Embolic stroke

I9_STR_EMBOLIC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I63.1
  • Hospital discharge: ICD-9 4341A
  • Hospital discharge: ICD-8 43400|43499
  • Cause of death: ICD-10 I63.1
  • Cause of death: ICD-9 4341A
  • Cause of death: ICD-8 43400|43499

2 out of 7 registries used, show all original rules.

1699

4. Check minimum number of events

None

1699

5. Include endpoints

None

1699

6. Filter based on genotype QC (FinnGen only)

1639

Control definitions (FinnGen only)

Control exclude
I9_CEREBVASC

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 28696 13054 14985
Only index persons 13155 5750 7405
Unadjusted period prevalence (%)
Whole population 0.40 0.37 0.42
Only index persons 0.25 0.21 0.28
Median age at first event (years)
Whole population 72.78 75.89 70.17
Only index persons 71.63 74.92 69.08

-FinnGen-

Key figures

All Female Male
Number of individuals 1639 523 1116
Unadjusted period prevalence (%) 0.45 0.21 0.56
Median age at first event (years) 70.10 70.11 70.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1697
Matched controls
16963
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
842.4
323.0
974
27
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
391.8
323.0
821
40
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
323.0
1430
*
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
+∞
323.0
310
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
1165.7
306.8
291
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
3208.5
300.9
282
*
4341A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral embolism
+∞
241.4
226
*
K90
ICPC
Stroke/cerebrovascular accident
59.4
219.6
258
51
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
1103.7
204.4
196
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
312.9
194.3
194
7
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.4
185.8
373
409
AA1AD
NOMESCO Finland
CT of head and brain
5.2
185.6
754
2275
B01AA03
ATC
warfarin; systemic
4.1
155.8
863
3382
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
1229.7
119.2
115
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
14.0
118.3
210
169
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
1172.4
113.9
110
*
R4120
NOMESCO Finland
Occupational therapy
10.1
113.3
237
267
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
6.3
112.6
329
621
XA800
NOMESCO Finland
Neuropsychological investigation
19.6
111.1
172
97
B01AC04
ATC
clopidogrel; oral
3.7
100.3
540
1892
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
8.8
94.7
214
273
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.0
94.5
801
3881
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
32.8
81.7
108
35
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
+∞
80.8
77
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
78.7
502
1944
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
+∞
71.3
68
*
C10AA05
ATC
atorvastatin; oral
2.5
67.2
822
4643
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
67.1
64
*
K91
ICPC
Cerebrovascular disease
34.8
63.8
83
25
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
7.4
60.5
151
221
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
58.6
56
*
N18
ICPC
Paralysis/weakness
18.5
57.7
90
51
I63.8
ICD-10 Finland
Other cerebral infarction
565.2
55.9
55
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.6
52.6
194
458
H53.4
ICD-10 Finland
Visual field defects
13.6
52.2
92
71
I63
ICD-10 Finland
Cerebral infarction
85.7
52.2
58
7
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
52.0
396
1661
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
51.3
49
*
Z2445
NOMESCO Finland
Psychologist
11.2
48.8
94
88
207
Kela drug reimbursment
Chronic arrhythmias
2.6
48.7
448
2086
AA5PD
NOMESCO Finland
CT examination of brain pefusion
41.4
48.1
60
15
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
56.7
46.7
55
10
B01AC07
ATC
dipyridamole; systemic
3.8
46.3
212
610
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
46.0
44
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
235.9
45.1
