Gangrene and necrosis of lung

J10_LUNGNECROSIS

No definition available.

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J85.0 Cause of death: ICD-10 — J85.0 2 out of 7 registries used, show all original rules.	10
4. Check minimum number of events None	10
5. Include endpoints None	10
6. Filter based on genotype QC (FinnGen only)	10

Control definitions (FinnGen only)

Control exclude: J10_NECROTIC

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J85
Name in latin: Necrosis pulmonis

NAME	J10_LUNGNECROSIS
CONTROL_EXCLUDE	J10_NECROTIC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J850
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J850
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Gangrene and necrosis of lung based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	263	84	175
Only index persons	158	58	100
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	61.42	64.70	59.89
Only index persons	58.09	56.91	58.78

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	10	-	8
Unadjusted period prevalence (%)	0.00	-	0.00
Median age at first event (years)	63.30	-	71.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

7.84

2.25

3.0

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

7.84

2.25

3.0

1.4

—

(3033658) Prothrombin time (PT) actual/Normal

4.19

1.41

4.6

4.4

81.2

73.8

—

(42870588) Differential panel, method unspecified - Blood

3.71

1.27

2.4

2.0

—

(3044640) Blood type and Crossmatch panel - Blood

3.13

0.90

2.4

2.3

—

(3026008) Bacteria identified in Urine by Culture

2.82

0.85

2.4

2.0

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

0.00

0.45

0.0

2.0

—

516.5

—

(3021589) Normoblasts [#/volume] in Blood

1.77

0.30

12.8

7.2

e9/l

0.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.23

0.0

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.23

0.0

2.4

—

(40761535) Cells panel - Urine sediment

0.00

0.23

0.0

4.5

—

(3000991) Gas panel - Venous blood

0.00

0.23

0.0

14.0

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

3.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.4

—

(3009343) pH of Capillary blood

0.00

0.0

1.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

3.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.0

1.3

—

0.1

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

6.0

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.00

0.0

2.3

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

0.00

0.0

7.8

—

106.3

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

0.00

0.0

2.1

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

10.6

—

0.8

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

3.9

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

10.6

—

0.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

3.9

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.00

0.0

2.9

—

(3012544) pH of Venous blood

0.00

-0.00

0.0

7.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

-0.00

0.0

11.6

—

95.6

—

Mortality – FinRegistry

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Association

Association between endpoint J10_LUNGNECROSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_LUNGNECROSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: J10_LUNGNECROSIS – Gangrene and necrosis of lung

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Gangrene and necrosis of lung

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints