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Pneumoconiosis due to dust containing silica

DOID EFO Endpoint Browser PheWeb

J10_SILICAPNEUMOC

silicosis: Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition.

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Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — J62
  • Hospital discharge: ICD-9 — 502
  • Hospital discharge: ICD-8 — 5150
  • Cause of death: ICD-10 — J62
  • Cause of death: ICD-9 — 502
  • Cause of death: ICD-8 — 5150

2 out of 7 registries used, show all original rules.

125

4. Check minimum number of events

None

125

5. Include endpoints

None

125

6. Filter based on genotype QC (FinnGen only)

125

Control definitions (FinnGen only)

Control exclude
J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
J60-J70
Name in latin
Silicosis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1139 103 997
Only index persons 595 70 525
Unadjusted period prevalence (%)
Whole population 0.03 0.00 0.03
Only index persons 0.02 0.00 0.02
Median age at first event (years)
Whole population 64.26 62.16 64.36
Only index persons 62.00 51.82 63.36

-FinnGen-

Key figures

All Female Male
Number of individuals 125 11 114
Unadjusted period prevalence (%) 0.05 0.00 0.05
Median age at first event (years) 64.12 41.77 66.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
108
Matched controls
1081
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
+∞
74.9
63
*
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
+∞
48.7
43
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
12.4
24.9
50
70
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
34.0
17.3
22
8
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
15.9
14.2
23
18
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.3
12.5
32
59
51500
ICD-8 Finland
Pneumoconiosis due to silica and silicates, Silicosis
+∞
11.7
11
*
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
+∞
11.7
11
*
J62
ICD-10 Finland
Pneumoconiosis due to dust containing silica
+∞
11.7
11
*
5020A
ICD-9 Finland
Pneumoconiosis due to other silica or silicates[SILICOSIS]
+∞
10.6
10
*
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
19.8
9.7
14
8
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
4.2
8.4
35
110
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
7.6
67
366
H02AB06
ATC
prednisolone; systemic
3.0
7.0
63
343
Z57.2
ICD-10 Finland
Occupational exposure to dust
74.0
6.5
7
*
TGC00
NOMESCO Finland
Bronchial lavation
12.1
6.5
11
10
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
22
40
6.46
12.13
2.4
2.7
—
—
—
0
0
(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma
16
29
6.18
8.75
2.6
1.8
u/l
48.6
42.5
0.37
16
24
(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain
10
14
7.68
6.80
1.1
1.2
—
—
—
0
0
(3042631) Mycobacterium sp identified in Specimen
9
15
6.37
3.89
2.6
2.7
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
9
17
5.61
3.58
1.4
1.5
—
—
—
0
0
(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection
8
14
6.02
3.40
1.6
1.1
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
9
21
4.53
3.06
1.6
1.5
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
9
22
4.32
2.94
1.4
1.5
—
—
—
0
0
(3044927) Protein electrophoresis panel - Urine
6
9
6.93
2.90
1.0
1.1
—
—
—
0
0
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
6
9
6.93
2.90
1.2
1.9
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
6
9
6.93
2.90
1.2
1.9
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
6
9
6.93
2.90
1.2
1.9
—
—
—
0
0
(3019060) Gas panel - Arterial blood
18
80
2.46
2.76
4.8
2.9
—
—
—
0
0
(3023419) Bacteria identified in Sputum by Culture
6
10
6.24
2.73
4.7
2.4
—
—
—
0
0
(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection
6
11
5.67
2.57
1.2
1.6
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
47
314
1.80
2.45
4.9
4.3
—
—
—
0
0
(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection
6
12
5.19
2.43
1.2
1.6
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
47
319
1.76
2.30
9.3
5.3
—
—
—
0
0
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
6
13
4.79
2.30
2.0
1.5
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
6
13
4.79
2.30
1.8
2.9
e9/l
5.1
4.4
—
6
13
(1616796) Gas panel - Central venous blood
8
24
3.49
2.22
2.1
4.0
—
—
—
0
0
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
6
14
4.44
2.18
1.8
1.5
—
—
—
0
0
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
6
14
4.44
2.18
1.8
1.5
—
—
—
0
0
(3001604) Monocytes [#/volume] in Blood
59
435
1.67
2.10
6.3
5.6
e9/l
0.7
0.6
0.99
53
367
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
6
15
4.14
2.06
1.8
3.1
%
59.3
59.1
—
6
15
(3006315) Basophils [#/volume] in Blood
59
437
1.66
2.06
6.3
5.7
e9/l
0.0
0.0
0.46
53
372
(3037522) Nuclear Ab [Titer] in Serum
18
92
2.12
2.02
1.1
1.3
titre
2128.0
417.8
—
5
18
(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma
58
430
1.65
2.00
6.1
5.3
mmol/l
1.2
1.2
0.59
53
373
(3042936) Bacteria identified in Isolate by Culture
25
146
1.89
1.96
1.8
2.0
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
6
16
3.88
1.96
1.8
1.5
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
28
170
1.83
1.95
2.2
1.8
—
—
—
0
0
(3022313) Gas panel - Capillary blood
13
59
2.34
1.92
3.7
2.6
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
59
447
1.61
1.82
6.4
5.7
e9/l
1.7
1.9
0.36
54
391
(3020891) Body temperature
10
41
2.56
1.80
5.2
4.5
—
—
—
0
0
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
16
82
2.09
1.79
3.8
2.7
kpa
5.1
5.0
0.36
16
71
(3023199) Leukocytes [#/volume] in Pleural fluid
5
14
3.67
1.63
1.2
1.4
e6/l
4313.4
2742.7
—
5
9
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
6
20
3.10
1.60
2.5
1.9
—
—
—
0
0
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
48
356
1.57
1.58
3.9
3.5
ng/l
1520.9
1848.3
0.37
42
310
(3018418) pH of Serum or Plasma
38
268
1.60
1.54
4.0
3.9
ph
7.4
7.4
—
9
51
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
6
21
2.95
1.52
1.5
1.1
—
—
—
0
0
(3019225) pH of Specimen
17
96
1.89
1.48
5.2
3.4
—
—
—
0
0
(4010399)
14
74
2.00
1.46
1.5
1.4
—
—
—
0
0
(4035726)
14
74
2.00
1.46
1.6
1.5
—
—
—
0
0
(1761482) Bacteria [#/volume] in Urine by Culture
0
39
0.00
1.36
0.0
7.1
—
—
—
0
0
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
16
92
1.85
1.32
1.2
1.3
u/ml
1.1
15.9
—
6
31
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
54
425
1.48
1.30
4.6
4.5
ng/l
40.5
51.6
0.43
42
333
(3022145) Colonoscopy Study observation
15
86
1.85
1.25
1.3
1.3
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
12
64
1.97
1.23
2.2
1.7
—
—
—
0
0
(40760888) Immunoglobulin light chains.free panel - Serum
6
26
2.37
1.20
4.2
2.4
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
0
33
0.00
1.18
0.0
2.0
—
—
—
0
0
(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay
5
20
2.56
1.16
1.4
1.3
—
—
—
0
0
(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay
5
20
2.56
1.16
1.4
1.3
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
8
40
2.07
1.14
2.3
2.1
—
—
—
0
0
(3000492) Spirometry study
12
66
1.91
1.13
1.4
1.5
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
31
224
1.51
1.11
2.1
1.8
nmol/l
1040.9
1203.2
0.46
23
170
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
19
122
1.66
1.10
2.2
1.7
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
14
82
1.80
1.10
1.9
2.3
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
7
33
2.19
1.07
1.6
1.5
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
58
480
1.39
1.01
6.9
5.8
mmol/l
1.2
1.2
0.74
47
395
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
0
28
0.00
0.99
0.0
1.8
—
—
—
0
0
(3049717) Cytology report of Urine Cyto stain
9
52
1.79
0.94
2.0
2.3
—
—
—
0
0
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