46
*
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
43.4
410
1919
R47.0
ICD-10 Finland
Dysphasia and aphasia
29.9
43.2
58
20
PA7BD
NOMESCO Finland
CT angiography of neck and brain
14.6
42.9
73
52
WX892
NOMESCO Finland
Monitored bed care
3.6
41.5
207
637
C07AB07
ATC
bisoprolol; oral
2.0
41.5
990
6959
C01AA05
ATC
digoxin; systemic
2.6
41.1
356
1585
R4150
NOMESCO Finland
Neuropsychological rehabilitation
78.8
41.0
46
6
C03CA01
ATC
furosemide; systemic
2.0
40.7
811
5292
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.7
40.7
320
1344
R1260
NOMESCO Finland
Evaluation of communicative skills
11.1
40.5
78
73
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
10.2
39.2
79
81
C09AA05
ATC
ramipril; oral
2.1
38.4
585
3401
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
17.4
37.3
59
35
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
374.7
37.1
37
*
Z3226
NOMESCO Finland
Physiotherapist
2.4
36.8
352
1643
43499
ICD-8 Finland
Cerebral embolism, Without mention of hypertension
+∞
36.6
35
*
R4130
NOMESCO Finland
Speech therapy
9.3
36.4
77
86
R4110
NOMESCO Finland
Physiotherapy
2.2
36.4
468
2515
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
36.1
412
2096
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
99.6
35.8
39
*
N19
ICPC
Speech disorder
21.4
35.4
52
25
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.8
35.0
123
274
K78
ICPC
Atrial fibrillation/flutter
2.7
32.1
247
1014
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.7
31.7
147
424
205
Kela drug reimbursment
Chronic hypertension
1.9
31.3
676
4407
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
30.0
362
1869
Z3231
NOMESCO Finland
Registered nurse
2.0
28.9
499
2976
I10
ICD-10 Finland
Essential (primary) hypertension
1.8
28.9
1085
8407
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
3.9
28.9
125
340
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
44.5
28.7
35
8
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
28.5
604
3874
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
16.4
28.1
45
28
C10AA01
ATC
simvastatin; oral
1.8
28.0
877
6387
ZXD05
NOMESCO Finland
Urgent procedure
1.9
27.8
552
3455
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.9
27.5
180
667
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
76.3
26.8
30
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
274.8
26.8
27
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
26.0
317
1633
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.9
25.1
479
2936
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
25.0
24
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.2
24.8
79
159
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
24.5
302
1558
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.5
24.5
211
917
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
242.9
23.7
24
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
8.6
23.4
51
61
N03AF02
ATC
oxcarbazepine; oral
5.8
23.4
67
119
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
2.0
23.2
360
2037
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
4.7
23.2
81
180
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
54.7
23.1
27
5
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
23.0
414
2473
C01DA14
ATC
isosorbide mononitrate; oral
1.8
22.9
473
2965
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
22.4
559
3713
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
22.0
398
2378
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
21.9
21
*
TKC20
NOMESCO Finland
Catheterisation of bladder
2.5
21.5
185
802
I50.0
ICD-10 Finland
Congestive heart failure
2.2
21.4
250
1255
C08CA01
ATC
amlodipine; oral
1.7
21.2
664
4697
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
21.0
371
2189
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
20.9
590
4048
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
9.0
20.9
44
50
43399
ICD-8 Finland
Cerebral thrombosis, Without mention of hypertension
+∞
20.9
20
*
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
+∞
20.9
20
*
R51.80
ICD-10 Finland
Headache
2.4
20.4
180
790
43400
ICD-8 Finland
Cerebral embolism, With hypertension (benign)
+∞
19.8
19
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.1
19.6
112
378
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.5
19.4
93
277
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.2
19.3
216
1062
A28
ICPC
Limited function/disability NOS
1.9
19.1
346
2055
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.9
18.8
313
1804
PA6AD
NOMESCO Finland
CT of neck arteries
9.4
18.6
38
41
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
18.6
526
3583
B01AF02
ATC
apixaban; oral
2.1
18.4
223
1132
N03AX14
ATC
levetiracetam; systemic
5.9
18.2
51
89
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
18.0
190
908
C07AB02
ATC
metoprolol; systemic
1.7
17.7
477
3197
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
95.9
17.6
19
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
181.5
17.5
18
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
17.5
723
5423
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.1
17.4
68
170
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.6
17.2
44
68
R42
ICD-10 Finland
Dizziness and giddiness
1.8
17.2
377
2373
WX872
NOMESCO Finland
Intensive care
2.9
17.1
107
383
Z50.5
ICD-10 Finland
Speech therapy
8.4
17.0
37
45
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
16.8
197
984
81
HP
Angiography of the heart and coronary arteries
2.1
16.8
199
998
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
12.2
16.8
30
25
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
16.6
613
4450
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
16.5
515
3582
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
1.6
16.1
502
3487
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
47.9
16.0
19
*
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
24.7
16.0
22
9
WX882
NOMESCO Finland
High dependency care
3.9
15.9
65
170
WX002
NOMESCO Finland
Sedation and analgesia
1.8
15.8
318
1942
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
15.7
137
598
4331A
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS CUM INFARCTU CEREBRI]
+∞
15.6
15
*
Z2221
NOMESCO Finland
Medical doctor
1.7
15.5
407
2690
N03AG01
ATC
valproic acid; systemic, rectal
3.1
15.5
86
286
B01AB05
ATC
enoxaparin; parenteral
1.6
15.5
478
3300
315
Kela drug reimbursment
Clopidogrel
6.5
15.5
40
63
XF404
NOMESCO Finland
Ambulatory ECG
2.1
15.1
177
886
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.8
14.7
94
342
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
14.4
451
3119
C07AA07
ATC
sotalol; systemic
2.4
14.2
121
520
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
4.8
14.1
46
97
I25.2
ICD-10 Finland
Old myocardial infarction
2.0
14.1
201
1087
C09AA02
ATC
enalapril; systemic
1.6
14.1
415
2823
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
8.9
14.0
29
33
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.3
13.8
127
568
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
13.7
107
440
4019X
ICD-9 Finland
Essential hypertension, Unspecified
2.6
13.7
103
415
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
13.6
523
3791
C10AX09
ATC
ezetimibe; oral
2.0
13.4
171
887
ZXE00
NOMESCO Finland
One hour or less
1.5
13.4
588
4393
L28
ICPC
Limited function/disability (L)
1.7
13.3
292
1825
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
11.6
13.3
24
21
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
13.2
373
2502
PWE00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of peripheral vessels and lymphatic system
9.7
13.2
26
27
G81.9
ICD-10 Finland
Hemiplegia, unspecified
12.2
13.1
23
19
R47.1
ICD-10 Finland
Dysarthria and anarthria
8.3
13.0
28
34
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.8
12.8
220
1268
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
+∞
12.5
12
*
I61.3
ICD-10 Finland
Intracerebral haemorrhage in brain stem
+∞
12.5
12
*
I65.3
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral precerebral arteries
130.7
12.4
13
*
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
130.7
12.4
13
*
Z2446
NOMESCO Finland
Social worker
2.4
12.4
105
452
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.7
12.3
52
142
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.1
11.9
130
632
I69
ICD-10 Finland
Sequelae of cerebrovascular disease
46.9
11.9
14
*
PA2AD
NOMESCO Finland
CT angiography of brain
46.9
11.9
14
*
AN1
HP
Coronary angiography
1.7
11.7
261
1635
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
30.2
11.6
15
5
A10BA02
ATC
metformin; oral
1.5
11.6
494
3636
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.0
11.6
36
73
201
Kela drug reimbursment
Chronic cardiac insufficiency
1.9
11.5
164
883
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.0
11.5
152
795
RS222
NOMESCO Finland
NA
5.5
11.5
33
61
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
11.5
240
1473
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.6
11.5
81
317
4349A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral artery occlusion, unspecified[OCCL/STENOS ARTER.CEREBRALES NUD CUM INFARCTU CEREB]
+∞
11.5
11
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
+∞
11.5
11
*
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.0
11.5
158
844
WX730
NOMESCO Finland
Conventional respirator
4.3
11.2
41
98
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
3.1
11.2
62
208
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
6.2
11.2
29
47
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
11.2
11.0
20
18
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
60.3
10.6
12
*
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
2.1
10.6
122
606
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.1
10.5
122
608
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
10.5
239
1506
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
10.4
530
4032
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
3.5
10.4
47
136
I65.9
ICD-10 Finland
Occlusion and stenosis of unspecified precerebral artery
110.5
10.4
11
*
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
+∞
10.4
10
*
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
+∞
10.4
10
*
G46.3*I67.9
ICD-10 Finland
Brain stem stroke syndrome (I60-I67+)
+∞
10.4
10
*
RL110
NOMESCO Finland
NA
+∞
10.4
10
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
1.8
10.4
199
1190
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.4
10.3
86
369
ZXA05
NOMESCO Finland
Left side
1.5
10.3
423
3081
A06AD11
ATC
lactulose; oral
1.6
10.2
321
2196
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
10.2
244
1557
R53
ICD-10 Finland
Malaise and fatigue
1.6
10.1
320
2191
ZX120
NOMESCO Finland
Intravenous
1.9
10.1
155
861
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.4
10.1
87
378
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.4
10.0
84
361
N28
ICPC
Limited function/disability (N)
4.2
9.9
36
87
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
6.0
9.8
26
44
C03DA01
ATC
spironolactone; oral
1.7
9.8
217
1355
K89
ICPC
Transient cerebral ischaemia
5.7
9.8
27
48
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.7
9.8
63
235
N06AB04
ATC
citalopram; systemic
1.6
9.7
292
1972
K99
ICPC
Cardiovascular disease other
2.8
9.7
62
229
PA6YT
NOMESCO Finland
Dilatation of carotid artery with stent
55.2
9.6
11
*
A12BA01
ATC
potassium chloride; oral
1.9
9.6
132
705
280
Kela drug reimbursment
Clopidogrel
3.4
9.6
45
135
C01BD01
ATC
amiodarone; systemic
2.6
9.6
68
267
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
15.1
9.5
15
10
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
1.8
9.5
157
894
4331X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS SINE INFARCTU CEREBR]
+∞
9.4
9
*
PAF12
NOMESCO Finland
Thrombendarterectomy of common carotid artery
+∞
9.4
9
*
N02BE01
ATC
paracetamol; systemic, rectal
1.4
9.3
1254
11279
M01AH05
ATC
etoricoxib; oral
0.7
9.2
434
5565
A10BB01
ATC
glibenclamide; oral
1.9
9.2
132
716
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.1
9.1
103
508
M01AE01
ATC
ibuprofen; systemic, rectal
0.7
9.1
942
10704
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
2.9
9.1
53
185
TFP20
NOMESCO Finland
Cardiodefibrillation
1.8
9.1
152
870
I67.2
ICD-10 Finland
Cerebral atherosclerosis
15.6
9.0
14
9
ZXA00
NOMESCO Finland
Right side
1.4
9.0
430
3214
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.9
8.9
140
784
Z72.0
ICD-10 Finland
Tobacco use
4.0
8.8
34
87
N03AF01
ATC
carbamazepine; oral, rectal
2.2
8.8
84
385
A10BB12
ATC
glimepiride; oral
1.7
8.6
167
1002
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.9
8.6
50
175
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.1
8.6
95
467
R41.0
ICD-10 Finland
Disorientation, unspecified
2.4
8.5
68
284
RS122
NOMESCO Finland
NA
27.6
8.5
11
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
6.4
8.5
21
33
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.8
8.4
153
899
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
8.4
102
520
4100X
ICD-9 Finland
Acute myocardial infarction, Of anterolateral wall[INFARCTUS MYOCARDII ACUTUS DEFINITUS,MÄÄRITTELEMÄT]
2.2
8.3
79
363
K92.1
ICD-10 Finland
Melaena
2.0
8.3
104
537
4360A
ICD-9 Finland
Acute but ill-defined cerebrovascular disease[MORBUS CEREBROVASCULARIS ACUTUS NON DEFINITUS]
+∞
8.3
8
*
I65.0
ICD-10 Finland
Occlusion and stenosis of vertebral artery
+∞
8.3
8
*
J63.1
ICD-10 Finland
Bauxite fibrosis (of lung)
+∞
8.3
8
*
I65.1
ICD-10 Finland
Occlusion and stenosis of basilar artery
+∞
8.3
8
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
8.3
223
1464
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.0
8.3
105
543
11
HP
Coronary artery bypass surgery
2.3
8.3
75
336
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.6
8.2
35
98
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
3.4
8.1
38
115
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
2.2
8.0
79
371
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.0
7.9
98
502
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.4
7.9
64
272
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
7.9
100
519
A46
ICD-10 Finland
Erysipelas
1.6
7.8
240
1625
RD211
NOMESCO Finland
NA
2.3
7.7
66
288
A10AE04
ATC
insulin glargine; parenteral
1.7
7.7
145
862
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
7.7
205
1344
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.2
7.7
74
343
C10AA03
ATC
pravastatin; oral
1.8
7.6
130
749
N88
ICPC
Epilepsy
11.9
7.6
13
11
RS221
NOMESCO Finland
NA
4.0
7.6
28
70
SPAT1216
SPAT
Assessment of functional ability
1.5
7.6
272
1913
I62.9
ICD-10 Finland
Intracranial haemorrhage (nontraumatic), unspecified
80.3
7.4
8
*
AA9CW
NOMESCO Finland
NA
80.3
7.4
8
*
RT120
NOMESCO Finland
NA
80.3
7.4
8
*
I69.2
ICD-10 Finland
Sequelae of other nontraumatic intracranial haemorrhage
80.3
7.4
8
*
Z3229
NOMESCO Finland
Other healthcare associate professional
1.7
7.4
142
849
SPAT1229
SPAT
Assessment of need for aid
1.7
7.3
137
814
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
+∞
7.3
7
*
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
+∞
7.3
7
*
43300
ICD-8 Finland
Cerebral thrombosis, Wtih hypertension (benign)
+∞
7.3
7
*
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
+∞
7.3
7
*
4300A
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOID. POST ANEURYSMA SACCULARE]
+∞
7.3
7
*
C02EA02
ATC
NA
1.8
7.3
115
647
M10.9
ICD-10 Finland
Gout, unspecified
1.8
7.2
124
718
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
7.2
437
3399
R04.0
ICD-10 Finland
Epistaxis
1.7
7.2
135
804
PA7CC
NOMESCO Finland
Very extensive angiography of arteries of neck and brain
30.1
7.1
9
*
PA6AM
NOMESCO Finland
Simple MRI examination of neck vasculature with 3 Tesla magnet
30.1
7.1
9
*
M04AA01
ATC
allopurinol; systemic
1.5
7.1
269
1914
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
8.8
7.0
14
16
I42.0
ICD-10 Finland
Dilated cardiomyopathy
2.3
7.0
62
277
SPAT1252
SPAT
Overall medication plan or its review
1.8
7.0
125
730
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
2.1
7.0
79
393
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.6
7.0
186
1219
N02AX02
ATC
tramadol; systemic, rectal
1.3
7.0
622
5134
B01AE07
ATC
dabigatran etexilate; oral
2.1
7.0
76
371
SPAT1251
SPAT
Organisation of medication
2.1
7.0
78
385
XPX08
NOMESCO Finland
Intraoperative flow measurement
3.8
7.0
27
71
N30.0
ICD-10 Finland
Acute cystitis
1.6
6.9
184
1205
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.4
6.9
55
233
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
3.1
6.9
35
114
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.5
6.9
49
196
N03AB02
ATC
phenytoin; systemic
4.6
6.9
22
48
C09AA04
ATC
perindopril; oral
1.9
6.9
102
561
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
1.9
6.8
102
565
XCK00
NOMESCO Finland
Perimetry
1.8
6.8
109
615
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.7
6.8
150
935
C08DB01
ATC
diltiazem; oral
1.7
6.8
135
816
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
2.0
6.8
81
410
W19
ICD-10 Finland
Unspecified fall
1.7
6.8
143
880
N06AX11
ATC
mirtazapine; oral
1.4
6.7
397
3065
C03AA03
ATC
hydrochlorothiazide; oral
1.6
6.7
174
1131
I50.1
ICD-10 Finland
Left ventricular failure
1.7
6.7
124
732
A02BC02
ATC
pantoprazole; systemic
1.3
6.7
916
8022
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
6.7
227
1574
RL130
NOMESCO Finland
NA
22.6
6.7
9
*
R4190
NOMESCO Finland
Nutritional therapy
2.9
6.6
38
132
127
Kela drug reimbursment
Transplant complication
4.4
6.5
22
51
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
10.0
6.5
12
12
XF620
NOMESCO Finland
Examination of circulation with color method
10.0
6.5
12
12
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.5
6.5
210
1441
3A064
NOMESCO Finland
NA
6.9
6.5
15
22
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.2
6.5
61
282
D21
ICPC
Swallowing problem
3.7
6.5
26
71
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.4
253
1811
C08CA02
ATC
felodipine; oral
1.6
6.4
184
1229
T90
ICPC
Diabetes non-insulin dependent
1.4
6.4
349
2657
G45.3
ICD-10 Finland
Amaurosis fugax
3.0
6.3
33
110
C08CA05
ATC
nifedipine; systemic
1.7
6.3
131
805
RT132
NOMESCO Finland
NA
+∞
6.2
6
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
+∞
6.2
6
*
RT152
NOMESCO Finland
NA
+∞
6.2
6
*
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
+∞
6.2
6
*
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.3
6.2
54
240
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.0
6.2
73
370
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
26.7
6.2
8
*
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
7.0
6.2
14
20
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
6.2
418
3297
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.6
6.2
142
894
R5599
NOMESCO Finland
Other rehabilitation service
2.6
6.2
42
166
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.1
6.1
68
337
R06.0
ICD-10 Finland
Dyspnoea
1.4
6.1
376
2918
K92
ICPC
Atherosclerosis/periph vascular dis
3.4
6.1
27
80
C10AA07
ATC
rosuvastatin; oral
1.4
6.1
310
2327
N05CF01
ATC
zopiclone; oral
1.3
6.1
519
4238
C01BA01
ATC
quinidine; oral
3.3
6.1
28
86
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.7
6.1
118
709
PD4CM
NOMESCO Finland
Extensive MRI examination of abdominal aorta and vasculature of lower extremities with 3 Tesla magnet
8.6
6.0
12
14
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
6.0
226
1600

Mortality – FinRegistry

Association

Association between endpoint I9_STR_EMBOLIC and mortality.

Females

Parameter HR [95% CI] p-value
I9_STR_EMBOLIC 2.405 [2.14, 2.7] < 0.001
Birth year 0.995 [0.99, 1.0] 0.196

During the follow-up period (1.1.1998 — 31.12.2019), 2865 out of 4903 females with I9_STR_EMBOLIC died.

Males

Parameter HR [95% CI] p-value
I9_STR_EMBOLIC 1.916 [1.72, 2.13] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 3377 out of 6534 males with I9_STR_EMBOLIC died.

Mortality risk

Mortality risk for people of age

years, who have I9_STR_EMBOLIC.

N-year risk Females Males
1 0.166% 0.377%
5 1.3% 1.977%
10 3.466% 4.817%
15 6.705% 9.438%
20 11.651% 15.913%

Relationships between endpoints

Index endpoint: I9_STR_EMBOLIC – Embolic stroke

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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