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Non-small cell lung cancer, adenocarcinoma, helper endpoint

HLP_C3_NSCLC_ADENO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

2303

4. Check minimum number of events

None

2303

5. Include endpoints

None

2303

6. Filter based on genotype QC (FinnGen only)

2303

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Non-small cell lung cancer, adenocarcinoma, helper endpoint based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 2303 887 1416
Unadjusted period prevalence (%) 0.50 0.30 0.62
Median age at first event (years) 70.34 69.06 71.15

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2148
Matched controls
21478
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
8140/3-C34.3
ICD-O-3
Adenocarcinoma, NOS, of lower lobe, lung
+∞
323.0
466
*
H02AB02
ATC
dexamethasone; systemic
9.9
323.0
814
1245
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
19.9
323.0
1280
1483
C34.82
ICD-10 Finland
Malignant overall tumor of bronchial and pulmonary adenocarcinoma
319.0
323.0
348
13
8140/3-C34.9
ICD-O-3
Adenocarcinoma, NOS, of lung, NOS
+∞
323.0
831
*
130
Kela drug reimbursment
Malignant tumour
21.2
323.0
1197
1204
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
32.0
323.0
710
326
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
127.8
323.0
446
44
UGC12
NOMESCO Finland
Flexible bronchoscopy
12.2
323.0
861
1118
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
66.4
323.0
493
96
C34.32
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung adenocarcinoma
270.5
323.0
604
31
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
268.5
323.0
965
65
8140/3-C34.1
ICD-O-3
Adenocarcinoma, NOS, of upper lobe, lung
3538.0
323.0
755
*
A03FA01
ATC
metoclopramide; systemic, rectal
5.9
273.8
986
2699
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
26.7
263.2
372
167
WF049
NOMESCO Finland
Radiotherapy of metastasis
14.5
230.8
409
342
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
18.9
214.9
340
211
L01CA04
ATC
vinorelbine; systemic
51.5
211.4
255
56
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
9.2
202.7
461
622
A04AA01
ATC
ondansetron; systemic, rectal
8.9
202.2
470
658
N02AA05
ATC
oxycodone; systemic
5.1
200.3
784
2191
C34.92
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary adenocarcinoma
150.9
195.2
205
15
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
27.6
187.2
261
107
GDC00
NOMESCO Finland
Lobectomy of lung
62.0
186.6
218
39
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
30.9
181.3
245
89
Z51.5
ICD-10 Finland
Palliative care
6.9
165.3
456
808
JN4BD
NOMESCO Finland
Extensive body CT
4.8
154.2
603
1612
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
30.4
135.9
184
66
C34.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bronchus and lung
28.2
133.2
184
71
GD1AD
NOMESCO Finland
Thorax CT examination
7.9
131.5
322
469
WF004
NOMESCO Finland
Palliative radiotherapy
13.5
129.8
234
193
C34.90
ICD-10 Finland
Malignant tumor in unspecified location in bronchus and lung without histology
23.9
129.6
188
86
WZC30
NOMESCO Finland
Teaching
4.1
122.4
554
1660
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
121.4
1315
7511
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.8
119.6
454
1142
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
7.6
119.4
298
444
C34.9
ICD-10 Finland
Malignant neoplasm: Bronchus or lung, unspecified
18.3
111.7
177
105
C34.22
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung adenocarcinoma
290.7
109.0
110
*
R84
ICPC
Malignant neoplasm bronchus/lung
52.7
107.5
129
26
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.6
107.2
575
1965
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
12.4
102.8
192
169
155
Kela drug reimbursment
Afatinib and gefitinib
527.3
102.5
101
*
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
17.0
98.5
160
101
XGX32
NOMESCO Finland
Bronchoscopic ultrasonography
24.1
95.8
138
61
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
7.4
94.2
238
356
C34.30
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung without histology
28.2
90.8
125
47
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
