This is a non-core endpoint: only basic statistics are computed.
Coalworker pneumoconiosis
J10_COALPNEUMOC
anthracosis: A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal MINERS, but can be seen in urban dwellers and tobacco smokers.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
25 |
4. Check minimum number of eventsNone |
25 |
5. Include endpointsNone |
25 |
6. Filter based on genotype QC (FinnGen only) |
25 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Anthracosis pulmonum
Similar endpoints
↥List of similar endpoints to
Coalworker pneumoconiosis
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 237 | 70 | 160 |
| Only index persons | 147 | 47 | 100 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 66.66 | 62.39 | 68.05 |
| Only index persons | 57.89 | 56.57 | 58.52 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 25 | 9 | 16 |
| Unadjusted period prevalence (%) | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | 62.94 | 56.57 | 66.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
No data available
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3042936) Bacteria identified in Isolate by Culture
7
22
4.00
2.06
1.7
2.6
—
—
—
0
0
(3020630) Protein [Mass/volume] in Serum or Plasma
5
15
3.89
1.60
1.8
2.5
g/l
60.2
66.8
—
5
15
(3012544) pH of Venous blood
5
15
3.89
1.60
2.2
2.0
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
5
15
3.89
1.60
1.8
2.0
kpa
6.3
5.1
—
5
15
(3003694) ABO and Rh group [Type] in Blood
0
37
0.00
1.49
0.0
1.2
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
5
19
3.02
1.28
3.0
1.3
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
9
48
2.36
1.17
2.6
2.5
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
5
21
2.71
1.15
3.0
1.3
—
—
—
0
0
(3019309) Folate [Moles/volume] in Red Blood Cells
7
37
2.23
1.04
2.1
1.4
nmol/l
1202.3
1236.0
—
7
29
(3037467) Urinalysis macro (dipstick) panel - Urine
17
124
2.15
1.02
6.3
5.2
—
—
—
0
0
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
11
69
2.06
0.87
2.3
2.7
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
9
57
1.90
0.83
4.0
3.7
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
7
42
1.92
0.76
3.1
5.7
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
8
50
1.88
0.71
3.9
3.9
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
8
52
1.79
0.68
11.5
5.1
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
6
34
2.00
0.64
1.8
2.7
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
0
19
0.00
0.63
0.0
5.2
—
12.6
—
0
14
(3013650) Neutrophils [#/volume] in Blood by Automated count
12
87
1.73
0.56
13.6
10.4
e9/l
4.4
4.0
0.25
12
78
(3015736) pH of Urine
10
69
1.75
0.55
3.8
4.7
—
—
—
0
0
(3013512) EKG study
8
58
1.56
0.48
5.5
3.9
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
5
30
1.83
0.47
3.0
2.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
0
15
0.00
0.43
0.0
1.8
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
0
15
0.00
0.43
0.0
2.9
—
0.1
—
0
15
(3044640) Blood type and Crossmatch panel - Blood
7
50
1.55
0.36
2.1
2.4
—
—
—
0
0
(40758558) Short blood count panel - Blood
5
38
1.39
0.25
5.6
6.9
—
—
—
0
0
(3022621) pH of Urine by Test strip
0
11
0.00
0.22
0.0
4.0
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
0
11
0.00
0.22
0.0
1.1
—
—
—
0
0
(3018405) Lactate [Moles/volume] in Arterial blood
0
12
0.00
0.21
0.0
2.5
—
1.1
—
0
12
(21494755) Public health laboratory ask at order entry panel
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma
0
13
0.00
0.21
0.0
3.9
—
1.5
—
0
13
(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)
0
13
0.00
0.21
0.0
2.0
—
66.8
—
0
6
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
6
74
0.75
0.19
5.3
4.8
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
14
125
1.27
0.14
5.0
5.5
—
1223.3
—
0
7
(3009542) Hematocrit [Volume Fraction] of Blood
15
136
1.26
0.13
21.9
15.5
%
41.0
39.5
—
10
96
(3013826) Glucose [Moles/volume] in Serum or Plasma
10
112
0.82
0.10
4.5
4.4
mmol/l
6.0
6.5
—
10
104
(3035941) MCH [Entitic mass]
18
185
0.90
0.09
31.6
23.0
pg
30.5
30.4
0.03
18
180
(3000963) Hemoglobin [Mass/volume] in Blood
18
185
0.90
0.09
31.8
23.1
g/l
131.1
135.1
0.44
18
180
(3010813) Leukocytes [#/volume] in Blood
18
185
0.90
0.09
31.7
23.1
e9/l
6.6
6.6
0.01
18
177
(3026361) Erythrocytes [#/volume] in Blood
18
185
0.90
0.09
31.7
23.1
e12/l
4.3
4.5
0.38
18
177
(3007461) Platelets [#/volume] in Blood
18
185
0.90
0.09
31.6
23.1
e9/l
253.2
238.6
0.42
18
178
(3024731) MCV [Entitic volume]
18
184
0.92
0.09
31.6
23.1
fl
92.7
91.6
0.45
18
179
(3020564) Creatinine [Moles/volume] in Serum or Plasma
17
178
0.86
0.09
26.3
18.7
umol/l
82.1
80.4
0.14
17
178
(40761511) CBC panel - Blood by Automated count
18
170
1.21
0.08
18.1
15.7
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
8
88
0.87
0.08
2.5
3.7
—
—
—
0
0
(3002385) Erythrocyte distribution width [Ratio]
14
132
1.14
0.03
27.4
18.2
%
14.1
13.9
0.32
14
126
(3044889) 12 lead EKG panel
12
117
1.05
0.00
4.5
3.9
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
7
75
0.91
0.00
3.3
4.1
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3019550) Sodium [Moles/volume] in Serum or Plasma
17
171
0.98
0.00
25.2
18.4
mmol/l
139.8
139.4
0.18
17
166
(3044290) Cell count panel - Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(40768443) Skin Pathology biopsy report
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
0
8
0.00
0.00
0.0
4.5
—
—
—
0
0
(42529406) Shigella sp [Presence] in Stool by Culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3013139) Helicobacter pylori Ag [Presence] in Stool
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
(3004716) Salmonella sp identified in Stool by Organism specific culture
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
3.4
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3034770) Mitochondria Ab [Titer] in Serum
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3040151) Glucose [Moles/volume] in Capillary blood
0
6
0.00
0.00
0.0
5.0
—
7.0
—
0
6
(40768793) Breast Pathology biopsy report
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma
18
178
1.04
0.00
15.4
10.6
u/l
24.0
24.3
0.03
18
172
(3005988) Vibrio sp identified in Specimen by Organism specific culture
0
5
0.00
0.00
0.0
2.8
—
—
—
0
0
(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
17
172
0.96
0.00
25.3
18.2
mmol/l
4.0
4.0
0.01
17
167
(4094501)
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3014765) Yersinia sp identified in Stool by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(44816559) Phosphatidylethanol [Mass/volume] in Blood
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(1002224) Polysomnography panel
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
(3008898) HLA-B27 [Presence]
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3001019) Free T4 and TSH panel - Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(3006418) Campylobacter sp identified in Tissue by Organism specific culture
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint J10_COALPNEUMOC and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have J10_COALPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: J10_COALPNEUMOC – Coalworker pneumoconiosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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