No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
99 |
4. Check minimum number of eventsNone |
99 |
5. Include endpointsNone |
99 |
6. Filter based on genotype QC (FinnGen only) |
99 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H92
- Name in latin
- Otorrhoea
Similar endpoints
↥List of similar endpoints to
Otorrhoea
based on the number of shared cases.
Similar with more cases:
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1405 | 620 | 781 |
| Only index persons | 922 | 434 | 488 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 14.43 | 23.40 | 7.15 |
| Only index persons | 38.46 | 44.95 | 32.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 99 | 65 | 34 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 54.85 | 51.87 | 60.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 89
- Matched controls
- 889
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H92.1
ICD-10 Finland
Otorrhoea
+∞
126.2
89
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
107.8
23.0
24
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
90.2
19.7
21
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
17.8
16.5
26
20
UDC00
NOMESCO Finland
Ear microscopy
14.0
16.0
28
28
H66.0
ICD-10 Finland
Acute suppurative otitis media
7.6
14.5
39
83
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
12.4
13.6
25
27
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.9
11.7
32
67
H66.9
ICD-10 Finland
Otitis media, unspecified
6.9
11.1
30
61
H65.2
ICD-10 Finland
Chronic serous otitis media
25.4
11.1
15
7
DC1AD
NOMESCO Finland
Temporalbone CT
+∞
9.5
9
*
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
+∞
9.5
9
*
DFF00
NOMESCO Finland
Pure tone audiometry
12.1
9.5
17
17
H60.9
ICD-10 Finland
Otitis externa, unspecified
10.8
9.0
17
19
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
99.0
8.6
9
*
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
99.0
8.6
9
*
H04
ICPC
Ear discharge
16.6
8.5
13
9
UDH02
NOMESCO Finland
Rhinopharyngoscopy
8.5
7.9
17
24
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
20.6
7.8
11
6
DCD00
NOMESCO Finland
Myringoplasty
+∞
7.4
7
*
H92.0
ICD-10 Finland
Otalgia
9.5
7.1
14
17
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
18.5
6.9
10
6
TDA90
NOMESCO Finland
Removal wax from ear
28.9
6.3
8
*
H60.3
ICD-10 Finland
Other infective otitis externa
28.9
6.3
8
*
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(3007853) Bacteria identified in Skin by Aerobe culture
36
96
5.32
13.49
2.8
1.6
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
33
111
3.96
8.81
2.4
2.0
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
24
84
3.45
5.85
2.2
1.9
—
—
—
0
0
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
23
79
3.49
5.77
2.2
1.8
—
—
—
0
0
(3000494) Fungus identified in Specimen by Culture
24
92
3.12
5.02
2.1
1.5
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
24
97
2.95
4.56
2.5
1.9
—
—
—
0
0
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
10
23
4.72
4.19
1.8
2.2
—
—
—
0
0
(4062490)
8
10
8.58
4.14
2.5
1.4
—
—
—
0
0
(44816844) Macroprolactin [Units/volume] in Serum or Plasma
7
7
10.63
4.07
1.4
1.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
49
301
2.24
3.78
6.8
7.2
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
13
41
3.50
3.64
1.6
1.8
—
—
—
0
0
(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood
7
9
8.26
3.62
3.1
4.7
—
—
—
0
0
(3013650) Neutrophils [#/volume] in Blood by Automated count
69
507
2.19
3.18
7.8
10.5
e9/l
4.1
4.0
0.03
56
436
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
10
29
3.72
3.14
1.9
1.1
—
—
—
0
0
(3019198) Lymphocytes [#/volume] in Blood
62
443
2.07
3.01
7.3
7.1
e9/l
2.1
2.3
0.39
50
385
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
42
264
2.03
2.87
2.2
1.9
pmol/l
102.3
93.3
0.48
26
127
(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection
6
10
6.30
2.74
1.2
1.5
—
—
—
0
0
(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection
6
10
6.30
2.74
1.2
1.5
—
—
—
0
0
(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection
6
10
6.30
2.74
1.2
1.5
—
—
—
0
0
(3013707) Erythrocyte sedimentation rate by Westergren method
76
598
2.17
2.70
5.2
3.9
mm/h
13.6
11.6
0.50
70
548
(3013115) Eosinophils [#/volume] in Blood
61
445
1.97
2.66
7.5
7.6
e9/l
0.2
0.2
0.34
49
383
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
9
25
3.85
2.65
1.1
1.1
—
—
—
0
0
(3005702) Mycobacterium sp identified in Specimen by Organism specific culture
7
15
4.93
2.65
1.4
1.3
—
—
—
0
0
(3006315) Basophils [#/volume] in Blood
60
436
1.95
2.64
7.4
7.0
e9/l
0.0
0.0
0.35
48
372
(3001604) Monocytes [#/volume] in Blood
60
438
1.94
2.58
7.4
6.9
e9/l
0.6
0.6
0.73
48
373
(3016914) Bacteria identified in Cerebral spinal fluid by Culture
5
7
7.44
2.58
1.8
1.3
—
—
—
0
0
(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood
5
7
7.44
2.58
2.0
4.4
%
25.2
29.4
—
5
7
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
39
248
1.94
2.52
1.4
1.5
u/ml
2.0
2.3
—
9
43
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
8
22
3.86
2.42
2.4
2.2
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
7
17
4.34
2.40
1.1
2.3
—
—
—
0
0
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
6
13
4.84
2.30
9.0
4.6
%
50.2
57.7
—
6
13
(3030905) Polymorphonuclear cells [#/volume] in Blood
6
13
4.84
2.30
5.2
3.3
e9/l
3.1
4.7
—
6
13
(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma
74
595
1.97
2.22
7.6
6.8
u/l
75.8
91.9
2.24
68
550
(3009508) Creatinine [Moles/volume] in Urine
36
232
1.87
2.19
4.6
3.5
mmol/l
6.3
7.8
2.00
31
200
(3006245) CD3-CD19+ cells/100 cells in Blood
5
10
5.20
2.09
2.0
4.1
%
14.8
7.7
—
5
10
(40768797) Stomach Pathology biopsy report
19
99
2.14
2.08
1.0
1.4
—
—
—
0
0
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
54
403
1.75
1.97
15.9
7.4
mmol/l
1.2
1.2
0.52
47
350
(3013512) EKG study
30
189
1.84
1.93
6.5
3.7
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
69
555
1.80
1.92
6.0
4.2
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
10
40
2.67
1.90
1.1
1.1
—
—
—
0
0
(3032080) INR in Blood by Coagulation assay
40
277
1.75
1.88
7.9
5.7
inr
1.0
1.1
1.11
14
82
(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay
5
12
4.33
1.84
2.4
1.2
—
—
—
0
0
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
7
23
3.19
1.83
3.0
2.2
—
—
—
0
0
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
12
54
2.39
1.82
1.7
1.5
—
—
—
0
0
(3019225) pH of Specimen
12
54
2.39
1.82
5.7
3.9
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
27
169
1.82
1.76
2.6
2.6
mg/l
1.6
1.5
0.03
21
130
(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma
22
129
1.91
1.75
4.7
3.0
ng/l
767.7
407.6
0.36
15
94
(3007164) IgA [Mass/volume] in Serum or Plasma
34
229
1.74
1.74
2.4
1.5
g/l
2.3
2.0
0.33
19
113
(3021901) Oxygen saturation in Capillary blood
6
19
3.29
1.69
4.3
5.3
—
—
—
0
0
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
6
20
3.12
1.60
1.8
1.4
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
36
253
1.66
1.56
5.7
3.9
ng/l
17.5
28.9
1.57
19
176
(3044889) 12 lead EKG panel
61
496
1.60
1.43
4.1
3.6
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
26
171
1.71
1.42
2.5
2.8
—
—
—
0
0
(3020682) Albumin/Creatinine [Ratio] in Urine
31
214
1.65
1.42
4.7
3.7
mg/mmol
15.2
14.6
0.02
20
130
(3012516) Albumin [Mass/volume] in Urine
29
200
1.64
1.33
3.8
3.0
mg/l
54.1
393.3
0.56
19
132
(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma
58
473
1.55
1.29
2.7
3.3
u/l
31.9
40.9
1.02
53
443
(3044640) Blood type and Crossmatch panel - Blood
32
229
1.59
1.26
2.4
2.7
—
—
—
0
0
(3011288) Drugs identified in Urine by Screen method
5
19
2.71
1.23
1.8
1.9
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
89
810
1.98
1.22
23.1
13.6
mg/l
18.9
24.5
0.95
73
607
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
16
96
1.80
1.19
2.4
2.4
—
—
—
0
0
(3023024) Carbon dioxide [Partial pressure] in Capillary blood
16
97
1.77
1.15
10.1
5.5
kpa
4.8
5.1
1.09
16
91
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
44
345
1.50
1.13
4.0
4.1
—
—
—
0
0
(3017766) Complement C4 [Mass/volume] in Serum or Plasma
7
31
2.35
1.13
2.3
1.5
g/l
0.3
0.3
—
7
31
(3000991) Gas panel - Venous blood
17
106
1.73
1.12
20.5
9.5
—
—
—
0
0
(3014007) Fractional oxyhemoglobin in Arterial blood
8
41
2.03
1.11
33.9
10.8
%
94.3
94.6
—
8
41
(1616796) Gas panel - Central venous blood
5
21
2.45
1.10
17.8
4.4
—
—
—
0
0
(3000620) Complement C3 [Mass/volume] in Serum or Plasma
7
33
2.20
1.08
2.3
1.5
g/l
1.3
1.2
—
7
33
(3019309) Folate [Moles/volume] in Red Blood Cells
18
116
1.67
1.06
1.6
1.7
nmol/l
758.2
1068.0
0.73
13
93
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
5
22
2.34
1.04
2.0
1.5
nmol/l
41.8
38.2
—
5
22
(3006184) Hemoglobin [Mass/volume] in Capillary blood
5
22
2.34
1.04
5.2
2.4
g/l
128.2
138.3
—
5
16
(3013139) Helicobacter pylori Ag [Presence] in Stool
9
48
1.96
1.04
1.2
1.3
—
—
—
0
0
(3012336) Haptoglobin [Mass/volume] in Serum or Plasma
7
35
2.07
1.02
1.9
2.0
g/l
1.5
1.6
—
7
30
(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation
15
93
1.72
1.01
10.7
5.7
mmol/l
-0.2
1.6
—
9
73
(36660697) Celiac disease serology panel - Serum
16
103
1.66
0.94
1.4
1.2
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
14
87
1.71
0.93
2.4
2.4
—
—
—
0
0
(3023368) Bacteria identified in Blood by Culture
27
199
1.49
0.91
6.2
4.8
—
—
—
0
0
(3025941) Bacteria identified in Stool by Culture
8
44
1.89
0.88
1.0
1.3
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
37
293
1.42
0.87
5.9
3.9
—
—
—
0
0
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
74
662
1.47
0.86
4.6
3.9
mmol/l
1.4
1.2
0.94
67
602
(3022948) Iron [Moles/volume] in Serum or Plasma
17
115
1.58
0.84
4.9
2.7
umol/l
10.2
13.4
1.58
17
107
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
76
685
1.47
0.83
5.1
4.3
mmol/l
1.5
1.5
0.31
71
625
(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection
10
58
1.81
0.83
1.9
2.1
—
—
—
0
0
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
64
560
1.40
0.83
3.8
3.2
—
—
—
0
0
(40758558) Short blood count panel - Blood
33
258
1.42
0.82
5.8
9.4
—
—
—
0
0
(3031040) Bacteria [#/volume] in Urine by Automated count
62
540
1.40
0.82
6.5
4.4
—
33.0
—
0
10
(3009261) Glucose [Presence] in Urine by Test strip
48
401
1.38
0.82
5.8
3.8
estimate
0.0
0.0
—
9
71
(3029937) Albumin [Presence] in Urine by Test strip
28
213
1.44
0.81
7.1
3.8
estimate
0.0
0.0
—
9
71
(3021601) Nitrite [Presence] in Urine by Test strip
47
394
1.37
0.77
7.0
5.4
estimate
0.0
0.0
—
7
75
(3017895) Helicobacter pylori Ab [Units/volume] in Serum
5
23
2.23
0.77
1.4
1.7
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
76
689
1.44
0.77
5.3
4.4
mmol/l
4.7
4.6
0.16
71
634
(3022145) Colonoscopy Study observation
12
76
1.66
0.75
1.3
1.2
—
—
—
0
0
(4034850)
5
24
2.14
0.75
14.0
16.0
—
—
—
0
0
(3016251) Hemoglobin.gastrointestinal [Presence] in Stool
7
38
1.90
0.75
1.9
2.4
—
—
—
0
0
(3035350) Ketones [Presence] in Urine by Test strip
47
396
1.36
0.74
5.8
3.8
estimate
0.0
0.0
—
8
74
(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma
5
25
2.05
0.74
2.8
2.0
—
—
—
0
0
(3033319) Streptococcus pyogenes Ag [Presence] in Throat
7
120
0.55
0.73
1.6
1.9
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
36
293
1.36
0.70
1.9
1.9
—
—
—
0
0
(3018418) pH of Serum or Plasma
29
229
1.38
0.68
7.8
3.9
ph
7.4
7.4
—
8
41
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
14
96
1.53
0.66
5.4
3.0
%
17.6
23.6
1.67
14
87
(3004789) Transferrin [Mass/volume] in Serum or Plasma
15
105
1.51
0.64
5.5
2.8
g/l
2.3
2.4
0.53
15
97
(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection
8
51
1.62
0.62
2.1
1.9
—
—
—
0
0
(3020891) Body temperature
5
30
1.70
0.62
5.4
4.4
—
—
—
0
0
(43054914) Glucose tolerance 2 hours panel - Serum or Plasma
11
72
1.59
0.62
2.0
1.8
—
—
—
0
0
(3021589) Normoblasts [#/volume] in Blood
48
415
1.30
0.60
11.8
10.4
e9/l
0.0
0.0
0.80
34
331
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
27
215
1.35
0.60
2.3
1.7
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
6
35
1.76
0.59
24.3
9.2
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
76
702
1.36
0.58
6.1
4.8
mmol/l
2.8
2.7
0.27
71
638
(3011397) Hemoglobin [Presence] in Urine by Test strip
26
207
1.35
0.57
4.0
3.4
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
9
60
1.55
0.56
15.6
4.6
mmol/l
1.2
1.2
—
9
53
(4010399)
9
61
1.52
0.55
2.2
1.4
—
—
—
0
0
(3009201) Thyrotropin [Units/volume] in Serum or Plasma
79
736
1.36
0.55
5.7
4.7
mu/l
1.9
2.0
0.52
74
673
(3027946) Carbon dioxide [Partial pressure] in Arterial blood
12
83
1.51
0.55
23.3
7.3
kpa
5.0
5.1
0.14
12
78
(3027801) Oxygen [Partial pressure] in Arterial blood
12
83
1.51
0.55
23.2
7.3
kpa
14.5
11.6
0.64
12
78
(3003694) ABO and Rh group [Type] in Blood
18
232
0.73
0.54
2.2
1.7
—
—
—
0
0
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
14
101
1.45
0.53
18.4
9.5
mmol/l
23.7
25.1
0.48
14
101
(3003396) Base excess in Arterial blood by calculation
12
84
1.49
0.52
23.3
7.3
mmol/l
-2.2
1.4
1.10
12
66
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
37
316
1.27
0.49
6.5
3.8
—
—
—
0
0
(3022313) Gas panel - Capillary blood
11
77
1.48
0.48
9.3
5.4
—
—
—
0
0
(3041096) Erythrocytes [Presence] in Urine by Automated
25
205
1.29
0.45
6.6
3.6
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
20
159
1.32
0.45
1.8
1.9
—
—
—
0
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
8
55
1.49
0.44
1.0
1.1
—
—
—
0
0
(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma
18
141
1.34
0.44
4.1
4.5
%
25.9
21.4
—
6
73
(40768443) Skin Pathology biopsy report
5
31
1.64
0.43
1.4
1.1
—
—
—
0
0
(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)
70
650
1.26
0.43
20.5
12.7
ml/min/173m2
78.1
82.8
0.88
60
517
(3016879) Cocaine [Presence] in Urine
5
32
1.59
0.43
1.6
1.4
—
—
—
0
0
(3035933) Granulocytes/100 leukocytes in Blood
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
(3014599) Egg white IgE Ab [Units/volume] in Serum
0
15
0.00
0.41
0.0
1.2
—
1.6
—
0
10
(3027008) Opiates [Presence] in Urine
5
34
1.49
0.41
1.6
1.4
—
—
—
0
0
(3028300) Cannabinoids [Presence] in Urine
5
34
1.49
0.41
1.6
1.4
—
—
—
0
0
(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma
0
18
0.00
0.40
0.0
3.8
—
55.2
—
0
18
(3024891) Influenza virus A+B Ag [Presence] in Specimen
5
35
1.45
0.40
1.6
1.3
—
—
—
0
0
(3027944) Amphetamines [Presence] in Urine
5
35
1.45
0.40
1.6
1.5
—
—
—
0
0
(3000764) Benzodiazepines [Presence] in Urine
5
35
1.45
0.40
1.6
1.4
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
9
66
1.40
0.40
3.9
3.4
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
9
67
1.38
0.39
14.8
3.9
—
—
—
0
0
(1761868) Lipid panel - Serum or Plasma
19
232
0.78
0.39
2.9
2.9
—
—
—
0
0
(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma
5
77
0.63
0.37
8.4
4.2
ug/l
2.4
12.3
—
5
62
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
6
41
1.49
0.37
3.2
4.1
%
44.8
45.6
—
6
41
(3030981) Hyaline casts [#/volume] in Urine by Automated count
6
42
1.46
0.36
5.5
2.9
e6/l
0.2
0.1
—
6
42
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
10
74
1.39
0.34
12.1
5.6
mmol/l
22.7
24.4
—
10
74
(36304419) Bacteria [Presence] in Urine
22
258
0.81
0.32
8.5
3.8
—
—
—
0
0
(40761535) Cells panel - Urine sediment
7
55
1.29
0.30
2.9
3.4
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
18
149
1.25
0.30
4.5
3.8
e6/l
3.3
3.2
0.03
12
89
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
5
37
1.37
0.24
1.2
1.4
—
—
—
0
0
(3023323) Follitropin [Units/volume] in Serum or Plasma
5
38
1.33
0.23
1.8
2.3
iu/l
18.6
19.1
—
5
29
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
5
38
1.33
0.23
1.8
4.1
%
1.4
1.2
—
5
38
(40760892) CBC W Ordered Manual Differential panel - Blood
20
173
1.20
0.23
9.7
5.9
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
5
42
1.20
0.22
1.2
1.2
—
—
—
0
0
(3016650) Hepatitis A virus Ab [Presence] in Serum
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
(3042111) Morphology [Interpretation] in Bone marrow Narrative
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells
0
10
0.00
0.21
0.0
4.3
—
—
—
0
0
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
(40759836) Histone Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(3045142) Bone marrow Pathology biopsy report
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
(40768800) Prostate Pathology biopsy report
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells
0
10
0.00
0.21
0.0
4.3
—
—
—
0
0
(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
12
0.00
0.21
0.0
4.8
—
108.1
—
0
12
(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma
6
47
1.29
0.21
3.3
3.7
pmol/l
4.1
4.7
—
6
42
(3004588) Protein electrophoresis panel - Serum or Plasma
6
47
1.29
0.21
1.3
1.5
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
2.8
—
17.5
—
0
13
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
0
13
0.00
0.21
0.0
2.8
—
3.8
—
0
13
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
10
82
1.24
0.18
3.6
6.9
—
—
—
0
0
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
8
70
1.16
0.17
1.1
1.1
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
7
87
0.79
0.15
1.6
1.3
—
—
—
0
0
(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma
9
107
0.83
0.13
3.1
3.2
ug/l
0.5
0.7
—
9
76
(3030467) Casts [#/volume] in Urine by Automated count
24
261
0.89
0.13
8.5
3.9
e6/l
0.7
0.3
0.41
19
206
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
14
157
0.87
0.12
3.6
3.6
e6/l
1.7
0.8
—
8
97
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
14
126
1.13
0.09
1.9
1.3
—
—
—
0
0
(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma
6
72
0.82
0.08
1.2
2.6
u/l
26.8
32.1
—
6
61
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
12
132
0.90
0.07
2.3
1.6
—
—
—
0
0
(3002256) Pathology report gross observation
8
93
0.85
0.07
1.0
1.3
—
—
—
0
0
(3026008) Bacteria identified in Urine by Culture
27
257
1.07
0.06
3.6
2.7
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
75
761
0.94
0.05
20.6
15.1
%
37.4
38.9
0.62
52
599
(40761511) CBC panel - Blood by Automated count
84
832
1.06
0.02
18.6
11.1
—
—
—
0
0
(3018095) Leukocytes [#/volume] in Urine
33
332
0.99
0.00
9.1
4.4
e6/l
149.8
53.3
0.40
25
234
(3029075) Extractable nuclear Ab panel - Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(1617658) Protocol used for examination of sentinel lymph nodes
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma
0
7
0.00
0.00
0.0
4.3
—
26.1
—
0
7
(3013327) Hepatitis A virus IgM Ab [Presence] in Serum
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3044242) Glucose [Moles/volume] in Arterial blood
0
7
0.00
0.00
0.0
1.9
—
—
—
0
0
(4027681)
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3024474) Albumin [Mass/volume] in Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
163.0
—
0
7
(3027231) Wheat IgE Ab [Units/volume] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3000492) Spirometry study
6
66
0.90
0.00
1.5
1.5
—
—
—
0
0
(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011648) Oxygen content in Venous blood
0
7
0.00
0.00
0.0
6.6
—
12.7
—
0
7
(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40765089) Chromosome analysis panel - Blood by G-banded
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
(3053028) Streptococcus sp identified in Specimen by Organism specific culture
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(40768795) Lymph node Pathology biopsy report
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(40767663) Brazil Nut recombinant (rBer e) 1 IgE Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(4146454)
0
9
0.00
0.00
0.0
2.4
—
—
—
0
0
(3002670) Multiple inhalant allergen IgE Ab [Units/volume] in Serum
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
(3020491) Glucose [Moles/volume] in Blood
0
9
0.00
0.00
0.0
2.2
—
6.3
—
0
9
(3019832) Treponema pallidum Ab [Presence] in Serum
9
91
0.99
0.00
1.9
1.8
—
—
—
0
0
(3002621) Streptococcal DNAse B [Units/volume] in Serum
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(4035726)
7
70
1.00
0.00
1.3
1.4
—
—
—
0
0
(3039443) Prostate specific Ag panel - Serum or Plasma
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
(3012565) Volume of 24 hour Urine
0
6
0.00
0.00
0.0
2.8
—
2500.0
—
0
6
(4281824)
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma
5
54
0.92
0.00
2.2
1.5
—
—
—
0
0
(21494434) Karyotype in Bone marrow
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
(40768441) Liver Pathology biopsy report
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
9
0.00
0.00
0.0
4.2
—
—
—
0
0
(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3035320) C reactive protein [Mass/volume] in Body fluid
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
5
58
0.85
0.00
1.0
1.3
—
—
—
0
0
(3045781) Inhibin B [Mass/volume] in Serum or Plasma
0
5
0.00
-0.00
0.0
1.6
—
121.0
—
0
5
(3005570) Glucose [Moles/volume] in Urine
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
(3012441) Differential panel - Pleural fluid
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(44816893) Food Allergen Mix 50 (Kiwi+Pineapple+Banana+Mango) IgE Ab [Units/volume] in Serum by Multidisk
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3045716) Anion gap in Serum or Plasma
0
5
0.00
-0.00
0.0
2.0
—
7.8
—
0
5
(3045788) Cell count panel - Pleural fluid
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
(3010838) Calcium [Moles/time] in 24 hour Urine
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3019420) Tryptase [Mass/volume] in Serum or Plasma
0
5
0.00
-0.00
0.0
1.4
—
8.5
—
0
5
(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
(3039429) Cortisol [Moles/volume] in Saliva (oral fluid)
0
5
0.00
-0.00
0.0
2.8
—
2.0
—
0
5
(3019083) Insulin-like growth factor [Moles/volume] in Serum or Plasma
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
-0.00
0.0
1.6
—
12.0
—
0
5
(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
(3019977) pH of Arterial blood
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTORRHOEA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTORRHOEA | 1.491 [1.02, 2.18] | 0.04 |
| Birth year | 0.997 [0.99, 1.01] | 0.447 |
During the follow-up period (1.1.1998 — 31.12.2019), 55 out of 558 females with H8_OTORRHOEA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTORRHOEA | 1.271 [0.9, 1.79] | 0.173 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 74 out of 707 males with H8_OTORRHOEA died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTORRHOEA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.182% | 0.25% |
| 5 | 1.008% | 1.486% |
| 10 | 2.378% | 3.85% |
| 15 | 4.442% | 7.101% |
| 20 | 8.02% | 11.758% |
Relationships between endpoints
↥Index endpoint: H8_OTORRHOEA – Otorrhoea
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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