6.3
88.5
251
440
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
87.7
592
2349
C34.99
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary other or unspecified histology
19.4
86.0
133
73
1BA04
NOMESCO Finland
NA
296.4
84.3
85
*
191
Kela drug reimbursment
Erlotinib
50.4
83.6
101
21
WF002
NOMESCO Finland
Radical radiotherapy
5.0
82.3
287
642
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
6.2
78.8
225
396
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
5.0
78.4
275
618
B01AB05
ATC
enoxaparin; parenteral
2.5
77.2
883
4742
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
72.9
824
4360
R03BB04
ATC
tiotropium bromide; inhalant
3.2
72.4
450
1658
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
8.6
71.9
163
204
XX3DW
NOMESCO Finland
Time consuming IT work
3.5
71.8
383
1259
JN4AD
NOMESCO Finland
Body CT examination
3.7
68.2
335
1027
8140/3-C34.2
ICD-O-3
Adenocarcinoma, NOS, of middle lobe, lung
+∞
68.1
65
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.3
66.1
803
4353
A04AA55
ATC
palonosetron, combinations; systemic
8.5
63.3
144
181
GDB21
NOMESCO Finland
Thoracoscopic segmental resection of lung
55.4
63.3
75
14
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
6.7
62.7
168
270
GD1AT
NOMESCO Finland
Biopsy of the lung with ultrasound guidance
30.8
62.0
83
28
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.2
61.0
249
645
C34.02
ICD-10 Finland
Malignant tumor of the main bronchial adenocarcinoma
131.8
60.2
64
5
L01XE03
ATC
[U] erlotinib; oral
39.3
60.1
76
20
L01XE13
ATC
[U] afatinib; oral
310.9
59.6
60
*
A04AA02
ATC
granisetron; systemic, transdermal
4.1
59.4
249
661
AA1BD
NOMESCO Finland
Extensive CT of head and brain
6.5
59.3
161
263
R4110
NOMESCO Finland
Physiotherapy
2.3
59.1
711
3787
C34.19
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung other or unspecified histology
18.7
58.0
90
50
C34.00
ICD-10 Finland
Malignant tumor of the main bronchus without histology
16.6
57.9
94
59
J93.8
ICD-10 Finland
Other pneumothorax
28.2
57.8
79
29
3004
Kela drug reimbursment
Osimertinib
299.8
57.5
58
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
5.4
56.6
181
363
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.5
56.2
284
884
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
14.7
54.1
92
65
1519
Kela drug reimbursment
NA
272.3
52.4
53
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
51.4
688
3796
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
51.4
443
1963
TGD00
NOMESCO Finland
Needle biopsy of lung
18.8
50.4
78
43
ZX050
NOMESCO Finland
Stereotactic radiotherapy
15.3
50.2
84
57
TGA30
NOMESCO Finland
Thoracocentesis
14.5
49.7
85
61
YG1CD
NOMESCO Finland
Very extensive CT examination of thorax for dose design of radiotherapy
20.7
49.4
74
37
A06AH03
ATC
naloxegol; oral
11.3
48.4
93
86
J94.8
ICD-10 Finland
Other specified pleural conditions
7.6
48.3
117
162
C34.39
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung other or unspecified histology
18.0
47.8
75
43
341
Kela drug reimbursment
Afatinib and gefitinib
478.0
47.5
47
*
TGE00
NOMESCO Finland
Needle biopsy of mediastinum
34.8
47.1
61
18
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
17.8
47.0
74
43
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
6.0
46.2
133
234
B01AB10
ATC
tinzaparin; parenteral
3.4
45.8
238
752
ZX120
NOMESCO Finland
Intravenous
2.9
45.7
316
1220
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.6
45.6
221
660
N03AX16
ATC
pregabalin; oral
2.2
45.4
593
3202
L01EB04
ATC
osimertinib; oral
234.9
45.1
46
*
GD2CT
NOMESCO Finland
Cytology of the lungs with CT guidance
54.3
44.7
53
10
C34.80
ICD-10 Finland
Malignant overall tumor of bronchus and lung without histology
18.9
44.2
68
37
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.5
44.1
226
705
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
8.5
44.0
99
122
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
13.8
43.6
76
57
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.7
43.6
202
581
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.1
43.0
142
294
WX892
NOMESCO Finland
Monitored bed care
3.0
43.0
267
956
M05BX04
ATC
denosumab; parenteral
3.8
42.7
191
533
GD2AT
NOMESCO Finland
Cytology of the lungs with ultrasound guidance
44.3
42.4
52
12
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
42.0
561
3042
WX250
NOMESCO Finland
Intercostal blockade
43.4
41.4
51
12
N02AX02
ATC
tramadol; systemic, rectal
1.9
41.0
1004
6867
XG410
NOMESCO Finland
Flow-volume spirometry
3.8
39.1
173
478
H02AB06
ATC
prednisolone; systemic
1.8
38.9
1074
7600
C78.2
ICD-10 Finland
Secondary malignant neoplasm of pleura
27.1
38.6
53
20
J01MA14
ATC
moxifloxacin; systemic
2.7
37.8
277
1100
L01XE02
ATC
[U] gefitinib; oral
+∞
37.6
36
*
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
22.1
37.1
54
25
J01MA12
ATC
levofloxacin; systemic
2.1
37.0
522
2875
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.5
36.9
187
577
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.4
36.3
188
590
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.4
36.3
188
590
C34.2
ICD-10 Finland
Malignant neoplasm: Middle lobe, bronchus or lung
30.6
36.1
48
16
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
6.7
35.5
93
145
GDB11
NOMESCO Finland
Thoracoscopic wedge resection of lung
18.2
35.4
55
31
ZX090
NOMESCO Finland
Other technic of radiotherapy
4.6
35.2
128
294
C79.31
ICD-10 Finland
Secondary malignant tumor of the cerebellum
43.8
35.1
43
10
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
5.5
34.8
106
200
JN4CD
NOMESCO Finland
Very extensive body CT
3.7
34.5
160
459
N02AA01
ATC
morphine; systemic, rectal
6.5
33.9
90
143
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
6.4
33.4
90
146
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
19.7
33.1
50
26
1623C
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Upper lobe, bronchus or lung[NEOPL MAL LOB SUPER PULMONIS,ADENOCARCINOMA]
172.6
32.8
34
*
C34.20
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung without histology
31.3
32.6
43
14
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.6
32.1
155
460
C34
ICD-10 Finland
Malignant neoplasm of bronchus and lung
44.1
31.9
39
9
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
14.2
31.7
54
39
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
11.2
30.6
58
53
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
9.9
30.2
61
63
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
8.5
29.1
64
77
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
14.8
28.8
48
33
N07BA03
ATC
varenicline; oral
4.0
28.7
120
315
A79
ICPC
Malignancy NOS
6.5
28.6
76
121
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
28.6
463
2656
A04AD12
ATC
aprepitant; systemic
6.0
28.4
80
138
1504
Kela drug reimbursment
Alectinib
+∞
28.2
27
*
3001
Kela drug reimbursment
Alectinib
+∞
28.2
27
*
GAA96
NOMESCO Finland
Other open or percutaneous drainage of pleural cavity
12.5
27.8
50
41
B03BA03
ATC
hydroxocobalamin; parenteral
2.7
27.6
202
798
A98
ICPC
Health maint/preventive medicine
0.6
27.6
1478
17071
Z2446
NOMESCO Finland
Social worker
2.9
27.1
174
632
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.8
26.8
186
710
R03AC02
ATC
salbutamol; inhalant
1.6
26.6
1018
7604
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
4.7
26.5
92
202
L01XE35
ATC
[U] osimertinib; oral
+∞
26.1
25
*
169
Kela drug reimbursment
Crizotinib
+∞
26.1
25
*
A02BC02
ATC
pantoprazole; systemic
1.6
26.0
1368
11099
R06.0
ICD-10 Finland
Dyspnoea
1.8
25.8
593
3816
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
5.1
25.8
83
168
GEA00
NOMESCO Finland
Mediastinoscopy
17.7
25.7
40
23
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
7.3
25.1
61
86
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
3.8
24.9
109
298
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
7.9
24.8
57
74
GD5CD
NOMESCO Finland
Thorax and upper abdomen combined very extensive CT examination of
10.2
24.8
49
49
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.7
24.1
178
705
L01EB03
ATC
afatinib; oral
+∞
24.0
23
*
L01ED03
ATC
alectinib; oral
+∞
24.0
23
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
23.9
275
1366
R04.2
ICD-10 Finland
Haemoptysis
3.2
23.4
128
418
C77.1
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intrathoracic lymph nodes
15.9
22.4
36
23
J93.9
ICD-10 Finland
Pneumothorax, unspecified
10.7
22.4
43
41
TGC00
NOMESCO Finland
Bronchial lavation
3.8
22.0
95
258
L01XE16
ATC
[U] crizotinib; oral
+∞
21.9
21
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.5
21.5
171
705
C34.11
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary epidermoid carcinoma
6.3
21.4
57
92
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
5.7
21.3
62
112
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
21.0
823
6065
8140/3-C34.0
ICD-O-3
Adenocarcinoma, NOS, of main bronchus
+∞
20.9
20
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
20.6
780
5692
GDC10
NOMESCO Finland
Bilobectomy of lung
25.8
20.4
28
11
C34.0
ICD-10 Finland
Malignant neoplasm: Main bronchus
13.2
20.2
35
27
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
5.5
19.8
59
110
L01XE36
ATC
[U] alectinib; oral
+∞
19.8
19
*
Z3231
NOMESCO Finland
Registered nurse
1.6
19.5
603
4165
B01AB04
ATC
dalteparin; parenteral
2.6
19.2
144
574
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
6.5
18.9
49
77
5826
FHL
Lobectomy or bilobectomy
18.9
18.6
28
15
GDC11
NOMESCO Finland
Thoracoscopic bilobectomy of lung
191.6
18.6
19
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
18.4
903
6949
GAC00
NOMESCO Finland
Biopsy of pleura
11.9
18.3
33
28
YA1AD
NOMESCO Finland
CT examination of head and neck for dose design of radiotherapy
6.6
18.3
47
73
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
10.4
18.2
35
34
Z2221
NOMESCO Finland
Medical doctor
1.6
18.1
554
3803
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
18.0
373
2290
PJD99
NOMESCO Finland
Excision of other lymph nodes
26.9
17.8
24
9
C79.7
ICD-10 Finland
Secondary malignant neoplasm of adrenal gland
67.2
17.7
20
*
Z3226
NOMESCO Finland
Physiotherapist
1.7
17.7
400
2518
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
17.6
344
2074
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
17.4
290
1655
D70.82
ICD-10 Finland
Drug-induced neutropenia
4.9
17.3
56
116
1CD01
NOMESCO Finland
NA
14.9
17.1
28
19
D38.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Respiratory organ, unspecified
13.3
16.9
29
22
ZX070
NOMESCO Finland
Intensity modified radiotherapy
3.8
16.9
72
194
GDD00
NOMESCO Finland
Pneumonectomy
25.8
16.9
23
9
YX8VG
NOMESCO Finland
Stereotactic MRI exmaination with high intensity magnet for dose design of radiotherapy
16.4
16.5
26
16
J70.0
ICD-10 Finland
Acute pulmonary manifestations due to radiation
23.2
16.4
23
10
WX402
NOMESCO Finland
General anaesthesia
1.8
16.3
300
1769
C34.89
ICD-10 Finland
Malignant overall tumor of the bronchus and lung other or unspecified histology
12.4
15.3
27
22
WW200
SPAT
NA
0.3
15.3
25
926
ZX080
NOMESCO Finland
Image guided radiotherapy
4.0
15.1
60
153
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
4.5
14.9
52
117
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
7.0
14.9
36
52
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
3.1
14.8
81
267
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
14.8
374
2422
ZXA00
NOMESCO Finland
Right side
1.5
14.6
601
4387
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
2.0
14.4
181
925
R85
ICPC
Malignant neopl respiratory other
19.3
14.2
21
11
C34.29
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung other or unspecified histology
22.4
14.2
20
9
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.5
14.0
112
465
L03AA13
ATC
pegfilgrastim; parenteral
2.8
14.0
91
336
C78.1
ICD-10 Finland
Secondary malignant neoplasm of mediastinum
23.9
13.8
19
8
J93.1
ICD-10 Finland
Other spontaneous pneumothorax
6.8
13.7
34
51
G30.1
ICD-10 Finland
Alzheimer disease with late onset
0.3
13.7
23
839
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
7.7
13.6
31
41
N06DX01
ATC
memantine; oral
0.3
13.6
29
939
363
Kela drug reimbursment
Crizotinib
+∞
13.6
13
*
C79.3
ICD-10 Finland
Secondary malignant neoplasm of brain and cerebral meninges
34.2
13.5
17
5
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.3
13.4
123
550
J43.9
ICD-10 Finland
Emphysema, unspecified
3.6
13.3
60
171
ZXE00
NOMESCO Finland
One hour or less
1.4
13.2
764
5961
R03AL03
ATC
vilanterol and umeclidinium bromide; inhalant
4.7
13.1
44
96
C34.09
ICD-10 Finland
Malignant tumor of the main bronchus other or unspecified histology
16.8
13.0
20
12
C34.13
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary bronchoalveolar carcinoma
22.7
12.9
18
8
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.3
12.9
119
532
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
12.8
236
1386
D38.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Mediastinum
9.1
12.7
26
29
A06AD11
ATC
lactulose; oral
1.6
12.6
358
2386
C34.01
ICD-10 Finland
Malignant tumor of the main bronchial epidermoid carcinoma
11.1
12.5
23
21
1625C
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Lower lobe, bronchus or lung[NEOPL MAL LOBI INFERIORIS PULMONIS,ADENOCARCINOMA]
+∞
12.5
12
*
8140/3-C34.8
ICD-O-3
Adenocarcinoma, NOS, of overlapping lesion of lung
+∞
12.5
12
*
L01EB01
ATC
gefitinib; oral (epidermal growth factor receptor (egfr) tyrosine kinase inhibitors)
+∞
12.5
12
*
TXQ05
NOMESCO Finland
Puncture of skin, site unspecified
130.7
12.4
13
*
RS221
NOMESCO Finland
NA
4.5
12.4
43
97
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.5
12.4
96
392
R2110
NOMESCO Finland
Giving the first information
2.2
12.4
121
556
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.6
12.2
322
4599
C34.21
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung epidermoid carcinoma
21.4
12.0
17
8
WX330
NOMESCO Finland
Paravertebral ansthesia
46.9
11.9
14
*
WF099
NOMESCO Finland
Other radiotherapy
8.0
11.8
26
33
F03
ICD-10 Finland
Unspecified dementia
0.2
11.8
14
616
C34.33
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung bronchoalveolar carcinoma
30.2
11.6
15
5
J86.9
ICD-10 Finland
Pyothorax without fistula
4.4
11.6
41
95
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.6
11.6
302
1964
M17.1
ICD-10 Finland
Other primary gonarthrosis
0.6
11.5
205
3184
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
3.0
11.5
66
226
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
11.3
389
2707
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
10.6
11.3
21
20
C79.39
ICD-10 Finland
Secondary malignant tumor of the meninges, ventricle or other part of the brain
20.1
11.1
16
8
N06DA02
ATC
donepezil; oral
0.3
11.1
26
807
SPAT1109
SPAT
Analgesia with portable analgesic pump
5.6
11.0
31
56
325
Kela drug reimbursment
Erlotinib
43.5
10.9
13
*
N05CF01
ATC
zopiclone; oral
1.4
10.9
685
5381
C80.92
ICD-10 Finland
Malignant tumor without specified localization adenocarcinoma
15.6
10.8
17
11
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
3.3
10.8
52
158
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
0.3
10.8
18
658
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.4
10.8
89
378
WW500
NOMESCO Finland
Blood transfusion
2.3
10.7
100
451
GD2FN
NOMESCO Finland
Lung ventilation distribution isotope examination (radiospirometry)
60.3
10.6
12
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
2.4
10.6
90
387
R52.0
ICD-10 Finland
Acute pain
2.9
10.5
63
223
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
10.5
140
736
C34.31
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung epidermoid carcinoma
4.5
10.4
35
78
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
0.7
10.3
581
7294
GA2AT
NOMESCO Finland
Pleural biopsy with ultrasound guidance
23.5
10.2
14
6
SFA10
NOMESCO Finland
Fillning on one surface of tooth
0.7
10.2
551
6967
GDA11
NOMESCO Finland
Thoracoscopic biopsy of lung
8.5
10.0
21
25
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.3
10.0
90
400
JN6AD
NOMESCO Finland
CT of torso and neck
3.9
9.9
39
101
GDA21
NOMESCO Finland
Thoracoscopic excision of lesion of lung
16.8
9.9
15
9
N06DA03
ATC
rivastigmine; oral, transdermal
0.2
9.8
13
537
1BC05
NOMESCO Finland
NA
20.1
9.8
14
7
R50.9
ICD-10 Finland
Fever, unspecified
1.6
9.8
272
1795
P20
ICPC
Memory disturbance
0.6
9.8
119
2034
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.3
9.8
85
371
A02BC01
ATC
omeprazole; systemic
1.4
9.7
549
4218
R03BB01
ATC
ipratropium bromide; inhalant
2.0
9.7
118
598
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
9.6
612
4796
GA3AT
NOMESCO Finland
Pleural cytology with ultrasound guidance
6.8
9.6
23
34
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.7
9.5
441
5725
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
0.7
9.5
312
4297
SPAT1053
SPAT
Memory test
0.6
9.5
174
2698
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.2
9.5
34
81
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
0.4
9.4
49
1093
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
0.2
9.4
12
510
C34.23
ICD-10 Finland
Malignant tumor of the middle lobe, bronchus or lung bronchoalveolar carcinoma
+∞
9.4
9
*
GDB10
NOMESCO Finland
Wedge resection of lung
9.5
9.3
18
19
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
2.7
9.2
62
236
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.5
9.1
374
2698
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.6
9.1
248
1631
WX600
NOMESCO Finland
Single shot through catheter
4.4
9.0
31
71
SAA02
NOMESCO Finland
Basic examination of mouth
0.7
8.9
696
8382
GAA31
NOMESCO Finland
Thoracoscopy
7.2
8.7
20
28
R95
ICPC
Chron obstructive pulmonary disease
2.3
8.7
78
345
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.9
8.7
50
173
G20
ICD-10 Finland
Parkinson disease
0.2
8.6
11
466
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.0
8.6
46
153
N03AX14
ATC
levetiracetam; systemic
2.6
8.6
59
229
C38.4
ICD-10 Finland
Malignant neoplasm: Pleura
20.1
8.5
12
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
8.4
642
5162
OAB42
SPAT
NA
0.2
8.4
6
361
D38.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pleura
9.5
8.3
16
17
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
0.2
8.2
11
450
L03AA02
ATC
filgrastim; parenteral
2.5
8.2
60
242
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
2.0
8.1
98
495
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
0.2
8.1
9
409
WW200
NOMESCO Finland
Immunization
2.6
8.1
57
226
C34.15
ICD-10 Finland
Malignant tumor of the anterior, bronchial or lung other non-microcellular carcinoma
8.9
8.0
16
18
SAA01
NOMESCO Finland
Simple examination of mouth
0.8
8.0
831
9685
ZXD05
NOMESCO Finland
Urgent procedure
1.3
8.0
573
4559
C34.91
ICD-10 Finland
Malignant tumor in unspecified localization in bronchial and pulmonary epidermoid carcinoma
7.3
8.0
18
25
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
4.4
7.9
27
62
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
2.7
7.9
52
198
205
Kela drug reimbursment
Chronic hypertension
0.7
7.8
449
5674
HA1AA
NOMESCO Finland
X-ray mammography
1.9
7.8
114
621
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.9
7.8
106
564
I31.3
ICD-10 Finland
Pericardial effusion (noninflammatory)
7.0
7.8
18
26
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.4
7.7
27
698
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
3.1
7.7
40
131
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
4.1
7.7
28
69
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
4.2
7.6
27
65
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
8.0
7.6
16
20
A04AA03
ATC
tropisetron; systemic
8.0
7.6
16
20
J85.2
ICD-10 Finland
Abscess of lung without pneumonia
11.9
7.6
13
11
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
3.3
7.6
36
111
L57.0
ICD-10 Finland
Actinic keratosis
0.6
7.5
96
1623
XX9XW
NOMESCO Finland
NA
5.2
7.5
22
43
L03AA14
ATC
lipegfilgrastim; parenteral
3.0
7.5
40
134
K02.1
ICD-10 Finland
Caries of dentine
0.8
7.5
600
7255
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
4.8
7.4
23
48
1CD02
NOMESCO Finland
NA
4.8
7.4
23
48
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.1
7.4
79
381
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
4.3
7.3
25
58
OAA67
SPAT
NA
0.1
7.3
*
286
L01ED01
ATC
crizotinib; oral
+∞
7.3
7
*
1XC18
NOMESCO Finland
NA
+∞
7.3
7
*
1629C
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Bronchus and lung, unspecified[NEOPL MAL PULMONIS LOCO ALIO/NUD,ADENOCARCINOMA]
+∞
7.3
7
*
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
0.7
7.3
414
5246
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
4.5
7.3
24
54
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
5.4
7.2
20
37
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
4.8
7.1
22
46
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
0.7
7.1
173
2532
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
0.5
7.1
55
1066
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
3.4
7.0
32
96
SPAT1312
SPAT
General health counselling
0.7
7.0
338
4391
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
6.9
207
1388
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
5.2
6.9
20
39
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.2
6.9
24
57
J43.2
ICD-10 Finland
Centrilobular emphysema
7.5
6.9
15
20
Z72.0
ICD-10 Finland
Tobacco use
2.6
6.9
46
178
GCA32
NOMESCO Finland
Endoscopic insertion of stent into bronch
13.8
6.9
11
8
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
0.7
6.9
326
4249
XG466
NOMESCO Finland
Sleep oxymetry
2.2
6.8
68
319
N07BC02
ATC
methadone; systemic
8.3
6.8
14
17
1623X
ICD-9 Finland
Malignant neoplasm of trachea, bronchus and lung, Upper lobe, bronchus or lung[NEOPL MAL LOB SUPER PULMONIS,EI HIST/SYTOL DG]
11.0
6.8
12
11
GA2CT
NOMESCO Finland
Pleural biopsy with CT guidance
40.2
6.8
8
*
XW3AT
NOMESCO Finland
Biopsy of other superficial organ with ultrasound guidance
5.7
6.8
18
32
J94.9
ICD-10 Finland
Pleural condition, unspecified
4.7
6.7
21
45
R02
ICPC
Shortness of breath/dyspnoea
1.5
6.7
223
1536
S27.0
ICD-10 Finland
Traumatic pneumothorax
3.9
6.7
25
64
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
3.8
6.7
26
69
SDA01
NOMESCO Finland
Simple parodonthologic therapy
0.7
6.6
188
2672
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
6.6
1594
14795
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
3.5
6.6
28
80
SPAT1310
SPAT
Counselling related to known health issue
0.7
6.6
366
4663
J96.1
ICD-10 Finland
Chronic respiratory failure
2.3
6.6
59
266
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
2.6
6.6
44
171
QBC00
NOMESCO Finland
Removal of foreign body from skin of trunk or subcutaneous tissue
8.7
6.5
13
15
C79.2
ICD-10 Finland
Secondary malignant neoplasm of skin
10.0
6.5
12
12
C34.35
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung other non-microcellular carcinoma
10.0
6.5
12
12
N05BA06
ATC
lorazepam; systemic, sublingual
1.8
6.5
102
574
GAC01
NOMESCO Finland
Endoscopic biopsy of pleura
6.9
6.5
15
22
1240
FHL
Bronchoscopy
2.9
6.4
35
120
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.4
200
1356
L15
ICPC
Knee symptom/complaint
0.7
6.4
194
2724
ZXA05
NOMESCO Finland
Left side
1.3
6.4
510
4103
P01AB01
ATC
metronidazole; oral, rectal
1.3
6.4
634
5258
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
4.9
6.4
19
39
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.4
6.3
51
216
M84.4
ICD-10 Finland
Pathological fracture, not elsewhere classified
8.2
6.3
13
16
JN4DD
NOMESCO Finland
Scout CT scan of torso
8.2
6.3
13
16
J98.4
ICD-10 Finland
Other disorders of lung
9.3
6.3
12
13
R05
ICD-10 Finland
Cough
1.4
6.3
329
2474
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
0.6
6.3
123
1883
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
2.9
6.3
34
117
3017
Kela drug reimbursment
Brigatinib
+∞
6.3
6
*
GEB40
NOMESCO Finland
Mediastinotomy and extended excision of lesion
+∞
6.3
6
*
N04BD01
ATC
selegiline; oral
0.1
6.2
*
187
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
2.1
6.2
64
308
ZXC50
NOMESCO Finland
Cryotherapy
0.3
6.2
12
404
ZX095
NOMESCO Finland
Combined chemoradiotherapy
4.5
6.2
20
45
R03AC13
ATC
formoterol; inhalant
1.8
6.1
95
533
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
7.7
6.1
13
17
Z01.2
ICD-10 Finland
Dental examination
0.8
6.1
395
4936
N05AX08
ATC
risperidone; systemic
0.5
6.1
51
965
N40
ICD-10 Finland
Hyperplasia of prostate
0.8
6.1
384
4812
ZXE30
NOMESCO Finland
More than five and less than seven hours
1.8
6.0
103
596
GEA20
NOMESCO Finland
Mediastinoscopy with excision of lesion
6.7
6.0
14
21
J93.0
ICD-10 Finland
Spontaneous tension pneumothorax
10.0
6.0
11
11
ZYC01
SPAT
NA
0.3
6.0
12
400
SPAT1111
SPAT
Planning of analgesia
3.2
6.0
29
92
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
3.2
6.0
29
92
XG460
NOMESCO Finland
Short time oxymetry
2.5
6.0
46
190
JN3KE
NOMESCO Finland
Abdominal ultrasound with added contrast
4.1
6.0
21
51

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: HLP_C3_NSCLC_ADENO – Non-small cell lung cancer, adenocarcinoma, helper endpoint

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).