skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.
Other and unspecified atrophic disorders of skin
DOID EFO Endpoint Browser PheWeb
L12_ATROPHICSKINNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
156 |
4. Check minimum number of eventsNone |
156 |
5. Include endpointsNone |
156 |
6. Filter based on genotype QC (FinnGen only) |
156 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified atrophic disorders of skin
based on the number of shared cases.
Similar with more cases:
- Atrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1119 | 918 | 192 |
| Only index persons | 1014 | 852 | 162 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 60.87 | 47.68 |
| Only index persons | 57.84 | 60.26 | 45.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 156 | 137 | 19 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.01 |
| Median age at first event (years) | 59.36 | 59.92 | 55.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 142
- Matched controls
- 1418
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L90.9
ICD-10 Finland
Atrophic disorder of skin, unspecified
+∞
97.4
82
*
L90.8
ICD-10 Finland
Other atrophic disorders of skin
+∞
53.6
48
*
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
51.5
34.8
41
11
D07AD01
ATC
clobetasol; topical
8.8
26.6
67
130
ULA02
NOMESCO Finland
Kolposcopy
9.0
20.5
47
74
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
29.9
19.0
25
10
7018X
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ATROPHIA CUTIS ALIA DEFINITA]
+∞
12.7
12
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.2
9.7
26
49
J01CA04
ATC
amoxicillin; systemic
3.7
7.3
126
963
LEB00
NOMESCO Finland
Biopsy of vagina
9.4
6.7
13
15
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.4
6.7
33
115
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
+∞
6.3
6
*
R03BA01
ATC
beclometasone; inhalant
3.2
6.2
34
126
D07AC01
ATC
betamethasone; topical
2.6
6.2
61
323
Mortality – FinRegistry
↥Association
Association between endpoint L12_ATROPHICSKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ATROPHICSKINNAS | 1.125 [0.9, 1.41] | 0.311 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 703 females with L12_ATROPHICSKINNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_ATROPHICSKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | No data |
| 5 | 0.588% | No data |
| 10 | 1.835% | No data |
| 15 | 3.623% | No data |
| 20 | 6.507% | No data |
Relationships between endpoints
↥Index endpoint: L12_ATROPHICSKINNAS – Other and unspecified atrophic disorders of skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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