11
63
1.82
0.93
1.7
1.3
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
60
506
1.36
0.90
11.3
8.6
e9/l
4.7
4.3
0.73
53
426
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
73
821
0.73
0.90
4.9
5.3
mmol/l
2.3
2.5
0.92
66
738
(3032080) INR in Blood by Coagulation assay
52
430
1.36
0.88
10.0
11.1
inr
1.3
1.4
0.16
14
128
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
6
31
1.98
0.85
1.8
1.4
—
—
—
0
0
(40760892) CBC W Ordered Manual Differential panel - Blood
24
175
1.46
0.83
4.5
5.6
—
—
—
0
0
(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence
6
33
1.86
0.80
1.8
1.5
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
26
338
0.71
0.79
4.0
4.3
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
27
0.00
0.78
0.0
1.3
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
17
117
1.52
0.76
4.5
3.6
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
7
39
1.84
0.74
1.6
1.3
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
5
25
2.04
0.73
2.8
1.5
g/l
1.1
1.1
—
5
25
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
7
40
1.79
0.72
2.0
1.8
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
7
41
1.75
0.71
5.3
2.9
—
1.6
—
0
5
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
5
27
1.89
0.69
1.0
1.7
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
17
120
1.48
0.69
2.1
1.6
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
72
797
0.77
0.69
4.4
4.7
mmol/l
3.9
4.2
2.64
66
722
(3009542) Hematocrit [Volume Fraction] of Blood
63
705
0.79
0.63
25.3
18.5
%
40.0
39.1
0.25
37
437
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
50
1.64
0.63
1.5
1.5
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
70
773
0.79
0.62
4.1
4.2
mmol/l
1.2
1.3
0.54
62
685
(3041096) Erythrocytes [Presence] in Urine by Automated
19
250
0.72
0.62
3.0
4.0
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
11
72
1.58
0.61
1.1
1.6
—
—
—
0
0
(3004410) Hemoglobin A1c/Hemoglobin.total in Blood
71
781
0.79
0.60
5.3
6.9
mmol/mol
39.2
41.5
1.73
61
718
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
72
790
0.79
0.59
4.4
4.7
mmol/l
1.2
1.3
2.80
65
703
(3020682) Albumin/Creatinine [Ratio] in Urine
24
298
0.76
0.54
3.8
4.0
mg/mmol
4.3
12.8
1.77
18
197
(40768797) Stomach Pathology biopsy report
15
109
1.43
0.54
1.1
1.2
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
21
265
0.75
0.53
2.5
3.3
—
—
—
0
0
(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum
6
40
1.52
0.52
2.3
2.3
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
9
65
1.41
0.52
1.2
1.4
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
14
103
1.40
0.47
7.8
9.3
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
58
639
0.83
0.44
5.0
5.3
ug/l
1.7
2.8
1.16
47
547
(36304419) Bacteria [Presence] in Urine
31
261
1.25
0.44
3.0
3.0
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
25
205
1.27
0.44
4.2
2.2
—
—
—
0
0
(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma
26
311
0.79
0.44
2.9
2.3
nmol/l
78.3
74.7
0.18
20
268
(3028626) Oxygen [Partial pressure] in Capillary blood
5
31
1.64
0.43
4.2
2.6
kpa
7.9
8.4
—
5
24
(4034850)
5
33
1.54
0.42
17.8
15.9
—
—
—
0
0
(3033705) Calcium.ionized [Moles/volume] in Venous blood
0
18
0.00
0.40
0.0
3.5
—
—
—
0
0
(3041354) Potassium [Moles/volume] in Venous blood
0
18
0.00
0.40
0.0
3.5
—
4.1
—
0
18
(3035285) Chloride [Moles/volume] in Venous blood
0
18
0.00
0.40
0.0
3.5
—
106.2
—
0
18
(3026008) Bacteria identified in Urine by Culture
21
255
0.79
0.40
2.9
3.1
—
—
—
0
0
(3021387) Prolactin [Units/volume] in Serum or Plasma
0
19
0.00
0.39
0.0
1.2
—
263.6
—
0
19
(3018677) aPTT in Platelet poor plasma by Coagulation assay
21
171
1.27
0.39
3.0
1.8
s
33.1
29.7
0.84
21
165
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
6
43
1.41
0.35
2.3
3.9
pmol/l
4.3
4.4
—
6
37
(3046279) Procalcitonin [Mass/volume] in Serum or Plasma
6
43
1.41
0.35
2.7
2.0
ug/l
1.1
1.1
—
6
36
(3000850) Epithelial cells [#/volume] in Urine
27
230
1.22
0.35
2.2
2.5
e6/l
5.1
3.3
0.37
22
199
(3021601) Nitrite [Presence] in Urine by Test strip
37
417
0.84
0.35
4.0
5.5
estimate
0.1
0.0
—
10
98
(3026782) Osmolality of Urine
26
221
1.22
0.34
2.5
3.4
mosm/kgh2o
546.8
613.3
0.64
20
191
(40761511) CBC panel - Blood by Automated count
81
856
0.85
0.34
23.8
17.0
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
73
777
0.85
0.33
21.8
17.1
ml/min/173m2
73.4
72.7
0.10
66
650
(3000991) Gas panel - Venous blood
12
92
1.34
0.33
3.5
7.1
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
38
423
0.85
0.30
3.7
4.1
estimate
0.0
0.0
—
10
92
(3037467) Urinalysis macro (dipstick) panel - Urine
64
595
1.15
0.30
3.6
4.3
—
—
—
0
0
(3012516) Albumin [Mass/volume] in Urine
24
278
0.83
0.30
3.1
3.2
mg/l
58.2
311.7
0.60
19
187
(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma
11
85
1.32
0.29
2.5
3.5
ng/l
298.8
256.8
0.11
11
75
(3018251) Fasting glucose [Moles/volume] in Serum or Plasma
76
802
0.87
0.29
4.3
5.1
mmol/l
5.8
6.2
3.03
62
710
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
44
400
1.15
0.28
2.0
2.1
pmol/l
99.3
89.8
0.38
24
224
(46235355) HIV 1 and 2 tests - Meaningful Use set
12
95
1.29
0.27
2.0
1.8
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
40
363
1.15
0.26
3.3
3.3
—
—
—
0
0
(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis
5
40
1.26
0.22
2.4
3.0
g/l
38.8
37.3
—
5
31
(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
(3017569) Oxygen content in Arterial blood
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
(3004775) Volume in Urine collected for unspecified duration
0
12
0.00
0.21
0.0
1.8
—
491.3
—
0
7
(3029937) Albumin [Presence] in Urine by Test strip
22
247
0.87
0.19
4.5
3.9
estimate
0.0
0.0
—
7
90
(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis
6
52
1.16
0.19
2.2
2.7
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
11
91
1.23
0.18
1.3
1.4
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
46
490
0.90
0.17
4.4
4.7
%
24.5
21.7
0.51
23
250
(40758558) Short blood count panel - Blood
24
216
1.14
0.17
5.8
5.7
—
—
—
0
0
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
6
77
0.77
0.16
1.3
1.9
%
1.6
1.8
—
6
66
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
9
80
1.13
0.15
1.7
1.5
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
19
170
1.14
0.14
2.8
2.8
e6/l
2.3
1.1
0.27
12
108
(3002256) Pathology report gross observation
12
104
1.17
0.13
1.5
1.4
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
10
85
1.19
0.13
3.4
3.6
—
—
—
0
0
(3044889) 12 lead EKG panel
59
614
0.93
0.12
4.8
4.4
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
33
351
0.92
0.11
3.7
3.2
ug/l
0.7
0.8
0.60
20
231
(3018095) Leukocytes [#/volume] in Urine
37
350
1.08
0.11
3.5
3.7
e6/l
74.9
83.6
0.06
30
280
(40768804) Tissue Pathology biopsy report
32
301
1.08
0.10
2.0
2.3
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
12
106
1.15
0.10
1.8
1.8
—
—
—
0
0
(3022621) pH of Urine by Test strip
5
45
1.12
0.10
2.4
2.4
—
—
—
0
0
(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis
5
46
1.09
0.09
2.4
2.8
g/l
11.2
10.9
—
5
37
(3044640) Blood type and Crossmatch panel - Blood
30
283
1.08
0.09
4.0
2.3
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
6
54
1.12
0.09
1.2
1.2
—
—
—
0
0
(3001122) Ferritin [Mass/volume] in Serum or Plasma
34
357
0.93
0.08
2.6
2.8
ug/l
269.3
169.1
1.00
28
327
(3017143) Hepatitis C virus Ab [Presence] in Serum
8
77
1.04
0.07
1.8
1.6
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
39
406
0.94
0.07
2.7
2.5
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
40
416
0.94
0.07
3.5
4.1
estimate
0.0
0.0
0.00
11
99
(3026493) Urate [Moles/volume] in Serum or Plasma
28
266
1.07
0.07
3.2
2.8
umol/l
381.9
7688.3
1.32
23
214
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
41
395
1.06
0.06
5.2
4.0
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
83
845
0.95
0.06
26.4
17.3
mg/l
29.6
28.3
0.13
76
702
(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma
22
232
0.94
0.05
2.0
1.9
pmol/l
457.9
29381855.7
0.50
16
194
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
53
518
1.04
0.04
3.5
3.1
u/l
67.3
54.5
0.65
47
482
(3021589) Normoblasts [#/volume] in Blood
41
399
1.04
0.04
15.5
10.7
e9/l
0.0
0.0
0.53
34
331
(3007164) IgA [Mass/volume] in Serum or Plasma
15
144
1.05
0.00
1.5
1.5
g/l
3.0
2.8
—
8
81
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
19
184
1.04
0.00
5.5
3.7
ng/l
2806.4
181.0
0.46
19
157
(3003694) ABO and Rh group [Type] in Blood
21
204
1.04
0.00
1.4
1.3
—
—
—
0
0
(3013512) EKG study
30
306
0.97
0.00
4.2
4.6
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
72
726
0.98
0.00
4.1
4.1
mu/l
2.3
2.1
0.61
62
626
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
17
171
0.99
0.00
3.3
3.0
e6/l
2.3
0.9
—
10
110
(3011397) Hemoglobin [Presence] in Urine by Test strip
17
173
0.98
0.00
4.0
3.7
—
—
—
0
0
(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma
57
569
1.00
0.00
3.5
3.3
pmol/l
14.9
14.7
0.21
50
484
(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3006442) Creatine [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
(3024263) Appearance of Synovial fluid
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(3043410) Blood group antigens tested for on Red Blood Cells
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(44806420)
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
(3011544) Albumin [Mass/volume] in Pleural fluid
0
6
0.00
0.00
0.0
1.0
—
16.9
—
0
6
(3008536) Aspergillus sp Ab [Presence] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(42869593) Oxyhemoglobin/Hemoglobin.total [Pure mass fraction] in Capillary blood
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3050129) First trimester maternal screen panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(4024509)
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(40761535) Cells panel - Urine sediment
7
72
0.97
0.00
5.9
3.6
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(40768793) Breast Pathology biopsy report
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3035999) Lactate [Moles/volume] in Cerebral spinal fluid
0
5
0.00
0.00
0.0
1.2
—
1.7
—
0
5
(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
3.8
—
87.2
—
0
5
(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
0.00
0.0
1.2
—
108.2
—
0
5
(3014148) Varicella zoster virus Ab [Titer] in Serum
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
6
68
0.88
0.00
1.0
1.6
—
—
—
0
0
(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3051611) Lipemic interference index of Serum or Plasma
0
8
0.00
0.00
0.0
3.8
—
—
—
0
0
(3003888) Timothy IgE Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.1
—
12.2
—
0
7
(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
16.9
—
0
5
(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
2.9
—
217.6
—
0
7
(3029634) Reagin Ab [Titer] in Serum by VDRL
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0
(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint J10_SILICAPNEUMOC and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
J10_SILICAPNEUMOC 1.875 [1.51, 2.33] < 0.001
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 466 males with J10_SILICAPNEUMOC died.

Mortality risk

Mortality risk for people of age

years, who have J10_SILICAPNEUMOC.

N-year risk Females Males
1 No data 0.447%
5 No data 2.501%
10 No data 5.67%
15 No data 10.948%
20 No data 18.021%

Relationships between endpoints

↥

Index endpoint: J10_SILICAPNEUMOC – Pneumoconiosis due to dust containing silica

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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