Thromboangiitis obliterans

I9_THROMBANG

thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — I73.1 Hospital discharge: ICD-9 — 4431A Hospital discharge: ICD-8 — 44310 Cause of death: ICD-10 — I73.1 Cause of death: ICD-9 — 4431A Cause of death: ICD-8 — 44310 2 out of 7 registries used, show all original rules.	136
4. Check minimum number of events None	136
5. Include endpoints None	136
6. Filter based on genotype QC (FinnGen only)	136

Control definitions (FinnGen only)

Control exclude: I9_DOAAC

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: I73
Name in latin: Tromboangi(i)tis obliterans (Bürger)

NAME	I9_THROMBANG
CONTROL_EXCLUDE	I9_DOAAC
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I731
HD_ICD_9	4431A
HD_ICD_8	44310
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I731
COD_ICD_9	4431A
COD_ICD_8	44310
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Thromboangiitis obliterans based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1319	389	900
Only index persons	869	322	547
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.03
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	52.80	53.06	52.44
Only index persons	51.00	51.70	50.59

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	136	49	87
Unadjusted period prevalence (%)	0.03	0.02	0.04
Median age at first event (years)	49.49	46.58	51.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
120: Matched controls
1198

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

I73.1

ICD-10 Finland

Thromboangiitis obliterans [Buerger]

+∞

102.2

I70.2

ICD-10 Finland

Atherosclerosis of arteries of extremities

210.9

51.5

44310

ICD-8 Finland

Other peripheral vascular disease, Thrombo-angiitis obliterans (Buerger's disease)

+∞

35.1

XPX99

NOMESCO Finland

Other diagnostic examination of periferal vessel

32.8

23.1

4431A

ICD-9 Finland

Other peripheral vascular disease, Thromboangiitis obliterans [Buerger's disease]

+∞

21.5

4402A

ICD-9 Finland

Atherosclerosis, Of native arteries of the extremities

+∞

13.8

C08CA05

ATC

nifedipine; systemic

7.6

12.4

2424

FHL

Sympatectomy, lumbar

+∞

10.6

I71.4

ICD-10 Finland

Abdominal aortic aneurysm, without mention of rupture

60.0

9.8

I70.9

ICD-10 Finland

Generalized and unspecified atherosclerosis

+∞

8.4

I71.3

ICD-10 Finland

Abdominal aortic aneurysm, ruptured

+∞

8.4

I73.0

ICD-10 Finland

Raynaud syndrome

36.0

8.2

PD4BC

NOMESCO Finland

Extensive arterigography of lower extremity with X-ray

+∞

7.4

I73.9

ICD-10 Finland

Peripheral vascular disease, unspecified

+∞

7.4

PE1AT

NOMESCO Finland

Femoral artery PTA

+∞

7.4

I73.8

ICD-10 Finland

Other specified peripheral vascular diseases

+∞

7.4

9571

FHL

Amputation of toe or toes

+∞

7.4

J01FF01

ATC

clindamycin; systemic

3.2

6.8

168

QDB10

NOMESCO Finland

Major dressing of wound of skin of lower limb

8.2

6.6

9573

FHL

Leg amputation

+∞

6.3

2423

FHL

Sympatectomy, thoracic

+∞

6.3

PD4AC

NOMESCO Finland

Arterigography of lower extremity with X-ray

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

7.88

9.01

1.4

1.6

—

(3042936) Bacteria identified in Isolate by Culture

130

2.79

5.38

2.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.97

5.37

1.7

1.6

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

4.90

4.87

1.4

u/ml

72.8

17.8

—

(3023368) Bacteria identified in Blood by Culture

297

2.22

4.58

4.4

3.9

—

(3032080) INR in Blood by Coagulation assay

429

2.05

4.05

11.9

10.1

inr

1.4

1.3

0.30

130

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

181

2.26

3.85

5.4

3.3

ng/l

347.9

83.9

0.53

148

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

430

1.87

3.14

5.1

4.2

—

(3002032) Base excess in Venous blood by calculation

2.43

2.97

3.1

3.8

mmol/l

3.3

2.2

0.40

(3022096) Basophils/100 leukocytes in Blood

455

1.82

2.94

9.8

5.1

0.7

0.6

0.23

423

(3006504) Eosinophils/100 leukocytes in Blood

465

1.81

2.92

10.0

5.0

2.7

0.05

429

(42870588) Differential panel, method unspecified - Blood

341

1.85

2.90

11.3

4.7

—

(3044640) Blood type and Crossmatch panel - Blood

307

1.87

2.89

3.4

2.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

265

1.85

2.61

2.5

2.0

mg/l

5.8

3.0

1.60

218

(3018095) Leukocytes [#/volume] in Urine

370

1.76

2.55

5.8

3.3

e6/l

828.5

64.4

0.46

262

(3037522) Nuclear Ab [Titer] in Serum

118

2.14

2.54

1.6

1.3

titre

1653.3

397.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

104

2.21

2.53

3.0

1.5

—

(3018010) Neutrophils/100 leukocytes in Blood

471

1.73

2.51

9.9

5.0

62.9

58.5

1.88

441

(3009261) Glucose [Presence] in Urine by Test strip

491

1.72

2.47

4.2

3.6

estimate

0.0

0.00

(3002582) Erythrocytes [#/volume] in Urine

320

1.77

2.47

4.8

2.9

e6/l

51.9

298.7

0.63

241

(3004789) Transferrin [Mass/volume] in Serum or Plasma

158

1.97

2.41

3.4

2.2

g/l

2.5

2.3

0.99

136

(3045788) Cell count panel - Pleural fluid

6.43

2.39

1.8

1.1

—

(36304419) Bacteria [Presence] in Urine

272

1.79

2.37

4.5

2.8

—

(3035350) Ketones [Presence] in Urine by Test strip

487

1.69

2.34

4.0

3.5

estimate

0.0

0.00

(3021601) Nitrite [Presence] in Urine by Test strip

487

1.69

2.34

5.6

5.0

estimate

0.0

0.00

(3041096) Erythrocytes [Presence] in Urine by Automated

282

1.77

2.33

4.1

3.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

4.77

2.29

2.0

1.3

ug/l

21.1

15.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

500

1.67

2.25

8.0

6.8

mmol/l

1.2

0.13

414

(3004616) Nuclear Ab [Presence] in Serum

4.43

2.17

1.2

1.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

386

1.66

2.11

2.8

2.2

nmol/l

79.0

78.0

0.08

335

(3019198) Lymphocytes [#/volume] in Blood

509

1.62

2.05

9.8

5.1

e9/l

1.6

1.9

1.51

457

(40760888) Immunoglobulin light chains.free panel - Serum

3.46

1.99

1.0

3.7

—

(3012441) Differential panel - Pleural fluid

4.67

1.96

1.6

1.4

—

(3017181) Myelocytes/100 leukocytes in Blood

2.06

1.84

5.8

3.8

1.3

0.9

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

1.96

1.78

4.2

3.5

—

(3029937) Albumin [Presence] in Urine by Test strip

267

1.65

1.76

4.3

3.8

estimate

0.0

0.00

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.02

1.74

1.3

—

(3024928) Oxygen saturation in Venous blood

3.02

1.74

1.0

3.1

—

(3020630) Protein [Mass/volume] in Serum or Plasma

2.05

1.73

1.5

3.1

g/l

63.1

66.6

1.11

(3030467) Casts [#/volume] in Urine by Automated count

286

1.62

1.72

4.7

2.7

e6/l

1.2

0.3

0.39

208

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

235

1.66

1.70

3.4

2.1

—

(3001604) Monocytes [#/volume] in Blood

499

1.53

1.65

9.9

4.9

e9/l

0.6

0.10

435

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

370

1.56

1.63

4.8

2.9

—

(3013115) Eosinophils [#/volume] in Blood

521

1.52

1.60

11.0

5.4

e9/l

0.2

0.13

458

(3006315) Basophils [#/volume] in Blood

503

1.51

1.57

10.4

4.9

e9/l

0.0

0.82

443

(3000991) Gas panel - Venous blood

2.01

1.56

9.1

6.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

133

1.78

1.54

9.0

4.9

mmol/l

103.0

103.8

0.29

127

(3023520) Reticulocytes [#/volume] in Blood

1.90

1.51

1.6

2.6

e9/l

80.3

67.8

0.67

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.21

1.49

2.3

2.5

1.5

1.3

0.26

(3026008) Bacteria identified in Urine by Culture

296

1.55

1.47

3.4

2.9

—

(3021440) Promyelocytes/100 leukocytes in Blood

1.96

1.47

6.5

3.9

0.0

0.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.80

1.45

1.0

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

219

1.60

1.44

5.9

4.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.17

1.43

10.3

4.1

mmol/l

24.4

24.6

0.04

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.01

1.38

1.3

1.5

—

(40768806) Pleura Pathology biopsy report

3.01

1.37

1.4

1.6

—

(3022313) Gas panel - Capillary blood

2.13

1.37

5.8

3.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

115

1.76

1.33

2.3

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

394

1.47

1.32

4.3

3.8

—

(3025159) Blasts/100 leukocytes in Blood

1.91

1.31

6.9

3.9

0.0

0.3

—

(1616796) Gas panel - Central venous blood

2.84

1.29

4.6

2.7

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

125

1.70

1.26

8.1

6.1

mmol/l

1.0

0.08

113

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.12

1.25

1.9

2.5

0.6

0.7

—

(3018418) pH of Serum or Plasma

306

1.49

1.25

5.0

3.9

7.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

253

1.52

1.24

2.1

1.6

nmol/l

15.5

21.4

1.34

209

(3013650) Neutrophils [#/volume] in Blood by Automated count

591

1.42

1.21

12.2

9.1

e9/l

4.9

4.3

0.95

515

(3037467) Urinalysis macro (dipstick) panel - Urine

682

1.42

1.18

6.2

4.3

—

(3027315) Oxygen [Partial pressure] in Blood

2.55

1.16

3.2

2.5

kpa

9.7

8.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.55

1.16

3.2

2.5

kpa

4.9

4.8

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.55

1.16

1.2

1.6

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.55

1.16

1.2

1.6

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.86

1.15

3.7

1.9

g/l

9.2

10.4

0.59

(3021589) Normoblasts [#/volume] in Blood

403

1.42

1.15

17.7

9.7

e9/l

0.0

0.26

332

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

900

0.71

1.14

4.6

4.4

mu/l

2.0

1.9

0.20

801

(40761536) Microorganisms panel - Urine sediment

1.81

1.14

5.7

3.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

154

1.59

1.13

4.7

2.5

e6/l

1.1

1.4

0.21

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

180

1.55

1.11

2.5

1.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.25

1.10

2.9

3.3

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

463

1.36

0.94

7.3

6.1

mmol/l

1.2

0.41

411

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.81

0.93

1.9

1.7

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

2.19

0.93

1.0

1.1

—

(3019060) Gas panel - Arterial blood

1.68

0.91

6.1

9.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

971

0.73

0.91

4.5

4.8

mmol/l

6.0

5.9

0.15

876

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.85

0.90

1.2

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

923

0.74

0.89

6.4

5.9

mmol/mol

40.7

40.0

0.28

845

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

1.87

0.87

15.3

19.9

—

(3049717) Cytology report of Urine Cyto stain

1.83

0.86

2.5

3.0

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.75

0.85

3.6

2.6

e6/l

0.0

0.1

1.56

(4035726)

1.62

0.82

1.6

1.5

—

(40768800) Prostate Pathology biopsy report

0.00

0.80

0.0

1.2

—

(40768797) Stomach Pathology biopsy report

133

1.50

0.79

1.2

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

116

1.53

0.79

2.5

1.7

—

(3003694) ABO and Rh group [Type] in Blood

221

1.40

0.79

1.4

1.3

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.22

0.77

1.8

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.67

0.74

1.1

3.0

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.66

0.68

2.1

1.9

u/l

28.7

39.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

129

1.46

0.67

2.1

4.9

ug/l

3.0

44.1

0.71

111

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

227

1.35

0.67

1.8

pmol/l

350.7

459.4

1.67

191

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

1.62

0.66

1.0

2.9

—

(3027801) Oxygen [Partial pressure] in Arterial blood

130

1.44

0.65

10.8

8.7

kpa

10.0

11.5

1.24

124

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

130

1.44

0.65

10.8

8.7

kpa

5.2

5.0

0.21

124

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

124

1.42

0.59

3.2

3.5

u/l

254.9

237.2

0.59

117

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.57

0.58

1.0

1.6

—

(40768443) Skin Pathology biopsy report

1.61

0.55

1.2

—

(40758558) Short blood count panel - Blood

235

1.30

0.54

9.9

6.5

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

445

1.23

0.52

5.9

3.9

ng/l

44.1

44.0

0.00

339

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

163

1.34

0.52

4.0

2.4

e6/l

0.4

1.0

0.98

(3022145) Colonoscopy Study observation

1.42

0.48

1.3

1.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.45

0.46

3.1

1.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

129

0.68

0.46

1.7

1.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.42

0.46

3.3

1.8

—

(3019225) pH of Specimen

1.41

0.45

3.5

—

(3000492) Spirometry study

1.45

0.44

1.7

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.41

0.0

1.3

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.41

0.0

1.4

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

3.8

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.39

0.39

12.7

6.8

93.0

94.3

—

(40761511) CBC panel - Blood by Automated count

1014

0.85

0.33

26.3

14.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

719

0.87

0.32

3.5

3.7

pmol/l

15.5

14.9

0.94

643

(46235355) HIV 1 and 2 tests - Meaningful Use set

138

1.27

0.32

1.5

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

994

0.85

0.32

4.9

5.1

mmol/l

2.5

2.6

0.85

898

(40768804) Tissue Pathology biopsy report

415

0.85

0.32

2.0

2.2

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

1.34

0.31

14.3

6.5

mmol/l

25.1

24.7

—

(3002385) Erythrocyte distribution width [Ratio]

765

1.15

0.29

32.1

18.8

14.8

13.8

3.09

750

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

117

0.75

0.29

1.6

1.4

—

(3012516) Albumin [Mass/volume] in Urine

294

1.16

0.26

3.9

3.0

mg/l

3991.8

267.8

0.72

190

(3000494) Fungus identified in Specimen by Culture

114

1.25

0.26

2.4

1.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

918

0.88

0.24

24.9

14.2

ml/min/173m2

79.5

76.6

0.49

740

(3011397) Hemoglobin [Presence] in Urine by Test strip

219

1.17

0.24

3.6

3.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

957

0.88

0.24

4.6

mmol/l

1.3

1.5

1.85

866

(1761868) Lipid panel - Serum or Plasma

324

0.87

0.23

3.4

3.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

261

0.86

0.23

2.7

3.1

ug/l

0.7

0.8

0.16

185

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

965

0.89

0.22

4.7

4.6

mmol/l

4.3

4.5

1.16

880

(3020682) Albumin/Creatinine [Ratio] in Urine

318

1.14

0.21

4.7

3.7

mg/mmol

15.9

7.6

0.51

195

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.21

0.0

1.1

—

(3013512) EKG study

328

1.13

0.21

7.3

4.0

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

0.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

845

0.90

0.21

29.3

16.2

36.5

39.5

1.10

586

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.2

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

8.2

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.21

0.0

2.0

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.2

—

0.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

195

0.85

0.19

1.3

1.1

u/ml

0.3

1.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

420

1.11

0.18

2.5

2.0

pmol/l

96.1

94.9

0.05

213

(21494755) Public health laboratory ask at order entry panel

1.15

0.16

1.1

1.3

—

(3044889) 12 lead EKG panel

681

1.09

0.15

4.4

4.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

366

0.91

0.15

3.9

4.3

23.5

21.8

0.17

195

(3002256) Pathology report gross observation

142

1.14

0.13

1.4

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

212

1.10

0.11

2.1

1.8

nmol/l

1142.6

1212.4

0.14

159

(3013707) Erythrocyte sedimentation rate by Westergren method

749

1.06

0.10

6.7

4.0

mm/h

15.6

14.0

0.31

678

(3025941) Bacteria identified in Stool by Culture

1.06

0.08

1.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.81

0.08

1.2

1.3

—

(40761535) Cells panel - Urine sediment

1.04

0.07

2.9

3.0

—

(4010399)

1.13

0.07

1.0

1.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

464

0.95

0.05

4.0

5.0

ug/l

2.7

3.2

0.21

401

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

110

1.10

0.05

1.5

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

933

0.96

0.05

4.2

4.1

mmol/l

1.3

1.2

0.36

840

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

136

0.95

0.00

15.2

7.7

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

101

0.99

0.00

1.3

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

975

1.02

0.00

30.3

15.2

mg/l

32.2

26.0

0.89

784

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

546

1.01

0.00

3.0

2.8

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

5.9

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

0.0

1.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

0.0

1.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

0.0

1.5

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.2

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.96

0.00

1.2

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

140

1.00

0.00

1.3

u/ml

25.8

6.6

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.9

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.1

—

(3020891) Body temperature

1.00

0.00

5.0

3.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.1

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

(3012565) Volume of 24 hour Urine

0.00

0.0

2.0

—

1800.0

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.1

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.6

—

(3041145) Herpes simplex virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

1.8

—

1.3

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.1

—

(3044936) Clostridioides difficile toxin A+B [Presence] in Stool by Immunoassay

0.00

0.0

1.0

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

2.6

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(4024509)

0.00

0.0

1.0

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

0.0

1.1

—

265.4

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

995.4

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.1

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.1

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

29.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.8

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

4.6

—

(3022621) pH of Urine by Test strip

0.97

0.00

3.7

2.0

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

0.8

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint I9_THROMBANG and mortality.

Females

Parameter	HR [95% CI]	p-value
I9_THROMBANG	2.288 [1.72, 3.04]	< 0.001
Birth year	0.996 [0.99, 1.0]	0.357

During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 256 females with I9_THROMBANG died.

Males

Parameter	HR [95% CI]	p-value
I9_THROMBANG	1.982 [1.58, 2.48]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 390 males with I9_THROMBANG died.

Mortality risk

Mortality risk for people of age

years, who have I9_THROMBANG.

N-year risk	Females	Males
1	0.265%	0.289%
5	1.479%	2.21%
10	3.389%	5.427%
15	6.828%	9.841%
20	11.912%	16.326%

Relationships between endpoints

↥

Index endpoint: I9_THROMBANG – Thromboangiitis obliterans

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Thromboangiitis obliterans

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints