Labyrinthine fistula

H8_LABYRFISTU

labyrinthitis: Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. [ https://en.wikipedia.org/wiki/Labyrinthitis NCIT:C128369 ]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H83.1 Cause of death: ICD-10 — H83.1 2 out of 7 registries used, show all original rules.	107
4. Check minimum number of events None	107
5. Include endpoints None	107
6. Filter based on genotype QC (FinnGen only)	107

Control definitions (FinnGen only)

Control exclude: H8_INNER

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H83
Name in latin: Fistula labyrinthi

NAME	H8_LABYRFISTU
CONTROL_EXCLUDE	H8_INNER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H831
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H831
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Labyrinthine fistula based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	700	312	387
Only index persons	674	299	375
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	52.09	53.73	50.77
Only index persons	51.93	53.52	50.66

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	107	46	61
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	52.32	47.49	55.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1008

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H83.1

ICD-10 Finland

Labyrinthine fistula

+∞

145.6

101

DFD20

NOMESCO Finland

Closure of rupture of round window

+∞

21.6

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

27.1

18.4

H81.3

ICD-10 Finland

Other peripheral vertigo

77.0

17.4

N07CA01

ATC

betahistine; oral

15.5

15.7

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

50.5

14.6

DC1AD

NOMESCO Finland

Temporalbone CT

160.7

13.8

UDC00

NOMESCO Finland

Ear microscopy

10.5

13.1

H71

ICD-10 Finland

Cholesteatoma of middle ear

37.5

13.0

DFF00

NOMESCO Finland

Pure tone audiometry

9.6

12.8

H81.0

ICD-10 Finland

Ménière disease

+∞

12.8

Z01.1

ICD-10 Finland

Examination of ears and hearing

7.5

12.6

R42

ICD-10 Finland

Dizziness and giddiness

5.6

12.3

114

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

5.8

12.1

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

73.7

11.9

H80.0

ICD-10 Finland

Otosclerosis involving oval window, nonobliterative

+∞

10.6

DFD30

NOMESCO Finland

Closure of perilymphatic fistula

+∞

10.6

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

+∞

10.6

DFF59

NOMESCO Finland

Other assessment of balance

61.0

9.9

ZXC10

NOMESCO Finland

Use of laser

24.5

9.6

H80.9

ICD-10 Finland

Otosclerosis, unspecified

+∞

9.5

DCA30

NOMESCO Finland

Exploration of middle ear

+∞

9.5

DDA00

NOMESCO Finland

Stapedotomy

+∞

9.5

H81.1

ICD-10 Finland

Benign paroxysmal vertigo

9.1

9.2

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

24.4

8.2

DCD00

NOMESCO Finland

Myringoplasty

+∞

7.4

H93.1

ICD-10 Finland

Tinnitus

6.6

6.8

H66.9

ICD-10 Finland

Otitis media, unspecified

12.2

6.5

H90.0

ICD-10 Finland

Conductive hearing loss, bilateral

+∞

6.3

DEB30

NOMESCO Finland

Radical mastoidectomy

+∞

6.3

H60.3

ICD-10 Finland

Other infective otitis externa

11.0

6.2

AA1AD

NOMESCO Finland

CT of head and brain

3.3

6.2

146

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3013512) EKG study

274

3.19

8.06

5.2

4.3

—

(3019225) pH of Specimen

3.87

7.44

3.7

4.7

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

108

3.47

7.04

4.7

31.5

32.6

0.20

(3032080) INR in Blood by Coagulation assay

347

2.12

3.58

6.4

7.9

inr

1.2

0.01

103

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

367

2.03

3.19

4.2

4.0

ng/l

36.7

35.1

0.04

262

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

386

1.81

2.33

3.8

5.9

mmol/l

1.2

0.02

347

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

4.08

2.29

1.6

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

190

1.89

2.16

2.1

2.4

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

528

1.79

2.16

3.4

4.4

mmol/l

6.5

6.8

0.63

488

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

5.18

2.09

1.6

1.1

—

(4034850)

2.97

2.05

2.9

14.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

426

1.72

2.02

4.8

6.9

mmol/l

1.2

0.02

361

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.71

1.85

1.3

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

107

1.94

1.68

4.4

9.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

615

1.66

1.60

2.7

3.1

u/l

41.0

50.2

0.79

582

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

286

1.64

1.59

3.1

3.6

ng/l

2403.0

1218.1

0.57

250

(3004616) Nuclear Ab [Presence] in Serum

3.44

1.54

1.2

1.1

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.49

1.50

1.4

2.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.29

1.45

1.3

1.2

—

(42870588) Differential panel, method unspecified - Blood

293

1.58

1.42

3.6

5.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

407

1.54

1.37

3.5

4.3

—

(3049717) Cytology report of Urine Cyto stain

2.19

1.21

2.4

2.9

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

2.38

1.20

1.3

1.4

—

(3007853) Bacteria identified in Skin by Aerobe culture

105

1.74

1.14

1.5

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.45

1.10

1.2

1.5

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

838

1.70

1.08

5.4

5.9

mmol/mol

38.5

40.0

0.84

788

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.07

1.02

1.3

1.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

2.01

0.99

3.6

5.0

mmol/l

25.1

25.0

—

(3044889) 12 lead EKG panel

630

0.71

0.94

4.8

4.2

—

(3031040) Bacteria [#/volume] in Urine by Automated count

573

1.40

0.88

4.6

4.3

—

4631.2

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

243

0.64

0.87

3.4

3.0

ug/l

0.7

0.12

163

(3045414) Leukocytes [Presence] in Urine

1.99

0.86

4.3

1.5

—

(1761868) Lipid panel - Serum or Plasma

347

0.70

0.80

2.6

2.9

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.62

0.80

1.9

1.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.79

0.0

1.2

—

(3020891) Body temperature

1.85

0.74

2.0

5.1

—

(3022313) Gas panel - Capillary blood

1.76

0.71

3.6

4.4

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.53

0.71

2.0

1.8

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.50

0.70

1.8

nmol/l

480.4

351.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

660

1.33

0.66

4.5

4.2

mm/h

10.0

11.4

0.34

610

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

148

1.43

0.66

1.4

1.2

u/ml

3.7

5.1

—

(3052851) Hemolysis interference index of Serum or Plasma

1.76

0.64

2.6

3.1

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

140

1.43

0.64

1.7

2.1

28.1

29.4

0.68

133

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

100

959

1.65

0.62

10.3

10.5

u/l

23.4

26.3

1.87

931

(3017143) Hepatitis C virus Ab [Presence] in Serum

111

0.60

0.62

1.7

1.5

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.61

0.0

1.3

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.60

0.0

1.2

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.59

0.0

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.52

0.59

1.4

1.6

—

(3013115) Eosinophils [#/volume] in Blood

474

1.28

0.58

3.8

6.4

e9/l

0.2

0.15

422

(3006504) Eosinophils/100 leukocytes in Blood

425

1.28

0.58

4.0

6.2

2.6

2.8

0.41

397

(3044640) Blood type and Crossmatch panel - Blood

262

1.32

0.58

1.9

2.5

—

(3019309) Folate [Moles/volume] in Red Blood Cells

179

1.36

0.58

2.0

1.7

nmol/l

1230.1

1297.8

0.13

138

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

555

1.28

0.57

2.8

3.0

—

(3019060) Gas panel - Arterial blood

1.57

0.56

2.0

4.5

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.59

0.55

1.0

2.7

umol/l

3.5

9.0

—

(3023520) Reticulocytes [#/volume] in Blood

1.50

0.54

2.5

2.7

e9/l

73.8

69.3

0.16

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

296

0.76

0.53

1.7

2.9

u/l

24.7

31.2

1.73

279

(3019069) Monocytes/100 leukocytes in Blood

429

1.26

0.53

4.5

6.3

8.0

8.5

0.44

404

(3021601) Nitrite [Presence] in Urine by Test strip

449

0.79

0.50

6.4

5.2

estimate

0.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

250

0.75

0.48

4.5

3.5

—

(3026008) Bacteria identified in Urine by Culture

241

1.28

0.47

3.5

2.9

—

(3018010) Neutrophils/100 leukocytes in Blood

434

1.24

0.46

3.9

5.9

58.3

57.1

0.27

409

(3009261) Glucose [Presence] in Urine by Test strip

456

0.80

0.46

4.4

3.9

estimate

0.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

887

1.37

0.45

5.3

4.5

mmol/l

1.4

0.00

822

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

855

1.33

0.44

12.6

13.7

ml/min/173m2

78.6

80.7

0.46

693

(3037467) Urinalysis macro (dipstick) panel - Urine

616

1.23

0.44

5.5

4.1

—

(3002030) Lymphocytes/100 leukocytes in Blood

437

1.22

0.43

4.3

6.2

27.8

28.0

0.05

409

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

867

1.33

0.43

4.7

4.0

mmol/l

1.2

1.3

0.24

803

(3024928) Oxygen saturation in Venous blood

0.00

0.41

0.0

3.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

283

1.24

0.41

4.7

3.4

mmol/l

2.4

2.3

0.52

241

(3022096) Basophils/100 leukocytes in Blood

409

1.22

0.41

4.2

6.2

0.8

0.7

1.08

382

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.41

0.0

2.0

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.40

0.0

1.8

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.40

0.0

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

891

1.33

0.39

15.5

14.3

mg/l

22.4

21.9

0.05

711

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

0.39

0.0

1.3

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.39

0.0

1.3

—

(36304419) Bacteria [Presence] in Urine

253

0.79

0.38

2.5

2.8

—

(36660697) Celiac disease serology panel - Serum

1.33

0.38

1.3

1.1

—

(40761535) Cells panel - Urine sediment

1.43

0.38

2.5

3.5

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

892

1.33

0.38

5.2

4.5

mmol/l

4.6

0.16

831

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

191

1.26

0.37

1.6

1.8

pmol/l

433.5

464.5

0.24

160

(3011397) Hemoglobin [Presence] in Urine by Test strip

199

0.77

0.37

4.1

3.9

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

344

0.82

0.35

4.6

4.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

203

1.23

0.34

1.5

1.7

mg/l

0.6

1.2

1.26

157

(40758558) Short blood count panel - Blood

238

0.80

0.33

6.4

—

(3042936) Bacteria identified in Isolate by Culture

141

0.75

0.32

1.5

1.7

—

(21494755) Public health laboratory ask at order entry panel

1.37

0.31

1.3

—

(3009343) pH of Capillary blood

1.29

0.30

3.6

4.1

—

7.4

—

(3035350) Ketones [Presence] in Urine by Test strip

441

0.85

0.30

4.4

3.8

estimate

0.0

—

101

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

814

1.22

0.29

5.1

4.3

mu/l

1.6

2.0

2.57

741

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

317

0.84

0.28

4.7

18.1

21.6

0.88

150

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

401

1.17

0.28

5.2

5.1

ug/l

2.1

2.8

0.38

356

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

141

1.24

0.28

1.4

1.9

—

(3019198) Lymphocytes [#/volume] in Blood

472

1.15

0.26

3.8

6.1

e9/l

1.9

1.8

0.18

421

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

912

1.25

0.25

5.5

5.0

mmol/l

2.7

0.03

848

(40761536) Microorganisms panel - Urine sediment

0.73

0.25

3.3

3.5

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

153

1.21

0.24

1.4

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

268

1.17

0.24

2.9

4.2

mg/mmol

2.0

11.6

3.35

179

(40768443) Skin Pathology biopsy report

1.33

0.23

1.8

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.26

0.23

11.0

4.5

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.26

0.23

1.0

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

102

0.77

0.22

1.1

1.8

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

1.3

—

1.2

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.0

—

277.4

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

2.8

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

3.3

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.4

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.21

0.0

4.4

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(4062490)

0.00

0.21

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.3

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.21

0.0

1.5

—

(44790049)

0.00

0.21

0.0

1.5

—

(44806118)

0.00

0.21

0.0

1.5

—

(3014959) Toxoplasma gondii IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

2.3

—

(44790048)

0.00

0.21

0.0

1.5

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

5.8

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

4.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

18.8

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.21

0.0

1.8

—

64.5

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

(44790047)

0.00

0.21

0.0

1.5

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

361

0.88

0.21

2.2

2.4

nmol/l

79.0

77.3

0.15

317

(4146454)

0.00

0.21

0.0

2.8

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.3

—

3.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.24

0.20

6.0

3.4

48.8

51.8

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

0.00

0.20

0.0

2.2

—

4.6

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

0.00

0.20

0.0

3.3

—

59.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

371

1.12

0.19

3.1

2.7

ug/l

221.7

132.5

0.43

341

(3008152) Bicarbonate [Moles/volume] in Arterial blood

1.18

0.18

3.7

8.4

mmol/l

23.7

24.6

—

(40768804) Tissue Pathology biopsy report

354

1.11

0.16

2.6

2.1

—

(3007461) Platelets [#/volume] in Blood

101

994

1.29

0.16

21.8

21.3

e9/l

235.1

243.7

0.97

965

(3009542) Hematocrit [Volume Fraction] of Blood

796

1.13

0.16

13.3

14.9

41.9

40.2

0.95

586

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

664

1.11

0.16

4.0

3.6

pmol/l

14.5

14.9

0.54

598

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.12

0.15

1.0

1.5

—

(3012516) Albumin [Mass/volume] in Urine

257

1.12

0.15

2.3

3.2

mg/l

17.8

82.9

2.49

170

(3024561) Albumin [Mass/volume] in Serum or Plasma

375

1.11

0.15

3.4

4.7

g/l

37.0

35.6

1.21

357

(3000492) Spirometry study

1.11

0.15

1.7

1.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.21

0.14

1.6

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.80

0.14

1.1

1.7

—

(3000494) Fungus identified in Specimen by Culture

106

0.84

0.13

1.3

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

105

0.84

0.13

1.6

1.4

—

(3022145) Colonoscopy Study observation

109

0.81

0.13

1.1

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

127

0.85

0.13

1.6

1.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

883

1.12

0.11

5.0

4.5

mmol/l

5.9

6.0

0.31

818

(46235355) HIV 1 and 2 tests - Meaningful Use set

156

0.88

0.11

1.6

1.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

329

0.92

0.10

3.5

3.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.09

0.10

4.4

3.3

mmol/l

24.7

24.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

214

1.10

0.09

1.4

1.6

nmol/l

13.0

21.9

2.89

178

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.14

0.09

3.2

2.6

pmol/l

3.6

4.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

254

1.08

0.09

2.1

2.9

umol/l

324.8

8405.8

1.53

217

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

723

1.08

0.09

6.3

7.6

u/l

73.0

77.2

0.87

680

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.81

0.08

1.8

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

275

1.07

0.07

2.3

3.1

mmol/l

8.1

7.9

0.10

237

(3004588) Protein electrophoresis panel - Serum or Plasma

1.07

0.07

1.3

2.7

—

(3012544) pH of Venous blood

0.84

0.07

3.4

4.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

213

0.92

0.06

3.4

5.8

—

(3002256) Pathology report gross observation

103

0.86

0.06

1.7

1.2

—

(40768797) Stomach Pathology biopsy report

111

0.89

0.06

1.1

1.3

—

(3023368) Bacteria identified in Blood by Culture

242

0.94

0.05

2.9

4.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

358

1.05

0.05

1.8

1.9

pmol/l

93.7

95.2

0.07

189

(3003694) ABO and Rh group [Type] in Blood

231

0.94

0.04

1.4

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

953

1.07

0.02

17.2

17.1

umol/l

82.0

80.2

0.32

953

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.07

0.01

1.6

2.0

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

214

1.04

0.00

1.8

2.0

mg/l

2.6

3.0

0.46

184

(3027801) Oxygen [Partial pressure] in Arterial blood

1.02

0.00

2.0

7.1

kpa

10.5

11.0

—

(40761511) CBC panel - Blood by Automated count

938

1.02

0.00

15.8

13.4

—

(3007164) IgA [Mass/volume] in Serum or Plasma

183

0.98

0.00

1.3

1.5

g/l

2.3

2.4

—

111

(3013650) Neutrophils [#/volume] in Blood by Automated count

541

1.00

0.00

7.4

10.4

e9/l

4.0

4.1

0.14

479

(4268621)

0.00

0.0

2.0

—

(4027681)

0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.6

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.0

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.00

0.00

1.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.0

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

5.0

—

(4281824)

0.00

0.0

1.1

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.02

0.00

1.0

2.4

1.6

1.4

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

0.0

12.7

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

0.0

1.7

—

(3004451) EKG impression Narrative

0.00

0.0

1.1

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

0.0

1.0

—

(3016502) Oxygen saturation in Arterial blood

1.01

0.00

2.0

7.5

96.7

95.3

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

1.8

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.6

—

(3011648) Oxygen content in Venous blood

0.00

0.0

1.0

—

10.9

—

(40768441) Liver Pathology biopsy report

0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

0.0

1.2

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

19.9

—

1684.6

—

(3047189) Immunofixation for 24 hour Urine

0.00

0.0

2.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

5.0

—

146.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3025577) Chromium [Mass/volume] in Blood

0.00

0.0

2.5

—

2.5

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.0

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

0.0

1.1

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.6

—

(3022621) pH of Urine by Test strip

1.00

0.00

3.7

2.7

—

(3000012) Reticulocyte production index

0.00

0.0

1.5

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

3.6

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.5

—

4.7

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(4035726)

0.99

0.00

1.8

1.3

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

1.2

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.1

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

0.0

1.2

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

1.6

—

16.8

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

63.8

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

0.0

1.6

—

13.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.6

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

3.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

0.0

1.8

—

12.3

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.1

—

(42868414) European tick borne encephalitis virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

0.0

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.90

0.00

3.2

3.9

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

0.0

1.4

—

11.1

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.6

—

10.4

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

15.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_LABYRFISTU and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_LABYRFISTU.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_LABYRFISTU – Labyrinthine fistula

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Labyrinthine fistula

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints