This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
ILD medications: acetylcysteine
ILD_ASETYLCYSTEINE
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
367 |
4. Check minimum number of events
Min. number of events
3
|
367 |
5. Include endpointsNone |
367 |
6. Filter based on genotype QC (FinnGen only) |
367 |
Control definitions (FinnGen only)
- Control exclude
- ILD_MEDICATIONS
Extra metadata
- First used in FinnGen datafreeze
- DF2
ILD medications: acetylcysteine
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 367 | 154 | 213 |
| Unadjusted period prevalence (%) | 0.08 | 0.05 | 0.09 |
| Median age at first event (years) | 61.57 | 53.77 | 67.22 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 338
- Matched controls
- 3378
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R05CB01
ATC
acetylcysteine; inhalant, oral
+∞
323.0
338
17
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
19.7
115.4
201
234
R03AC12
ATC
salmeterol; inhalant
46.4
92.5
113
36
H02AB06
ATC
prednisolone; systemic
11.0
87.2
236
587
R03DA04
ATC
theophylline; systemic, rectal
19.0
83.7
137
117
R03BB01
ATC
ipratropium bromide; inhalant
16.3
69.8
120
110
R03BA05
ATC
fluticasone; inhalant
11.5
67.2
141
197
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
11.3
60.4
126
169
H02AB07
ATC
prednisone; oral
12.8
57.0
109
121
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
8.8
56.5
140
250
R03AK06
ATC
salmeterol and fluticasone; inhalant
10.2
56.5
125
184
R03BA02
ATC
budesonide; inhalant
10.1
56.1
125
186
J45.9
ICD-10 Finland
Asthma, unspecified
10.1
53.6
118
170
H02AB04
ATC
methylprednisolone; systemic
11.9
52.7
104
121
R03AC02
ATC
salbutamol; inhalant
5.6
47.8
218
829
R03BA01
ATC
beclometasone; inhalant
8.0
41.7
105
180
R03DC03
ATC
montelukast; oral
10.1
37.5
79
99
J45.1
ICD-10 Finland
Nonallergic asthma
17.0
34.7
56
39
R03AC03
ATC
terbutaline; inhalant
7.6
34.5
88
150
J01AA02
ATC
doxycycline; systemic
5.7
34.4
295
1844
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
10.0
33.0
69
84
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
16.7
30.3
49
34
J01FA06
ATC
roxithromycin; oral
3.9
30.2
180
761
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
60.6
28.7
33
6
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
18.5
28.5
44
27
R03BB04
ATC
tiotropium bromide; inhalant
6.2
27.7
81
163
R03AC13
ATC
formoterol; inhalant
12.3
27.1
50
47
J45.0
ICD-10 Finland
Predominantly allergic asthma
13.2
23.7
42
36
J46
ICD-10 Finland
Status asthmaticus
28.7
21.7
29
11
R03DC01
ATC
zafirlukast; oral
21.8
20.8
30
15
R05FB02
ATC
cough suppressants and expectorants
3.0
20.0
173
875
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
8.3
19.4
44
60
J47
ICD-10 Finland
Bronchiectasis
25.7
17.6
24
10
R03AK07
ATC
formoterol and budesonide; inhalant
4.5
17.0
64
166
R05CB02
ATC
bromhexine; systemic
10.0
16.6
33
36
J96.1
ICD-10 Finland
Chronic respiratory failure
13.8
16.5
28
22
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.5
15.8
81
276
A01AB09
ATC
miconazole; local oral
4.5
15.2
56
142
J01FA10
ATC
azithromycin; systemic
2.6
15.1
153
812
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
15.0
147
766
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
83.8
14.7
16
*
J01DA01
ATC
[U] cefalexin; systemic
2.5
14.5
226
1502
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.6
14.3
70
228
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.9
14.3
102
436
J01FA09
ATC
clarithromycin; systemic
3.0
14.2
95
389
R06AE07
ATC
cetirizine; oral
2.7
14.2
126
616
A02BA02
ATC
ranitidine; systemic
2.8
14.1
106
467
49300
ICD-8 Finland
Asthma, bronchiale
12.2
14.0
25
22
R01AD08
ATC
fluticasone; nasal
3.1
13.9
87
340
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.5
12.8
135
714
J01DA06
ATC
[U] cefuroxime; systemic
3.4
12.4
67
232
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
16.7
12.3
19
12
J45
ICD-10 Finland
Asthma
5.7
12.2
35
67
J45.8
ICD-10 Finland
Mixed asthma
14.1
12.1
20
15
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
48.5
12.0
14
*
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
19.8
11.7
17
9
R03BB02
ATC
oxitropium bromide; inhalant
14.3
11.6
19
14
J01MA14
ATC
moxifloxacin; systemic
4.7
11.3
39
92
J01FA01
ATC
erythromycin; systemic
3.6
10.8
50
155
R05CB03
ATC
carbocisteine; oral
7.4
10.8
25
36
A01AB10
ATC
natamycin; local oral
6.8
10.5
26
41
A01AB04
ATC
amphotericin B; local oral
4.7
10.4
35
81
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
19.5
10.3
15
8
R03BC03
ATC
nedocromil; inhalant
5.1
10.1
31
65
N05BA01
ATC
diazepam; systemic, rectal
2.9
9.6
63
251
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.8
9.5
16
13
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.2
9.4
52
184
M09AA72
ATC
quinine, combinations with psycholeptics; systemic
4.0
9.3
37
101
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
5.0
9.3
29
62
R01BA52
ATC
pseudoephedrine, combinations; oral
2.4
9.0
86
420
J02AC01
ATC
fluconazole; systemic
2.2
8.9
105
566
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.7
8.8
38
112
C01AA05
ATC
digoxin; systemic
2.4
8.7
83
405
C03CA01
ATC
furosemide; systemic
2.0
8.7
167
1107
M05BA04
ATC
alendronic acid; oral
3.4
8.6
41
130
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
20.7
8.5
12
6
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
8.4
8
*
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.3
8.3
90
467
A07AA02
ATC
nystatin; oral
3.9
8.0
32
88
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
4.1
8.0
30
78
R05DB05
ATC
pentoxyverine; oral, rectal
5.1
7.9
24
50
N02AC04
ATC
dextropropoxyphene; oral
3.7
7.8
33
96
J01FA15
ATC
telithromycin; oral
3.8
7.7
32
91
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
7.6
141
908
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.2
7.5
89
478
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.1
7.5
96
536
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
16.2
7.3
11
7
R01AD05
ATC
budesonide; nasal
4.0
7.3
28
75
A06AD11
ATC
lactulose; oral
2.1
7.2
87
472
M01CB01
ATC
sodium aurothiomalate; parenteral
30.7
7.2
9
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
20.5
7.2
10
5
R03DA05
ATC
aminophylline; systemic, rectal
9.1
7.1
14
16
R05FA02
ATC
opium derivatives and expectorants; systemic
1.9
6.9
131
846
L04AX01
ATC
azathioprine; systemic
40.9
6.8
8
*
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
40.9
6.8
8
*
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
17.1
6.8
10
6
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
17.1
6.8
10
6
C08DA01
ATC
verapamil; systemic
3.6
6.7
29
86
R05CA10
ATC
expectorants - combinations
6.7
6.7
16
25
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
8.1
6.7
14
18
R96
ICPC
Asthma
3.8
6.7
27
76
R03AK08
ATC
formoterol and beclometasone; inhalant
10.3
6.6
12
12
N05CF01
ATC
zopiclone; oral
1.9
6.6
134
883
A02BA04
ATC
nizatidine; systemic
2.6
6.5
48
203
J01MA12
ATC
levofloxacin; systemic
2.2
6.5
71
367
R05DB20
ATC
other cough suppressants - combinations
3.7
6.5
27
78
R06AX12
ATC
terfenadine; oral
5.1
6.5
19
39
R03AK
ATC
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
71.1
6.4
7
*
N06AB03
ATC
fluoxetine; oral
2.7
6.4
42
167
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
8.4
6.4
13
16
R03AK11
ATC
formoterol and fluticasone; inhalant
11.3
6.3
11
10
C03DA01
ATC
spironolactone; oral
2.4
6.3
55
255
N02AX02
ATC
tramadol; systemic, rectal
1.8
6.3
128
839
L04AA13
ATC
leflunomide; oral
+∞
6.3
6
*
51899
ICD-8 Finland
Bronchiectasis
27.2
6.3
8
*
H02AB09
ATC
hydrocortisone; systemic
27.2
6.3
8
*
R01AD01
ATC
beclometasone; nasal
2.6
6.2
44
183
G47.3
ICD-10 Finland
Sleep apnoea
2.6
6.2
46
195
P01BA02
ATC
hydroxychloroquine; oral
5.9
6.2
16
28
R03DA54
ATC
theophylline, combinations excl. psycholeptics; systemic
5.9
6.2
16
28
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
7.9
6.2
13
17
N05AA02
ATC
levomepromazine; systemic
4.1
6.1
22
56
J01DA08
ATC
[U] cefaclor; oral
3.0
6.1
34
120
R95
ICPC
Chron obstructive pulmonary disease
6.2
6.1
15
25
M02AA07
ATC
piroxicam; topical
1.8
6.0
123
803
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: ILD_ASETYLCYSTEINE – ILD medications: acetylcysteine
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).