Chronic myringitis

H8_MYRINGCHRON

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H73.1 Hospital discharge: ICD-9 — 3841 Cause of death: ICD-10 — H73.1 Cause of death: ICD-9 — 3841 2 out of 7 registries used, show all original rules.	167
4. Check minimum number of events None	167
5. Include endpoints None	167
6. Filter based on genotype QC (FinnGen only)	167

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H73
Name in latin: Myringitis chronica

NAME	H8_MYRINGCHRON
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H731
HD_ICD_9	3841
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H731
COD_ICD_9	3841
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chronic myringitis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1468	726	734
Only index persons	1375	692	683
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.03	0.03	0.03
Median age at first event (years)
Whole population	43.87	44.67	43.07
Only index persons	44.96	45.66	44.24

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	167	89	78
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	55.85	55.17	56.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
145: Matched controls
1450

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H73.1

ICD-10 Finland

Chronic myringitis

+∞

203.5

143

UDC00

NOMESCO Finland

Ear microscopy

62.5

79.1

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

1118.1

71.5

DCD00

NOMESCO Finland

Myringoplasty

+∞

44.0

H66.0

ICD-10 Finland

Acute suppurative otitis media

25.3

32.4

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

299.5

25.5

H65.3

ICD-10 Finland

Chronic mucoid otitis media

299.5

25.5

H66.9

ICD-10 Finland

Otitis media, unspecified

19.3

25.3

H72.2

ICD-10 Finland

Other marginal perforations of tympanic membrane

+∞

21.4

S03CA01

ATC

dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)

47.4

20.2

H66.4

ICD-10 Finland

Suppurative otitis media, unspecified

216.9

19.0

DBD20

NOMESCO Finland

Plastic repair of external auditory canal

+∞

18.1

H60.9

ICD-10 Finland

Otitis externa, unspecified

11.5

17.4

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

40.5

17.2

DC1AD

NOMESCO Finland

Temporalbone CT

191.1

16.9

H04

ICPC

Ear discharge

20.2

16.3

S02CA02

ATC

flumetasone and antiinfectives; otic

11.9

16.2

H60.8

ICD-10 Finland

Other otitis externa

30.4

16.1

Z01.1

ICD-10 Finland

Examination of ears and hearing

6.0

14.6

H66.3

ICD-10 Finland

Other chronic suppurative otitis media

+∞

13.8

DCA10

NOMESCO Finland

Paracentesis of tympanic membrane

153.8

13.7

H01

ICPC

Ear pain/earache

6.3

12.5

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

3.6

12.0

315

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

70.8

11.8

H65.2

ICD-10 Finland

Chronic serous otitis media

+∞

11.6

H60.3

ICD-10 Finland

Other infective otitis externa

22.2

11.4

TDA90

NOMESCO Finland

Removal wax from ear

47.3

11.1

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

4.6

11.1

118

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

3.6

10.6

246

DFF00

NOMESCO Finland

Pure tone audiometry

5.7

10.5

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

3.1

9.8

519

H74.1

ICD-10 Finland

Adhesive middle ear disease

+∞

9.5

DCD10

NOMESCO Finland

Tympanoplasty

+∞

9.5

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

9.5

WX720

NOMESCO Finland

Own respiration

8.0

9.4

H72.9

ICD-10 Finland

Perforation of tympanic membrane, unspecified

39.3

9.2

SPAT1044

SPAT

Tympanometry

20.2

9.1

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

29.5

8.6

3812A

ICD-9 Finland

Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media

+∞

8.4

H70.1

ICD-10 Finland

Chronic mastoiditis

+∞

8.4

DCW99

NOMESCO Finland

Other operation on eardrum and middle ear

+∞

8.4

H73.0

ICD-10 Finland

Acute myringitis

47.6

7.8

H65.9

ICD-10 Finland

Nonsuppurative otitis media, unspecified

84.2

7.5

H65.1

ICD-10 Finland

Other acute nonsuppurative otitis media

+∞

7.3

H65.0

ICD-10 Finland

Acute serous otitis media

31.7

7.2

H71

ICPC

Acute otitis media/myringitis

31.7

7.2

TDW99

NOMESCO Finland

Other minor procedure in surgery of ear, nose and larynx

7.7

7.2

S03CA04

ATC

hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)

10.9

7.2

QAA05

NOMESCO Finland

Incision for biopsy of skin of head or neck

11.8

6.9

H90.0

ICD-10 Finland

Conductive hearing loss, bilateral

42.1

6.8

4122

FHL

Tympanostomy (tympanic tube)

72.9

6.5

WX704

NOMESCO Finland

Intubation

4.5

6.4

DCA40

NOMESCO Finland

Fat patching or other similar technique without opening of tympanic membrane

+∞

6.3

H72.8

ICD-10 Finland

Other perforations of tympanic membrane

+∞

6.3

H60

ICD-10 Finland

Otitis externa

6.3

6.0

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

151

6.09

26.89

2.2

1.7

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

4.71

12.93

2.5

ng/l

54.9

166.1

2.53

(3000494) Fungus identified in Specimen by Culture

176

3.23

9.54

1.7

1.5

—

(3042936) Bacteria identified in Isolate by Culture

191

2.60

6.14

1.8

2.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.32

5.62

3.0

18.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

239

2.35

5.35

2.4

3.4

ng/l

111.5

102.4

0.04

178

(3019150) Specific gravity of Urine by Refractometry

305

2.20

5.07

3.7

3.6

kg/l

1.0

0.82

(3037467) Urinalysis macro (dipstick) panel - Urine

122

920

2.21

4.94

4.5

4.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

133

1046

2.33

4.74

4.2

3.9

pmol/l

14.8

14.7

0.15

121

934

(3020682) Albumin/Creatinine [Ratio] in Urine

407

1.98

4.22

3.7

4.0

mg/mmol

4.0

11.2

1.39

247

(3009508) Creatinine [Moles/volume] in Urine

421

1.94

4.02

2.9

3.1

mmol/l

7.5

0.03

353

(3013826) Glucose [Moles/volume] in Serum or Plasma

105

781

1.93

4.00

3.8

5.9

mmol/l

7.0

6.8

0.27

728

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

131

1059

2.10

3.83

6.0

7.8

u/l

72.8

79.3

1.54

122

991

(3012516) Albumin [Mass/volume] in Urine

384

1.88

3.54

3.1

3.3

mg/l

1462.2

245.3

0.40

243

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

647

1.76

3.21

5.4

7.8

mmol/l

1.2

0.86

542

(3032080) INR in Blood by Coagulation assay

530

1.75

3.12

8.0

9.4

inr

1.1

1.2

1.64

166

(3044889) 12 lead EKG panel

116

937

1.78

2.93

4.0

3.8

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

145

1269

2.08

2.68

5.4

4.6

mu/l

1.9

0.09

136

1152

(3036481) Cortisol [Moles/volume] in Serum or Plasma

123

2.11

2.61

1.8

2.1

nmol/l

413.5

399.8

0.13

112

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

291

1.75

2.47

1.7

1.6

pmol/l

143243632.8

469.4

0.49

250

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

112

1292

0.60

2.42

11.0

13.1

ml/min/173m2

85.0

82.8

0.56

1057

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

399

1.65

2.33

1.6

2.1

u/l

109.6

158.2

1.94

380

(3024561) Albumin [Mass/volume] in Serum or Plasma

563

1.60

2.31

3.6

5.3

g/l

36.6

35.7

0.78

531

(3033658) Prothrombin time (PT) actual/Normal

347

0.49

2.29

2.6

3.8

90.7

90.1

0.03

339

(3031040) Bacteria [#/volume] in Urine by Automated count

108

886

1.62

2.28

3.5

4.1

—

14.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

153

1389

2.21

2.19

11.0

13.9

mg/l

21.0

22.7

0.25

126

1074

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

523

1.58

2.17

4.0

3.6

—

(36660697) Celiac disease serology panel - Serum

118

2.00

2.14

1.1

1.2

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

496

1.55

1.95

2.2

1.9

pmol/l

95.6

94.4

0.08

254

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

145

1.85

1.95

1.6

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

139

1.85

1.88

1.8

1.7

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

4.26

1.83

1.0

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

235

1.62

1.65

1.5

1.7

nmol/l

1014.5

1214.9

0.95

185

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

540

1.47

1.63

2.5

2.4

nmol/l

82.1

76.5

0.84

473

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

2.01

1.60

3.1

3.8

pmol/l

4.6

4.5

0.18

(3008898) HLA-B27 [Presence]

2.19

1.59

1.2

1.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

323

0.57

1.58

2.0

2.4

—

(3021589) Normoblasts [#/volume] in Blood

620

0.66

1.57

9.6

9.1

e9/l

0.0

0.91

502

(3009542) Hematocrit [Volume Fraction] of Blood

142

1292

1.66

1.54

14.6

14.8

39.9

40.1

0.07

966

(3052851) Hemolysis interference index of Serum or Plasma

0.00

1.52

0.0

3.2

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

709

1.44

1.52

5.5

6.9

umol/l

9.9

11.6

1.98

679

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

426

1.47

1.51

2.2

2.9

u/l

56.0

55.9

0.01

397

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

137

1.70

1.38

1.6

1.8

—

(4094501)

0.00

1.36

0.0

1.1

—

(3018418) pH of Serum or Plasma

400

1.44

1.30

2.9

3.7

7.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

145

1340

1.62

1.30

5.3

4.4

mmol/l

6.1

5.9

0.76

134

1237

(42870588) Differential panel, method unspecified - Blood

457

1.41

1.27

3.9

5.1

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

2.45

1.25

1.2

1.6

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

149

1389

1.67

1.25

5.5

4.9

mmol/l

2.7

2.8

0.56

135

1282

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

234

1.51

1.24

1.3

u/ml

1.1

6.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

147

1367

1.63

1.23

4.9

4.4

mmol/l

4.5

4.6

0.61

137

1271

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

1.78

1.22

1.3

1.1

iu/ml

53.8

198.0

2.17

(3026389) Candida sp identified in Specimen by Organism specific culture

2.68

1.22

4.2

1.1

—

(36304419) Bacteria [Presence] in Urine

381

0.65

1.21

2.0

2.7

—

(3035350) Ketones [Presence] in Urine by Test strip

670

1.37

1.21

3.9

3.5

estimate

0.0

—

134

(3049717) Cytology report of Urine Cyto stain

2.00

1.20

1.9

2.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

1.17

0.0

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

203

1.52

1.15

1.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

636

1.36

1.14

4.4

4.3

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

227

0.58

1.13

1.8

3.2

mmol/l

2.5

0.48

194

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

138

1273

1.48

1.12

6.5

5.6

mmol/mol

40.7

39.9

0.43

128

1191

(3037522) Nuclear Ab [Titer] in Serum

179

1.54

1.11

1.3

titre

440.0

417.7

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

460

1.36

1.06

3.9

3.6

u/l

27.9

29.8

0.35

437

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

508

1.35

1.05

2.7

3.7

ng/l

17.1

33.0

2.35

356

(3041096) Erythrocytes [Presence] in Urine by Automated

379

1.37

1.02

3.1

3.2

—

(1002224) Polysomnography panel

1.88

1.00

1.1

—

(3003396) Base excess in Arterial blood by calculation

150

1.54

0.99

3.1

13.0

mmol/l

1.9

1.1

0.32

122

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.98

0.0

3.3

—

30.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.84

0.98

1.3

1.8

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.98

0.0

3.3

—

4.7

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.98

0.0

3.9

—

59.0

—

(3030467) Casts [#/volume] in Urine by Automated count

385

0.70

0.94

2.2

2.9

e6/l

0.2

0.6

1.24

279

(3019060) Gas panel - Arterial blood

1.69

0.94

1.7

10.5

—

(3021960) Folate [Moles/volume] in Serum or Plasma

293

1.38

0.93

1.5

nmol/l

21.2

21.9

0.12

244

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.18

0.92

1.3

1.4

—

(4010399)

104

1.60

0.88

1.6

1.4

—

(3044290) Cell count panel - Cerebral spinal fluid

2.04

0.88

1.2

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

207

1.42

0.87

1.6

1.3

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

144

1357

1.44

0.86

4.6

4.4

mmol/l

1.4

1.5

2.14

131

1252

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.97

0.85

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

431

0.73

0.83

2.1

2.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

1.74

0.82

1.8

1.7

—

(3018095) Leukocytes [#/volume] in Urine

482

0.75

0.80

2.6

3.6

e6/l

10.7

44.2

3.04

329

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.79

0.0

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.79

0.0

1.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.74

0.77

3.1

2.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

183

0.63

0.77

1.5

1.9

1.7

1.5

0.93

159

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

461

1.29

0.77

5.9

4.8

ug/l

2.4

1.9

0.40

411

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

248

1.36

0.76

1.3

1.2

iu/ml

17.2

27.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

340

1.31

0.76

1.2

1.3

u/ml

0.9

1.4

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.12

0.75

1.6

1.5

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

143

1.45

0.74

2.2

4.4

u/l

209.2

239.1

1.54

138

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.03

0.73

1.4

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

370

1.30

0.72

4.7

4.4

18.6

21.3

0.80

168

(3021601) Nitrite [Presence] in Urine by Test strip

679

1.25

0.70

5.4

4.8

estimate

0.0

—

134

(3009261) Glucose [Presence] in Urine by Test strip

689

1.25

0.70

3.9

3.5

estimate

0.0

—

122

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

129

0.60

0.67

1.9

1.7

—

(3002582) Erythrocytes [#/volume] in Urine

407

0.76

0.66

2.3

3.1

e6/l

11.8

197.3

0.60

306

(3023511) Choriogonadotropin [Units/volume] in Urine

1.81

0.66

1.2

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

104

0.56

0.64

1.0

1.4

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.61

0.0

2.1

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.60

0.0

3.7

—

(3013115) Eosinophils [#/volume] in Blood

698

1.22

0.60

4.1

5.7

e9/l

0.2

0.63

613

(3042631) Mycobacterium sp identified in Specimen

0.00

0.60

0.0

4.0

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

104

959

1.22

0.59

2.7

3.4

u/l

38.7

49.7

1.55

900

(40768804) Tissue Pathology biopsy report

535

0.81

0.57

2.2

2.1

—

(3045414) Leukocytes [Presence] in Urine

1.48

0.57

1.8

1.5

—

(40768797) Stomach Pathology biopsy report

181

0.69

0.56

1.5

1.3

—

(3026008) Bacteria identified in Urine by Culture

393

1.24

0.54

3.3

2.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.60

0.54

1.0

2.0

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.56

0.53

1.5

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

309

1.25

0.53

2.1

2.2

mg/l

2.7

3.0

0.56

263

(3015377) Calcium [Moles/volume] in Serum or Plasma

452

1.22

0.52

2.5

3.4

mmol/l

2.3

2.4

0.32

393

(3000991) Gas panel - Venous blood

109

0.63

0.50

6.4

11.4

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

256

1.26

0.49

1.5

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

789

1.19

0.48

6.5

9.3

e9/l

4.2

4.1

0.07

682

(3019225) pH of Specimen

119

0.66

0.47

5.0

4.5

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.42

0.47

1.0

1.2

—

37.1

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.45

0.46

1.3

1.5

iu/l

24.2

20.7

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

1.45

0.43

1.0

2.3

u/l

26.6

39.5

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.58

0.42

1.4

1.7

—

(3002256) Pathology report gross observation

171

0.74

0.42

1.5

1.3

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.41

0.0

1.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

0.41

0.0

1.3

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.41

0.0

1.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

137

1317

1.22

0.41

3.9

4.0

mmol/l

1.4

1.3

1.11

123

1208

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.41

0.0

3.8

—

20.6

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.41

0.0

1.1

—

(3023368) Bacteria identified in Blood by Culture

347

1.20

0.41

3.1

4.4

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.41

0.0

1.2

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(4268621)

0.00

0.41

0.0

2.1

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

310

0.81

0.40

1.3

1.4

g/l

2.3

2.5

0.21

182

(3019832) Treponema pallidum Ab [Presence] in Serum

146

0.74

0.38

1.5

1.8

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.48

0.36

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

155

0.76

0.35

5.4

7.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

283

0.82

0.34

1.4

2.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

287

1.19

0.33

1.3

1.7

mg/l

1.0

1.5

0.70

224

(40758558) Short blood count panel - Blood

344

0.84

0.32

4.0

6.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.33

0.31

1.3

1.4

—

(3013512) EKG study

383

0.86

0.29

4.9

4.0

—

(1761868) Lipid panel - Serum or Plasma

516

0.88

0.29

3.1

2.7

—

(3022621) pH of Urine by Test strip

1.28

0.27

2.1

2.2

—

(21494755) Public health laboratory ask at order entry panel

147

0.80

0.24

1.1

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.26

0.23

1.2

1.6

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

1.33

0.23

3.0

1.9

iu/l

2.9

5.9

—

(3023024) Carbon dioxide [Partial pressure] in Capillary blood

0.76

0.23

4.0

2.9

kpa

5.0

5.2

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.29

0.23

1.8

1.4

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.26

0.22

1.0

1.3

g/l

0.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

145

0.81

0.22

3.0

3.5

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.21

0.0

2.5

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.21

0.0

3.4

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.0

—

(3000012) Reticulocyte production index

0.00

0.21

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

0.21

0.0

1.1

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.0

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.4

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.27

0.21

1.1

1.2

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.21

0.0

1.0

—

9.3

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.21

0.0

3.2

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.21

0.0

2.2

—

528.7

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

1.26

0.20

1.3

1.7

mu/l

210.0

345.2

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

2.6

—

(40768806) Pleura Pathology biopsy report

0.00

0.20

0.0

1.8

—

(3020891) Body temperature

1.21

0.20

2.7

4.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

269

0.87

0.20

3.2

3.0

ug/l

1.0

0.7

0.45

176

(4035726)

122

0.81

0.20

1.4

—

(3029937) Albumin [Presence] in Urine by Test strip

370

1.11

0.18

4.2

3.6

estimate

0.0

—

131

(3003327) Ova and parasites identified in Stool by Light microscopy

1.13

0.17

1.6

1.7

—

(3000330) Specific gravity of Urine by Test strip

1.15

0.16

6.9

3.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

0.81

0.15

6.1

8.6

mmol/l

25.1

25.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.82

0.15

1.4

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

476

0.93

0.13

2.4

3.1

—

(3022145) Colonoscopy Study observation

147

0.87

0.12

1.3

—

(3006315) Basophils [#/volume] in Blood

675

1.06

0.11

4.4

5.4

e9/l

0.0

0.04

579

(3000492) Spirometry study

124

0.88

0.09

1.2

1.3

—

(3003694) ABO and Rh group [Type] in Blood

401

1.06

0.09

1.3

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.05

0.08

1.5

1.7

—

(3012544) pH of Venous blood

117

1.12

0.08

3.4

4.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

176

1.09

0.08

1.5

2.2

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.03

0.08

1.6

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

921

1.05

0.08

3.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.09

0.07

1.3

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.09

0.07

1.1

1.3

—

(3015736) pH of Urine

513

1.05

0.07

4.4

3.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.04

0.07

1.6

1.8

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

187

1.08

0.06

1.6

2.4

—

(40761535) Cells panel - Urine sediment

100

1.11

0.05

2.1

3.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

100

1.11

0.05

1.5

2.1

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

159

1.08

0.05

5.5

4.6

29.0

31.8

—

100

(3000850) Epithelial cells [#/volume] in Urine

272

0.95

0.05

1.5

2.4

e6/l

2.6

4.9

0.97

244

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

161

1.06

0.03

1.3

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

319

0.97

0.02

4.5

3.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

304

1.02

0.00

3.8

4.9

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

166

1.03

0.00

1.1

1.6

—

(40761536) Microorganisms panel - Urine sediment

119

1.01

0.00

2.8

3.6

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

219

1.01

0.00

1.3

1.6

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

232

0.99

0.00

2.0

3.4

mmol/l

0.8

0.50

220

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.4

—

(43055514) Macroprolactin [Presence] in Serum or Plasma

0.00

0.0

1.0

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.0

—

18.4

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

0.0

8.9

—

(3034426) Prothrombin time (PT)

0.00

0.0

1.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.4

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3024263) Appearance of Synovial fluid

0.00

0.0

1.4

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.9

—

(3013005) Retinol [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

1.5

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

1.3

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

1.9

—

(4211845)

0.00

0.0

1.0

—

(44813793)

0.00

0.0

1.2

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

0.0

5.2

—

43.2

—

(3027944) Amphetamines [Presence] in Urine

0.84

0.00

1.2

1.4

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.9

—

(40758990) Choriogonadotropin.beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.87

0.00

1.4

—

(3028300) Cannabinoids [Presence] in Urine

0.84

0.00

1.4

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.8

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

6.6

—

206.8

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.0

—

(3028029) Mesothelial cells/100 leukocytes in Pleural fluid

0.00

0.0

1.8

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

1061.1

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

12.7

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.89

0.00

1.6

g/l

1.6

1.1

—

(3012565) Volume of 24 hour Urine

0.00

0.0

1.8

—

1965.8

—

(3036071) Salmonella sp Ab [Titer] in Serum

0.00

0.0

1.0

—

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(40768443) Skin Pathology biopsy report

1.02

0.00

1.3

1.2

—

(3010838) Calcium [Moles/time] in 24 hour Urine

0.00

0.0

1.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.90

0.00

1.1

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.0

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

2.3

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.8

—

(3027008) Opiates [Presence] in Urine

0.86

0.00

1.4

1.3

—

(3015183) Erythrocyte sedimentation rate

0.00

0.0

1.0

—

(4034850)

0.86

0.00

3.8

9.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.2

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

0.0

12.4

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.3

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.8

—

11.8

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

0.0

3.7

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

3.9

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

11.2

—

1198.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

14.4

—

2260.3

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

30.0

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(3010375) cycloSPORINE [Mass/volume] in Blood

0.00

0.0

34.7

—

95.2

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_MYRINGCHRON and mortality.

Females

Parameter	HR [95% CI]	p-value
H8_MYRINGCHRON	0.971 [0.69, 1.37]	0.867
Birth year	0.995 [0.99, 1.0]	0.274

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 610 females with H8_MYRINGCHRON died.

Males

Parameter	HR [95% CI]	p-value
H8_MYRINGCHRON	0.866 [0.64, 1.18]	0.359
Birth year	0.987 [0.98, 1.0]	0.006

During the follow-up period (1.1.1998 — 31.12.2019), 53 out of 607 males with H8_MYRINGCHRON died.

Mortality risk

Mortality risk for people of age

years, who have H8_MYRINGCHRON.

N-year risk	Females	Males
1	0.117%	0.183%
5	0.575%	0.998%
10	1.505%	2.504%
15	2.861%	4.861%
20	4.939%	8.169%

Relationships between endpoints

↥

Index endpoint: H8_MYRINGCHRON – Chronic myringitis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chronic myringitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints