Other/unspecified postprocedural disorders of ear and mastoid process

H8_POSTOPNAS

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H95.8, H95.9 Cause of death: ICD-10 — H95.8, H95.9 2 out of 7 registries used, show all original rules.	98
4. Check minimum number of events None	98
5. Include endpoints None	98
6. Filter based on genotype QC (FinnGen only)	98

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H8_POSTOPNAS
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H95[8-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H95[8-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other/unspecified postprocedural disorders of ear and mastoid process based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	977	479	495
Only index persons	935	464	471
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	64.74	67.98	61.54
Only index persons	64.84	67.85	61.88

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	98	48	50
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	65.34	61.51	69.00

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
85: Matched controls
848

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H95.8

ICD-10 Finland

Other postprocedural disorders of ear and mastoid process

+∞

87.0

UDC00

NOMESCO Finland

Ear microscopy

115.3

57.7

H71

ICD-10 Finland

Cholesteatoma of middle ear

680.1

42.0

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

113.7

29.0

H95.1

ICD-10 Finland

Other disorders following mastoidectomy

+∞

24.1

H95.9

ICD-10 Finland

Postprocedural disorder of ear and mastoid process, unspecified

+∞

20.7

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

+∞

18.4

H95.0

ICD-10 Finland

Recurrent cholesteatoma of postmastoidectomy cavity

+∞

17.3

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

60.3

16.8

DBD20

NOMESCO Finland

Plastic repair of external auditory canal

+∞

16.1

H66.9

ICD-10 Finland

Otitis media, unspecified

22.0

15.9

H66.4

ICD-10 Finland

Suppurative otitis media, unspecified

69.8

15.4

WX720

NOMESCO Finland

Own respiration

21.0

14.4

Z97.8

ICD-10 Finland

Presence of other specified devices

+∞

13.9

38700

ICD-8 Finland

Other disease of ear and mastoid process, Cholesteatoma of ear

+∞

12.8

WX704

NOMESCO Finland

Intubation

10.2

12.7

DFF00

NOMESCO Finland

Pure tone audiometry

17.1

12.2

H66.3

ICD-10 Finland

Other chronic suppurative otitis media

41.3

11.7

Z01.1

ICD-10 Finland

Examination of ears and hearing

8.7

11.5

H65.3

ICD-10 Finland

Chronic mucoid otitis media

68.9

10.9

DEB25

NOMESCO Finland

Attico-antro-mastoidectomy and tympanoplasty

+∞

10.6

3853A

ICD-9 Finland

Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid

+∞

10.6

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

10.6

H66.0

ICD-10 Finland

Acute suppurative otitis media

13.8

10.1

TDA90

NOMESCO Finland

Removal wax from ear

62.4

9.9

DEA10

NOMESCO Finland

Attico-antrotomy

+∞

9.5

DCD00

NOMESCO Finland

Myringoplasty

56.0

8.9

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

31.1

8.7

H72.2

ICD-10 Finland

Other marginal perforations of tympanic membrane

99.5

8.6

H60.9

ICD-10 Finland

Otitis externa, unspecified

10.7

8.5

H74.2

ICD-10 Finland

Discontinuity and dislocation of ear ossicles

+∞

8.5

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

8.5

WX702

NOMESCO Finland

Supraglottic ventilation device

13.7

8.4

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

6.5

8.3

S03CA01

ATC

dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)

17.2

8.0

38210

ICD-8 Finland

Chronic otitis media with mastoiditis

49.7

7.9

38110

ICD-8 Finland

Otitis media without mention of mastoiditis, Chronic

28.0

7.8

4147

FHL

Radical surgery, cavity filling and middle ear and / or eardrum plastic

+∞

7.4

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

7.4

WX725

NOMESCO Finland

Noninvasive ventilation

8.0

6.9

Z01.8

ICD-10 Finland

Other specified special examinations

3.8

6.6

111

DCD10

NOMESCO Finland

Tympanoplasty

75.3

6.5

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

7.3

6.5

DAX08

NOMESCO Finland

Fitting of hearing aid

29.1

6.3

H73.1

ICD-10 Finland

Chronic myringitis

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

7.33

15.06

7.4

6.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

5.21

12.45

3.0

1.6

—

(3019060) Gas panel - Arterial blood

5.26

10.69

6.3

3.8

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

760

0.27

9.57

12.9

14.7

ml/min/173m2

79.3

76.7

0.31

624

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.93

8.18

1.7

—

(3003396) Base excess in Arterial blood by calculation

107

3.60

7.23

7.0

6.3

mmol/l

2.5

1.0

1.57

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

105

3.50

6.79

1.7

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

7.31

6.44

2.6

1.5

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

168

2.93

5.85

5.3

3.4

ng/l

30.6

288.8

1.85

139

(3019150) Specific gravity of Urine by Refractometry

162

2.93

5.77

5.3

4.5

kg/l

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

142

2.73

4.70

1.9

1.8

—

(3026389) Candida sp identified in Specimen by Organism specific culture

14.91

4.65

1.3

1.2

—

(3000494) Fungus identified in Specimen by Culture

100

2.85

4.31

2.2

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

257

0.28

4.15

2.4

3.0

e6/l

0.0

0.4

—

201

(3038177) Helicobacter pylori Ab [Presence] in Serum

8.27

3.62

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

3.00

3.62

1.6

1.7

—

(3042936) Bacteria identified in Isolate by Culture

124

2.49

3.55

3.0

1.6

—

(3032080) INR in Blood by Coagulation assay

362

2.18

3.51

12.4

8.4

inr

1.7

1.3

0.60

100

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.86

3.29

3.1

2.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

696

2.92

3.20

25.9

16.8

41.1

38.9

2.39

475

(40768804) Tissue Pathology biopsy report

318

0.38

3.15

1.7

2.1

—

(4035726)

0.00

3.12

0.0

1.4

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.00

3.12

0.0

3.6

—

1.2

—

(3013512) EKG study

257

0.36

2.79

1.8

4.0

—

(3045788) Cell count panel - Pleural fluid

8.69

2.78

1.2

—

(3005715) Vancomycin [Mass/volume] in Serum or Plasma

6.31

2.74

6.2

6.4

mg/l

10.2

10.3

—

(1761868) Lipid panel - Serum or Plasma

242

0.35

2.72

2.7

3.4

—

(3018418) pH of Serum or Plasma

260

1.99

2.72

3.0

3.8

—

7.4

—

(3044640) Blood type and Crossmatch panel - Blood

252

0.37

2.66

3.7

2.3

—

(40761536) Microorganisms panel - Urine sediment

0.00

2.52

0.0

3.7

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

393

1.91

2.51

6.1

5.3

mmol/l

1.2

1.23

352

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

181

0.39

2.10

4.4

2.4

—

(3044290) Cell count panel - Cerebral spinal fluid

4.19

2.07

1.3

1.0

—

(3037756) Immunofixation for Serum or Plasma

3.51

2.00

1.0

1.2

—

(3023368) Bacteria identified in Blood by Culture

241

1.78

1.91

5.0

4.5

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.67

1.90

3.0

2.0

—

(36304419) Bacteria [Presence] in Urine

240

0.47

1.76

2.1

2.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.93

1.68

2.0

1.8

—

(3026008) Bacteria identified in Urine by Culture

270

1.67

1.59

4.9

3.0

—

(3044889) 12 lead EKG panel

575

1.68

1.50

5.3

4.1

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

444

1.61

1.48

6.0

6.2

umol/l

9.2

11.2

1.59

422

(3037467) Urinalysis macro (dipstick) panel - Urine

559

1.63

1.40

6.2

4.2

—

(3012516) Albumin [Mass/volume] in Urine

247

1.58

1.26

2.2

3.2

mg/l

73.2

66.7

0.05

165

(3022313) Gas panel - Capillary blood

0.00

1.18

0.0

3.8

—

(3020682) Albumin/Creatinine [Ratio] in Urine

269

1.53

1.17

2.3

4.0

mg/mmol

8.3

11.7

0.27

172

(36660697) Celiac disease serology panel - Serum

1.94

1.08

1.3

1.2

—

(40758558) Short blood count panel - Blood

230

0.59

1.06

4.5

6.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.14

1.05

1.0

1.1

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

100

1.72

1.04

1.1

1.3

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.99

0.0

4.3

—

24.9

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.87

0.99

2.8

1.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.97

0.0

5.4

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.85

0.86

1.1

1.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

491

1.38

0.80

7.0

4.2

mmol/l

6.9

6.8

0.19

462

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.80

0.0

5.3

—

37.3

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.80

0.0

1.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.80

0.0

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

157

0.60

0.77

1.2

1.5

g/l

2.3

2.6

—

(3031040) Bacteria [#/volume] in Urine by Automated count

545

1.37

0.75

6.3

4.3

—

40.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

310

1.37

0.74

5.1

4.1

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

128

1.50

0.72

2.5

2.2

g/l

2.1

2.4

1.10

116

(3020891) Body temperature

1.90

0.69

4.8

4.4

—

(4010399)

1.64

0.68

1.8

1.4

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.64

0.66

1.6

2.2

pmol/l

4.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

314

0.73

0.65

3.1

—

(3043409) Potassium [Moles/volume] in Arterial blood

1.76

0.64

3.6

3.4

mmol/l

3.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

356

1.31

0.61

7.1

3.8

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.61

0.0

1.3

—

(1002224) Polysomnography panel

0.00

0.61

0.0

1.0

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.61

0.0

2.4

—

106.7

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.61

0.0

2.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.61

0.0

2.4

—

4.0

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.60

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.60

0.0

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.59

0.0

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

428

1.29

0.56

2.8

2.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

100

1.47

0.55

1.1

1.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

183

1.34

0.51

7.0

3.8

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

150

1.33

0.44

1.9

3.1

mmol/l

0.9

0.8

0.77

139

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.8

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.3

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.41

0.0

2.4

—

4.9

—

(3012501) Base excess in Blood by calculation

0.00

0.41

0.0

2.4

—

1.3

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.41

0.0

3.0

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.41

0.0

1.3

—

(40761535) Cells panel - Urine sediment

1.34

0.40

8.3

3.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.40

0.0

1.2

—

(3024928) Oxygen saturation in Venous blood

0.00

0.40

0.0

3.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

343

1.23

0.39

2.5

2.2

nmol/l

82.0

76.2

0.66

296

(40767503) Oxygen content in Capillary blood by calculation

0.00

0.39

0.0

2.3

—

16.5

—

(4094501)

0.00

0.39

0.0

1.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.39

0.0

1.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.33

0.38

1.3

1.5

—

(3022217) INR in Platelet poor plasma by Coagulation assay

122

0.71

0.38

47.7

28.4

—

1.3

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

219

0.78

0.36

3.2

2.0

mg/l

2.2

3.1

1.12

192

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

291

0.81

0.34

4.4

3.1

ng/l

2392.8

1255.7

0.42

250

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.39

0.34

3.0

3.4

ng/l

75.7

85.6

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

101

1.33

0.34

4.7

4.1

u/l

263.5

239.7

0.22

(3005719) IgG [Mass/volume] in Serum or Plasma

1.32

0.31

2.3

2.9

g/l

6.4

9.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

352

1.18

0.29

2.2

2.1

pmol/l

100.3

93.9

0.47

183

(40761511) CBC panel - Blood by Automated count

812

1.24

0.25

24.7

14.0

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

637

1.16

0.24

7.9

7.4

u/l

84.3

79.4

0.40

595

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.74

0.23

35.0

9.0

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(4281824)

0.00

0.21

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.21

0.0

3.2

—

61.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

0.21

0.0

1.1

—

90.4

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.3

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.21

0.0

1.7

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.1

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.21

0.0

1.8

—

5.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.21

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.21

0.0

1.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.29

0.21

1.5

1.2

—

(1616796) Gas panel - Central venous blood

0.00

0.20

0.0

2.8

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.20

0.0

1.2

—

199.0

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

109

1.22

0.20

4.8

4.2

mmol/l

1.0

0.13

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.22

0.18

1.3

1.4

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

772

0.88

0.16

5.2

4.7

mmol/l

4.6

4.5

0.25

694

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.78

0.15

1.7

3.6

kpa

5.6

5.8

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

832

1.16

0.13

26.2

18.2

umol/l

82.0

79.6

0.21

832

(3021960) Folate [Moles/volume] in Serum or Plasma

220

0.89

0.13

1.4

1.6

nmol/l

23.9

21.6

0.20

182

(3019309) Folate [Moles/volume] in Red Blood Cells

181

1.13

0.13

1.9

1.7

nmol/l

1061.4

1161.7

0.36

145

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

771

1.13

0.12

5.1

4.8

mmol/l

6.0

0.04

690

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

330

1.09

0.11

3.8

3.7

ng/l

26.5

38.9

0.71

242

(3029937) Albumin [Presence] in Urine by Test strip

212

1.11

0.11

6.9

4.1

—

0.0

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

339

0.92

0.11

3.4

2.6

ug/l

142.6

130.1

0.11

312

(40760892) CBC W Ordered Manual Differential panel - Blood

166

0.89

0.10

10.0

5.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

227

0.90

0.10

1.9

3.7

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.17

0.10

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.17

0.10

2.8

2.6

1.6

1.0

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.14

0.10

1.0

2.2

g/l

0.6

1.8

—

(3035350) Ketones [Presence] in Urine by Test strip

402

1.08

0.09

4.9

3.9

—

0.0

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

1.14

0.09

1.7

1.8

nmol/l

6.5

13.0

—

(3026493) Urate [Moles/volume] in Serum or Plasma

215

1.09

0.08

2.4

2.6

umol/l

355.0

6169.7

1.00

178

(3022621) pH of Urine by Test strip

0.82

0.08

2.2

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.80

0.08

1.0

2.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

406

0.93

0.08

6.1

5.4

—

0.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

838

1.11

0.07

12.2

10.7

u/l

24.6

24.0

0.20

804

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

130

0.91

0.05

1.4

1.2

iu/ml

21.9

42.8

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

799

0.94

0.03

24.0

15.1

mg/l

25.2

24.8

0.04

630

(3003694) ABO and Rh group [Type] in Blood

189

0.94

0.03

1.1

1.4

—

(3007461) Platelets [#/volume] in Blood

863

1.07

0.02

32.1

22.4

e9/l

240.6

246.0

0.34

835

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

273

1.04

0.01

5.6

4.9

24.4

20.8

0.49

135

(3024731) MCV [Entitic volume]

864

1.06

0.01

32.2

22.3

91.0

91.4

0.37

848

(3035941) MCH [Entitic mass]

864

1.06

0.01

32.1

22.3

30.4

30.3

0.08

848

(3026361) Erythrocytes [#/volume] in Blood

864

1.06

0.01

32.3

22.4

e12/l

4.4

0.68

833

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

183

0.98

0.00

1.9

1.8

mg/l

2.1

1.5

0.17

143

(42870588) Differential panel, method unspecified - Blood

277

1.02

0.00

3.9

5.3

—

(3009261) Glucose [Presence] in Urine by Test strip

413

0.99

0.00

5.0

3.9

—

0.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

835

0.96

0.00

28.4

17.4

mmol/l

3.9

4.0

1.25

807

(3000963) Hemoglobin [Mass/volume] in Blood

865

1.05

0.00

32.5

22.5

g/l

132.4

133.9

0.40

848

(3010813) Leukocytes [#/volume] in Blood

865

1.05

0.00

32.3

22.4

e9/l

7.1

6.9

0.29

837

(3019550) Sodium [Moles/volume] in Serum or Plasma

834

0.97

0.00

28.3

17.3

mmol/l

139.7

0.09

806

(4146454)

0.00

0.0

2.5

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.3

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.4

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

3.7

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

2.1

—

32.4

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

2.3

—

(3011648) Oxygen content in Venous blood

0.00

0.0

2.0

—

9.9

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.4

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(4268621)

0.00

0.0

1.9

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

4.4

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

27.0

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

5.6

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.5

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

3.0

—

6.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

2.2

—

13.2

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.4

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.2

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.0

—

(3045424) Erythrocytes [Presence] in Urine

0.00

0.0

1.7

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.2

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.2

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.2

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.0

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.02

0.00

5.4

8.9

94.6

94.2

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

3.2

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.4

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

4.3

—

48.4

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

4.2

—

107.6

—

(44806420)

0.00

0.0

2.4

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.7

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.2

—

(3012544) pH of Venous blood

0.99

0.00

1.6

3.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_POSTOPNAS and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_POSTOPNAS	1.092 [0.84, 1.41]	0.506
Birth year	0.991 [0.98, 1.0]	0.038

During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 440 females with H8_POSTOPNAS died.

Males

Parameter	HR [95% CI]	p-value
H8_POSTOPNAS	1.324 [0.98, 1.79]	0.067
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 441 males with H8_POSTOPNAS died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTOPNAS.

N-year risk	Females	Males
1	0.087%	0.227%
5	0.539%	1.316%
10	1.37%	3.49%
15	2.665%	6.444%
20	4.665%	10.797%

Relationships between endpoints

↥

Index endpoint: H8_POSTOPNAS – Other/unspecified postprocedural disorders of ear and mastoid process

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other/unspecified postprocedural disorders of ear and mastoid process

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints