sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2381 |
4. Check minimum number of eventsNone |
2381 |
5. Include endpointsNone |
2381 |
6. Filter based on genotype QC (FinnGen only) |
2381 |
Control definitions (FinnGen only)
- Control exclude
- K11_GALLBILPANC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K83
- Name in latin
- Cholangitis
Similar endpoints
↥List of similar endpoints to
Cholangitis (primary sclerosing, PSC)
based on the number of shared cases.
Similar with more cases:
- Disorders of gallbladder, biliary tract and pancreas
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17623 | 8929 | 8513 |
| Only index persons | 14119 | 7308 | 6811 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.26 | 0.24 |
| Only index persons | 0.26 | 0.27 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 69.88 | 71.11 | 68.55 |
| Only index persons | 69.40 | 70.72 | 67.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2381 | 1129 | 1252 |
| Unadjusted period prevalence (%) | 0.47 | 0.38 | 0.55 |
| Median age at first event (years) | 63.25 | 60.05 | 66.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2140
- Matched controls
- 21400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
542.9
323.0
401
9
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
867.1
323.0
705
12
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
+∞
323.0
313
*
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
123.9
323.0
419
42
A05AA02
ATC
ursodeoxycholic acid; oral
198.0
323.0
678
50
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
399.8
323.0
467
15
K83.1
ICD-10 Finland
Obstruction of bile duct
+∞
323.0
446
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
599.1
323.0
543
12
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
297.3
323.0
519
23
K83.0
ICD-10 Finland
Cholangitis
+∞
323.0
2065
*
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
2547.3
323.0
389
*
UJK02
NOMESCO Finland
ERCP
484.0
323.0
774
25
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
18.1
323.0
743
609
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
3215.5
308.8
291
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
39.1
296.5
379
117
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
37.9
286.5
369
117
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
17.1
278.5
462
338
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
318.4
278.2
277
10
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
+∞
254.3
239
*
K51.5
ICD-10 Finland
Left sided colitis
26.7
254.2
359
160
A07EC02
ATC
mesalazine; oral, rectal
13.2
252.8
471
447
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.1
250.0
706
1378
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
48.2
238.9
292
70
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.6
217.7
1025
3541
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
19.6
205.6
321
191
J01MA12
ATC
levofloxacin; systemic
5.1
203.1
799
2253
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.4
201.6
534
916
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.3
196.3
602
1258
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
49.5
195.7
238
54
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
4.1
190.7
1061
4144
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
+∞
188.3
178
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
95.5
188.1
207
24
UJF30
NOMESCO Finland
Ileoscopy through colon
7.0
182.3
501
894
R10.1
ICD-10 Finland
Pain localized to upper abdomen
5.5
176.8
603
1413
A09AA02
ATC
multienzymes (lipase, protease etc.)
50.5
176.7
214
47
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
+∞
176.5
167
*
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
862.2
165.0
160
*
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
+∞
163.7
155
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
850.5
162.8
158
*
JN3AD
NOMESCO Finland
Abdominal CT examination
8.1
162.0
395
582
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
+∞
160.4
152
*
JKA20
NOMESCO Finland
Cholecystectomy
66.9
159.4
184
30
L04AX01
ATC
azathioprine; systemic
10.4
157.8
328
367
UJF32
NOMESCO Finland
Coloscopy
3.8
155.2
863
3214
K81.0
ICD-10 Finland
Acute cholecystitis
336.8
154.9
155
5
WX402
NOMESCO Finland
General anaesthesia
4.6
150.0
618
1737
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
180.3
145.5
151
9
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.9
140.4
709
2388
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
1381.9
134.9
130
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
37.3
133.6
172
50
R50.9
ICD-10 Finland
Fever, unspecified
4.4
131.9
568
1639
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
18.0
126.6
202
123
K85
ICD-10 Finland
Acute pancreatitis
431.7
124.1
123
*
K51.8
ICD-10 Finland
Other ulcerative colitis
29.5
123.9
169
62
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
328.7
122.6
123
*
Z94.4
ICD-10 Finland
Liver transplant status
115.2
120.5
130
12
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
+∞
119.9
114
*
J01MA02
ATC
ciprofloxacin; systemic
3.0
119.5
1099
5628
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
118.9
690
2545
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
10.4
118.2
242
258
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
33.3
112.8
149
48
JLC30
NOMESCO Finland
Pancreatoduodenectomy
163.9
104.2
109
7
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
103.6
444
1243
A07EA06
ATC
budesonide; oral, local oral
9.4
102.6
222
260
JJC00
NOMESCO Finland
Allogenic transplantation of liver
185.7
102.3
106
6
WX002
NOMESCO Finland
Sedation and analgesia
3.3
100.1
621
2358
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
97.7
1131
6379
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
8.8
97.4
219
273
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
38.3
96.3
123
34
127
Kela drug reimbursment
Transplant complication
17.5
91.5
147
90
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
466.9
90.9
90
*
K86.1
ICD-10 Finland
Other chronic pancreatitis
+∞
90.2
86
*
K80.4
ICD-10 Finland
Calculus of bile duct with cholecystitis
+∞
89.2
85
*
P01AB01
ATC
metronidazole; oral, rectal
2.6
88.9
957
5085
WX302
NOMESCO Finland
Thoracal epidural anesthesy
6.5
87.9
243
412
K85.8
ICD-10 Finland
Other acute pancreatitis
883.1
87.3
85
*
K76.9
ICD-10 Finland
Liver disease, unspecified
17.8
85.5
136
81
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
31.6
85.4
114
38
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
83.2
718
3324
K74.3
ICD-10 Finland
Primary biliary cirrhosis
54.5
83.1
99
19
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.3
81.9
269
563
K85.1
ICD-10 Finland
Biliary acute pancreatitis
+∞
80.7
77
*
K81.9
ICD-10 Finland
Cholecystitis, unspecified
+∞
80.7
77
*
130
Kela drug reimbursment
Malignant tumour
4.3
79.7
330
878
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
41.5
79.0
99
25
A02BC02
ATC
pantoprazole; systemic
2.4
78.6
1451
9968
N02AA05
ATC
oxycodone; systemic
3.2
77.4
483
1793
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
266.3
75.9
77
*
K50.8
ICD-10 Finland
Other Crohn disease
15.9
75.8
126
84
K80.8
ICD-10 Finland
Other cholelithiasis
60.4
74.3
87
15
N02AX02
ATC
tramadol; systemic, rectal
2.3
73.1
1005
5878
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
29.6
73.1
99
35
JKE25
NOMESCO Finland
Endoscopic external drainage of bile duct
114.0
71.3
77
7
L04AD01
ATC
ciclosporin; systemic
11.5
69.2
133
123
JN4CD
NOMESCO Finland
Very extensive body CT
6.5
69.1
189
313
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
68.1
465
1820
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
63.0
68.0
79
13
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
15.2
67.5
114
79
JK3FT
NOMESCO Finland
Exchange of bile duct catheter with radiological guidance
678.8
67.3
66
*
L04AA06
ATC
mycophenolic acid; systemic
12.9
66.7
121
99
JK4ZT
NOMESCO Finland
Percutaneous transhepatic implantation of bile duct prothesis
175.4
65.4
68
*
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
+∞
64.9
62
*
JK3SB
NOMESCO Finland
Endoscopic retrorade cholangiography
+∞
63.9
61
*
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
47.8
60.9
74
16
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
26.4
60.3
84
33
R74.0
ICD-10 Finland
Elevation of levels of transaminase and lactic acid dehydrogenase [LDH]
12.9
59.7
108
88
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.5
59.6
188
371
K50.9
ICD-10 Finland
Crohn disease, unspecified
12.0
58.9
110
96
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
16.8
58.7
95
59
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
18.1
58.5
92
53
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
5.6
58.0
178
340
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
48.1
57.7
70
15
JJ1CE
NOMESCO Finland
Liver, bile duct and pancreas endoscopic ultrasound examination
68.0
57.5
66
10
K50.1
ICD-10 Finland
Crohn disease of large intestine
13.7
57.0
100
76
JKD20
NOMESCO Finland
Anastomosis of bile duct to jejunum
572.7
56.9
56
*
JK3NT
NOMESCO Finland
Percutaneous transhepatic dilatation of bileducts
198.5
56.3
58
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
18.3
56.2
88
50
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
54.7
794
4578
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
39.0
53.8
68
18
JN4AD
NOMESCO Finland
Body CT examination
3.6
53.0
258
777
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
52.6
437
1898
JJ5AT
NOMESCO Finland
NA
272.3
52.4
53
*
ZX120
NOMESCO Finland
Intravenous
3.3
52.1
295
997
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
20.7
52.1
78
39
H02AB06
ATC
prednisolone; systemic
2.0
51.9
1052
6927
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.1
51.8
218
578
Z51.5
ICD-10 Finland
Palliative care
3.9
51.1
224
616
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
11.9
50.8
95
83
A03FA01
ATC
metoclopramide; systemic, rectal
2.4
49.3
504
2437
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
48.8
304
1098
WX004
NOMESCO Finland
Patient-controlled sedation
37.5
48.7
62
17
57505
ICD-8 Finland
Cholecystitis and cholangitis, without mention of calculus, Cholangitis alia sive NUD
+∞
48.1
46
*
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
10.6
46.6
92
90
D98
ICPC
Cholecystitis/cholelithiasis
87.1
46.0
51
6
JAH00
NOMESCO Finland
Laparotomy
6.9
45.9
119
182
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
457.0
45.4
45
*
A41.8
ICD-10 Finland
Other specified sepsis
8.6
45.0
100
121
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.2
44.4
178
450
C10AC01
ATC
colestyramine; oral
7.6
44.2
106
145
A04AA02
ATC
granisetron; systemic, transdermal
3.9
43.8
194
537
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
8.6
43.2
96
116
5761C
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SCLEROSIVA]
+∞
42.8
41
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.4
42.8
226
721
J01DB01
ATC
cefalexin; oral
2.0
42.5
1685
13779
K86.3
ICD-10 Finland
Pseudocyst of pancreas
+∞
40.7
39
*
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
12.8
40.6
73
59
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
49.0
39.9
48
10
TJK01
NOMESCO Finland
Laparoscopic cholangiography
+∞
39.7
38
*
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
65.6
39.2
45
7
K86.9
ICD-10 Finland
Disease of pancreas, unspecified
394.4
39.2
39
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
39.1
415
2019
B01AB05
ATC
enoxaparin; parenteral
2.0
38.8
661
3937
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
7.2
38.7
96
138
JN4BD
NOMESCO Finland
Extensive body CT
2.7
38.2
296
1217
A41.9
ICD-10 Finland
Sepsis, unspecified
4.3
37.9
147
360
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.9
37.8
714
4413
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
16.5
37.8
61
38
C24.9
ICD-10 Finland
Malignant neoplasm: Biliary tract, unspecified
51.0
37.7
45
9
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
37.1
255
971
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.6
37.0
295
1230
A07EA02
ATC
hydrocortisone; rectal
6.2
36.5
101
169
K50.0
ICD-10 Finland
Crohn disease of small intestine
8.3
35.9
81
101
JAH01
NOMESCO Finland
Laparoscopy
4.9
35.8
122
262
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.1
35.6
208
712
K92.1
ICD-10 Finland
Melaena
3.6
35.4
170
502
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
352.8
35.0
35
*
H02AB07
ATC
prednisone; oral
2.3
34.9
359
1709
L01BC06
ATC
capecitabine; oral
4.8
34.9
120
260
K83.3
ICD-10 Finland
Fistula of bile duct
+∞
34.5
33
*
TJK00
NOMESCO Finland
Intraoperative cholangiography
+∞
34.5
33
*
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
+∞
34.5
33
*
K86.8
ICD-10 Finland
Other specified diseases of pancreas
332.0
33.0
33
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.2
32.6
105
212
TK800
NOMESCO Finland
Hemodialysis
5.9
32.2
92
161
L01BB02
ATC
mercaptopurine; oral
11.6
32.1
60
53
UJF92
NOMESCO Finland
Capsular endoscopy
6.9
31.9
81
121
6663
FHL
Cholecystectomy and cholangiography
167.4
31.8
33
*
C03CA01
ATC
furosemide; systemic
1.8
31.5
683
4367
JLW98
NOMESCO Finland
Other transluminal endoscopic operation on pancreas
+∞
31.3
30
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
15.8
31.3
51
33
L04AA01
ATC
[U] ciclosporin; systemic
7.6
31.2
74
100
R4190
NOMESCO Finland
Nutritional therapy
4.4
31.2
118
282
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
31.1
1008
7304
K86.2
ICD-10 Finland
Cyst of pancreas
162.3
30.7
32
*
SPAT1262
SPAT
Handing over of treatment supplies
2.1
30.6
412
2203
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
18.8
30.1
46
25
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
4.1
29.9
121
308
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
4.4
29.7
112
267
WVA20
NOMESCO Finland
Medicine administration
5.9
29.6
85
150
H02AB04
ATC
methylprednisolone; systemic
2.2
29.3
341
1708
JKB00
NOMESCO Finland
Incision of bile duct
+∞
29.2
28
*
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
15.3
29.1
48
32
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.1
29.1
119
306
K73.9
ICD-10 Finland
Chronic hepatitis, unspecified
23.9
28.3
40
17
A02BC05
ATC
esomeprazole; systemic
1.7
28.2
785
5387
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
39.5
28.1
35
9
WX419
NOMESCO Finland
Other general anesthesy
8.7
28.0
61
72
R94.5
ICD-10 Finland
Abnormal results of liver function studies
10.4
28.0
55
54
K51
ICD-10 Finland
Ulcerative colitis
12.1
28.0
51
43
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
28.0
206
814
8140/3-C25.9
ICD-O-3
Adenocarcinoma, NOS, of pancreas, NOS
20.9
27.8
41
20
WX892
NOMESCO Finland
Monitored bed care
2.7
27.5
197
766
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
27.3
363
1922
JK3MB
NOMESCO Finland
Postoperative cholangiography
+∞
27.1
26
*
JKB20
NOMESCO Finland
Intraoperative cholangioscopy
+∞
27.1
26
*
JJA20
NOMESCO Finland
Open biopsy of liver
32.3
26.9
35
11
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
8.0
26.7
61
78
R11
ICD-10 Finland
Nausea and vomiting
2.6
26.6
202
813
SPAT1255
SPAT
Intravenous administration of medicine
2.9
26.6
172
628
JCA22
NOMESCO Finland
Endoscopic ligature of oesophageal varices
22.7
26.5
38
17
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.8
26.2
115
315
K75.0
ICD-10 Finland
Abscess of liver
37.2
26.2
33
9
K81.1
ICD-10 Finland
Chronic cholecystitis
+∞
26.1
25
*
JN1CM
NOMESCO Finland
Upper part of abdomen extensive MRI examination with 3 Tesla magnet
60.8
26.0
30
5
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
73.6
25.8
29
*
D13.6
ICD-10 Finland
Benign neoplasm: Pancreas
20.3
25.6
38
19
JN1CD
NOMESCO Finland
Very extensive CT examination of upper part of abdomen
11.4
25.6
48
43
A10AE04
ATC
insulin glargine; parenteral
2.5
25.6
222
961
JN1BD
NOMESCO Finland
Extensive CT examination of upper part of abdomen
15.3
25.6
42
28
R4110
NOMESCO Finland
Physiotherapy
1.8
25.3
547
3450
C24.00
ICD-10 Finland
Hepatic duct
+∞
25.0
24
*
5761X
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS ALIA]
+∞
25.0
24
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
11.1
24.9
47
43
WZC30
NOMESCO Finland
Teaching
2.2
24.8
287
1430
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.9
24.8
157
566
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.4
24.6
92
218
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.4
24.4
123
378
A06AD11
ATC
lactulose; oral
2.0
24.3
355
1943
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.2
24.2
133
436
JKE15
NOMESCO Finland
Endoscopic lithotripsy in bile duct
+∞
24.0
23
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
38.0
23.9
30
8
1280
FHL
Endoscopic retrograde cholangiography and pancreaticography
242.5
23.7
24
*
3AC01
NOMESCO Finland
NA
8.4
23.6
52
63
6662
FHL
Cholecystectomy
126.4
23.6
25
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
10.9
23.6
45
42
UJD02
NOMESCO Finland
Gastroscopy
3.1
23.5
137
467
H02AB02
ATC
dexamethasone; systemic
2.3
23.5
240
1127
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
19.7
23.5
35
18
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
23.3
351
1944
UJF02
NOMESCO Finland
Peroral enteroscopy
15.4
23.3
38
25
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
23.2
289
1484
B01AB10
ATC
tinzaparin; parenteral
2.7
23.2
165
640
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
5.2
23.1
72
141
8000/3-C25.9
ICD-O-3
Neoplasm, malignant of pancreas, NOS
18.7
23.0
35
19
H02AB09
ATC
hydrocortisone; systemic
4.7
23.0
79
172
57409
ICD-8 Finland
Cholelithiasis, Unspecified
+∞
23.0
22
*
D02
ICPC
Abdominal pain epigastric
3.2
22.6
122
395
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
32.6
22.4
29
9
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
5.9
22.4
63
109
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
3.6
22.2
103
296
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
21.7
230
1095
I85.0
ICD-10 Finland
Oesophageal varices with bleeding
20.9
21.2
31
15
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
21.2
527
3439
57401
ICD-8 Finland
Cholelithiasis, Cum cholecystitide chronica
+∞
20.9
20
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.8
20.8
135
494
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
19.6
20.8
31
16
WW500
NOMESCO Finland
Blood transfusion
3.2
20.8
114
373
Z94.0
ICD-10 Finland
Kidney transplant status
7.5
20.7
49
67
ZJX00
NOMESCO Finland
Double balloon technique in gastroenterological endoscopy
77.6
20.7
23
*
C03DA01
ATC
spironolactone; oral
2.1
20.6
250
1266
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
30.3
20.6
27
9
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
4.7
20.5
70
152
R18
ICD-10 Finland
Ascites
5.1
20.4
65
131
A04AA01
ATC
ondansetron; systemic, rectal
2.6
20.2
150
595
I81
ICD-10 Finland
Portal vein thrombosis
16.2
20.1
32
20
D76
ICPC
Malignant neoplasm pancreas
23.6
20.0
28
12
A02BC01
ATC
omeprazole; systemic
1.7
19.9
550
3686
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
19.8
468
2997
WX882
NOMESCO Finland
High dependency care
3.5
19.7
94
277
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
19.6
361
2138
8140/3-C25.0
ICD-O-3
Adenocarcinoma, NOS, of head of pancreas
201.7
19.6
20
*
K75.4
ICD-10 Finland
Autoimmune hepatitis
24.8
19.5
27
11
K72.0
ICD-10 Finland
Acute and subacute hepatic failure
19.6
19.5
29
15
A06AH03
ATC
naloxegol; oral
7.0
19.5
48
70
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.7
19.2
66
145
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
12.9
18.9
33
26
5761A
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS SUPPURATIVA]
+∞
18.8
18
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.1
18.8
236
1211
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
3.4
18.6
91
274
K83
ICD-10 Finland
Other diseases of biliary tract
100.9
18.6
20
*
K92.0
ICD-10 Finland
Haematemesis
4.0
18.5
74
188
WX110
NOMESCO Finland
Local anesthesy
1.5
18.4
1260
10433
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
5.3
18.3
56
108
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
21.9
18.2
26
12
R53
ICD-10 Finland
Malaise and fatigue
1.7
18.0
400
2508
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.3
17.9
168
754
8160/3-C22.1
ICD-O-3
Cholangiocarcinoma of intrahepatic bile duct
26.9
17.8
24
9
C24.09
ICD-10 Finland
Biliary duct or passage NOS
+∞
17.7
17
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
17.6
420
2688
JKD50
NOMESCO Finland
Hepatoportoenterostomy
181.4
17.5
18
*
R93.2
ICD-10 Finland
Abnormal findings on diagnostic imaging of liver and biliary tract
10.8
17.4
33
31
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
5.4
17.3
52
99
A07EC01
ATC
sulfasalazine; oral, rectal
2.2
17.3
181
857
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.3
17.2
171
788
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.7
17.0
75
208
K29.7
ICD-10 Finland
Gastritis, unspecified
3.4
16.9
83
252
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.3
16.8
158
712
K83.2
ICD-10 Finland
Perforation of bile duct
+∞
16.7
16
*
JL5CM
NOMESCO Finland
Bile and pancreas ducts extensive MRI examination with 3 Tesla magnet
+∞
16.7
16
*
JL5BM
NOMESCO Finland
Bile and pancreas ducts MRI examination with 3 Tesla magnet
+∞
16.7
16
*
JLB28
NOMESCO Finland
Endoscopic internal drainage of pancreatic duct
+∞
16.7
16
*
A07AA11
ATC
rifaximin; oral
35.3
16.7
21
6
JCA32
NOMESCO Finland
Endoscopic injection in oesophagus
35.3
16.7
21
6
R10.0
ICD-10 Finland
Acute abdomen
3.7
16.6
72
197
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
12.8
16.6
29
23
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
16.6
258
1434
JN1DM
NOMESCO Finland
Upper part of abdomen very extensive MRI examination with 3 Tesla magnet
90.8
16.6
18
*
WX872
NOMESCO Finland
Intensive care
2.6
16.5
119
466
JL5AM
NOMESCO Finland
Bile and pancreas ducts simple MRI examination with 3 Tesla magnet
171.2
16.5
17
*
C25.1
ICD-10 Finland
Malignant neoplasm: Body of pancreas
27.8
16.5
22
8
A28
ICPC
Limited function/disability NOS
1.8
16.5
323
1943
D97
ICPC
Liver disease NOS
13.5
16.5
28
21
1370
FHL
Colonoscopy, whole colon
12.2
16.3
29
24
L04AC05
ATC
ustekinumab; parenteral
14.4
16.3
27
19
A07EA01
ATC
prednisolone; rectal
11.2
16.2
30
27
B03BA03
ATC
hydroxocobalamin; parenteral
2.4
16.1
141
613
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.4
16.0
48
91
C24.1
ICD-10 Finland
Malignant neoplasm: Ampulla of Vater
47.9
16.0
19
*
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
4.1
16.0
62
154
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
5.6
15.9
46
84
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.9
15.8
99
356
Z93.2
ICD-10 Finland
Ileostomy status
15.8
15.7
25
16
L04AB04
ATC
adalimumab; parenteral
4.7
15.7
53
115
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
9.3
15.7
32
35
Q44.21
ICD-10 Finland
Atresia of extrahepatic bile ducts
+∞
15.6
15
*
UJK52
NOMESCO Finland
Endoscopy of biliary tract in connection with endoscopic retrograde cholangiopancreatography
+∞
15.6
15
*
L04AA05
ATC
[U] tacrolimus; systemic
85.7
15.6
17
*
C24.0
ICD-10 Finland
Malignant neoplasm: Extrahepatic bile duct
161.1
15.5
16
*
C24.02
ICD-10 Finland
Common bile duct
161.1
15.5
16
*
K86.01
ICD-10 Finland
Late effects of pancreatitis caused by alcohol
161.1
15.5
16
*
K72.9
ICD-10 Finland
Hepatic failure, unspecified
12.4
15.3
27
22
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
15.3
218
1172
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
6.5
15.2
39
61
D94
ICPC
Chronic enteritis/ulcerative colitis
9.2
15.2
31
34
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.1
15.1
83
274
JDE00
NOMESCO Finland
Gastrojejunostomy
20.2
15.1
22
11
A07AA09
ATC
vancomycin; oral
5.6
15.0
43
78
JX1XE
NOMESCO Finland
Other ultrasound examinaton of alimentary organs
31.9
14.8
19
6
N03AX16
ATC
pregabalin; oral
1.6
14.7
409
2718
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.4
14.7
72
219
A02BA02
ATC
ranitidine; systemic
1.6
14.7
382
2493
K83.5
ICD-10 Finland
Biliary cyst
+∞
14.6
14
*
57408
ICD-8 Finland
Cholelithiasis, Alia definita
+∞
14.6
14
*
JJC60
NOMESCO Finland
Total excision of transplanted liver
+∞
14.6
14
*
K85.2
ICD-10 Finland
Alcohol-induced acute pancreatitis
+∞
14.6
14
*
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
14.6
511
3597
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
14.5
441
2997
Q44.29
ICD-10 Finland
Atresia of bile ducts
150.9
14.5
15
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.2
14.4
155
745
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
14.4
337
2134
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
14.3
195
1032
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
14.3
278
1666
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.1
14.3
158
765
WX704
NOMESCO Finland
Intubation
2.3
14.2
141
650
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.6
14.2
101
393
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.4
14.2
117
494
C24.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of biliary tract
42.8
14.1
17
*
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
42.8
14.1
17
*
PC2DE
NOMESCO Finland
Ultrasound examination of liver vasculature with Doppler method
42.8
14.1
17
*
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.0
13.8
193
1029
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
17.7
13.8
21
12
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
13.7
442
3040
A10AE05
ATC
insulin detemir; parenteral
2.4
13.7
120
523
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
6.4
13.7
35
55
L04AA10
ATC
sirolimus; oral
75.6
13.6
15
*
K82.2
ICD-10 Finland
Perforation of gallbladder
+∞
13.6
13
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
4.3
13.5
49
115
K73.0
ICD-10 Finland
Chronic persistent hepatitis, not elsewhere classified
34.2
13.5
17
5
PHN73
NOMESCO Finland
Reconstruction of superior mesenteric or portal vein
140.8
13.5
14
*
8140/3-C23.9
ICD-O-3
Adenocarcinoma, NOS, of gallbladder
140.8
13.5
14
*
Z94.9
ICD-10 Finland
Transplanted organ and tissue status, unspecified
25.9
13.4
18
7
E0000UV
ATC
NA
1.5
13.3
714
5491
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
5.6
13.3
38
69
N02BE01
ATC
paracetamol; systemic, rectal
1.5
13.2
1640
14753
K80
ICD-10 Finland
Cholelithiasis
9.1
13.2
27
30
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
9.1
13.2
27
30
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
9.7
13.2
26
27
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
3.5
13.2
60
173
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
13.2
93
359
D01
ICPC
Abdominal pain/cramps general
2.0
13.1
182
971
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
4.1
13.1
50
124
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.5
13.0
103
427
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
12.9
275
1693
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
12.9
100
410
T90
ICPC
Diabetes non-insulin dependent
1.6
12.8
405
2770
E13.8
ICD-10 Finland
Other specified diabetes mellitus, with unspecified complications
50.3
12.8
15
*
XX3DW
NOMESCO Finland
Time consuming IT work
1.9
12.8
197
1090
A11CC03
ATC
alfacalcidol; systemic
3.5
12.8
60
177
B01AB04
ATC
dalteparin; parenteral
2.4
12.8
107
454
5770A
ICD-9 Finland
Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA NONALCOHOLICA NONHAEMORRHAGICA]
+∞
12.5
12
*
K81.8
ICD-10 Finland
Other cholecystitis
+∞
12.5
12
*
5741A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder with other cholecystitis[CHOLECYSTOLITHIASIS CUM CHOLECYSTITIDE CHR,SINE OBS]
+∞
12.5
12
*
K83.4
ICD-10 Finland
Spasm of sphincter of Oddi
+∞
12.5
12
*
RS220
NOMESCO Finland
NA
4.9
12.5
40
83
JN3CG
NOMESCO Finland
Extensive MRI examination of abdomen with high intensity magnet
9.4
12.5
25
27
C25.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of pancreas
20.1
12.4
18
9
XF612
NOMESCO Finland
Measurement of central venous pressure
13.2
12.4
21
16
L03AA02
ATC
filgrastim; parenteral
3.2
12.4
65
209
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.8
12.3
81
301
SPAT1254
SPAT
Administration of medicine
1.7
12.3
296
1886
J02AC01
ATC
fluconazole; systemic
1.4
12.1
621
4712
SPAT1263
SPAT
Sampling
1.4
12.1
776
6144
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.3
12.0
108
477
A02BC03
ATC
lansoprazole; oral
1.5
12.0
515
3770
J01FF01
ATC
clindamycin; systemic
1.5
11.8
482
3485
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.4
11.7
41
94
6611
FHL
Needle biopsy in the operating room
30.2
11.6
15
5
K31.5
ICD-10 Finland
Obstruction of duodenum
65.3
11.6
13
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.3
11.5
57
176
JK3RT
NOMESCO Finland
Percutaneous transhepatic removal of stones from bile ducts
+∞
11.5
11
*
JK1AT
NOMESCO Finland
Cathetrisation of bile cyst with radiological guidance
+∞
11.5
11
*
8160/3-C24.0
ICD-O-3
Cholangiocarcinoma of extrahepatic bile duct
+∞
11.5
11
*
6664
FHL
Cholecystectomy and choledocotomy
+∞
11.5
11
*
57403
ICD-8 Finland
Cholelithiasis, Choledocholithiasis
+∞
11.5
11
*
N30.0
ICD-10 Finland
Acute cystitis
1.7
11.5
247
1524
8500/3-C25.0
ICD-O-3
Infiltrating duct carcinoma, NOS, of head of pancreas
120.6
11.4
12
*
JKB21
NOMESCO Finland
Laparoscopic cholangioscopy
120.6
11.4
12
*
H26.3
ICD-10 Finland
Drug-induced cataract
7.5
11.4
26
35
S18
ICPC
Laceration/cut
1.4
11.2
760
6062
K74.0
ICD-10 Finland
Hepatic fibrosis
20.1
11.1
16
8
8170/3-C22.0
ICD-O-3
Hepatocellular carcinoma, NOS, of liver
8.1
11.1
24
30
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
10.1
11.0
21
21
8160/3-C24.9
ICD-O-3
Cholangiocarcinoma of billiary tract, NOS
43.5
10.9
13
*
JFB00
NOMESCO Finland
Partial resection of small intestine
4.1
10.9
41
101
J01MA14
ATC
moxifloxacin; systemic
1.9
10.9
160
869
RD210
NOMESCO Finland
NA
3.8
10.9
44
116
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.1
10.8
127
634
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.8
10.8
187
1075
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
10.8
693
5458
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
10.8
147
777
JL1AT
NOMESCO Finland
Biopsy of pancreas with ultrasound guidance
28.2
10.7
14
5
K30
ICD-10 Finland
Functional dyspepsia
1.9
10.7
166
920
K76.89
ICD-10 Finland
Other specified diseases of liver
21.6
10.7
15
7
JFC00
NOMESCO Finland
Entero-enterostomy
21.6
10.7
15
7
B01AA03
ATC
warfarin; systemic
1.5
10.6
425
3057
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
7.0
10.6
25
36
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.2
10.6
54
172
TBW99
NOMESCO Finland
Other minor procedure in endocrine surgery
6.6
10.5
26
40
57709
ICD-8 Finland
Diseases of pancreas, Pancreatitis NUD
+∞
10.4
10
*
Q44.20
ICD-10 Finland
Atresia of intrahepatic bile ducts
+∞
10.4
10
*
5714X
ICD-9 Finland
Chronic liver disease and cirrhosis, Chronic hepatitis[HEPATITIS CHRONICA ALIA SEU NUD]
+∞
10.4
10
*
Q44.3
ICD-10 Finland
Congenital stenosis and stricture of bile ducts
+∞
10.4
10
*
5740A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder with acute cholecystitis[CHOLECYSTOLITHIASIS CUM CHOLECYSTITIDE AC,SINE OBST]
+∞
10.4
10
*
A03
ICPC
Fever
1.6
10.4
265
1711
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.7
10.4
69
259
K65.0
ICD-10 Finland
Acute peritonitis
4.8
10.4
33
69
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.1
10.3
119
590
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
32.7
10.3
13
*
Z53.8
ICD-10 Finland
Procedure not carried out for other reasons
18.9
10.3
15
8
K72.1
ICD-10 Finland
Chronic hepatic failure
23.5
10.2
14
6
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
3.9
10.2
40
103
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
5.7
10.1
28
50
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
2.8
10.0
64
236
XX4AT
NOMESCO Finland
Other canalization with ultrasound guidance
10.1
10.0
19
19
K76.6
ICD-10 Finland
Portal hypertension
40.2
10.0
12
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
40.2
10.0
12
*
A41.4
ICD-10 Finland
Sepsis due to anaerobes
16.8
9.9
15
9
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
9.9
120
610
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
9.9
1066
9106
JJ1AT
NOMESCO Finland
Puncture of lesion of liver with ultrasound guidance
26.1
9.8
13
5
A12AA04
ATC
calcium carbonate; oral
3.9
9.8
39
102
AA1AD
NOMESCO Finland
CT of head and brain
1.5
9.8
439
3227
XX4BW
NOMESCO Finland
NA
13.4
9.7
16
12
57309
ICD-8 Finland
Other diseases of liver, Unspecified
11.4
9.6
17
15
JAD10
NOMESCO Finland
Repair of incisional hernia
6.4
9.5
24
38
JMA10
NOMESCO Finland
Transabdominal total splenectomy
7.2
9.5
22
31
E87.6
ICD-10 Finland
Hypokalaemia
2.7
9.5
62
233
JLD12
NOMESCO Finland
Endoscopic drainage of pancreatic pseudocyst
100.4
9.4
10
*
JK3PB
NOMESCO Finland
Peroperative cholangiography
100.4
9.4
10
*
JKD30
NOMESCO Finland
Extrahepatic anastomosis of right or left hepatic duct to jejunum
100.4
9.4
10
*
K73.89
ICD-10 Finland
Other long-term hepatitis, not classified differently
+∞
9.4
9
*
Q44.4
ICD-10 Finland
Choledochal cyst
+∞
9.4
9
*
5745A
ICD-9 Finland
Cholelithiasis, Calculus of bile duct without mention of cholecystitis[CHOLEDOCHOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
+∞
9.4
9
*
JK2AT
NOMESCO Finland
Puncture of bile cyst with ultrasound guidance
+∞
9.4
9
*
57400
ICD-8 Finland
Cholelithiasis, Cum cholecystitide acuta
+∞
9.4
9
*
57500
ICD-8 Finland
Cholecystitis and cholangitis, without mention of calculus, Cholecystitis acuta
+∞
9.4
9
*
5770D
ICD-9 Finland
Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICA NONHAEMORHAGICA]
+∞
9.4
9
*
JKC30
NOMESCO Finland
Partial excision of bile duct and anastomosis to jejunum
+∞
9.4
9
*
JLB12
NOMESCO Finland
Transduodenal endoscopic incision of pancreatic duct orifice
+∞
9.4
9
*
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
9.3
223
1414
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
9.3
493
3734
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
4.7
9.2
30
65
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
4.5
9.1
31
70
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
9.1
463
3483
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
4.0
9.0
34
85
C08CA01
ATC
amlodipine; oral
1.4
9.0
639
5090
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
9.0
546
4235
B81
ICPC
Anaemia vit B12/folate deficiency
2.3
9.0
78
343
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.6
8.9
64
253
K56.7
ICD-10 Finland
Ileus, unspecified
3.4
8.9
41
122
C07AA05
ATC
propranolol; systemic
1.5
8.8
307
2134
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
8.7
303
2109
T81.9
ICD-10 Finland
Unspecified complication of procedure
3.4
8.7
40
119
4AA12
NOMESCO Finland
NA
8.2
8.6
18
22
J01DA01
ATC
[U] cefalexin; systemic
1.3
8.5
1130
9855
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.0
8.5
46
154
XW4AT
NOMESCO Finland
Biopsy of other inner organ with ultrasound guidance
10.1
8.5
16
16
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
8.5
446
3370
JLC10
NOMESCO Finland
Distal pancreatectomy
20.1
8.5
12
6
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
8.5
463
3521
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
5.4
8.4
24
45
L28
ICPC
Limited function/disability (L)
1.5
8.4
283
1952
8000/3-C24.0
ICD-O-3
Neoplasm, malignant of extrahepatic bile duct
90.4
8.4
9
*
8500/3-C25.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of pancreas, NOS
90.4
8.4
9
*
7824A
ICD-9 Finland
Symptoms involving skin and other integumentary tissue, Jaundice, unspecified, not of newborn
90.4
8.4
9
*
JFF13
NOMESCO Finland
Terminal enterostomy
12.8
8.4
14
11
5750A
ICD-9 Finland
Other disorders of gallbladder, Acute cholecystitis
+∞
8.3
8
*
K82.0
ICD-10 Finland
Obstruction of gallbladder
+∞
8.3
8
*
JKB01
NOMESCO Finland
Laparoscopic incision of bile duct
+∞
8.3
8
*
K73.8
ICD-10 Finland
Other chronic hepatitis, not elsewhere classified
+∞
8.3
8
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
8.3
300
2102
T89
ICPC
Diabetes insulin dependent
2.4
8.3
70
302
SPAT1125
SPAT
Stoma care and guidance
3.1
8.3
43
140
D99
ICPC
Disease digestive system other
4.3
8.3
29
68
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
8.3
317
2250
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
8.3
746
6151
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.8
8.3
135
766
5AB14
NOMESCO Finland
NA
14.5
8.2
13
9
8000/3-C25.0
ICD-O-3
Neoplasm, malignant of head of pancreas
14.5
8.2
13
9
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
8.2
377
2777
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
4.5
8.2
27
60
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.4
8.2
64
268
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
8.2
47
163
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
4.7
8.1
26
56
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
2.8
8.1
48
171
C25
ICD-10 Finland
Malignant neoplasm of pancreas
33.5
8.1
10
*
4AA33
NOMESCO Finland
NA
33.5
8.1
10
*
R52.0
ICD-10 Finland
Acute pain
2.7
8.0
52
195
N18.8
ICD-10 Finland
Other chronic renal failure
2.4
8.0
63
264
E13
ICD-10 Finland
Other specified diabetes mellitus
22.1
8.0
11
5
N05CF01
ATC
zopiclone; oral
1.4
7.9
566
4496
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
7.9
161
979
A49.8
ICD-10 Finland
Other bacterial infections of unspecified site
5.2
7.8
23
45
M05BA04
ATC
alendronic acid; oral
1.7
7.8
157
948
ZX108
NOMESCO Finland
Inhalation
4.7
7.8
25
54
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
2.0
7.8
100
523
UKC02
NOMESCO Finland
Cystoscopy
1.5
7.7
297
2107
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
7.7
301
2144
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
5.0
7.7
23
46
JFA65
NOMESCO Finland
Endoscopic insertion of ileum stent
45.1
7.7
9
*
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
15.1
7.7
12
8
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
5.6
7.7
21
38
R31
ICD-10 Finland
Unspecified haematuria
1.6
7.6
184
1170
D77
ICPC
Malignant digestive neopl other/NOS
6.7
7.6
18
27
JFH10
NOMESCO Finland
Total colectomy and ileostomy
8.9
7.5
15
17
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
5.8
7.5
20
35
XX1XW
NOMESCO Finland
Extensive written report from radiologist
2.8
7.5
45
163
SPAT1234
SPAT
Support of social functional capacity
1.9
7.4
99
525
A06AC51
ATC
ispaghula, combinations; systemic
2.0
7.4
88
444
JFF10
NOMESCO Finland
Loop enterostomy
6.0
7.4
19
32
GD1AD
NOMESCO Finland
Thorax CT examination
2.2
7.3
74
350
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
7.3
525
4168
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
7.3
137
813
57608
ICD-8 Finland
Other diseases of gallbladder and biliary, Dyskinesia viarum biliferarum
+∞
7.3
7
*
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
7.3
7
*
JLA00
NOMESCO Finland
Exploration of pancreas
+∞
7.3
7
*
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
7.3
7
*
JLB35
NOMESCO Finland
Transduodenal endoscopic extraction of foreign body from pancreatic duct
+∞
7.3
7
*
57708
ICD-8 Finland
Diseases of pancreas, Pancreatitis acuta alia
+∞
7.3
7
*
T86.4
ICD-10 Finland
Liver transplant failure and rejection
+∞
7.3
7
*
6672
FHL
Cholecocenterostomy
+∞
7.3
7
*
57402
ICD-8 Finland
Cholelithiasis, Cum cholecystitide et choledocholithiasi
+∞
7.3
7
*
K86.0
ICD-10 Finland
Alcohol-induced chronic pancreatitis
+∞
7.3
7
*
5745B
ICD-9 Finland
Cholelithiasis, Calculus of bile duct without mention of cholecystitis[CHOLEDOCHOLITHIASIS SINE CHOLECYSTITIDE,CUM OBSTR]
+∞
7.3
7
*
6615
FHL
Liver transplant
+∞
7.3
7
*
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.1
7.3
83
412
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
6.2
7.2
18
29
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.6
7.2
191
1245
5739X
ICD-9 Finland
Other disorders of liver, Unspecified disorder of liver
15.8
7.2
11
7
K56.0
ICD-10 Finland
Paralytic ileus
4.3
7.2
25
59
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.4
7.1
32
95
A07DA03
ATC
loperamide; oral
2.2
7.1
70
328
107
Kela drug reimbursment
Pernicious anaemia
2.9
7.1
41
144
SPAT1325
SPAT
Vaccination
1.3
7.0
629
5157
A07AA02
ATC
nystatin; oral
1.8
7.0
109
610
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
5.5
6.9
19
35
WX725
NOMESCO Finland
Noninvasive ventilation
2.0
6.9
81
410
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
6.9
270
1922
TJF80
NOMESCO Finland
Ostomy education
3.7
6.9
28
77
N05BA04
ATC
oxazepam; oral
1.4
6.9
414
3191
NF1AA
NOMESCO Finland
Hip X-ray examination
1.6
6.8
156
980
K59.09
ICD-10 Finland
Constipation, unspecified
1.8
6.8
106
593
R06.0
ICD-10 Finland
Dyspnoea
1.4
6.8
411
3166
SPAT1216
SPAT
Assessment of functional ability
1.5
6.8
272
1946
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.9
6.8
90
474
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
5.0
6.8
20
40
ZXA00
NOMESCO Finland
Right side
1.3
6.8
469
3694
JF1BD
NOMESCO Finland
Very extensive small bowel CT
6.1
6.8
17
28
5550A
ICD-9 Finland
Regional enteritis, Small intestine
40.2
6.8
8
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
1.9
6.7
98
537
253
Kela drug reimbursment
NA
16.7
6.7
10
6
3042
Kela drug reimbursment
NA
16.7
6.7
10
6
4AB02
NOMESCO Finland
NA
7.2
6.7
15
21
SPAT1211
SPAT
Application of soft bandage
1.6
6.7
159
1009
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.3
6.7
564
4574
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
4.4
6.6
22
50
X59
ICD-10 Finland
Exposure to unspecified factor
1.4
6.6
299
2188
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.5
6.6
48
195
SPAT1301
SPAT
No procedures
1.3
6.6
551
4460
I50.9
ICD-10 Finland
Heart failure, unspecified
1.4
6.6
269
1932
Y69
ICD-10 Finland
Unspecified misadventure during surgical and medical care
3.5
6.6
28
80
XW000
NOMESCO Finland
Bone marrow biopsy
2.0
6.6
74
369
N17.8
ICD-10 Finland
Other acute renal failure
3.7
6.6
26
70
Q61.3
ICD-10 Finland
Polycystic kidney, unspecified
8.7
6.5
13
15
S97
ICPC
Chronic ulcer skin
1.9
6.5
96
527
B34.9
ICD-10 Finland
Viral infection, unspecified
2.4
6.5
50
208
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.2
6.5
59
268
A04
ICPC
Weakness/tiredness general
1.5
6.5
224
1555
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.7
6.5
123
735
A46
ICD-10 Finland
Erysipelas
1.5
6.5
243
1715
J01CA08
ATC
pivmecillinam; oral
1.3
6.4
592
4855
JK3AN
NOMESCO Finland
Biliary tract isotope imaging
70.0
6.4
7
*
K82.9
ICD-10 Finland
Disease of gallbladder, unspecified
70.0
6.4
7
*
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
2.3
6.4
53
231
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
4.1
6.4
23
57
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
6.4
108
624
K59.1
ICD-10 Finland
Functional diarrhoea
1.9
6.3
84
445
JN3DG
NOMESCO Finland
Very extensive MRI examination with high intensity magnet
5.5
6.3
17
31
RS120
NOMESCO Finland
NA
11.0
6.3
11
10
N03AX12
ATC
gabapentin; oral
1.5
6.3
238
1684
L29.8
ICD-10 Finland
Other pruritus
3.7
6.3
25
68
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
18.1
6.3
9
5
K71.2
ICD-10 Finland
Toxic liver disease with acute hepatitis
18.1
6.3
9
5
JJC10
NOMESCO Finland
Allogenic partial transplantation of liver
+∞
6.3
6
*
BE00A
NOMESCO Finland
NA
+∞
6.3
6
*
1282
FHL
ERCP and sphincterotomy
+∞
6.3
6
*
6673
FHL
Hepatic enterostomy
+∞
6.3
6
*
5770C
ICD-9 Finland
Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA NONALCOHOLICA RECIDIVANS]
+∞
6.3
6
*
JLC40
NOMESCO Finland
Total pancreatoduodenectomy
+∞
6.3
6
*
6653
FHL
Cholecocotomy or hepaticotomy and choledocoscopy (includes stone removal)
+∞
6.3
6
*
5762A
ICD-9 Finland
Other disorders of biliary tract, Obstruction of bile duct
+∞
6.3
6
*
JKF96
NOMESCO Finland
Other secondary operation on biliary tract
+∞
6.3
6
*
Q44.1
ICD-10 Finland
Other congenital malformations of gallbladder
+∞
6.3
6
*
5761B
ICD-9 Finland
Other disorders of biliary tract, Cholangitis[CHOLANGITIS CHRONICA]
+∞
6.3
6
*
XX9XB
NOMESCO Finland
Other X-ray examination with contrast
26.7
6.2
8
*
C25.4
ICD-10 Finland
Malignant neoplasm: Endocrine pancreas
26.7
6.2
8
*
J01XX08
ATC
linezolid; systemic
5.0
6.2
18
36
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
5.0
6.2
18
36
A40.8
ICD-10 Finland
Other streptococcal sepsis
3.8
6.2
24
64
SPAT1153
SPAT
Removal of sutures
1.3
6.2
532
4325
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
5.3
6.1
17
32
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
6.1
139
872
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.4
6.1
47
196
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
12.5
6.1
10
8
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
6.1
56
257
J01FA06
ATC
roxithromycin; oral
1.3
6.1
671
5635
TJD00
NOMESCO Finland
Insertion of nasogastric or naso-gastroduodenal tube
3.1
6.1
30
97
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.0
6.0
70
354
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.0
6.0
72
368
ZX121
NOMESCO Finland
Central venous catheter
6.7
6.0
14
21
JN1AD
NOMESCO Finland
CT examination of upper part of abdomen
6.7
6.0
14
21
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
3.2
6.0
29
92
K29.6
ICD-10 Finland
Other gastritis
3.4
6.0
26
76
V03AE01
ATC
polystyrene sulfonate; oral
3.0
6.0
32
109
Mortality – FinRegistry
↥Association
Association between endpoint K11_CHOLANGI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHOLANGI | 2.458 [2.14, 2.83] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 2720 out of 6016 females with K11_CHOLANGI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_CHOLANGI | 2.52 [2.17, 2.93] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 2735 out of 5897 males with K11_CHOLANGI died.
Mortality risk
Mortality risk for people of age
years, who have K11_CHOLANGI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.165% | 0.495% |
| 5 | 1.088% | 2.92% |
| 10 | 3.025% | 7.448% |
| 15 | 5.777% | 13.209% |
| 20 | 9.879% | 21.994% |
Relationships between endpoints
↥Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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