Recurrent cholesteatoma of postmastoidectomy cavity

H8_POSTMASTCHOLEASTOMA

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H95.0 Cause of death: ICD-10 — H95.0 2 out of 7 registries used, show all original rules.	107
4. Check minimum number of events None	107
5. Include endpoints None	107
6. Filter based on genotype QC (FinnGen only)	107

Control definitions (FinnGen only)

Control exclude: H8_OTHEREAR

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H95
Name in latin: Cholesteatoma postoperativum recidivum auris mediae

NAME	H8_POSTMASTCHOLEASTOMA
CONTROL_EXCLUDE	H8_OTHEREAR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H950
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H950
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Recurrent cholesteatoma of postmastoidectomy cavity based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1043	467	574
Only index persons	986	440	546
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	55.47	58.07	53.39
Only index persons	54.74	57.43	52.57

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	107	47	60
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	57.63	57.10	58.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
104: Matched controls
1039

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H95.0

ICD-10 Finland

Recurrent cholesteatoma of postmastoidectomy cavity

+∞

149.9

104

H71

ICD-10 Finland

Cholesteatoma of middle ear

1075.3

83.7

UDC00

NOMESCO Finland

Ear microscopy

49.2

41.5

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

90.9

29.9

Z01.1

ICD-10 Finland

Examination of ears and hearing

19.1

23.6

DEA10

NOMESCO Finland

Attico-antrotomy

+∞

22.7

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

+∞

21.6

DEB30

NOMESCO Finland

Radical mastoidectomy

+∞

21.6

3853A

ICD-9 Finland

Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid

+∞

21.6

DFF00

NOMESCO Finland

Pure tone audiometry

25.5

19.5

DCD10

NOMESCO Finland

Tympanoplasty

+∞

19.4

H95.1

ICD-10 Finland

Other disorders following mastoidectomy

+∞

18.2

38110

ICD-8 Finland

Otitis media without mention of mastoiditis, Chronic

214.9

18.1

DBD20

NOMESCO Finland

Plastic repair of external auditory canal

+∞

16.0

38700

ICD-8 Finland

Other disease of ear and mastoid process, Cholesteatoma of ear

+∞

16.0

DEB25

NOMESCO Finland

Attico-antro-mastoidectomy and tympanoplasty

173.2

14.9

H70.1

ICD-10 Finland

Chronic mastoiditis

173.2

14.9

H95.8

ICD-10 Finland

Other postprocedural disorders of ear and mastoid process

+∞

13.8

4147

FHL

Radical surgery, cavity filling and middle ear and / or eardrum plastic

+∞

12.8

H74.1

ICD-10 Finland

Adhesive middle ear disease

+∞

12.8

Z46.1

ICD-10 Finland

Fitting and adjustment of hearing aid

22.2

12.0

Z97.4

ICD-10 Finland

Presence of external hearing-aid

26.6

12.0

DEB20

NOMESCO Finland

Attico-antro-mastoidectomy and tympanotomy

134.1

11.7

H66.4

ICD-10 Finland

Suppurative otitis media, unspecified

134.1

11.7

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

10.6

ZXE20

NOMESCO Finland

More than three and less than five hours

5.2

10.1

DC1AD

NOMESCO Finland

Temporalbone CT

109.5

9.6

38210

ICD-8 Finland

Chronic otitis media with mastoiditis

+∞

9.5

Z3229

NOMESCO Finland

Other healthcare associate professional

7.7

9.4

H66.9

ICD-10 Finland

Otitis media, unspecified

9.0

9.1

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

6.2

9.1

H66.3

ICD-10 Finland

Other chronic suppurative otitis media

54.7

8.8

DCD00

NOMESCO Finland

Myringoplasty

97.5

8.5

H60.4

ICD-10 Finland

Cholesteatoma of external ear

+∞

8.4

ZZG00

NOMESCO Finland

Graft of cartilage

+∞

8.4

4151

FHL

Reoperation for chronic otitis media

+∞

8.4

H72.2

ICD-10 Finland

Other marginal perforations of tympanic membrane

+∞

8.4

H60.9

ICD-10 Finland

Otitis externa, unspecified

8.5

8.4

H66.0

ICD-10 Finland

Acute suppurative otitis media

8.6

8.1

DAX00

NOMESCO Finland

Adjustment or review of hearing aid

48.7

7.8

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

48.7

7.8

H65.3

ICD-10 Finland

Chronic mucoid otitis media

20.2

7.8

DFF30

NOMESCO Finland

Loudness discomfort Level (LDL)

27.3

7.7

H61.2

ICD-10 Finland

Impacted cerumen

9.0

7.4

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

7.4

S02CA02

ATC

flumetasone and antiinfectives; otic

6.6

7.2

ZXA05

NOMESCO Finland

Left side

3.4

7.1

167

H72.9

ICD-10 Finland

Perforation of tympanic membrane, unspecified

42.9

6.9

R5120

NOMESCO Finland

Preparation of an aid

42.9

6.9

DFF15

NOMESCO Finland

Speech audiometry

15.6

6.5

WX704

NOMESCO Finland

Intubation

6.1

6.5

DEB10

NOMESCO Finland

Attico-antro-mastoidectomy

+∞

6.3

4150

FHL

Tympanoplasty (including for reasons other than inflammation)

+∞

6.3

M95.0

ICD-10 Finland

Acquired deformity of nose

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

3.72

7.44

2.1

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.20

4.99

8.0

8.1

—

(3019060) Gas panel - Arterial blood

2.97

3.60

3.5

4.4

—

(3042936) Bacteria identified in Isolate by Culture

123

2.35

3.14

2.0

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.76

3.04

2.5

1.6

—

(3032080) INR in Blood by Coagulation assay

349

1.88

2.61

11.7

8.7

inr

1.3

0.07

105

(3003396) Base excess in Arterial blood by calculation

2.25

2.46

6.4

7.3

mmol/l

1.4

1.3

0.00

(3000494) Fungus identified in Specimen by Culture

2.19

2.22

1.4

1.5

—

(3019230) Fractional oxyhemoglobin in Venous blood

4.17

2.07

1.2

2.2

67.5

63.6

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

361

1.72

2.01

6.0

4.3

g/l

33.6

35.5

1.17

342

(3023368) Bacteria identified in Blood by Culture

247

1.76

1.94

4.5

4.4

—

(40761511) CBC panel - Blood by Automated count

857

2.41

1.94

18.1

14.1

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.00

1.92

0.0

2.8

—

4.3

—

(4034850)

2.80

1.76

4.3

13.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

566

1.68

1.76

5.6

4.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

759

1.90

1.75

3.5

4.4

mu/l

1.8

1.9

0.32

674

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

100

1.96

1.65

1.8

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.06

1.52

2.0

1.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

104

1.88

1.48

1.6

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

414

1.56

1.43

6.2

6.4

mmol/l

1.2

0.02

349

(3009542) Hematocrit [Volume Fraction] of Blood

720

1.68

1.41

23.5

16.0

39.1

40.2

0.46

517

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

799

1.80

1.39

4.5

4.6

mmol/l

4.5

0.33

732

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

822

1.85

1.39

5.3

5.2

mmol/l

2.6

2.7

0.34

742

(3024928) Oxygen saturation in Venous blood

3.03

1.37

1.4

2.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

437

1.53

1.35

7.8

6.2

umol/l

10.6

11.5

0.42

415

(3000963) Hemoglobin [Mass/volume] in Blood

904

2.00

1.33

25.2

22.0

g/l

132.9

135.6

1.13

889

(3024731) MCV [Entitic volume]

904

2.00

1.33

25.1

21.8

91.0

91.2

0.18

890

(3026361) Erythrocytes [#/volume] in Blood

904

2.00

1.33

25.1

21.9

e12/l

4.4

4.5

0.77

874

(3035941) MCH [Entitic mass]

904

2.00

1.33

25.1

21.8

30.4

30.3

0.05

890

(3007461) Platelets [#/volume] in Blood

904

2.00

1.33

25.2

21.9

e9/l

250.4

245.1

0.40

881

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

141

1.71

1.30

1.8

1.9

—

(3020779) Urea [Moles/volume] in Serum or Plasma

1.95

1.26

6.6

7.5

mmol/l

9.6

9.4

0.05

(3027944) Amphetamines [Presence] in Urine

2.71

1.23

5.6

1.3

—

(3010813) Leukocytes [#/volume] in Blood

905

1.98

1.21

25.1

21.9

e9/l

6.9

6.7

0.77

877

(3013826) Glucose [Moles/volume] in Serum or Plasma

498

1.47

1.13

5.1

4.8

mmol/l

6.6

6.8

0.38

469

(3031040) Bacteria [#/volume] in Urine by Automated count

551

1.46

1.07

5.3

4.4

—

632.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

795

1.60

1.04

4.2

4.6

mmol/l

1.4

0.32

717

(3044889) 12 lead EKG panel

575

1.44

1.01

4.1

4.0

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.99

0.0

1.2

—

0.2

—

(3026008) Bacteria identified in Urine by Culture

240

1.48

0.99

4.2

3.1

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

112

1.62

0.92

1.3

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.13

0.91

2.5

—

(40768797) Stomach Pathology biopsy report

112

0.51

0.89

1.8

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.88

0.88

1.9

3.0

0.5

0.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.84

0.86

1.9

3.1

1.3

1.0

—

(3002256) Pathology report gross observation

1.66

0.86

1.4

1.2

—

(1761868) Lipid panel - Serum or Plasma

272

0.67

0.81

3.7

3.2

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.80

0.0

1.9

—

6.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

766

1.45

0.80

3.7

4.1

mmol/l

1.3

0.02

690

(3019198) Lymphocytes [#/volume] in Blood

423

1.34

0.75

4.0

5.8

e9/l

1.8

0.03

377

(42870588) Differential panel, method unspecified - Blood

280

1.37

0.75

3.8

5.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.89

0.69

3.6

2.4

—

(3052851) Hemolysis interference index of Serum or Plasma

1.89

0.69

3.6

2.3

—

(3012544) pH of Venous blood

1.61

0.69

2.5

4.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

101

0.57

0.66

2.7

3.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

267

1.34

0.65

3.6

4.0

mg/mmol

24.2

9.1

0.58

167

(3018010) Neutrophils/100 leukocytes in Blood

392

1.30

0.63

4.4

5.7

60.6

58.9

0.50

368

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

530

1.30

0.63

4.4

2.9

u/l

55.8

51.2

0.18

495

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.51

0.63

1.2

1.5

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.61

0.0

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.61

0.0

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

482

1.29

0.61

2.7

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.60

0.0

1.2

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.60

0.0

2.5

—

154.0

—

(3019150) Specific gravity of Urine by Refractometry

178

1.37

0.59

4.9

4.4

kg/l

1.0

0.25

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

771

0.76

0.59

16.9

14.2

ml/min/173m2

77.6

79.6

0.30

640

(3002030) Lymphocytes/100 leukocytes in Blood

395

1.29

0.59

4.5

6.0

25.3

26.3

0.25

365

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.56

0.59

2.2

2.5

ug/l

15.2

5.7

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

274

1.30

0.54

2.6

3.3

ng/l

1083.0

1277.5

0.23

225

(3000850) Epithelial cells [#/volume] in Urine

200

1.33

0.53

2.9

2.2

e6/l

3.7

5.0

0.52

177

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.53

0.52

1.5

2.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

367

1.24

0.45

5.1

3.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.41

0.42

1.3

1.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

1.1

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.41

0.0

4.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

264

1.25

0.41

4.4

4.7

23.5

21.6

0.33

129

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.41

0.0

1.7

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

826

1.28

0.40

18.8

15.0

mg/l

26.8

23.5

0.34

655

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.40

0.0

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.45

0.40

1.4

2.0

—

(40768793) Breast Pathology biopsy report

0.00

0.39

0.0

1.4

—

(3013512) EKG study

243

0.78

0.39

4.4

4.3

—

(3012516) Albumin [Mass/volume] in Urine

247

1.24

0.38

3.3

3.4

mg/l

66.4

64.4

0.02

167

(3022096) Basophils/100 leukocytes in Blood

374

1.20

0.36

4.7

5.9

0.6

0.27

347

(3006504) Eosinophils/100 leukocytes in Blood

385

1.20

0.35

4.6

5.8

2.8

2.7

0.07

358

(3019069) Monocytes/100 leukocytes in Blood

387

1.19

0.33

4.7

6.1

8.4

8.7

0.27

364

(3048689) Calprotectin [Mass/mass] in Stool

0.70

0.32

1.4

2.0

ug/g

109.7

117.0

—

(3044640) Blood type and Crossmatch panel - Blood

258

0.81

0.32

2.7

2.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

330

1.19

0.31

2.0

pmol/l

80.8

89.9

0.80

170

(3018418) pH of Serum or Plasma

265

1.18

0.28

3.3

3.2

7.4

—

(21494755) Public health laboratory ask at order entry panel

0.68

0.27

1.2

1.4

—

(40761535) Cells panel - Urine sediment

0.65

0.26

3.4

3.6

—

(3033658) Prothrombin time (PT) actual/Normal

210

1.18

0.24

4.4

3.4

84.3

90.4

0.54

205

(3004789) Transferrin [Mass/volume] in Serum or Plasma

126

1.22

0.22

2.7

2.4

g/l

2.7

2.3

1.13

111

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.23

0.22

2.4

2.6

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(4268621)

0.00

0.21

0.0

2.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.21

0.0

1.5

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.21

0.0

1.9

—

597.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.21

0.0

1.3

—

(4281824)

0.00

0.21

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.3

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.7

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

1.5

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.21

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.21

0.0

1.3

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

2.8

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

108

1.23

0.21

9.5

6.4

mmol/l

105.2

103.4

0.47

102

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

146

1.20

0.21

2.0

2.6

e6/l

1.0

0.01

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

3.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.2

—

4.2

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

2.9

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.24

0.20

1.7

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

193

0.86

0.17

2.4

2.3

—

(40761536) Microorganisms panel - Urine sediment

0.79

0.16

8.8

3.5

—

(3029937) Albumin [Presence] in Urine by Test strip

233

0.88

0.16

7.0

4.2

estimate

0.0

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

202

0.87

0.16

3.2

3.1

ug/l

0.7

0.8

—

133

(40768804) Tissue Pathology biopsy report

314

0.90

0.15

2.6

1.9

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.19

0.13

1.1

1.8

1.3

1.6

—

(3022948) Iron [Moles/volume] in Serum or Plasma

133

1.15

0.13

2.9

2.5

umol/l

12.1

12.4

0.08

120

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

319

0.92

0.10

6.5

4.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

408

0.93

0.09

6.5

5.1

estimate

0.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

313

1.08

0.09

4.4

3.0

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

185

1.10

0.09

3.6

3.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.10

0.09

1.7

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.77

0.08

1.8

1.7

—

(4010399)

1.12

0.08

1.9

1.5

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

137

1.11

0.08

2.2

3.0

e6/l

1.8

2.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.07

0.07

1.0

1.7

g/l

62.0

66.5

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.84

0.07

2.6

3.3

mmol/l

1.2

—

(3041096) Erythrocytes [Presence] in Urine by Automated

234

0.92

0.07

6.4

3.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.09

0.07

1.9

2.0

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

119

1.11

0.06

2.9

2.4

17.6

21.3

—

105

(3015377) Calcium [Moles/volume] in Serum or Plasma

281

0.95

0.04

3.6

3.4

mmol/l

2.4

0.28

243

(3018095) Leukocytes [#/volume] in Urine

320

1.05

0.03

3.9

3.5

e6/l

29.8

69.1

0.87

233

(3012095) Magnesium [Moles/volume] in Serum or Plasma

138

0.93

0.02

3.8

3.2

mmol/l

0.8

0.14

130

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

117

0.93

0.02

1.7

1.4

—

(3030467) Casts [#/volume] in Urine by Automated count

253

1.04

0.01

3.8

2.8

e6/l

0.3

0.5

0.47

192

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

162

0.99

0.00

2.9

2.8

mmol/l

2.5

—

138

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

107

1.03

0.00

1.2

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

341

1.00

0.00

3.3

4.1

ng/l

325.7

43.0

0.43

252

(40760892) CBC W Ordered Manual Differential panel - Blood

187

1.02

0.00

2.0

4.6

—

(3003694) ABO and Rh group [Type] in Blood

223

0.98

0.00

1.3

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

417

1.01

0.00

5.2

3.8

estimate

0.0

—

(3022217) INR in Platelet poor plasma by Coagulation assay

119

1.01

0.00

59.8

27.6

—

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.84

0.00

1.0

1.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3000492) Spirometry study

1.00

0.00

1.3

1.6

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.0

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(40758558) Short blood count panel - Blood

220

1.00

0.00

5.0

6.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.1

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

98.1

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

3.4

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3019225) pH of Specimen

0.96

0.00

2.3

4.6

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

2.3

—

6.3

—

(3000991) Gas panel - Venous blood

0.88

0.00

14.3

7.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.7

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.1

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

6.5

—

(3000012) Reticulocyte production index

0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.4

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.8

—

950.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(36304419) Bacteria [Presence] in Urine

240

1.00

0.00

4.0

2.8

—

(3045716) Anion gap in Serum or Plasma

0.00

0.0

2.0

—

6.8

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.91

0.00

2.8

9.1

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

0.8

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

236.9

—

(3014037) CD3+CD4+ (T4 helper) cells/100 cells in Blood

0.00

0.0

4.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.92

0.00

1.9

1.8

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

140

1.00

0.00

1.5

1.7

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.7

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.8

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.4

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

1.02

0.00

5.7

4.0

ng/l

135.0

86.3

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.98

0.00

2.6

2.3

nmol/l

12.2

13.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

4.4

—

227.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3022621) pH of Urine by Test strip

0.90

0.00

8.4

1.9

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3011951) Aspergillus fumigatus IgE Ab [Units/volume] in Serum

0.00

0.0

2.0

—

0.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.96

0.00

1.1

1.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

3.7

—

112.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_POSTMASTCHOLEASTOMA and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_POSTMASTCHOLEASTOMA	0.987 [0.78, 1.24]	0.91
Birth year	0.991 [0.98, 1.0]	0.042

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 423 females with H8_POSTMASTCHOLEASTOMA died.

Males

Parameter	HR [95% CI]	p-value
H8_POSTMASTCHOLEASTOMA	1.045 [0.85, 1.29]	0.679
Birth year	0.985 [0.98, 0.99]	0.003

During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 516 males with H8_POSTMASTCHOLEASTOMA died.

Mortality risk

Mortality risk for people of age

years, who have H8_POSTMASTCHOLEASTOMA.

N-year risk	Females	Males
1	0.117%	0.199%
5	0.516%	1.236%
10	1.229%	2.987%
15	2.24%	5.244%
20	3.872%	9.083%

Relationships between endpoints

↥

Index endpoint: H8_POSTMASTCHOLEASTOMA – Recurrent cholesteatoma of postmastoidectomy cavity

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Recurrent cholesteatoma of postmastoidectomy cavity

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints