androgenetic alopecia:
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
296 |
4. Check minimum number of eventsNone |
296 |
5. Include endpointsNone |
296 |
6. Filter based on genotype QC (FinnGen only) |
296 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L60-L75
- Name in latin
- Alopecia androgenica
Similar endpoints
↥List of similar endpoints to
Androgenic alopecia
based on the number of shared cases.
Similar with more cases:
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1684 | 1684 | - |
| Only index persons | 1625 | 1625 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | - |
| Only index persons | 0.06 | 0.06 | - |
| Median age at first event (years) | |||
| Whole population | - | 43.96 | - |
| Only index persons | - | 43.20 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 296 | 296 | - |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | - |
| Median age at first event (years) | 50.59 | 50.59 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 260
- Matched controls
- 2599
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L64.9
ICD-10 Finland
Androgenic alopecia, unspecified
4439.5
197.4
165
*
L64.8
ICD-10 Finland
Other androgenic alopecia
+∞
103.2
92
*
C03DA01
ATC
spironolactone; oral
12.2
40.3
78
88
L65.9
ICD-10 Finland
Nonscarring hair loss, unspecified
+∞
25.4
24
*
L63.9
ICD-10 Finland
Alopecia areata, unspecified
143.8
25.1
26
*
L63.8
ICD-10 Finland
Other alopecia areata
204.1
18.8
19
*
D07AC01
ATC
betamethasone; topical
3.3
17.9
134
640
D07AC13
ATC
mometasone; topical
3.2
16.6
116
520
L64.0
ICD-10 Finland
Drug-induced androgenic alopecia
+∞
12.6
12
*
L63.0
ICD-10 Finland
Alopecia (capitis) totalis
+∞
12.6
12
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.8
12.0
55
173
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
9.8
96
490
D07AD01
ATC
clobetasol; topical
2.9
9.3
63
261
S23
ICPC
Hair loss/baldness
19.5
9.0
13
7
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
46.4
7.8
9
*
L68.0
ICD-10 Finland
Hirsutism
46.4
7.8
9
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
7.5
35
111
L65.8
ICD-10 Finland
Other specified nonscarring hair loss
82.3
7.5
8
*
L64
ICD-10 Finland
Androgenic alopecia
82.3
7.5
8
*
H03AA01
ATC
levothyroxine sodium; systemic
2.1
6.9
91
523
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
6.8
116
741
XQ802
NOMESCO Finland
Epicutan test
4.5
6.6
22
52
B07.9
ICD-10 Finland
Verruca simplex
5.2
6.5
19
39
E0000UV
ATC
NA
2.0
6.5
122
806
G03HA01
ATC
cyproterone; systemic
71.5
6.5
7
*
L21.0
ICD-10 Finland
Seborrhoea capitis
18.6
6.3
9
5
SPAT1260
SPAT
Consultation of another employee
2.4
6.1
57
277
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
6.1
124
836
K03.00
ICD-10 Finland
Approximal wear
4.3
6.1
21
52
Mortality – FinRegistry
↥Association
Association between endpoint L12_ALOPECANDRO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ALOPECANDRO | 1.266 [1.01, 1.59] | 0.043 |
| Birth year | 0.997 [0.99, 1.01] | 0.532 |
During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 1383 females with L12_ALOPECANDRO died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_ALOPECANDRO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | No data |
| 5 | 0.796% | No data |
| 10 | 1.985% | No data |
| 15 | 3.694% | No data |
| 20 | 6.598% | No data |
Relationships between endpoints
↥Index endpoint: L12_ALOPECANDRO – Androgenic alopecia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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