This is a non-core endpoint: only basic statistics are computed.

Atrophoderma of Pasini and Pierini

L12_ATROPODERMAPASINI

skin disease: Any deviation from the normal structure or function of the skin or subcutaneous tissue that is manifested by a characteristic set of symptoms and signs.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L90.3 Hospital discharge: ICD-9 — 7019A Cause of death: ICD-10 — L90.3 Cause of death: ICD-9 — 7019A 2 out of 7 registries used, show all original rules.	16
4. Check minimum number of events None	16
5. Include endpoints None	16
6. Filter based on genotype QC (FinnGen only)	16

Control definitions (FinnGen only)

Control exclude: L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L90
Name in latin: Atrophoderma Pasini-Pierini

NAME	L12_ATROPODERMAPASINI
CONTROL_EXCLUDE	L12_OTHERSKINSUBCUTIS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L903
HD_ICD_9	7019A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L903
COD_ICD_9	7019A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Atrophoderma of Pasini and Pierini based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	80	63	17
Only index persons	77	62	15
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	55.41	47.95
Only index persons	53.42	55.03	46.79

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	16	13	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	44.16	44.08	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

114

0.41

1.03

5.6

2.8

—

(3013512) EKG study

2.30

0.90

2.0

3.4

—

(42870588) Differential panel, method unspecified - Blood

2.11

0.80

9.3

6.8

—

(40768797) Stomach Pathology biopsy report

2.33

0.78

1.0

1.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

102

0.44

0.76

6.9

3.6

mm/h

19.7

8.9

—

(3031040) Bacteria [#/volume] in Urine by Automated count

0.49

0.70

4.3

3.6

—

(3003338) MCHC [Mass/volume]

124

0.49

0.66

26.4

11.8

g/l

333.8

332.0

—

124

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

0.00

0.65

0.0

2.9

—

6.7

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

0.00

0.64

0.0

2.8

—

1.6

—

(3019309) Folate [Moles/volume] in Red Blood Cells

0.00

0.64

0.0

1.7

—

1128.1

—

(3021589) Normoblasts [#/volume] in Blood

1.92

0.59

12.3

11.0

e9/l

0.0

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.00

0.44

0.0

1.3

—

29.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.43

0.0

1.5

—

(3002256) Pathology report gross observation

0.00

0.43

0.0

1.2

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.42

0.0

1.4

—

(1761868) Lipid panel - Serum or Plasma

1.37

0.23

2.0

2.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

0.84

0.10

4.3

—

(3044889) 12 lead EKG panel

1.19

0.10

3.6

3.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.2

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.13

0.00

20.4

9.0

e9/l

5.0

3.6

—

(3020779) Urea [Moles/volume] in Serum or Plasma

0.00

0.0

13.2

—

15.8

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.0

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.9

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

37.2

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.7

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.4

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.2

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

2.1

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.1

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

2.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.88

0.00

4.3

3.6

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

0.95

0.00

5.3

2.8

mmol/l

6.9

6.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

2.4

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.2

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

1.14

0.00

14.7

6.0

u/l

80.3

74.1

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

3.2

—

280.2

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

Mortality – FinRegistry

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Association

Association between endpoint L12_ATROPODERMAPASINI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ATROPODERMAPASINI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: L12_ATROPODERMAPASINI – Atrophoderma of Pasini and Pierini

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Atrophoderma of Pasini and Pierini

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints