photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
264 |
4. Check minimum number of eventsNone |
264 |
5. Include endpointsNone |
264 |
6. Filter based on genotype QC (FinnGen only) |
264 |
Control definitions (FinnGen only)
- Control exclude
- L12_RADIATIONRELATEDSKIN
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L57
- Name in latin
- Cutis laxa senilis
Similar endpoints
↥List of similar endpoints to
Cutis laxa senilis
based on the number of shared cases.
Similar with more cases:
- Skin changes due to chronic exposure to nonionizing radiation
- Radiation-related disorders of the skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1483 | 1319 | 155 |
| Only index persons | 1385 | 1244 | 141 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.00 |
| Only index persons | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 55.73 | 54.96 | 62.05 |
| Only index persons | 55.47 | 54.72 | 62.05 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 264 | 241 | 23 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.01 |
| Median age at first event (years) | 55.58 | 54.76 | 64.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 233
- Matched controls
- 2330
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L57.4
ICD-10 Finland
Cutis laxa senilis
+∞
294.8
216
*
QAJ30
NOMESCO Finland
Other facelift
+∞
76.3
69
*
QBJ30
NOMESCO Finland
Correction of abdominal apron
109.5
54.9
58
7
7018B
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ELASTOSIS SENILIS]
+∞
17.9
17
*
9862
FHL
Facial skin shaping surgery (Faclift)
103.0
17.8
19
*
QBJ00
NOMESCO Finland
Liposuction in trunk
34.3
15.1
19
6
L57.0
ICD-10 Finland
Actinic keratosis
7.4
11.9
28
42
H02.3
ICD-10 Finland
Blepharochalasis
4.5
11.9
44
115
J01DB01
ATC
cefalexin; oral
3.6
10.5
209
1647
E66.8
ICD-10 Finland
Other obesity
6.7
10.3
26
43
QAJ99
NOMESCO Finland
Other aesthetic operations on skin of head or neck
104.1
9.5
10
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.3
8.7
131
835
Z41.1
ICD-10 Finland
Other plastic surgery for unacceptable cosmetic appearance
21.0
8.6
12
6
N06AB04
ATC
citalopram; systemic
2.6
8.3
71
339
A02BC05
ATC
esomeprazole; systemic
2.2
7.8
123
783
QAJ15
NOMESCO Finland
Browlift using video-endoscope
82.6
7.5
8
*
Z42.2
ICD-10 Finland
Follow-up care involving plastic surgery of other parts of trunk
+∞
7.3
7
*
J01EA01
ATC
trimethoprim; systemic
2.2
7.1
91
526
M62.0
ICD-10 Finland
Diastasis of muscle
71.7
6.5
7
*
J02AC01
ATC
fluconazole; systemic
2.0
6.3
126
861
QAJ05
NOMESCO Finland
Other correction of loose or redundant skin of head or neck
+∞
6.3
6
*
J01DA01
ATC
[U] cefalexin; systemic
2.0
6.2
160
1206
N05CF01
ATC
zopiclone; oral
2.1
6.2
94
573
E66.01
ICD-10 Finland
Obesity due to excess calories
3.6
6.1
26
78
Mortality – FinRegistry
↥Association
Association between endpoint L12_CUTLAXSEN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_CUTLAXSEN | 0.901 [0.73, 1.12] | 0.345 |
| Birth year | 0.992 [0.98, 1.0] | 0.089 |
During the follow-up period (1.1.1998 — 31.12.2019), 91 out of 879 females with L12_CUTLAXSEN died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_CUTLAXSEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.068% | No data |
| 5 | 0.471% | No data |
| 10 | 1.246% | No data |
| 15 | 2.254% | No data |
| 20 | 3.936% | No data |
Relationships between endpoints
↥Index endpoint: L12_CUTLAXSEN – Cutis laxa senilis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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