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Ulcerative colitis (strict definition, all Crohn cases excluded)

K11_UC_NOCD

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • K11_KELAIBD
  • and not K11_CROHN
7014

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K51
  • Hospital discharge: ICD-9 556
  • Hospital discharge: ICD-8 5631|569
  • Hospital discharge: excluded ICD-9 5564A
  • Cause of death: ICD-10 K51
  • Cause of death: ICD-9 556
  • Cause of death: ICD-8 5631|569
  • Cause of death: excluded ICD-9 5564A

2 out of 7 registries used, show all original rules.

6543

4. Check minimum number of events

None

6543

5. Include endpoints

None

6543

6. Filter based on genotype QC (FinnGen only)

6543

Control definitions (FinnGen only)

Control conditions
not K11_KELAIBD

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
K50-K52
Name in latin
Colitis ulcerosa

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 6543 3278 3265
Unadjusted period prevalence (%) 1.28 1.12 1.44
Median age at first event (years) 39.81 36.64 42.99

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
5841
Matched controls
58407
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L01BB02
ATC
mercaptopurine; oral
132.9
323.0
629
53
K51.5
ICD-10 Finland
Left sided colitis
1149.6
323.0
3652
85
A07EA02
ATC
hydrocortisone; rectal
231.2
323.0
2224
155
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
323.0
5841
*
K51.8
ICD-10 Finland
Other ulcerative colitis
409.9
323.0
1374
44
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
11.3
323.0
1496
1734
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.9
323.0
2339
8504
K51
ICD-10 Finland
Ulcerative colitis
450.6
323.0
1017
27
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
741.3
323.0
718
11
A07EA06
ATC
budesonide; oral, local oral
113.0
323.0
1930
254
UJF30
NOMESCO Finland
Ileoscopy through colon
18.0
323.0
2291
2019
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
183.1
323.0
377
22
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
1673.9
323.0
2503
26
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
524.0
323.0
3407
158
UJF32
NOMESCO Finland
Coloscopy
19.4
323.0
4218
6910
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
10.7
323.0
674
706
A07EC02
ATC
mesalazine; oral, rectal
2972.3
323.0
5554
366
A07EC01
ATC
sulfasalazine; oral, rectal
8.9
323.0
1405
2008
L04AX01
ATC
azathioprine; systemic
59.0
323.0
2108
553
H02AB07
ATC
prednisone; oral
6.0
323.0
1709
3790
D94
ICPC
Chronic enteritis/ulcerative colitis
187.9
323.0
435
25
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
528.9
323.0
1675
45
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
708.0
323.0
953
16
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
965.8
323.0
363
*
A07EA01
ATC
prednisolone; rectal
338.3
323.0
492
16
H02AB06
ATC
prednisolone; systemic
8.0
323.0
4495
17220
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
237.7
307.8
315
14
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
45.3
282.0
350
82
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
1391.3
273.9
265
*
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
1288.0
254.9
247
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
778.2
229.9
225
*
J01MA02
ATC
ciprofloxacin; systemic
2.4
208.2
2479
13524
A07EC03
ATC
olsalazine; oral
1023.2
203.3
198
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
345.5
201.0
202
6
ZX120
NOMESCO Finland
Intravenous
4.0
192.1
852
2375
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
329.3
191.6
193
6
P01AB01
ATC
metronidazole; oral, rectal
2.3
190.8
2564
14671
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
11.3
172.3
337
316
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
165.9
168.5
177
11
K83.0
ICD-10 Finland
Cholangitis
17.1
167.5
272
166
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
134.2
1672
8855
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
33.6
133.3
176
54
4AB02
NOMESCO Finland
NA
56.4
129.4
154
28
4AA12
NOMESCO Finland
NA
63.7
127.7
149
24
A05AA02
ATC
ursodeoxycholic acid; oral
9.0
123.7
272
315
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
123.4
1387
6944
WX002
NOMESCO Finland
Sedation and analgesia
2.3
110.9
1188
5772
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
110.8
106
*
A02BC02
ATC
pantoprazole; systemic
1.9
110.5
3520
26229
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
99.7
1248
6477
L04AD01
ATC
ciclosporin; systemic
7.0
99.2
256
380
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
329.1
97.3
98
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
95.6
1128
5688
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
9.2
91.2
197
221
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
299.9
86.9
88
*
L04AB04
ATC
adalimumab; parenteral
6.3
85.6
239
395
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
12.7
82.7
151
122
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.1
82.3
343
879
A07DA03
ATC
loperamide; oral
4.7
80.2
286
629
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
79.4
2171
14786
1370
FHL
Colonoscopy, whole colon
22.1
79.3
117
54
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
79.3
76
*
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.5
78.6
394
1180
253
Kela drug reimbursment
NA
+∞
78.3
75
*
3042
Kela drug reimbursment
NA
+∞
78.3
75
*
JFH10
NOMESCO Finland
Total colectomy and ileostomy
47.2
76.0
93
20
4AA33
NOMESCO Finland
NA
382.3
75.9
76
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
73.1
573
2319
C05AA08
ATC
fluocortolone; rectal, topical
2.2
71.7
836
4137
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
696.5
70.2
69
*
3005
Kela drug reimbursment
Tofacitinib
23.4
68.5
99
43
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.3
66.0
356
1126
K92.1
ICD-10 Finland
Melaena
3.4
62.5
322
983
Z93.2
ICD-10 Finland
Ileostomy status
28.7
62.4
85
30
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
59.6
607
2804
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
57.4
55
*
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
198.6
57.1
59
*
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
104.4
56.9
62
6
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.6
54.5
197
439
JFF10
NOMESCO Finland
Loop enterostomy
13.8
54.4
95
70
L04AB06
ATC
golimumab; parenteral
8.2
52.9
121
150
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.8
52.6
357
1318
L04AA29
ATC
tofacitinib; oral
17.7
51.9
82
47
3AC01
NOMESCO Finland
NA
7.7
51.6
123
163
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
49.4
604
3021
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
48.9
722
3898
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.4
48.7
182
420
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.2
47.8
269
876
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.6
47.7
172
383
UJF92
NOMESCO Finland
Capsular endoscopy
4.9
47.2
161
338
H02AB04
ATC
methylprednisolone; systemic
1.9
47.0
761
4251
D16
ICPC
Rectal bleeding
4.5
46.7
172
391
6419
FHL
Other measure in this category
37.2
46.3
59
16
A07AA09
ATC
vancomycin; oral
7.0
46.0
117
171
H02AB09
ATC
hydrocortisone; systemic
4.0
45.2
189
485
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
15.5
43.5
72
47
WVA20
NOMESCO Finland
Medicine administration
4.3
43.2
165
389
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
430.8
43.2
43
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
4.8
42.2
146
312
N02BE01
ATC
paracetamol; systemic, rectal
1.5
41.3
4550
40636
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
400.2
40.1
40
*
Z2221
NOMESCO Finland
Medical doctor
1.5
37.8
1423
10091
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.7
37.4
170
470
L04AA33
ATC
vedolizumab; parenteral
+∞
36.5
35
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
34.7
1799
13628
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.8
34.5
150
400
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
34.4
661
3885
C10AC01
ATC
colestyramine; oral
3.6
33.7
157
444
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
4.5
33.6
121
271
A02BC01
ATC
omeprazole; systemic
1.5
33.4
1249
8796
D18
ICPC
Change in faeces/bowel movements
3.9
33.0
142
375
UJK12
NOMESCO Finland
Peroral cholangioscopy
20.6
33.0
49
24
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
10.6
32.8
64
61
L04AC05
ATC
ustekinumab; parenteral
13.1
32.3
57
44
1490
FHL
Sigmoideoscopy (fiberscope)
13.2
31.3
55
42
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
4.8
30.8
105
222
UJG02
NOMESCO Finland
Proctoscopy
3.7
30.7
139
384
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
160.8
30.7
32
*
A02BC05
ATC
esomeprazole; systemic
1.4
30.3
1891
14747
UJF34
NOMESCO Finland
Left colonoscopy
7.9
30.3
70
90
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.0
30.1
75
108
D11
ICPC
Diarrhoea
1.7
29.7
620
3732
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.9
28.8
465
2573
B01AB05
ATC
enoxaparin; parenteral
1.5
28.8
1273
9258
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
25.1
28.7
40
16
UJK02
NOMESCO Finland
ERCP
3.6
27.6
129
367
A02BC03
ATC
lansoprazole; oral
1.5
27.0
1276
9391
UJF30
SPAT
NA
9.0
26.8
57
64
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
272.3
26.7
27
*
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.2
26.6
142
448
N02AX02
ATC
tramadol; systemic, rectal
1.4
26.3
1928
15371
J01MA12
ATC
levofloxacin; systemic
1.6
25.9
786
5234
D06BX01
ATC
metronidazole; topical
1.8
25.7
473
2734
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.8
25.6
444
2517
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
25.5
1853
14739
L04AA01
ATC
[U] ciclosporin; systemic
4.1
25.1
100
248
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
4.3
25.1
94
220
TJF80
NOMESCO Finland
Ostomy education
5.6
25.1
74
134
M45
ICD-10 Finland
Ankylosing spondylitis
3.0
25.1
151
518
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.7
24.7
594
3718
K59.1
ICD-10 Finland
Functional diarrhoea
2.3
24.7
246
1117
6410
FHL
Panprococolectomy and ileostomy
251.2
24.7
25
*
A06AC51
ATC
ispaghula, combinations; systemic
2.3
24.6
238
1066
ZXE00
NOMESCO Finland
One hour or less
1.4
24.3
1916
15416
C05AA01
ATC
hydrocortisone; rectal, topical
2.2
23.7
244
1126
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.9
22.8
333
1777
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.0
22.8
293
1487
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.3
22.3
209
922
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
22.3
980
7072
R50.9
ICD-10 Finland
Fever, unspecified
1.6
21.9
670
4460
JN3AD
NOMESCO Finland
Abdominal CT examination
1.9
21.8
337
1834
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
26.5
21.3
29
11
JFF13
NOMESCO Finland
Terminal enterostomy
14.1
20.8
35
25
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
10.6
20.3
39
37
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
20.1
299
1605
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
19.8
19
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.2
19.7
199
910
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.5
19.5
784
5545
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.0
19.5
253
1289
ZXC86
NOMESCO Finland
Use of endoscopic device
6.7
19.3
49
74
Z93
ICD-10 Finland
Artificial opening status
12.2
19.0
34
28
UJF32
SPAT
NA
3.6
18.8
86
243
SPAT1131
SPAT
Colonoscopy
2.5
18.8
146
585
6525
FHL
Enterostomy occlusion
27.9
18.7
25
9
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
4.0
18.4
74
188
JF2AB
NOMESCO Finland
Colongraphy with X-ray
9.1
18.3
38
42
K76.9
ICD-10 Finland
Liver disease, unspecified
3.6
18.2
83
234
1380
FHL
Colonoscopy, left side
17.6
18.2
28
16
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
3.0
18.1
104
347
K50
ICD-10 Finland
Crohn disease [regional enteritis]
52.7
17.9
21
*
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
3.4
17.8
85
249
R01AD08
ATC
fluticasone; nasal
1.3
17.8
1394
11088
WX402
NOMESCO Finland
General anaesthesia
1.5
17.7
778
5591
SPAT1262
SPAT
Handing over of treatment supplies
1.5
17.6
742
5290
WW200
NOMESCO Finland
Immunization
2.4
17.5
154
661
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
3.9
17.5
72
187
J01DB01
ATC
cefalexin; oral
1.3
17.3
4362
40471
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.1
17.2
54
107
K56.7
ICD-10 Finland
Ileus, unspecified
3.7
17.2
76
210
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
8.5
17.1
37
44
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
17.0
1216
9522
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
16.8
2204
18797
J01FA10
ATC
azithromycin; systemic
1.3
16.5
3044
27047
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
3.0
16.5
97
331
5563A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctosigmoiditis
170.4
16.5
17
*
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
13.4
16.4
28
21
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.8
16.4
305
1765
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
10.0
16.4
32
32
E0000UV
ATC
NA
1.3
16.3
1872
15673
JHD00
NOMESCO Finland
Anal dilatation
5.2
16.1
49
94
D07AC01
ATC
betamethasone; topical
1.3
16.0
1500
12213
M01AE01
ATC
ibuprofen; systemic, rectal
0.8
15.9
4457
47246
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
6.9
15.9
39
57
ZXE20
NOMESCO Finland
More than three and less than five hours
1.5
15.7
572
3949
JAH00
NOMESCO Finland
Laparotomy
2.5
15.7
120
479
A03CA02
ATC
clidinium and psycholeptics; oral
1.9
15.5
214
1120
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
15.4
1689
14033
JF1BD
NOMESCO Finland
Very extensive small bowel CT
5.8
15.3
43
75
-
ICD-10 Finland
NA
2.6
15.3
111
432
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.4
14.9
129
552
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
14.8
1821
15335
M05BA04
ATC
alendronic acid; oral
1.9
14.8
230
1258
SPAT1263
SPAT
Sampling
1.3
14.6
1978
16856
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
10.0
14.4
28
28
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
9.4
14.4
29
31
Y0599
ICD-8 Finland
Investigation of digestive system
3.0
14.3
80
266
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.7
14.2
273
1598
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.7
14.2
309
1876
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
2.2
14.2
146
680
5604
FHL
Vascular preparation or cannulation in the operating room
9.7
14.2
28
29
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
13.8
902
6937
K50.1
ICD-10 Finland
Crohn disease of large intestine
7.9
13.5
30
38
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
6.6
13.5
34
52
Z43.2
ICD-10 Finland
Attention to ileostomy
11.5
13.3
24
21
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
3.9
13.2
54
141
R01AD12
ATC
fluticasone furoate; nasal
1.3
13.2
1454
12039
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.0
13.1
163
820
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
6.0
13.0
35
59
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
10.0
12.9
25
25
K52.1
ICD-10 Finland
Toxic gastroenteritis and colitis
22.6
12.9
18
8
6522
FHL
Ileostomy
+∞
12.5
12
*
D99
ICPC
Disease digestive system other
3.4
12.1
57
168
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.6
12.1
343
2237
K62.4
ICD-10 Finland
Stenosis of anus and rectum
11.0
12.0
22
20
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
3.6
12.0
52
144
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
3.8
11.9
49
130
E86
ICD-10 Finland
Volume depletion
2.6
11.8
87
344
UJH02
NOMESCO Finland
Anoscopy
1.9
11.8
172
922
J01CA04
ATC
amoxicillin; systemic
1.2
11.7
4338
40818
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
2.8
11.7
74
268
UJF02
NOMESCO Finland
Peroral enteroscopy
4.7
11.6
38
81
6408
FHL
Colectomy and ileostomy
+∞
11.5
11
*
JFH31
NOMESCO Finland
Laparoscopic total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
11.5
11
*
A07AA02
ATC
nystatin; oral
1.7
11.4
219
1283
B80
ICPC
Iron deficiency anaemia
2.4
11.4
91
377
K50.9
ICD-10 Finland
Crohn disease, unspecified
4.7
11.3
37
79
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
1.9
11.0
164
887
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.3
11.0
95
410
K56.0
ICD-10 Finland
Paralytic ileus
3.7
11.0
47
129
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
4.4
11.0
38
86
L88
ICD-10 Finland
Pyoderma gangrenosum
9.2
11.0
22
24
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.0
11.0
136
687
UJD02
NOMESCO Finland
Gastroscopy
1.8
10.8
177
989
D07AD01
ATC
clobetasol; topical
1.4
10.8
607
4547
J05AB01
ATC
aciclovir; systemic
1.3
10.7
859
6796
JHA00
NOMESCO Finland
Anal or perianal incision
2.6
10.7
75
288
SPAT1255
SPAT
Intravenous administration of medicine
1.6
10.6
254
1589
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
6.3
10.6
27
43
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
1.9
10.6
150
799
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
3.0
10.5
60
203
Z90.4
ICD-10 Finland
Acquired absence of other parts of digestive tract
110.2
10.4
11
*
JGB61
NOMESCO Finland
Laparoscopic excision of rectum and ileoanal anastomosis
+∞
10.4
10
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.5
10.4
366
2509
A02BA02
ATC
ranitidine; systemic
1.3
10.3
701
5414
JFA45
NOMESCO Finland
Endoscopic contact coagulation in colon
5.7
10.2
28
49
Z94.4
ICD-10 Finland
Liver transplant status
5.2
10.1
30
58
R01AD09
ATC
mometasone; nasal
1.2
10.0
2171
19236
Z3231
NOMESCO Finland
Registered nurse
1.3
10.0
1151
9534
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.4
9.9
424
3026
K74.3
ICD-10 Finland
Primary biliary cirrhosis
4.4
9.9
34
77
K90.0
ICD-10 Finland
Coeliac disease
2.0
9.9
121
609
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.1
9.8
111
541
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
55.1
9.6
11
*
ZXD05
NOMESCO Finland
Urgent procedure
1.2
9.6
1389
11801
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
5.8
9.6
26
45
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.4
9.6
527
3932
J05AB11
ATC
valaciclovir; oral
1.4
9.6
519
3865
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
1.6
9.4
233
1469
J02AC01
ATC
fluconazole; systemic
1.2
9.4
1730
15061
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
2.3
9.4
81
352
K61.0
ICD-10 Finland
Anal abscess
2.3
9.3
86
384
D01
ICPC
Abdominal pain/cramps general
1.4
9.3
450
3283
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.6
9.3
150
2425
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.5
9.2
313
2132
M13.9
ICD-10 Finland
Arthritis, unspecified
1.5
9.0
274
1820
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.5
9.0
335
2324
L04AB02
ATC
infliximab; parenteral
36.7
9.0
11
*
B02.9
ICD-10 Finland
Zoster without complication
1.7
8.9
178
1060
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
24.0
8.9
12
5
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
2.3
8.9
80
355
K91.8
ICD-10 Finland
Other postprocedural disorders of digestive system, not elsewhere classified
12.5
8.8
15
12
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
8.6
8.8
18
21
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
3.2
8.7
43
134
M03BC51
ATC
orphenadrine, combinations; systemic
1.2
8.6
1240
10516
A98
ICPC
Health maint/preventive medicine
1.4
8.6
5446
53134
D29
ICPC
Digestive symptom/complaint other
2.2
8.6
81
367
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
2.4
8.5
66
273
SPAT1249
SPAT
Treatment-related counselling outside office
1.2
8.5
1782
15687
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
2.5
8.4
61
241
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.2
8.3
1498
12988
JD1AB
NOMESCO Finland
Gastro-duodenography with X-ray
14.5
8.2
13
9
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
2.8
8.2
52
190
D07AB02
ATC
hydrocortisone butyrate; topical
1.2
8.2
1179
9994
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.2
8.1
1192
10120
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
1.9
8.1
116
623
ZXE10
NOMESCO Finland
More than one and less than three hours
1.2
8.1
1499
13023
K60.3
ICD-10 Finland
Anal fistula
2.1
8.1
83
392
F29
ICD-10 Finland
Unspecified nonorganic psychosis
0.5
8.1
62
1221
JFA76
NOMESCO Finland
Closure of fistula of small intestine
33.4
8.1
10
*
D07AC13
ATC
mometasone; topical
1.2
8.1
1224
10429
A01AB09
ATC
miconazole; local oral
1.5
7.9
295
2053
J01AA02
ATC
doxycycline; systemic
1.2
7.9
3742
35196
6451
FHL
Dilatation
3.6
7.8
33
92
D62
ICPC
Digestive, Administrative procedure
3.8
7.8
31
82
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
4.6
7.8
25
54
D64.9
ICD-10 Finland
Anaemia, unspecified
1.5
7.8
298
2085
54099
ICD-8 Finland
Acute appendicitis, Without mention of peritonitis
0.4
7.7
25
673
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
15.0
7.7
12
8
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
7.4
7.7
17
23
JJC00
NOMESCO Finland
Allogenic transplantation of liver
5.5
7.7
21
38
E000001
ATC
NA
1.2
7.6
887
7335
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
1.9
7.6
102
536
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
18.4
7.6
11
6
K55.1
ICD-10 Finland
Chronic vascular disorders of intestine
11.8
7.6
13
11
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
4.1
7.5
27
66
K83
ICD-10 Finland
Other diseases of biliary tract
80.2
7.4
8
*
6437
FHL
Rectum resection and sphincter-sparing through-anastomosis
80.2
7.4
8
*
JFG96
NOMESCO Finland
Other operation on intestinal stoma or pouch
80.2
7.4
8
*
5781A
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[MELAENA]
6.4
7.4
18
28
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
1.8
7.3
121
684
5781B
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[HAEMORRHAGIA EX ANO]
8.3
7.3
15
18
N05AH03
ATC
olanzapine; systemic
0.6
7.3
122
1954
M075, K515
ICD-10 Finland
NA
+∞
7.3
7
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.4
7.2
346
2521
6611
FHL
Needle biopsy in the operating room
15.7
7.2
11
7
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.5
7.2
203
1330
A03BA03
ATC
hyoscyamine; oral
3.1
7.2
36
115
K83.1
ICD-10 Finland
Obstruction of bile duct
2.6
7.2
50
195
WZC30
NOMESCO Finland
Teaching
1.3
7.1
493
3812
N05AH02
ATC
clozapine; systemic
0.3
7.1
20
569
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.5
7.1
255
1763
TPH07
NOMESCO Finland
Cathetrisation of artery
1.4
7.1
345
2524
JG1JB
NOMESCO Finland
Defekography with X-ray
3.2
7.1
34
106
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
7.0
1895
16980
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
1.7
7.0
125
722
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
4.3
7.0
24
56
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
1.7
7.0
125
725
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.2
7.0
902
7548
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
2.4
6.9
56
239
SPAT1325
SPAT
Vaccination
1.2
6.9
1290
11200
D07XC01
ATC
betamethasone, combinations; topical
1.3
6.8
453
3486
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.2
6.8
1326
11555
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
2.1
6.8
73
354
5694X
ICD-9 Finland
Other disorders of intestine, Other specified disorders of rectum and anus
40.1
6.8
8
*
K83.3
ICD-10 Finland
Fistula of bile duct
16.7
6.7
10
6
WD315
NOMESCO Finland
Multiple therapy of methastized malignancy with biomodifiers
7.2
6.7
15
21
J01FA09
ATC
clarithromycin; systemic
1.2
6.7
1405
12319
A07AA11
ATC
rifaximin; oral
5.5
6.6
18
33
J01DA01
ATC
[U] cefalexin; systemic
1.2
6.6
2992
27854
D48
ICPC
Digestive, Clarification/discussion RFE/demand
4.8
6.5
20
42
Z98.8
ICD-10 Finland
Other specified postsurgical states
2.3
6.5
56
246
K75.4
ICD-10 Finland
Autoimmune hepatitis
6.8
6.5
15
22
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
6.8
6.5
15
22
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
0.7
6.5
140
2125
SPAT1125
SPAT
Stoma care and guidance
2.6
6.5
44
172
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
3.1
6.5
33
108
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.4
6.5
286
2057
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
2.6
6.4
43
166
K62.9
ICD-10 Finland
Disease of anus and rectum, unspecified
3.3
6.4
30
92
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
5.7
6.4
17
30
A04.6
ICD-10 Finland
Enteritis due to Yersinia enterocolitica
7.4
6.4
14
19
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.4
6.4
340
2531
N20.1
ICD-10 Finland
Calculus of ureter
1.6
6.4
135
826
WX004
NOMESCO Finland
Patient-controlled sedation
3.2
6.4
30
93
N05AX08
ATC
risperidone; systemic
0.7
6.3
143
2149
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
4.9
6.3
19
39
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.5
6.3
179
1179
SPAT1153
SPAT
Removal of sutures
1.2
6.3
1217
10586
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.4
6.3
250
1765
392
Kela drug reimbursment
Ferric maltol
+∞
6.2
6
*
O996, K515
ICD-10 Finland
NA
+∞
6.2
6
*
JFH40
NOMESCO Finland
Proctocolectomy and continent ileostomy
+∞
6.2
6
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
6.2
3636
34385
J01FA06
ATC
roxithromycin; oral
1.2
6.2
1741
15612
K63.9
ICD-10 Finland
Disease of intestine, unspecified
4.3
6.2
21
49
5589X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis, Other and unspecified non-infectious gastro-enteritis and colitis
7.0
6.2
14
20
WX600
NOMESCO Finland
Single shot through catheter
1.9
6.2
82
433
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
2.0
6.2
69
342
L52
ICD-10 Finland
Erythema nodosum
3.1
6.2
31
101
L88
ICPC
Rheumatoid/seropositive arthritis
1.7
6.1
124
746
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.1
6.1
2557
23610
H20.1
ICD-10 Finland
Chronic iridocyclitis
2.4
6.1
47
195
K62.1
ICD-10 Finland
Rectal polyp
3.0
6.1
32
108
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
2.0
6.0
76
392

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: K11_UC_NOCD – Ulcerative colitis (strict definition, all Crohn cases excluded)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).