skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.
Other and unspecified atrophic disorders of skin
DOID EFO Endpoint Browser PheWeb
L12_ATROPHICSKINNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
156 |
4. Check minimum number of eventsNone |
156 |
5. Include endpointsNone |
156 |
6. Filter based on genotype QC (FinnGen only) |
156 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified atrophic disorders of skin
based on the number of shared cases.
Similar with more cases:
- Atrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1119 | 918 | 192 |
| Only index persons | 1014 | 852 | 162 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 60.87 | 47.68 |
| Only index persons | 57.84 | 60.26 | 45.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 156 | 137 | 19 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | 59.36 | 59.92 | 55.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 142
- Matched controls
- 1418
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L90.9
ICD-10 Finland
Atrophic disorder of skin, unspecified
+∞
97.4
82
*
L90.8
ICD-10 Finland
Other atrophic disorders of skin
+∞
53.6
48
*
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
51.5
34.8
41
11
D07AD01
ATC
clobetasol; topical
8.8
26.6
67
130
ULA02
NOMESCO Finland
Kolposcopy
9.0
20.5
47
74
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
29.9
19.0
25
10
7018X
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ATROPHIA CUTIS ALIA DEFINITA]
+∞
12.7
12
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.2
9.7
26
49
J01CA04
ATC
amoxicillin; systemic
3.7
7.3
126
963
LEB00
NOMESCO Finland
Biopsy of vagina
9.4
6.7
13
15
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.4
6.7
33
115
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
+∞
6.3
6
*
R03BA01
ATC
beclometasone; inhalant
3.2
6.2
34
126
D07AC01
ATC
betamethasone; topical
2.6
6.2
61
323
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(40768443) Skin Pathology biopsy report
18
48
4.11
6.29
1.3
1.3
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
83
548
2.10
4.92
2.7
2.0
—
—
—
0
0
(3037522) Nuclear Ab [Titer] in Serum
33
155
2.43
4.46
1.3
1.3
titre
365.7
582.7
—
7
37
(40760892) CBC W Ordered Manual Differential panel - Blood
50
292
2.05
3.96
4.6
4.5
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
58
360
1.97
3.87
4.1
4.1
estimate
0.1
0.0
0.47
13
123
(3026389) Candida sp identified in Specimen by Organism specific culture
9
18
5.24
3.42
1.4
1.2
—
—
—
0
0
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
14
49
3.04
3.28
1.7
1.3
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
31
167
2.07
2.99
1.6
1.4
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
27
141
2.11
2.82
2.0
1.5
—
—
—
0
0
(3016921) Smith extractable nuclear Ab [Units/volume] in Serum
10
32
3.27
2.70
1.2
1.3
—
2.8
—
0
7
(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum
10
33
3.17
2.57
1.2
1.3
—
2.5
—
0
9
(3021601) Nitrite [Presence] in Urine by Test strip
88
681
1.67
2.53
5.6
5.0
estimate
0.1
0.0
0.48
16
123
(3045424) Erythrocytes [Presence] in Urine
7
16
4.53
2.50
1.9
1.3
—
—
—
0
0
(3024561) Albumin [Mass/volume] in Serum or Plasma
76
573
1.64
2.37
5.3
4.0
g/l
36.4
35.7
0.61
71
539
(3035350) Ketones [Presence] in Urine by Test strip
87
679
1.64
2.36
4.7
3.7
estimate
0.0
0.0
0.00
15
121
(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay
9
28
3.35
2.35
1.4
1.2
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
84
652
1.62
2.31
6.9
5.1
e9/l
1.9
2.0
0.43
74
578
(3000850) Epithelial cells [#/volume] in Urine
44
289
1.73
2.30
3.3
2.5
e6/l
5.7
5.8
0.03
38
259
(3001604) Monocytes [#/volume] in Blood
82
637
1.61
2.22
6.9
5.1
e9/l
0.6
0.6
0.36
68
552
(3009261) Glucose [Presence] in Urine by Test strip
87
687
1.60
2.19
4.8
3.8
estimate
0.0
0.0
0.00
15
115
(3026008) Bacteria identified in Urine by Culture
67
498
1.61
2.17
3.6
3.1
—
—
—
0
0
(3015736) pH of Urine
71
541
1.57
2.04
4.6
3.5
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
118
1013
1.68
2.03
5.5
4.2
mm/h
13.2
12.6
0.15
113
924
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
70
532
1.57
2.03
4.6
3.8
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
111
939
1.63
2.02
4.9
4.4
—
—
—
0
0
(4034850)
11
45
2.55
1.98
12.7
14.5
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
81
641
1.55
1.94
7.0
5.1
e9/l
0.0
0.0
0.05
69
556
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
122
1062
1.68
1.93
5.4
4.1
pmol/l
15.1
15.0
0.18
116
961
(3019150) Specific gravity of Urine by Refractometry
45
313
1.62
1.87
5.9
4.0
kg/l
1.0
1.0
—
5
44
(3042936) Bacteria identified in Isolate by Culture
29
179
1.76
1.87
2.3
1.8
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
42
291
1.61
1.77
1.8
1.7
mg/l
1.2
1.2
0.04
36
234
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
138
1255
1.86
1.71
6.3
5.0
mu/l
1.7
1.8
0.73
129
1150
(40761536) Microorganisms panel - Urine sediment
20
113
1.88
1.70
2.9
3.5
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
38
260
1.61
1.68
1.5
1.7
nmol/l
1137.1
1232.3
0.33
29
193
(3013115) Eosinophils [#/volume] in Blood
82
665
1.49
1.67
7.1
5.3
e9/l
0.2
0.2
0.28
72
587
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
63
484
1.51
1.67
4.4
3.2
—
—
—
0
0
(4062490)
5
14
3.65
1.63
1.0
1.3
—
—
—
0
0
(4010399)
17
93
1.93
1.59
1.6
1.4
—
—
—
0
0
(3044889) 12 lead EKG panel
106
914
1.50
1.54
4.5
3.8
—
—
—
0
0
(3021788) Differential panel - Synovial fluid
5
15
3.41
1.53
1.0
1.6
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
18
102
1.86
1.52
1.1
1.3
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
21
127
1.76
1.45
2.6
3.5
—
—
—
0
0
(3045414) Leukocytes [Presence] in Urine
12
60
2.08
1.42
2.1
2.2
—
—
—
0
0
(3048689) Calprotectin [Mass/mass] in Stool
26
169
1.65
1.40
3.0
1.9
ug/g
312.7
100.8
0.41
18
125
(42870588) Differential panel, method unspecified - Blood
53
406
1.46
1.39
7.3
4.9
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
90
761
1.43
1.38
9.7
9.3
e9/l
4.6
4.1
0.86
77
662
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
38
274
1.51
1.33
1.9
1.4
—
—
—
0
0
(40761535) Cells panel - Urine sediment
20
123
1.72
1.32
4.5
3.5
—
—
—
0
0
(3050238) Crystals [Presence] in Synovial fluid by Light microscopy
6
24
2.56
1.31
1.3
1.1
—
—
—
0
0
(3002030) Lymphocytes/100 leukocytes in Blood
75
618
1.41
1.31
6.5
5.3
%
28.4
28.4
0.00
69
571
(3018010) Neutrophils/100 leukocytes in Blood
74
609
1.41
1.30
6.4
5.1
%
58.3
57.2
0.32
69
570
(3024891) Influenza virus A+B Ag [Presence] in Specimen
8
35
2.35
1.29
1.1
1.3
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
42
312
1.47
1.27
4.5
3.9
—
—
—
0
0
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
139
1291
1.70
1.26
4.8
4.6
mmol/l
5.8
5.9
0.55
131
1178
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
18
109
1.74
1.25
1.5
3.3
ml/min/173m2
56.3
60.7
—
6
52
(3018095) Leukocytes [#/volume] in Urine
61
488
1.41
1.25
4.5
3.8
e6/l
209.0
61.3
0.55
47
342
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
142
1327
1.78
1.24
18.8
13.7
mg/l
23.1
22.7
0.05
115
1039
(3021589) Normoblasts [#/volume] in Blood
71
586
1.39
1.20
10.2
8.7
e9/l
0.0
0.0
0.13
59
487
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
8
38
2.16
1.20
1.3
1.4
—
—
—
0
0
(3002582) Erythrocytes [#/volume] in Urine
53
416
1.42
1.20
4.5
3.3
e6/l
230.0
200.8
0.04
41
317
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
32
228
1.51
1.18
3.1
2.9
e6/l
0.7
1.2
1.23
23
123
(3022096) Basophils/100 leukocytes in Blood
70
578
1.38
1.18
6.7
5.1
%
0.8
0.7
0.86
65
535
(3025130) Human papilloma virus identified in Specimen
5
20
2.55
1.16
1.8
2.2
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
63
514
1.38
1.13
4.9
3.8
ng/l
18.6
39.5
1.77
44
368
(3006504) Eosinophils/100 leukocytes in Blood
72
601
1.37
1.12
6.8
5.1
%
3.0
2.7
0.67
65
558
(3030467) Casts [#/volume] in Urine by Automated count
49
386
1.39
1.08
4.3
3.2
e6/l
0.2
0.5
1.51
38
284
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
132
1223
1.52
1.06
3.8
3.9
mmol/l
1.2
1.2
0.30
122
1117
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
80
686
1.34
1.02
8.2
5.8
mmol/l
1.2
1.2
0.25
63
585
(3025941) Bacteria identified in Stool by Culture
14
84
1.73
1.01
1.6
1.1
—
—
—
0
0
(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum
13
77
1.75
0.98
1.2
1.3
—
52.5
—
0
7
(3002256) Pathology report gross observation
23
159
1.52
0.98
1.5
1.2
—
—
—
0
0
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
95
839
1.34
0.98
3.0
2.9
u/l
42.8
43.4
0.02
90
767
(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma
31
229
1.44
0.97
1.2
1.3
iu/ml
20.4
35.3
—
5
72
(40768797) Stomach Pathology biopsy report
27
195
1.47
0.94
1.3
1.2
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
139
1312
1.55
0.90
5.1
5.0
mmol/l
2.8
2.8
0.12
134
1201
(36304419) Bacteria [Presence] in Urine
47
378
1.35
0.90
3.8
3.1
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
136
1279
1.49
0.89
4.5
4.4
mmol/l
4.8
4.8
0.03
130
1180
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
6
31
1.97
0.85
1.2
1.4
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
6
33
1.85
0.80
1.0
1.4
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
71
617
1.28
0.76
4.5
3.8
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
5
24
2.12
0.75
2.6
2.6
%
57.6
60.1
—
5
24
(3000475) Leukocytes [#/volume] in Synovial fluid
5
24
2.12
0.75
1.8
1.4
e6/l
5605.2
4144.2
—
5
18
(3030905) Polymorphonuclear cells [#/volume] in Blood
5
24
2.12
0.75
2.6
2.3
e9/l
4.0
4.8
—
5
24
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
132
1245
1.39
0.74
16.9
12.9
ml/min/173m2
79.7
78.8
0.19
117
1003
(3027273) Bicarbonate [Moles/volume] in Venous blood
11
68
1.66
0.74
11.1
2.6
mmol/l
24.0
25.0
0.53
11
68
(3023368) Bacteria identified in Blood by Culture
42
343
1.31
0.72
4.6
3.9
—
—
—
0
0
(3027945) Reticulocytes/100 erythrocytes in Blood
10
156
0.62
0.72
9.4
3.3
%
1.8
1.7
—
10
141
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
5
26
1.95
0.71
1.6
1.7
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
5
26
1.95
0.71
1.6
1.7
—
—
—
0
0
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
36
289
1.32
0.69
1.7
1.8
pmol/l
414.4
473.3
0.68
26
241
(3018418) pH of Serum or Plasma
52
441
1.27
0.67
3.5
3.9
ph
7.4
7.4
0.20
13
75
(40758558) Short blood count panel - Blood
41
338
1.29
0.66
4.3
7.6
—
—
—
0
0
(3015235) Bicarbonate [Moles/volume] in Capillary blood
5
29
1.75
0.64
1.6
2.2
mmol/l
24.0
25.4
—
5
23
(3026782) Osmolality of Urine
33
265
1.31
0.64
2.6
2.7
mosm/kgh2o
513.8
518.6
0.04
28
232
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
5
30
1.69
0.62
2.0
1.5
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
11
73
1.55
0.58
3.2
2.5
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
133
1268
1.33
0.58
4.4
4.4
mmol/l
1.6
1.6
0.11
128
1164
(3022217) INR in Platelet poor plasma by Coagulation assay
21
160
1.36
0.57
32.0
21.2
inr
1.2
1.1
—
5
27
(3002032) Base excess in Venous blood by calculation
16
116
1.42
0.57
9.0
3.1
mmol/l
1.4
2.5
0.73
11
94
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
9
60
1.53
0.55
1.3
1.6
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
33
271
1.28
0.55
1.1
1.5
g/l
2.9
2.3
0.65
26
155
(3041096) Erythrocytes [Presence] in Urine by Automated
45
384
1.24
0.54
4.0
3.2
—
—
—
0
0
(3012544) pH of Venous blood
17
126
1.39
0.54
8.6
3.2
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
48
413
1.23
0.54
3.3
2.2
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
10
66
1.55
0.54
3.5
6.8
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
6
39
1.56
0.53
1.2
1.1
—
—
—
0
0
(3009343) pH of Capillary blood
9
63
1.45
0.53
1.6
3.1
—
7.4
—
0
8
(4035726)
16
118
1.40
0.52
1.6
1.3
—
—
—
0
0
(3003327) Ova and parasites identified in Stool by Light microscopy
6
40
1.52
0.52
1.7
1.5
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
36
301
1.25
0.52
1.1
1.2
u/ml
0.8
0.7
0.31
15
74
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
87
798
1.20
0.51
3.7
3.0
—
—
—
0
0
(3028026) IgM [Mass/volume] in Serum or Plasma
12
85
1.45
0.48
1.5
1.7
g/l
1.5
1.6
0.11
12
76
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
7
47
1.51
0.48
3.0
1.6
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
26
212
1.27
0.46
3.8
3.2
e6/l
2.0
4.0
1.30
17
109
(3013512) EKG study
45
391
1.21
0.46
4.9
3.9
—
—
—
0
0
(3000991) Gas panel - Venous blood
13
96
1.39
0.43
6.4
6.2
—
—
—
0
0
(3019225) pH of Specimen
16
123
1.34
0.42
11.4
4.1
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
30
252
1.24
0.42
1.6
1.6
—
—
—
0
0
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
15
0.00
0.41
0.0
2.2
—
4.8
—
0
15
(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
(3023410) Appearance of Cerebral spinal fluid
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
31
262
1.23
0.41
3.9
3.6
ng/l
140.6
150.0
0.03
23
200
(3027544) Mycobacterium sp identified in Sputum by Organism specific culture
0
17
0.00
0.41
0.0
3.8
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
(3016502) Oxygen saturation in Arterial blood
17
133
1.31
0.40
3.2
5.8
%
95.6
96.2
0.34
17
128
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose
0
18
0.00
0.40
0.0
1.7
—
7.0
—
0
12
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
14
180
0.76
0.39
1.4
1.5
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
12
158
0.74
0.39
3.9
2.3
umol/l
13.5
7.7
0.28
12
135
(3009508) Creatinine [Moles/volume] in Urine
44
390
1.18
0.36
3.8
2.9
mmol/l
5.6
6.8
2.04
34
324
(1761482) Bacteria [#/volume] in Urine by Culture
6
42
1.45
0.36
4.7
4.2
—
—
—
0
0
(3047181) Lactate [Moles/volume] in Blood
6
42
1.45
0.36
3.5
5.4
mmol/l
1.6
1.1
—
6
36
(3032080) INR in Blood by Coagulation assay
57
517
1.16
0.35
8.2
9.7
inr
1.1
1.3
1.32
18
154
(3049717) Cytology report of Urine Cyto stain
6
43
1.41
0.35
4.0
2.6
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
19
155
1.26
0.34
12.7
7.6
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
44
394
1.16
0.32
5.0
3.8
mg/mmol
16.3
9.0
0.29
19
242
(3019060) Gas panel - Arterial blood
7
96
0.72
0.32
4.7
3.9
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
7
53
1.34
0.31
3.0
1.6
—
—
—
0
0
(3000492) Spirometry study
13
102
1.30
0.31
1.5
1.6
—
—
—
0
0
(3008152) Bicarbonate [Moles/volume] in Arterial blood
11
84
1.33
0.31
4.9
5.9
mmol/l
26.2
25.2
0.28
11
78
(3020779) Urea [Moles/volume] in Serum or Plasma
11
84
1.33
0.31
13.7
4.8
mmol/l
11.8
9.0
0.45
11
77
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
26
223
1.20
0.31
1.2
1.3
u/ml
1.2
8.5
1.77
11
87
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
25
214
1.20
0.30
2.4
1.8
—
—
—
0
0
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
7
56
1.26
0.30
1.3
2.1
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
10
129
0.76
0.29
2.2
2.0
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
41
368
1.15
0.29
4.1
3.0
mg/l
1846.3
235.6
0.42
21
228
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
9
120
0.73
0.28
2.2
1.9
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
15
122
1.25
0.28
3.4
6.0
g/l
125.5
119.3
0.65
15
117
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
8
64
1.26
0.28
1.6
3.1
kpa
4.7
5.1
—
8
56
(3022145) Colonoscopy Study observation
18
150
1.23
0.28
1.6
1.2
—
—
—
0
0
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
10
77
1.32
0.27
1.5
1.8
—
—
—
0
0
(3005719) IgG [Mass/volume] in Serum or Plasma
13
105
1.26
0.25
1.3
2.9
g/l
10.2
9.9
0.10
13
94
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
12
96
1.27
0.25
1.3
1.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
7
93
0.74
0.23
1.0
1.2
—
—
—
0
0
(3052851) Hemolysis interference index of Serum or Plasma
5
39
1.29
0.23
2.0
2.7
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
10
79
1.28
0.23
4.2
3.4
—
—
—
0
0
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
60
561
1.11
0.23
2.1
2.0
pmol/l
90.2
96.8
0.51
30
257
(40761511) CBC panel - Blood by Automated count
140
1372
1.20
0.23
17.2
12.8
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
65
611
1.11
0.22
2.9
2.3
nmol/l
85.3
79.2
1.02
57
535
(3047189) Immunofixation for 24 hour Urine
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
0
11
0.00
0.21
0.0
1.6
—
37.9
—
0
11
(3000012) Reticulocyte production index
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
(3051593) INR in Capillary blood by Coagulation assay
0
10
0.00
0.21
0.0
16.4
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
(3016018) Differential panel - Cerebral spinal fluid
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(40768441) Liver Pathology biopsy report
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
1.3
—
14.5
—
0
13
(3044941) Cell count panel - Synovial fluid
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood
0
14
0.00
0.20
0.0
1.8
—
—
—
0
0
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
6
50
1.21
0.20
1.8
1.7
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
6
51
1.18
0.19
1.3
1.3
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
18
156
1.17
0.19
2.2
3.7
ug/l
2.4
9.1
1.51
13
127
(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction
12
143
0.83
0.19
3.7
5.4
u/l
224.3
311.7
0.82
12
128
(3007930) Methemoglobin/Hemoglobin.total in Blood
6
52
1.16
0.19
5.8
4.5
%
1.0
0.9
—
6
47
(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood
6
52
1.16
0.19
5.8
4.5
%
1.6
1.7
—
6
47
(1761868) Lipid panel - Serum or Plasma
47
438
1.10
0.18
3.2
3.0
—
—
—
0
0
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
5
65
0.76
0.17
4.0
2.9
g/l
0.8
1.4
—
5
57
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
8
70
1.15
0.16
3.8
4.4
mmol/l
25.0
25.3
—
8
70
(3013139) Helicobacter pylori Ag [Presence] in Stool
11
92
1.21
0.16
1.2
1.2
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
18
203
0.87
0.16
2.3
1.7
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
6
76
0.78
0.16
4.8
6.5
%
0.7
0.7
—
6
76
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
6
77
0.77
0.16
4.8
6.4
%
1.0
1.3
—
6
77
(3004716) Salmonella sp identified in Stool by Organism specific culture
10
83
1.22
0.16
2.2
1.4
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
9
78
1.16
0.15
1.8
1.6
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
114
1167
0.91
0.15
19.0
15.3
%
40.3
39.3
1.38
74
830
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
9
81
1.12
0.15
1.0
1.0
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
17
150
1.15
0.15
2.4
1.8
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
11
126
0.86
0.11
1.2
1.3
—
—
—
0
0
(3021960) Folate [Moles/volume] in Serum or Plasma
32
341
0.92
0.11
1.6
1.6
nmol/l
26.3
22.9
0.45
27
280
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
13
146
0.88
0.11
1.2
1.6
—
—
—
0
0
(3022313) Gas panel - Capillary blood
5
43
1.17
0.10
1.4
3.4
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
6
53
1.14
0.09
1.5
1.8
—
—
—
0
0
(3007628) Bicarbonate [Moles/volume] standard in Venous blood
6
54
1.12
0.09
3.8
3.5
mmol/l
23.8
24.8
—
6
47
(3018677) aPTT in Platelet poor plasma by Coagulation assay
19
176
1.09
0.08
2.3
1.8
s
28.6
29.0
0.18
19
168
(3004588) Protein electrophoresis panel - Serum or Plasma
11
98
1.13
0.08
1.2
3.0
—
—
—
0
0
(3014218) Bicarbonate [Moles/volume] standard in Arterial blood
6
73
0.81
0.08
3.5
6.4
mmol/l
24.1
24.7
—
6
67
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
9
102
0.88
0.06
2.0
1.6
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
33
316
1.06
0.06
3.3
2.1
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
16
150
1.07
0.04
2.1
1.8
—
—
—
0
0
(3025839) Triglyceride [Moles/volume] in Serum or Plasma
37
363
1.03
0.01
1.7
1.6
mmol/l
1.2
1.3
0.22
29
305
(21494755) Public health laboratory ask at order entry panel
10
104
0.96
0.00
1.2
1.3
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
11
111
0.99
0.00
2.0
1.7
—
—
—
0
0
(3003694) ABO and Rh group [Type] in Blood
36
362
0.99
0.00
1.4
1.4
—
—
—
0
0
(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma
34
338
1.01
0.00
3.4
2.1
mg/l
3.2
3.3
0.18
27
