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Atopic dermatitis

DOID EFO PheWeb

L12_ATOPIC

atopic eczema: A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

429209

1. Apply sex-specific rule

None

429209

2. Check conditions

None

429209

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L20
  • Hospital discharge: ICD-9 — 6918
  • Hospital discharge: ICD-8 — 691
  • Hospital discharge: excluded ICD-9 — 6918X
  • Cause of death: ICD-10 — L20
  • Cause of death: ICD-9 — 6918
  • Cause of death: ICD-8 — 691
  • Cause of death: excluded ICD-9 — 6918X
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — L20

3 out of 7 registries used, show all original rules.

15728

4. Check minimum number of events

None

15728

5. Include endpoints

None

15728

6. Filter based on genotype QC (FinnGen only)

15208

Control definitions (FinnGen only)

Control exclude L12_DERMATITISECZEMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L20-L30
Name in latin Dermatitis atopica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 240516 129321 110779
Only index persons 198606 111198 87408
Unadjusted prevalence (%)
Whole population 3.42 3.70 3.10
Only index persons 3.76 4.09 3.34
Median age at first event (years)
Whole population 11.53 16.93 5.13
Only index persons 14.96 19.91 8.65

-FinnGen-

Key figures

All Female Male
Number of individuals 15208 10846 4362
Unadjusted prevalence (%) 4.05 4.71 2.40
Median age at first event (years) 26.98 28.02 24.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Relationships between endpoints

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Index endpoint: L12_ATOPIC – Atopic dermatitis

GWS hits: 67

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