Apocrine sweat disorders, other sweat gland disorders

L12_APOCRINESWEAT

sweat gland disease: disorders or sweat glands

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L75 Hospital discharge: ICD-9 — 7058B\|7058X\|7059 Hospital discharge: ICD-8 — 705 Hospital discharge: excluded ICD-8 — 705[0-1] Cause of death: ICD-10 — L75 Cause of death: ICD-9 — 7058B\|7058X\|7059 Cause of death: ICD-8 — 705 Cause of death: excluded ICD-8 — 705[0-1] 2 out of 7 registries used, show all original rules.	148
4. Check minimum number of events None	148
5. Include endpoints None	148
6. Filter based on genotype QC (FinnGen only)	148

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L60-L75
Name in latin: Morbositates glandularum sudoriferarum apocrinarum

NAME	L12_APOCRINESWEAT
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L75
HD_ICD_9	7058B\|7058X\|7059
HD_ICD_8	705
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL	705[0-1]
COD_MAINONLY
COD_ICD_10	L75
COD_ICD_9	7058B\|7058X\|7059
COD_ICD_8	705
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL	705[0-1]
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Apocrine sweat disorders, other sweat gland disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1190	653	525
Only index persons	958	562	396
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	34.11	34.20	33.83
Only index persons	32.47	32.89	31.89

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	148	99	49
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	33.90	33.41	34.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
133: Matched controls
1328

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

70591

ICD-8 Finland

Diseases of sweat glands, Hidrosadenitis

+∞

45.5

L73.2

ICD-10 Finland

Hidradenitis suppurativa

+∞

25.9

70590

ICD-8 Finland

Diseases of sweat glands, Hidrosis

+∞

19.2

L75.9

ICD-10 Finland

Apocrine sweat disorder, unspecified

+∞

14.9

L75.8

ICD-10 Finland

Other apocrine sweat disorders

+∞

13.8

7058X

ICD-9 Finland

Disorders of sweat glands, Other specified disorders of sweat glands[MUU HIKIRAUHASSAIRAUS]

+∞

12.7

L02.2

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of trunk

10.5

8.6

QBE05

NOMESCO Finland

Excision of sweat glands or sweat gland bearing skin from trunk

+∞

8.4

7058C

ICD-9 Finland

Disorders of sweat glands, Other specified disorders of sweat glands[HIDRADENITIS SUPPURATIVA]

+∞

8.4

70599

ICD-8 Finland

Diseases of sweat glands, Other

+∞

8.4

J01FF01

ATC

clindamycin; systemic

3.0

7.0

218

S10

ICPC

Boil/carbuncle

6.3

6.4

9752

FHL

Surgical treatment of hyperhidrosis

+∞

6.3

L02

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle

9.3

6.2

Mortality – FinRegistry

↥

Association

Association between endpoint L12_APOCRINESWEAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_APOCRINESWEAT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: L12_APOCRINESWEAT – Apocrine sweat disorders, other sweat gland disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Apocrine sweat disorders, other sweat gland disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints