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
7.9
630
5039
A07EC02
ATC
mesalazine; oral, rectal
1.8
7.9
121
667
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.6
7.9
221
1454
A02BA02
ATC
ranitidine; systemic
1.4
7.9
436
3295
SPAT1058
SPAT
PEF monitoring instruction
1.6
7.9
186
1170
ZXX04
NOMESCO Finland
Extent of procedure, 4 units
7.8
7.9
17
22
SPAT1081
SPAT
Cardiorespiratory global assessment
1.8
7.8
139
806
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.8
459
3504
Z3231
NOMESCO Finland
Registered nurse
1.3
7.8
628
5033
L04AA06
ATC
mycophenolic acid; systemic
2.9
7.8
45
156
SPAT1229
SPAT
Assessment of need for aid
1.7
7.8
174
1080
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
2.5
7.8
58
236
TQW99
NOMESCO Finland
Other minor procedure on skin
1.9
7.8
114
620
L04AA17
ATC
[U] adalimumab; parenteral
9.4
7.8
15
16
L73.2
ICD-10 Finland
Hidradenitis suppurativa
4.1
7.8
28
68
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
7.8
301
2129
L13.0
ICD-10 Finland
Dermatitis herpetiformis
7.0
7.8
18
26
R03BB04
ATC
tiotropium bromide; inhalant
1.6
7.8
225
1492
D01AC03
ATC
econazole; topical
1.7
7.7
140
819
L04AB01
ATC
etanercept; parenteral
3.3
7.7
36
109
N06AX11
ATC
mirtazapine; oral
1.3
7.7
678
5503
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
1.9
7.7
105
557
WZA90
NOMESCO Finland
Other doctors statement
1.3
7.6
500
3884
L01
ICPC
Neck symptom/complaint
1.5
7.6
274
1905
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.0
7.6
90
452
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.6
7.5
195
1257
K10.3
ICD-10 Finland
Alveolitis of jaws
2.0
7.5
87
432
SPAT1255
SPAT
Intravenous administration of medicine
1.7
7.5
150
903
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.6
7.5
176
1105
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
7.5
193
1243
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
1.8
7.5
119
667
-50
ICPC
Medication/prescr/renewal
2.0
7.5
94
487
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.0
7.4
85
423
L27.2
ICD-10 Finland
Dermatitis due to ingested food
80.3
7.4
8
*
R03AK07
ATC
formoterol and budesonide; inhalant
1.4
7.4
396
2975
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.0
7.4
91
466
B35.6
ICD-10 Finland
Tinea inguinalis [Tinea cruris]
3.0
7.3
40
136
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
1.9
7.3
102
546
TPH07
NOMESCO Finland
Cathetrisation of artery
1.5
7.2
235
1600
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.2
7.2
71
332
XQ899
NOMESCO Finland
Other assessment of skin
7.3
7.2
16
22
J01CA04
ATC
amoxicillin; systemic
1.3
7.2
1999
18573
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.7
7.2
143
860
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.1
7.2
36
116
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
3.0
7.1
39
133
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
2.3
7.1
60
261
D07AC03
ATC
desoximetasone; topical
2.9
7.1
41
143
D05AX03
ATC
calcitriol; topical
3.0
7.1
38
128
XCH00
NOMESCO Finland
Eye pressure measurement
1.9
7.1
91
475
ZXA00
NOMESCO Finland
Right side
1.3
7.1
619
5013
J45
ICD-10 Finland
Asthma
1.6
7.1
192
1256
N06AA09
ATC
amitriptyline; systemic
1.5
7.1
201
1330
L84
ICD-10 Finland
Corns and callosities
2.1
7.1
77
375
L12
ICPC
Hand/finger symptom/complaint
1.4
7.0
285
2034
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.3
7.0
456
3535
L27.1
ICD-10 Finland
Localized skin eruption due to drugs and medicaments
10.0
7.0
13
13
K08.3
ICD-10 Finland
Retained dental root
1.7
7.0
152
938
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
7.0
399
3025
127
Kela drug reimbursment
Transplant complication
2.9
7.0
41
145
M54.4
ICD-10 Finland
Lumbago with sciatica
1.4
7.0
330
2422
R03BA02
ATC
budesonide; inhalant
1.4
7.0
360
2683
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
7.0
505
3977
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
2.7
7.0
45
169
C09CA01
ATC
losartan; oral
1.3
6.9
535
4255
Z2446
NOMESCO Finland
Social worker
1.7
6.9
134
799
B01AC04
ATC
clopidogrel; oral
1.4
6.9
363
2716
SPAT1216
SPAT
Assessment of functional ability
1.4
6.9
335
2476
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
6.9
613
4976
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
6.9
194
1279
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.5
6.9
245
1702
M10.0
ICD-10 Finland
Idiopathic gout
2.0
6.9
80
401
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.7
6.9
147
905
R31
ICD-10 Finland
Unspecified haematuria
1.5
6.8
239
1655
K50.0
ICD-10 Finland
Crohn disease of small intestine
3.0
6.8
37
126
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.5
6.8
219
1491
N18.8
ICD-10 Finland
Other chronic renal failure
2.2
6.8
66
307
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
1.8
6.8
119
690
ZX120
NOMESCO Finland
Intravenous
1.5
6.8
207
1393
R05
ICD-10 Finland
Cough
1.4
6.8
412
3161
WQ020
NOMESCO Finland
NA
40.1
6.8
8
*
M05BA04
ATC
alendronic acid; oral
1.6
6.7
154
965
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.7
484
3808
L82
ICD-10 Finland
Seborrhoeic keratosis
1.4
6.7
325
2397
B07.9
ICD-10 Finland
Verruca simplex
2.2
6.7
66
310
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.4
6.7
330
2439
ZZA00
NOMESCO Finland
Split skin graft
2.2
6.7
65
302
B02.9
ICD-10 Finland
Zoster without complication
1.7
6.7
120
702
J01XC01
ATC
fusidic acid; systemic
3.1
6.7
34
111
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.6
234
1624
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.4
6.6
51
213
N02AA05
ATC
oxycodone; systemic
1.4
6.6
314
2307
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.7
6.6
128
767
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.3
6.6
535
4282
A10BH01
ATC
sitagliptin; oral
1.5
6.6
209
1417
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
6.6
69
331
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.4
6.6
264
1877
RJ411
NOMESCO Finland
NA
5.5
6.6
18
33
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
2.4
6.6
51
214
L01
ICD-10 Finland
Impetigo
3.5
6.6
28
80
WX892
NOMESCO Finland
Monitored bed care
1.6
6.6
168
1082
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.3
6.6
436
3390
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.1
6.5
66
311
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.5
6.5
211
1437
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.6
6.5
150
940
SPAT1285
SPAT
Provision of consultation response
1.7
6.5
118
692
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
3.6
6.5
27
76
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
6.4
141
872
L23.4
ICD-10 Finland
Allergic contact dermatitis due to dyes
70.0
6.4
7
*
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
6.4
634
5210
ZXX01
NOMESCO Finland
Extent of proceudre, 1 unit
4.1
6.4
23
57
S01GX01
ATC
cromoglicic acid; ophthalmic
1.4
6.4
364
2762
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.0
6.4
79
408
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
6.4
970
8387
Z01.2
ICD-10 Finland
Dental examination
1.2
6.3
894
7664
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.6
6.3
43
169
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
6.3
156
998
A10BA02
ATC
metformin; oral
1.3
6.3
641
5284
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.5
6.3
217
1499
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.7
6.3
116
683
L95.8
ICD-10 Finland
Other vasculitis limited to skin
11.0
6.3
11
10
C08CA02
ATC
felodipine; oral
1.5
6.3
207
1418
R06AX18
ATC
acrivastine; oral
2.2
6.3
57
258
I50.9
ICD-10 Finland
Heart failure, unspecified
1.4
6.3
275
1994
N05BA04
ATC
oxazepam; oral
1.3
6.3
504
4029
WXQ24
NOMESCO Finland
UVB/UVA light therapy
+∞
6.2
6
*
6929A
ICD-9 Finland
Contact dermatitis and other eczema, Unspecified cause[ECZEMA NUMMULARE]
+∞
6.2
6
*
L85.1
ICD-10 Finland
Acquired keratosis [keratoderma] palmaris et plantaris
26.7
6.2
8
*
PHT99
NOMESCO Finland
Injection of therapeutic or sclerosing agent into other vein
4.8
6.2
19
40
C09AA05
ATC
ramipril; oral
1.3
6.1
566
4603
NG4AA
NOMESCO Finland
Lower leg X-ray examination
2.1
6.1
64
310
WZA10
NOMESCO Finland
Long statement of health and health related matters
2.9
6.1
33
113
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
1.9
6.1
81
429
R03BA08
ATC
ciclesonide; inhalant
1.6
6.1
157
1015
K03.64
ICD-10 Finland
Dental calculus supragingival
1.3
6.1
565
4602
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
2.2
6.1
56
256
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
1.8
6.1
102
587
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
6.1
2280
21653
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
6.0
512
4120
L09
ICPC
Arm symptom/complaint
1.9
6.0
84
452
UJF30
NOMESCO Finland
Ileoscopy through colon
1.5
6.0
189
1282
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
5.2
6.0
17
33

Mortality – FinRegistry

Association

Association between endpoint L12_DERM_NUMMULAR and mortality.

Females

Parameter HR [95% CI] p-value
L12_DERM_NUMMULAR 1.317 [1.19, 1.46] < 0.001
Birth year 0.994 [0.99, 1.0] 0.135

During the follow-up period (1.1.1998 — 31.12.2019), 1496 out of 8851 females with L12_DERM_NUMMULAR died.

Males

Parameter HR [95% CI] p-value
L12_DERM_NUMMULAR 1.417 [1.29, 1.56] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 2670 out of 11649 males with L12_DERM_NUMMULAR died.

Mortality risk

Mortality risk for people of age

years, who have L12_DERM_NUMMULAR.

N-year risk Females Males
1 0.113% 0.221%
5 0.597% 1.576%
10 1.655% 3.876%
15 3.315% 7.247%
20 5.847% 12.554%

Relationships between endpoints

Index endpoint: L12_DERM_NUMMULAR – Nummular dermatitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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