291
(3022621) pH of Urine by Test strip
10
98
1.02
0.00
3.6
3.2
—
—
—
0
0
(3027801) Oxygen [Partial pressure] in Arterial blood
16
155
1.04
0.00
3.7
5.4
kpa
10.2
12.4
2.41
16
148
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
16
155
1.04
0.00
3.7
5.5
kpa
5.1
5.2
0.24
16
148
(3020961) Endomysium IgA Ab [Titer] in Serum
6
63
0.95
0.00
1.0
1.0
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
8
87
0.92
0.00
1.9
1.3
—
—
—
0
0
(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
2.8
—
139.6
—
0
5
(3017704) Immunofixation for Urine
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
(3050898) Methicillin resistant Staphylococcus aureus [Presence] in Genital specimen by Organism specific culture
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(3051651) Icteric interference index of Serum or Plasma
0
8
0.00
0.00
0.0
2.9
—
—
—
0
0
(3015183) Erythrocyte sedimentation rate
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3045716) Anion gap in Serum or Plasma
0
5
0.00
0.00
0.0
3.2
—
9.2
—
0
5
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
7
74
0.94
0.00
1.7
1.4
—
—
—
0
0
(3023323) Follitropin [Units/volume] in Serum or Plasma
5
50
1.00
0.00
1.8
1.3
iu/l
15.5
29.2
—
5
43
(3027231) Wheat IgE Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008733) Herpes simplex virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum
0
8
0.00
0.00
0.0
1.4
—
30.6
—
0
8
(40768800) Prostate Pathology biopsy report
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3033386) Bacteria [Presence] in Cerebral spinal fluid by Light microscopy
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3029536) Hepatitis C virus RNA [Units/volume] (viral load) in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum
0
6
0.00
0.00
0.0
1.8
—
73.6
—
0
6
(3025018) Bordetella pertussis Ab [Titer] in Serum
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3001964) Herpes simplex virus Ag [Presence] in Specimen
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(4027681)
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
0
9
0.00
0.00
0.0
2.3
—
9.8
—
0
9
(40757494) Bilirubin.total [Moles/volume] in Blood
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3010838) Calcium [Moles/time] in 24 hour Urine
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(3024263) Appearance of Synovial fluid
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(40765096) Chromosome analysis panel by Banding
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma
6
66
0.91
0.00
1.5
3.4
u/ml
12.5
2150.7
—
6
56
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
1.6
—
0.8
—
0
7
(4211845)
0
6
0.00
0.00
0.0
6.8
—
—
—
0
0
(3020891) Body temperature
5
54
0.92
0.00
4.4
3.9
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3002619) Bacteria identified in Specimen by Culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3006462) Nitrate [Presence] in Urine
0
5
0.00
0.00
0.0
8.0
—
—
—
0
0
(3037692) Legionella sp identified in Specimen by Organism specific culture
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
(3009550) Parvovirus B19 IgG Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
80
1.00
0.00
1.0
1.3
—
—
—
0
0
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline
0
6
0.00
0.00
0.0
1.2
—
5.5
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint L12_ATROPHICSKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ATROPHICSKINNAS | 1.125 [0.9, 1.41] | 0.311 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 703 females with L12_ATROPHICSKINNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_ATROPHICSKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | No data |
| 5 | 0.588% | No data |
| 10 | 1.835% | No data |
| 15 | 3.623% | No data |
| 20 | 6.507% | No data |
Relationships between endpoints
↥Index endpoint: L12_ATROPHICSKINNAS – Other and unspecified atrophic disorders of skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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